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$300+ Cheap flights from Missouri to Prague (PRG)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PRG
Feb 13 — Feb 201
Fri 2/13
Fri 2/20
1 adult, Economy
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Cheap flight deals from Missouri to Prague

Keep the following information in mind while searching for Missouri to Prague flight deals. Data was last updated January 14, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$433
(oojo)

One-way from

$300
(oojo)

Popular in

May

Cheapest in

April
Provider with most accurate pricing for Lambert-St Louis-Václav Havel Prague flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Václav Havel Prague flights.
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From Missouri to Václav Havel Prague
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One-way flight from Missouri to Václav Havel Prague
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Highest demand for flights based on searches. 17% potential increase in price ($188 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($43 potential savings vs. average RT price).
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Find flight deals from Missouri to Prague

Cheapest flights from Missouri to Prague
Explore the most affordable flight options available from Missouri to Prague. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 14, 2026.

This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/102:54 pm
STL
-
PRG
2 stops24h 56m
British Airways
Tue 2/176:45 am
PRG
-
STL
2 stops24h 03m
British Airways
Deal found 1/13$433
This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/104:37 pm
MCI
-
PRG
2 stops23h 13m
British Airways
Tue 2/176:45 am
PRG
-
MCI
2 stops23h 58m
British Airways
Deal found 1/13$433
This oojo deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2911:44 am
STL
-
PRG
2 stops21h 01m
British Airways
Fri 5/810:10 am
PRG
-
STL
2 stops19h 04m
British Airways
Deal found 1/12$445
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:38 pm
STL
-
PRG
2 stops16h 32m
American Airlines
Tue 3/176:45 am
PRG
-
STL
2 stops19h 31m
American Airlines
Deal found 1/13$453
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1012:03 pm
STL
-
PRG
2 stops17h 52m
American Airlines
Tue 2/176:45 am
PRG
-
STL
2 stops19h 07m
American Airlines
Deal found 1/13$460
This Finnair deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/812:11 pm
STL
-
PRG
2 stops23h 34m
Multiple Airlines
Tue 4/148:40 am
PRG
-
STL
2 stops21h 24m
Multiple Airlines
Deal found 1/13$461
This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/272:00 pm
STL
-
PRG
2 stops24h 05m
British Airways
Wed 3/411:00 am
PRG
-
STL
2 stops19h 22m
British Airways
Deal found 1/13$470
This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1912:11 pm
STL
-
PRG
2 stops18h 24m
British Airways
Sun 4/266:50 am
PRG
-
STL
2 stops22h 24m
British Airways
Deal found 1/13$483
This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:24 am
MCI
-
PRG
2 stops22h 56m
British Airways
Fri 5/810:10 am
PRG
-
MCI
2 stops19h 40m
British Airways
Deal found 1/13$483
This Mytrip deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/44:05 pm
STL
-
PRG
2 stops14h 50m
Multiple Airlines
Wed 3/117:30 am
PRG
-
STL
1 stop13h 25m
Multiple Airlines
Deal found 1/14$484
This Finnair deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:00 am
STL
-
PRG
2 stops28h 50m
Multiple Airlines
Wed 3/117:35 pm
PRG
-
STL
2 stops43h 20m
Multiple Airlines
Deal found 1/13$486
This oojo deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:50 am
STL
-
PRG
2 stops28h 00m
British Airways
Sat 3/77:15 pm
PRG
-
STL
2 stops31h 56m
British Airways
Deal found 1/14$495

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from Missouri to Prague that are best for you.

Fly from

Missouri

Fly to

Prague

Route

Depart

Return

Price

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Wed 3/4

2:00 pm-8:40 pm

2 stops23h 40m

Václav Havel Prague

Wed 3/11

9:30 pm-11:48 pm

2 stops32h 18m

$445

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Wed 4/8

12:11 pm-6:45 pm

2 stops23h 34m

Václav Havel Prague

Tue 4/14

7:30 pm-11:04 pm

2 stops34h 34m

$461

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Fri 2/27

2:00 pm-9:05 pm

2 stops24h 05m

Václav Havel Prague

Mon 3/2

9:35 pm-11:48 pm

2 stops33h 13m

$470

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Wed 3/4

4:05 pm-1:55 pm

2 stops14h 50m

Václav Havel Prague

Wed 3/11

7:30 am-2:55 pm

1 stop13h 25m

$484

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Thu 3/5

9:35 am-6:50 pm

2 stops26h 15m

Václav Havel Prague

Thu 3/12

7:35 pm-8:55 am

2 stops43h 20m

$486

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Thu 3/5

7:00 am-6:50 pm

2 stops28h 50m

Václav Havel Prague

Wed 3/11

7:35 pm-8:55 am

2 stops43h 20m

$486

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Sat 2/28

11:50 am-10:50 pm

2 stops28h 00m

Václav Havel Prague

Sat 3/7

7:15 pm-8:11 pm

2 stops31h 56m

$495

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Thu 3/5

7:41 am-5:55 pm

2 stops27h 14m

Václav Havel Prague

Wed 3/11

7:30 am-2:55 pm

1 stop13h 25m

$500

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Wed 3/4

3:22 pm-4:05 pm

2 stops17h 43m

Václav Havel Prague

Sun 3/8

3:00 pm-12:19 pm

2 stops27h 19m

$500

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Wed 3/4

3:50 pm-9:45 am

1 stop10h 55m

Václav Havel Prague

Wed 3/11

7:30 am-2:55 pm

1 stop13h 25m

$505

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/14

Showing 1-10 of 33 results
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Best time to book a flight from Missouri to Prague

Have a flexible travel schedule? Discover the best time to fly to Prague from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Prague

What is the cheapest month to book a flight from Missouri to Prague?

Currently, December is the cheapest month in which you can book a flight from Missouri to Prague (average of $355). Flying from Missouri to Prague in June is currently the most expensive (average of $1,071). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Prague. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Prague from Missouri?

    Václav Havel Prague (PRG), located 6.9 mi from the city center, is the airport you fly into when you book flights from Missouri to Prague.

  • How long is the flight from Missouri to Prague?

    British Airways, United Airlines, and American Airlines can get you from Missouri to Prague in just under 17h 43m. Your travel time can differ by up to 5h 57m. The distance from Missouri to Prague is about 4907 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Missouri to Prague that include hotel bookings?

    Yes. In addition to deals on Missouri to Prague flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Prague?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Prague.

  • Can I find deals for business class flights from Missouri to Prague?

    Yes. Cheapflights offers flight deals from Missouri to Prague by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Prague?

    Currently, December is the cheapest month in which you can book a flight from Missouri to Prague (average of $355). Flying from Missouri to Prague in June is currently the most expensive (average of $1,071). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Prague

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to Prague

Discover the top 5 airlines that operate flights from Missouri to Prague. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$383Average$797FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$548Average$943FlexibilityNo cancel feeOn-time71%
LufthansaCheapest$556Average$888FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$582Average$742FlexibilityNo cancel feeOn-time70%
DeltaCheapest$608Average$1,217FlexibilityNo cancel feeOn-timeN/A

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