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$355+ Cheap flights from Missouri to Prague (PRG)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PRG
Mar 21 — Mar 281
Sat 3/21
Sat 3/28
1 adult, Economy
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Cheap flight deals from Missouri to Prague

Cheapest flights from Missouri to Prague
Explore the most affordable flight options available from Missouri to Prague. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 19, 2026.

This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:55 pm
STL
-
PRG
2 stops15h 10m
American Airlines
Fri 5/88:40 am
PRG
-
STL
2 stops17h 50m
American Airlines
Deal found 2/18$501
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/44:51 pm
MCI
-
PRG
2 stops17h 09m
American Airlines
Tue 5/128:40 am
PRG
-
MCI
2 stops17h 41m
American Airlines
Deal found 2/18$501
This United Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:45 am
STL
-
PRG
2 stops27h 10m
United Airlines
Thu 4/3011:40 am
PRG
-
STL
2 stops31h 26m
United Airlines
Deal found 2/16$510
This Finnair deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2012:27 pm
STL
-
PRG
2 stops23h 18m
Multiple Airlines
Mon 4/277:30 pm
PRG
-
STL
2 stops31h 00m
Multiple Airlines
Deal found 2/17$512
This Mytrip deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/214:05 pm
STL
-
PRG
2 stops33h 10m
Multiple Airlines
Thu 4/3011:40 am
PRG
-
STL
1 stop32h 45m
Multiple Airlines
Deal found 2/16$521
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:55 pm
STL
-
PRG
2 stops16h 45m
American Airlines
Sun 4/268:40 am
PRG
-
STL
2 stops17h 50m
American Airlines
Deal found 2/17$554
This FlightHub deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/193:30 pm
STL
-
PRG
1 stop19h 25m
Lufthansa
Sun 4/266:10 am
PRG
-
STL
1 stop14h 15m
Lufthansa
Deal found 2/17$557
This United Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/193:30 pm
STL
-
PRG
1 stop19h 25m
United Airlines
Sun 4/266:10 am
PRG
-
STL
1 stop14h 15m
United Airlines
Deal found 2/16$559
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:18 pm
MCI
-
PRG
2 stops21h 02m
United Airlines
Fri 5/86:00 am
PRG
-
MCI
2 stops18h 20m
United Airlines
Deal found 2/17$561
This oojo deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:19 am
MCI
-
PRG
2 stops23h 41m
British Airways
Fri 8/2110:15 am
PRG
-
MCI
1 stop18h 40m
British Airways
Deal found 2/17$566
This Finnair deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:30 am
MCI
-
PRG
2 stops30h 15m
Multiple Airlines
Mon 5/47:30 pm
PRG
-
MCI
2 stops34h 20m
Multiple Airlines
Deal found 2/16$567
This KLM deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/412:25 pm
MCI
-
PRG
2 stops15h 25m
Multiple Airlines
Tue 5/1211:00 am
PRG
-
MCI
1 stop15h 13m
Multiple Airlines
Deal found 2/18$568

Find flight deals from Missouri to Prague

Keep the following information in mind while searching for Missouri to Prague flight deals. Data was last updated February 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$501
(American Airlines)

One-way from

$355
(oojo)

Popular in

May

Cheapest in

April

Average price

$655
Provider with most accurate pricing for Lambert-St Louis-Václav Havel Prague flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Václav Havel Prague flights.
Search Deals
From Missouri to Václav Havel Prague
Search Deals
One-way flight from Missouri to Václav Havel Prague
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($193 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($45 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
Use the filters below to find and compare flights from Missouri to Prague that are best for you.

Fly from

Missouri

Fly to

Prague

Route

Depart

Return

Price

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Wed 4/29

6:55 pm-5:05 pm

2 stops15h 10m

Václav Havel Prague

Fri 5/8

8:40 am-7:30 pm

2 stops17h 50m

$501

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Tue 4/21

7:45 am-5:55 pm

2 stops27h 10m

Václav Havel Prague

Thu 4/30

11:40 am-12:06 pm

2 stops31h 26m

$510

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Mon 4/20

12:27 pm-6:45 pm

2 stops23h 18m

Václav Havel Prague

Mon 4/27

7:30 pm-10:59 pm

2 stops34h 29m

$512

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Wed 4/29

5:21 pm-6:45 pm

2 stops18h 24m

Václav Havel Prague

Fri 5/8

8:40 am-10:19 pm

2 stops20h 39m

$512

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Wed 4/29

9:34 am-6:45 pm

2 stops26h 11m

Václav Havel Prague

Fri 5/8

8:40 am-10:19 pm

2 stops20h 39m

$512

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Tue 4/21

4:05 pm-8:15 am

2 stops33h 10m

Václav Havel Prague

Thu 4/30

11:40 am-1:25 pm

1 stop32h 45m

$521

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Sun 4/19

3:30 pm-5:55 pm

1 stop19h 25m

Václav Havel Prague

Sun 4/26

6:10 am-1:25 pm

1 stop14h 15m

$559

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Fri 4/24

1:54 pm-9:20 pm

2 stops24h 26m

Václav Havel Prague

Fri 5/8

9:10 am-9:26 am

2 stops31h 16m

$561

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Fri 4/24

5:30 am-6:45 pm

2 stops30h 15m

Václav Havel Prague

Mon 5/4

7:30 pm-10:50 pm

2 stops34h 20m

$567

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Fri 4/24

5:18 pm-9:20 pm

2 stops21h 02m

Václav Havel Prague

Mon 5/4

1:25 pm-7:50 pm

2 stops37h 25m

$573

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/16

Showing 1-10 of 24 results
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Best time to book a flight from Missouri to Prague

Have a flexible travel schedule? Discover the best time to fly to Prague from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Prague

What is the cheapest month to book a flight from Missouri to Prague?

Currently, December is the cheapest month in which you can book a flight from Missouri to Prague (average of $349). Flying from Missouri to Prague in June is currently the most expensive (average of $1,104). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Missouri to Prague?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Prague. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Prague from Missouri?

    Václav Havel Prague (PRG), located 6.9 mi from the city center, is the airport you fly into when you book flights from Missouri to Prague.

  • How long is the flight from Missouri to Prague?

    American Airlines and United Airlines can get you from Missouri to Prague in just under 15h 10m. Your travel time can differ by up to 12h. The distance from Missouri to Prague is about 4783 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Missouri to Prague that include hotel bookings?

    Yes. In addition to deals on Missouri to Prague flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Prague?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Prague.

  • Can I find deals for business class flights from Missouri to Prague?

    Yes. Cheapflights offers flight deals from Missouri to Prague by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Prague?

    Currently, December is the cheapest month in which you can book a flight from Missouri to Prague (average of $349). Flying from Missouri to Prague in June is currently the most expensive (average of $1,104). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 5 airlines flying from Missouri to Prague

Discover the top 5 airlines that operate flights from Missouri to Prague. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$383Average$806FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$548Average$959FlexibilityNo cancel feeOn-time71%
LufthansaCheapest$556Average$823FlexibilityNo cancel feeOn-time76%
DeltaCheapest$608Average$1,217FlexibilityNo cancel feeOn-timeN/A
British AirwaysCheapest$648Average$780FlexibilityNo cancel feeOn-time70%

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