HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Prague

$333+ Cheap flights from Missouri to Prague (PRG)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PRG
Nov 22 — Nov 291
Sat 11/22
Sat 11/29
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Prague with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Missouri to Prague

Cheapest flights from Missouri to Prague
Explore the most affordable flight options available from Missouri to Prague. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

This Expedia deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:27 pmMCI - PRG
2 stops35h 18mScandinavian Airlines
Fri 12/123:00 pmPRG - MCI
2 stops39h 55mScandinavian Airlines
Deal found 10/20$546
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:27 pmSTL - PRG
2 stops15h 38mUnited Airlines
Sat 12/136:15 amPRG - STL
2 stops24h 29mUnited Airlines
Deal found 10/22$556
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:42 pmMCI - PRG
2 stops16h 23mDelta
Wed 1/1411:35 amPRG - MCI
2 stops19h 26mDelta
Deal found 10/23$556
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:27 pmMCI - PRG
2 stops20h 58mUnited Airlines
Fri 12/127:35 amPRG - MCI
2 stops21h 23mUnited Airlines
Deal found 10/21$568
This Cheapflightsfares deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/125:30 pmMCI - PRG
2 stops15h 35mLufthansa
Wed 11/197:30 amPRG - MCI
2 stops21h 20mLufthansa
Deal found 10/21$597
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1211:36 amMCI - PRG
3 stops18h 29mUnited Airlines
Wed 11/197:30 amPRG - MCI
2 stops21h 58mUnited Airlines
Deal found 10/21$605
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1611:41 amSTL - PRG
2 stops15h 09mLufthansa
Sat 11/223:10 pmPRG - STL
1 stop29h 45mLufthansa
Deal found 10/21$620
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1610:45 amSTL - PRG
2 stops17h 55mDelta
Sat 11/222:30 pmPRG - STL
2 stops33h 03mDelta
Deal found 10/21$656
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2011:36 amMCI - PRG
2 stops23h 19mUnited Airlines
Wed 11/267:30 amPRG - MCI
2 stops19h 27mUnited Airlines
Deal found 10/21$722
This Cheapflightsfares deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/56:43 pmMCI - PRG
2 stops20h 42mLufthansa
Sun 11/97:25 amPRG - MCI
2 stops20h 44mLufthansa
Deal found 10/21$740
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/74:43 pmSTL - PRG
2 stops22h 42mUnited Airlines
Sun 11/167:25 amPRG - STL
2 stops16h 55mUnited Airlines
Deal found 10/21$755
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/51:47 pmMCI - PRG
2 stops19h 18mUnited Airlines
Sun 11/93:00 pmPRG - MCI
2 stops24h 56mUnited Airlines
Deal found 10/22$755

Cheap flight deals from Missouri to Prague

Keep the following information in mind while searching for Missouri to Prague flight deals. Data was last updated October 23, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$512
(FlightHub)

One-way from

$333
(Kiwi.com)

Popular in

June

Cheapest in

March

Average price

$780
Provider with most accurate pricing for Lambert-St Louis-Václav Havel Prague flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Václav Havel Prague flights.
Search Deals
From Missouri to Václav Havel Prague
Search Deals
One-way flight from Missouri to Václav Havel Prague
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($306 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from Missouri to Prague that are best for you.

Fly from

Missouri

Fly to

Prague

Route

Depart

Return

Price

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Mon 2/9

11:51 am-9:45 am

2 stops38h 54m

Václav Havel Prague

Thu 2/12

10:25 am-8:39 pm

2 stops17h 14m

$512

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Fri 12/5

3:27 pm-9:45 am

2 stops35h 18m

Václav Havel Prague

Fri 12/12

3:00 pm-11:55 pm

2 stops39h 55m

$546

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Sun 1/11

6:30 pm-10:25 pm

2 stops20h 55m

Václav Havel Prague

Tue 1/20

7:25 am-9:59 pm

2 stops21h 34m

$552

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Sat 12/6

5:27 pm-4:05 pm

2 stops15h 38m

Václav Havel Prague

Sat 12/13

6:15 am-11:44 pm

2 stops24h 29m

$556

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Thu 1/8

9:59 am-11:40 am

2 stops18h 41m

Václav Havel Prague

Sat 1/17

2:30 pm-12:01 am

2 stops16h 31m

$556

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Sun 1/11

3:24 pm-4:05 pm

2 stops17h 41m

Václav Havel Prague

Tue 1/20

7:25 am-7:57 pm

2 stops19h 32m

$556

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Wed 12/31

10:42 am-11:40 am

2 stops17h 58m

Václav Havel Prague

Wed 1/14

11:35 am-12:01 am

2 stops19h 26m

$556

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Sun 1/4

5:00 pm-6:10 pm

2 stops18h 10m

Václav Havel Prague

Thu 1/15

10:30 am-11:12 pm

2 stops19h 42m

$567

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Sun 1/4

5:00 pm-8:45 pm

2 stops20h 45m

Václav Havel Prague

Wed 1/14

11:00 am-10:39 pm

2 stops18h 39m

$567

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Fri 12/5

6:27 pm-10:25 pm

2 stops20h 58m

Václav Havel Prague

Fri 12/12

7:35 am-9:58 pm

2 stops21h 23m

$568

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/22

Showing 1-10 of 27 results
1
2
3

Best time to book a flight from Missouri to Prague

Have a flexible travel schedule? Discover the best time to fly to Prague from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Prague

What is the cheapest month to book a flight from Missouri to Prague?

Currently, December is the cheapest month in which you can book a flight from Missouri to Prague (average of $530). Flying from Missouri to Prague in June is currently the most expensive (average of $1,071). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PRG?

Find hourly flight availability from Missouri to Prague. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 23, 2025.

A simple way to save on the total cost of your ticket is to fly from Missouri to Prague in the evening. If you’re flexible enough to do this you can expect to save up to 22% on your trip compared to booking a flight in the afternoon.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Prague. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Prague from Missouri?

    Václav Havel Prague (PRG), located 6.9 mi from the city center, is the airport you fly into when you book flights from Missouri to Prague.

  • How long is the flight from Missouri to Prague?

    Scandinavian Airlines, Lufthansa, and United Airlines can get you from Missouri to Prague in just under 15h 38m. Your travel time can differ by up to 23h 16m. The distance from Missouri to Prague is about 4783 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Missouri to Prague one-way?

    For one-way options, check prices for United Airlines. According to our data, you can fly for as low as $449. Users have also found prices from $456 and $472 on Lufthansa and Air France, respectively.

  • Can I find deals for flights from Missouri to Prague that include hotel bookings?

    Yes. In addition to deals on Missouri to Prague flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Prague?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Prague.

  • Can I find deals for business class flights from Missouri to Prague?

    Yes. Cheapflights offers flight deals from Missouri to Prague by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Prague?

    Currently, December is the cheapest month in which you can book a flight from Missouri to Prague (average of $530). Flying from Missouri to Prague in June is currently the most expensive (average of $1,071). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Prague

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Prague flights
Newark to Prague flights
Boston to Prague flights
Dulles Intl to Prague flights
LaGuardia to Prague flights
Los Angeles to Prague flights
Baltimore to Prague flights
O'Hare Intl to Prague flights
Reagan-National to Prague flights
Miami to Prague flights
San Francisco to Prague flights
Seattle to Prague flights
Atlanta to Prague flights
Dallas/Fort Worth to Prague flights
Ontario to Prague flights
Midway to Prague flights
Philadelphia to Prague flights
Fort Lauderdale to Prague flights
Orlando to Prague flights
Hobby to Prague flights
Charlotte to Prague flights
George Bush Intcntl to Prague flights
Portland to Prague flights
Raleigh to Prague flights
Denver to Prague flights
Love Field to Prague flights
Detroit to Prague flights
San Diego to Prague flights
Tampa to Prague flights
Nashville to Prague flights
Minneapolis to Prague flights
San Jose to Prague flights
West Palm Beach to Prague flights
Austin to Prague flights
Las Vegas to Prague flights
Pensacola to Prague flights
Santa Ana to Prague flights
Oakland to Prague flights
Indianapolis to Prague flights
Kansas City to Prague flights
Columbus to Prague flights
Jacksonville to Prague flights
Sky Harbor Intl to Prague flights
Salt Lake City to Prague flights
Blountville to Prague flights
Sacramento to Prague flights
Burbank to Prague flights
Cleveland to Prague flights
Grand Rapids to Prague flights
Pittsburgh to Prague flights

Top 7 airlines flying from Missouri to Prague

Discover the top 7 airlines that operate flights from Missouri to Prague. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$565Average$1,022FlexibilityNo cancel feeOn-time71%
LufthansaCheapest$571Average$968FlexibilityNo cancel feeOn-time76%
British AirwaysCheapest$582Average$771FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$596Average$975FlexibilityNo cancel feeOn-time69%
DeltaCheapest$628Average$1,169FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$731Average$1,303FlexibilityNo cancel feeOn-time75%
Air CanadaCheapest$745Average$1,087FlexibilityNo cancel feeOn-time67%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.