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Prague

$355+ Cheap flights from Missouri to Prague (PRG)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PRG
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
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Cheap flight deals from Missouri to Prague

Cheapest flights from Missouri to Prague
Explore the most affordable flight options available from Missouri to Prague. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This Gotogate deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/54:05 pm
STL
-
PRG
2 stops41h 00m
Air Canada
Tue 4/212:20 pm
PRG
-
STL
2 stops32h 04m
Air Canada
Deal found 2/9$484
This oojo deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/205:21 pm
STL
-
PRG
2 stops15h 44m
British Airways
Mon 4/278:55 pm
PRG
-
STL
2 stops26h 46m
British Airways
Deal found 2/10$496
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2912:15 pm
STL
-
PRG
2 stops22h 40m
United Airlines
Fri 5/86:00 am
PRG
-
STL
2 stops21h 05m
United Airlines
Deal found 2/9$504
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1910:00 am
STL
-
PRG
2 stops24h 55m
United Airlines
Tue 4/286:15 am
PRG
-
STL
2 stops40h 09m
United Airlines
Deal found 2/9$511
This Finnair deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:21 pm
STL
-
PRG
2 stops18h 24m
Finnair
Fri 5/811:35 am
PRG
-
STL
2 stops17h 44m
Finnair
Deal found 2/9$512
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/53:30 pm
STL
-
PRG
1 stop19h 25m
United Airlines
Tue 4/216:10 am
PRG
-
STL
2 stops21h 58m
United Airlines
Deal found 2/9$517
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:15 am
STL
-
PRG
2 stops23h 40m
United Airlines
Mon 4/271:25 pm
PRG
-
STL
2 stops56h 59m
United Airlines
Deal found 2/9$522
This Iberia deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:05 am
MCI
-
PRG
2 stops24h 45m
Multiple Airlines
Tue 4/286:35 am
PRG
-
MCI
2 stops19h 45m
Multiple Airlines
Deal found 2/11$524
This FlightHub deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/193:30 pm
STL
-
PRG
1 stop12h 15m
Lufthansa
Tue 4/286:40 pm
PRG
-
STL
1 stop25h 45m
Lufthansa
Deal found 2/9$527
This Lufthansa deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lufthansa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/53:30 pm
STL
-
PRG
1 stop19h 25m
Lufthansa
Tue 4/212:20 pm
PRG
-
STL
1 stop30h 05m
Lufthansa
Deal found 2/9$529
This oojo deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:06 pm
MCI
-
PRG
2 stops15h 44m
British Airways
Fri 5/87:05 am
PRG
-
MCI
2 stops22h 53m
British Airways
Deal found 2/9$546
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:55 pm
STL
-
PRG
2 stops16h 45m
American Airlines
Sun 4/268:40 am
PRG
-
STL
2 stops17h 50m
American Airlines
Deal found 2/10$553

Find flight deals from Missouri to Prague

Keep the following information in mind while searching for Missouri to Prague flight deals. Data was last updated February 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$484
(Gotogate)

One-way from

$355
(oojo)

Popular in

May

Cheapest in

April

Average price

$655
Provider with most accurate pricing for Lambert-St Louis-Václav Havel Prague flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Václav Havel Prague flights.
Search Deals
From Missouri to Václav Havel Prague
Search Deals
One-way flight from Missouri to Václav Havel Prague
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($196 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($45 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Missouri to Prague that are best for you.

Fly from

Missouri

Fly to

Prague

Route

Depart

Return

Price

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Sun 4/5

4:05 pm-4:05 pm

2 stops41h 00m

Václav Havel Prague

Tue 4/21

2:20 pm-3:24 pm

2 stops32h 04m

$484

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Wed 4/29

12:15 pm-5:55 pm

2 stops22h 40m

Václav Havel Prague

Fri 5/8

6:00 am-8:05 pm

2 stops21h 05m

$504

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Sun 4/19

10:00 am-5:55 pm

2 stops24h 55m

Václav Havel Prague

Tue 4/28

6:15 am-3:24 pm

2 stops40h 09m

$511

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Mon 4/20

11:15 am-5:55 pm

2 stops23h 40m

Václav Havel Prague

Tue 4/28

6:15 am-3:24 pm

2 stops40h 09m

$511

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Mon 4/20

7:12 am-6:45 pm

2 stops28h 33m

Václav Havel Prague

Mon 4/27

7:30 pm-7:30 pm

2 stops31h 00m

$512

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Wed 4/29

5:21 pm-6:45 pm

2 stops18h 24m

Václav Havel Prague

Fri 5/8

11:35 am-10:19 pm

2 stops17h 44m

$512

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Sun 4/19

7:05 am-6:45 pm

2 stops28h 40m

Václav Havel Prague

Mon 4/27

7:30 pm-7:30 pm

2 stops31h 00m

$512

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Sun 4/5

3:30 pm-5:55 pm

1 stop19h 25m

Václav Havel Prague

Tue 4/21

6:10 am-9:08 pm

2 stops21h 58m

$517

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Tue 4/14

7:05 am-2:50 pm

2 stops24h 45m

Václav Havel Prague

Tue 4/28

6:35 am-7:20 pm

2 stops19h 45m

$524

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Fri 4/24

6:15 am-12:45 pm

2 stops23h 30m

Václav Havel Prague

Fri 5/8

2:30 pm-11:01 pm

2 stops15h 31m

$561

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/10

Showing 1-10 of 29 results
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Best time to book a flight from Missouri to Prague

Have a flexible travel schedule? Discover the best time to fly to Prague from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Prague

What is the cheapest month to book a flight from Missouri to Prague?

Currently, December is the cheapest month in which you can book a flight from Missouri to Prague (average of $349). Flying from Missouri to Prague in June is currently the most expensive (average of $1,104). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Prague. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Prague from Missouri?

    Václav Havel Prague (PRG), located 6.9 mi from the city center, is the airport you fly into when you book flights from Missouri to Prague.

  • How long is the flight from Missouri to Prague?

    Air Canada, United Airlines, and British Airways can get you from Missouri to Prague in just under 18h 42m. Your travel time can differ by up to 22h 18m. The distance from Missouri to Prague is about 4907 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Missouri to Prague that include hotel bookings?

    Yes. In addition to deals on Missouri to Prague flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Prague?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Prague.

  • Can I find deals for business class flights from Missouri to Prague?

    Yes. Cheapflights offers flight deals from Missouri to Prague by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Prague?

    Currently, December is the cheapest month in which you can book a flight from Missouri to Prague (average of $349). Flying from Missouri to Prague in June is currently the most expensive (average of $1,104). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Prague

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to Prague

Discover the top 5 airlines that operate flights from Missouri to Prague. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$383Average$818FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$548Average$959FlexibilityNo cancel feeOn-time71%
LufthansaCheapest$556Average$848FlexibilityNo cancel feeOn-time76%
DeltaCheapest$608Average$1,217FlexibilityNo cancel feeOn-timeN/A
British AirwaysCheapest$648Average$780FlexibilityNo cancel feeOn-time70%

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