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$386+ Cheap flights from Missouri to Prague (PRG)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PRG
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Missouri to Prague

Keep the following information in mind while searching for Missouri to Prague flight deals. Data was last updated September 16, 2025.

Round-trip from

$506
(Flightnetwork)

One-way from

$386
(Ovago)

Popular in

June

Cheapest in

January

Average price

$867
From Missouri to Václav Havel Prague
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One-way flight from Missouri to Václav Havel Prague
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Highest demand for flights based on searches. 27% potential increase in price ($375 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($54 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to Prague

Cheapest flights from Missouri to Prague
Explore the most affordable flight options available from Missouri to Prague. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Flightnetwork deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/199:15 amSTL - PRG
2 stops23h 45mAir Canada
Tue 11/411:50 amPRG - STL
2 stops34h 39mAir Canada
Deal found 9/14$506
This Billigflug deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/193:30 pmSTL - PRG
1 stop19h 20mMultiple Airlines
Tue 11/43:05 pmPRG - STL
2 stops15h 39mMultiple Airlines
Deal found 9/14$516
This Billigflug deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/193:30 pmSTL - PRG
1 stop19h 20mLufthansa
Tue 11/43:05 pmPRG - STL
1 stop29h 50mLufthansa
Deal found 9/14$532
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/314:43 pmSTL - PRG
2 stops23h 42mUnited Airlines
Fri 11/77:35 amPRG - STL
1 stop13h 20mUnited Airlines
Deal found 9/15$578
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3012:31 pmSTL - PRG
2 stops21h 34mUnited Airlines
Thu 11/67:35 amPRG - STL
2 stops38h 54mUnited Airlines
Deal found 9/15$584
This Finnair deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:44 amMCI - PRG
2 stops26h 06mMultiple Airlines
Wed 1/147:35 pmPRG - MCI
2 stops33h 50mMultiple Airlines
Deal found 9/16$585
This Cheapflightsfares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/153:30 pmSTL - PRG
1 stop19h 25mLufthansa
Wed 10/226:00 amPRG - STL
2 stops16h 44mLufthansa
Deal found 9/14$586
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/151:30 pmSTL - PRG
2 stops21h 25mUnited Airlines
Wed 10/2211:40 amPRG - STL
2 stops34h 38mUnited Airlines
Deal found 9/16$589
This Air Canada deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/121:30 pmSTL - PRG
2 stops19h 30mAir Canada
Mon 10/202:30 pmPRG - STL
2 stops55h 48mAir Canada
Deal found 9/14$604
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1511:33 amMCI - PRG
2 stops21h 27mUnited Airlines
Wed 10/226:00 amPRG - MCI
2 stops15h 20mUnited Airlines
Deal found 9/15$643
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/314:50 pmMCI - PRG
2 stops23h 35mUnited Airlines
Fri 11/77:35 amPRG - MCI
2 stops21h 15mUnited Airlines
Deal found 9/16$648
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/167:56 pmMCI - PRG
2 stops17h 14mAmerican Airlines
Thu 10/237:10 amPRG - MCI
2 stops20h 42mAmerican Airlines
Deal found 9/16$688

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Missouri to Prague that are best for you.

Fly from

Missouri

Fly to

Prague

Route

Depart

Return

Price

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Sun 10/19

9:15 am-4:00 pm

2 stops23h 45m

Václav Havel Prague

Tue 11/4

11:50 am-3:29 pm

2 stops34h 39m

$506

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Sun 10/19

3:30 pm-9:40 am

1 stop11h 10m

Václav Havel Prague

Tue 11/4

11:50 am-11:44 pm

2 stops18h 54m

$534

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Tue 12/2

4:05 pm-8:45 am

2 stops33h 40m

Václav Havel Prague

Tue 12/23

7:25 am-3:29 pm

2 stops39h 04m

$534

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Sun 10/19

3:30 pm-5:50 pm

1 stop19h 20m

Václav Havel Prague

Tue 11/4

3:05 pm-1:55 pm

1 stop29h 50m

$547

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Fri 10/31

4:43 pm-10:25 pm

2 stops23h 42m

Václav Havel Prague

Fri 11/7

7:35 am-1:55 pm

1 stop13h 20m

$578

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Thu 10/30

12:31 pm-4:05 pm

2 stops21h 34m

Václav Havel Prague

Thu 11/6

7:35 am-3:29 pm

2 stops38h 54m

$584

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Wed 12/31

9:44 am-6:50 pm

2 stops26h 06m

Václav Havel Prague

Wed 1/14

7:35 pm-8:08 pm

2 stops31h 33m

$585

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Wed 10/15

3:30 pm-5:55 pm

1 stop19h 25m

Václav Havel Prague

Wed 10/22

6:00 am-3:44 pm

2 stops16h 44m

$586

St. LouisPrague

STL - PRG

STLPRG

Lambert-St Louis

Wed 10/15

1:30 pm-5:55 pm

2 stops21h 25m

Václav Havel Prague

Wed 10/22

11:40 am-3:18 pm

2 stops34h 38m

$589

Kansas CityPrague

MCI - PRG

MCIPRG

Kansas City

Sun 1/4

5:00 pm-6:10 pm

2 stops18h 10m

Václav Havel Prague

Thu 1/15

10:30 am-10:04 pm

2 stops18h 34m

$593

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 25 results
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Best time to book a flight from Missouri to Prague

Have a flexible travel schedule? Discover the best time to fly to Prague from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Prague

What is the cheapest month to book a flight from Missouri to Prague?

Currently, November is the cheapest month in which you can book a flight from Missouri to Prague (average of $651). Flying from Missouri to Prague in June is currently the most expensive (average of $1,119). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PRG?

Find hourly flight availability from Missouri to Prague. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Prague as you normally would.

How much does it cost to fly round-trip from Missouri to Prague?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Prague. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Prague from Missouri?

    Václav Havel Prague (PRG), located 6.9 mi from the city center, is the airport you fly into when you book flights from Missouri to Prague.

  • How long is the flight from Missouri to Prague?

    Air Canada, Lufthansa, and American Airlines can get you from Missouri to Prague in just under 18h 10m. Your travel time can differ by up to 5h 35m. The distance from Missouri to Prague is about 4907 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Missouri to Prague one-way?

    For one-way options, check prices for Scandinavian Airlines. According to our data, you can fly for as low as $386. Users have also found prices from $427 and $430 on American Airlines and United Airlines, respectively.

  • Can I find deals for flights from Missouri to Prague that include hotel bookings?

    Yes. In addition to deals on Missouri to Prague flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Prague?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Prague.

  • Can I find deals for business class flights from Missouri to Prague?

    Yes. Cheapflights offers flight deals from Missouri to Prague by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Prague?

    Currently, November is the cheapest month in which you can book a flight from Missouri to Prague (average of $651). Flying from Missouri to Prague in June is currently the most expensive (average of $1,119). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Prague

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Missouri to Prague

Discover the top 7 airlines that operate flights from Missouri to Prague. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$565Average$1,086FlexibilityNo cancel feeOn-time71%
British AirwaysCheapest$582Average$796FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$596Average$1,022FlexibilityNo cancel feeOn-time69%
DeltaCheapest$628Average$1,169FlexibilityNo cancel feeOn-timeN/A
LufthansaCheapest$639Average$986FlexibilityNo cancel feeOn-time76%
KLMCheapest$708Average$1,303FlexibilityNo cancel feeOn-time75%
Air CanadaCheapest$745Average$1,087FlexibilityNo cancel feeOn-time67%

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