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$449+ Cheap flights from Des Moines (DSM) to Prague (PRG)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PRG
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Find flight deals from Des Moines to Prague

Cheapest flights from Des Moines to Prague
Explore the most affordable flight options available from Des Moines to Prague. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This Expedia deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:50 pmDSM - PRG
2 stops14h 15mLufthansa
Mon 12/157:35 amPRG - DSM
2 stops21h 02mLufthansa
Deal found 10/27$546
This lol.travel deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/96:50 pmDSM - PRG
2 stops20h 35mLufthansa
Tue 12/161:45 pmPRG - DSM
2 stops15h 05mLufthansa
Deal found 10/29$548
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/91:31 pmDSM - PRG
2 stops25h 54mUnited Airlines
Tue 12/161:45 pmPRG - DSM
2 stops15h 05mUnited Airlines
Deal found 10/27$556
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:15 pmDSM - PRG
2 stops39h 50mUnited Airlines
Thu 12/183:10 pmPRG - DSM
2 stops38h 20mUnited Airlines
Deal found 10/27$579
This Expedia deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1110:20 amDSM - PRG
2 stops24h 15mMultiple Airlines
Thu 12/1811:35 amPRG - DSM
2 stops16h 11mMultiple Airlines
Deal found 10/27$606
This Expedia deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:28 pmDSM - PRG
2 stops16h 37mBritish Airways
Thu 12/186:45 amPRG - DSM
2 stops18h 20mBritish Airways
Deal found 10/27$723

Cheap flight deals from Des Moines to Prague

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Prague (PRG). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$546
(Expedia)

One-way from

$449
(United Airlines)

Popular in

June

Cheapest in

January

Average price

$827
Provider with most accurate pricing for Des Moines-Václav Havel Prague flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Václav Havel Prague flights.
Search Deals
From Des Moines to Václav Havel Prague
Search Deals
One-way flight from Des Moines to Václav Havel Prague
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($174 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($68 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Des Moines

Fly to

Prague

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 12/9

6:50 pm-10:25 pm

2 stops20h 35m

Václav Havel Prague

Tue 12/16

1:45 pm-9:50 pm

2 stops15h 05m

$546

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 12/8

6:50 pm-4:05 pm

2 stops14h 15m

Václav Havel Prague

Mon 12/15

7:35 am-9:37 pm

2 stops21h 02m

$546

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 12/10

5:15 pm-10:25 pm

2 stops22h 10m

Václav Havel Prague

Wed 12/17

6:15 am-11:44 pm

2 stops24h 29m

$556

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 12/9

1:31 pm-10:25 pm

2 stops25h 54m

Václav Havel Prague

Tue 12/16

1:45 pm-9:50 pm

2 stops15h 05m

$556

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 12/11

10:20 am-5:35 pm

2 stops24h 15m

Václav Havel Prague

Thu 12/18

11:35 am-8:46 pm

2 stops16h 11m

$606

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 3/27

3:15 pm-10:50 am

2 stops13h 35m

Václav Havel Prague

Tue 3/31

6:00 am-5:33 pm

2 stops18h 33m

$656

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 4/25

6:00 am-9:25 pm

2 stops32h 25m

Václav Havel Prague

Fri 5/1

1:25 pm-9:36 pm

2 stops39h 11m

$709

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 12/11

8:15 am-10:25 pm

2 stops31h 10m

Václav Havel Prague

Thu 12/18

7:35 am-9:40 pm

2 stops21h 05m

$712

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 12/11

5:15 pm-10:25 pm

2 stops22h 10m

$449

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 12/12

3:17 pm-10:25 pm

2 stops24h 08m

$462

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 14 results
1
2

Compare providers for flights from Des Moines to Prague

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Prague in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Prague flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Prague flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Prague flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Prague flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Prague flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Prague

Have a flexible travel schedule? Discover the best time to fly to Prague from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Prague

Get insights into the airlines that provide service to Prague. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Prague. Reviews last updated October 29, 2025.
See what other customers who have flown with United Airlines from Des Moines to Prague have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,999 reviews

Food

6.6

Crew

8.1

Boarding

7.7

Overall

7.4

Entertainment

7.1

Comfort

7.3

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
8,999 reviews
United Airlines
7.4
Good
8,999 reviews

Food

6.6

Crew

8.1

Boarding

7.7

Overall

7.4

Entertainment

7.1

Comfort

7.3

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Prague. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Prague?

    Lufthansa and United Airlines can get you from Des Moines to Prague in just under 20h 35m. Your travel time can differ by up to 1h 35m. Des Moines and Prague are separated by a distance of 4753 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Des Moines to Prague round-trip?

    Our cheapest airline available from Des Moines to Prague is United Airlines. Our recent data shows that you can find tickets from as low as $597 on this airline. United Airlines is priced at 34% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Prague one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $449. Delta flights start at $528 while deals on Air Canada start at $601 one-way.

  • Can I find deals for flights from Des Moines to Prague that include hotel bookings?

    Yes. In addition to deals on Des Moines to Prague flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Prague?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Prague.

  • Can I find deals for business class flights from Des Moines to Prague?

    Yes. Cheapflights offers flight deals from Des Moines to Prague by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top airline flying from Des Moines to Prague

Discover the top airline that operate flights from Des Moines to Prague. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$597Average$939FlexibilityNo cancel feeOn-time69%

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