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$404+ Cheap flights from Des Moines (DSM) to Prague (PRG)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PRG
ene. 11 — ene. 181
dom. 1/11
dom. 1/18
1 adult, Economy
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Cheap flight deals from Des Moines to Prague

Cheapest flights from Des Moines to Prague
Explore the most affordable flight options available from Des Moines to Prague. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.

This oojo deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/296:52 pmDSM - PRG
2 stops35h 03mBritish Airways
jue. 1/156:45 amPRG - DSM
2 stops21h 19mBritish Airways
Deal found 12/10$786
This FlightHub deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/296:46 pmDSM - PRG
2 stops55h 59mLufthansa
jue. 1/157:35 amPRG - DSM
2 stops21h 15mLufthansa
Deal found 12/11$803
This Air Canada deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/2911:35 amDSM - PRG
3 stops19h 20mAir Canada
jue. 1/157:35 amPRG - DSM
3 stops21h 15mAir Canada
Deal found 12/11$2,005
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/206:46 pmDSM - PRG
2 stops40h 09mUnited Airlines
sáb. 12/271:45 pmPRG - DSM
2 stops39h 45mUnited Airlines
Deal found 12/11$2,032
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/2210:29 amDSM - PRG
2 stops23h 36mDelta
jue. 12/256:00 amPRG - DSM
2 stops21h 45mDelta
Deal found 12/11$2,141
This Air Canada deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/2211:35 amDSM - PRG
3 stops19h 20mAir Canada
jue. 12/256:50 amPRG - DSM
3 stops21h 50mAir Canada
Deal found 12/11$2,554
This Air Canada deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/2011:35 amDSM - PRG
3 stops18h 30mAir Canada
sáb. 12/277:35 amPRG - DSM
3 stops21h 05mAir Canada
Deal found 12/11$3,583
This AranGrant deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure AranGrant is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/291:25 pmDSM - PRG
2 stops18h 30mMultiple Airlines
jue. 1/156:45 amPRG - DSM
2 stops21h 19mMultiple Airlines
Deal found 12/10$4,675

Find flight deals from Des Moines to Prague

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Prague (PRG). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated diciembre 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$465
(Ticket)

One-way from

$404
(Flightnetwork)
Provider with most accurate pricing for Des Moines-Václav Havel Prague flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Václav Havel Prague flights.
Search Deals
From Des Moines to Václav Havel Prague
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One-way flight from Des Moines to Václav Havel Prague
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Des Moines

Fly to

Prague

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

sáb. 1/24

6:48 pm-10:25 pm

2 stops20h 37m

Václav Havel Prague

sáb. 1/31

7:35 am-9:50 pm

2 stops21h 15m

$465

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

vie. 1/23

5:16 pm-5:05 pm

2 stops16h 49m

Václav Havel Prague

vie. 1/30

6:00 am-3:45 pm

2 stops16h 45m

$471

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

mar. 1/20

3:35 pm-1:05 pm

2 stops14h 30m

Václav Havel Prague

mar. 1/27

7:25 am-10:30 pm

2 stops22h 05m

$479

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

dom. 1/25

6:48 pm-4:05 pm

2 stops14h 17m

Václav Havel Prague

dom. 2/1

10:30 am-9:50 pm

2 stops18h 20m

$489

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

dom. 1/25

5:49 pm-5:05 pm

2 stops16h 16m

Václav Havel Prague

dom. 2/1

6:00 am-5:08 pm

2 stops18h 08m

$489

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

vie. 1/23

6:48 pm-10:25 pm

2 stops20h 37m

Václav Havel Prague

vie. 1/30

1:45 pm-9:50 pm

2 stops15h 05m

$491

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

sáb. 1/24

6:48 pm-10:25 pm

2 stops20h 37m

Václav Havel Prague

sáb. 1/31

10:30 am-9:50 pm

2 stops18h 20m

$494

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

sáb. 1/24

6:48 pm-10:25 pm

2 stops20h 37m

$404

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

dom. 1/25

6:48 pm-4:05 pm

2 stops14h 17m

$407

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

dom. 1/25

8:00 am-9:50 am

3 stops18h 50m

$422

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/9

Showing 1-10 of 11 results
1
2

Compare providers for flights from Des Moines to Prague

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Prague in December.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Prague flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Prague flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Prague flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Prague flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Prague flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Prague

Have a flexible travel schedule? Discover the best time to fly to Prague from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Prague

Get insights into the airlines that provide service to Prague. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Prague. Reviews last updated diciembre 12, 2025.
See what other customers who have flown with United Airlines from Des Moines to Prague have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,095 reviews

Boarding

7.7

Entertainment

7.1

Comfort

7.3

Crew

8.1

Overall

7.4

Food

6.6

Reviews

1 / 20
10.0
Excellent

Sunderesh,Dec 2025

AUS - EWR

Smooth flight from Austin to Newark. The crew was friendly.
United Airlines
7.4
Good
9,095 reviews
United Airlines
7.4
Good
9,095 reviews

Boarding

7.7

Entertainment

7.1

Comfort

7.3

Crew

8.1

Overall

7.4

Food

6.6

Reviews

1 / 20
10.0
Excellent

Sunderesh,Dec 2025

AUS - EWR

Smooth flight from Austin to Newark. The crew was friendly.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Prague. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Prague?

    Lufthansa can get you from Des Moines to Prague in just under 20h 37m. Your travel time can differ by up to . Des Moines and Prague are separated by a distance of 4753 mi.

  • What is the cheapest airline to fly from Des Moines to Prague round-trip?

    Our cheapest airline available from Des Moines to Prague is United Airlines. Our recent data shows that you can find tickets from as low as $597 on this airline.

  • Can I find deals for flights from Des Moines to Prague that include hotel bookings?

    Yes. In addition to deals on Des Moines to Prague flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Prague?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Prague.

  • Can I find deals for business class flights from Des Moines to Prague?

    Yes. Cheapflights offers flight deals from Des Moines to Prague by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top airline flying from Des Moines to Prague

Discover the top airline that operate flights from Des Moines to Prague. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$597Average$939FlexibilityNo cancel feeOn-time69%

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