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$422+ Cheap flights from Des Moines (DSM) to Prague (PRG)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PRG
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheap flight deals from Des Moines to Prague

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Prague (PRG). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 11, 2025.

Round-trip from

$534
(Ticket)

One-way from

$422
(American Airlines)

Popular in

June

Cheapest in

January

Average price

$989
From Des Moines to Václav Havel Prague
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One-way flight from Des Moines to Václav Havel Prague
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Highest demand for flights based on searches. 19% potential increase in price ($229 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($65 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Prague

Cheapest flights from Des Moines to Prague
Explore the most affordable flight options available from Des Moines to Prague. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This Ticket deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ticket is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/275:56 pmDSM - PRG
2 stops17h 09mAir France
lun. 11/36:05 pmPRG - DSM
2 stops35h 25mAir France
Deal found 9/11$534
This Billigflug deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/275:56 pmDSM - PRG
2 stops17h 09mMultiple Airlines
lun. 11/311:35 amPRG - DSM
2 stops37h 09mMultiple Airlines
Deal found 9/11$558
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/266:07 pmDSM - PRG
2 stops18h 03mAmerican Airlines
dom. 11/25:50 amPRG - DSM
2 stops23h 04mAmerican Airlines
Deal found 9/11$575
This Ticket deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ticket is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/2512:30 pmDSM - PRG
2 stops22h 35mAir France
sáb. 11/16:30 amPRG - DSM
2 stops16h 22mAir France
Deal found 9/10$608
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/256:22 pmDSM - PRG
2 stops19h 28mAmerican Airlines
sáb. 11/17:40 amPRG - DSM
2 stops19h 33mAmerican Airlines
Deal found 9/10$633
This British Airways deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/266:07 pmDSM - PRG
2 stops18h 03mBritish Airways
dom. 11/210:55 amPRG - DSM
2 stops19h 55mBritish Airways
Deal found 9/11$664

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Des Moines

Fly to

Prague

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

lun. 10/27

5:56 pm-5:05 pm

2 stops17h 09m

Václav Havel Prague

lun. 11/3

11:35 am-5:44 pm

2 stops37h 09m

$558

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

dom. 10/26

6:07 pm-6:10 pm

2 stops18h 03m

Václav Havel Prague

dom. 11/2

5:50 am-10:54 pm

2 stops23h 04m

$575

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

sáb. 10/25

6:22 pm-8:50 pm

2 stops19h 28m

Václav Havel Prague

sáb. 11/1

7:40 am-9:13 pm

2 stops19h 33m

$633

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

dom. 10/26

1:48 pm-1:35 pm

2 stops17h 47m

Václav Havel Prague

dom. 11/2

10:55 am-11:50 pm

2 stops19h 55m

$664

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

dom. 10/26

3:48 pm-6:10 pm

2 stops20h 22m

$422

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

lun. 10/27

6:39 pm-5:05 pm

2 stops16h 26m

$437

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

lun. 10/27

3:15 pm-2:15 pm

3 stops17h 00m

$496

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

dom. 10/26

11:26 am-9:50 am

3 stops16h 24m

$2,924

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Des Moines to Prague

Have a flexible travel schedule? Discover the best time to fly to Prague from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Prague

Get insights into the airlines that provide service to Prague. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Prague. Reviews last updated septiembre 11, 2025.
See what other customers who have flown with United Airlines from Des Moines to Prague have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,937 reviews

Comfort

7.3

Entertainment

7.1

Overall

7.4

Food

6.6

Crew

8.1

Boarding

7.7

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
United Airlines
7.4
Good
8,937 reviews
United Airlines
7.4
Good
8,937 reviews

Comfort

7.3

Entertainment

7.1

Overall

7.4

Food

6.6

Crew

8.1

Boarding

7.7

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Prague. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Prague?

    American Airlines can get you from Des Moines to Prague in just under 18h 03m. Your travel time can differ by up to . Des Moines and Prague are separated by a distance of 4753 mi.

  • What is the cheapest airline to fly from Des Moines to Prague round-trip?

    Our cheapest airline available from Des Moines to Prague is United Airlines. Our recent data shows that you can find tickets from as low as $588 on this airline. United Airlines is priced at 37% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Prague one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $422. Air France flights start at $437 while deals on Air Canada start at $496 one-way.

  • Can I find deals for flights from Des Moines to Prague that include hotel bookings?

    Yes. In addition to deals on Des Moines to Prague flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Prague?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Prague.

  • Can I find deals for business class flights from Des Moines to Prague?

    Yes. Cheapflights offers flight deals from Des Moines to Prague by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Prague?

    Currently, November is the cheapest month in which you can book a flight from Des Moines to Prague (average of $651). Flying from Des Moines to Prague in June is currently the most expensive (average of $1,119). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Des Moines to Prague

Discover the top airline that operate flights from Des Moines to Prague. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$588Average$903FlexibilityNo cancel feeOn-time69%

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