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$267+ Cheap flights from Des Moines (DSM) to Prague (PRG)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PRG
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Des Moines to Prague

Cheapest flights from Des Moines to Prague
Explore the most affordable flight options available from Des Moines to Prague. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/125:47 pm
DSM
-
PRG
2 stops18h 48m
Delta
Tue 4/216:00 am
PRG
-
DSM
2 stops16h 41m
Delta
Deal found 1/25$507
This Expedia deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/95:47 pm
DSM
-
PRG
2 stops17h 48m
KLM
Mon 3/166:30 pm
PRG
-
DSM
2 stops28h 24m
KLM
Deal found 1/27$508
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:59 pm
DSM
-
PRG
2 stops14h 06m
United Airlines
Fri 4/176:00 am
PRG
-
DSM
2 stops22h 27m
United Airlines
Deal found 1/25$510
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/74:25 pm
DSM
-
PRG
2 stops14h 20m
Delta
Mon 4/202:30 pm
PRG
-
DSM
2 stops32h 11m
Delta
Deal found 1/25$513
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:11 pm
DSM
-
PRG
2 stops21h 09m
United Airlines
Mon 4/201:25 pm
PRG
-
DSM
2 stops38h 09m
United Airlines
Deal found 1/25$522
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/93:21 pm
DSM
-
PRG
2 stops19h 34m
United Airlines
Tue 4/216:10 am
PRG
-
DSM
2 stops15h 15m
United Airlines
Deal found 1/25$560
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:59 pm
DSM
-
PRG
2 stops38h 06m
United Airlines
Sun 4/196:15 am
PRG
-
DSM
2 stops19h 00m
United Airlines
Deal found 1/25$561
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/93:21 pm
DSM
-
PRG
2 stops22h 59m
United Airlines
Mon 4/201:25 pm
PRG
-
DSM
2 stops52h 19m
United Airlines
Deal found 1/25$572
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/103:21 pm
DSM
-
PRG
2 stops39h 34m
United Airlines
Mon 4/201:25 pm
PRG
-
DSM
2 stops52h 19m
United Airlines
Deal found 1/25$579
This KAYAK deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:59 pm
DSM
-
PRG
2 stops32h 56m
Lufthansa
Sat 4/184:40 pm
PRG
-
DSM
2 stops35h 47m
Lufthansa
Deal found 1/25$589
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:04 am
DSM
-
PRG
2 stops19h 51m
United Airlines
Sat 4/182:40 pm
PRG
-
DSM
2 stops30h 45m
United Airlines
Deal found 1/25$593
This oojo deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:00 pm
DSM
-
PRG
2 stops16h 50m
British Airways
Sun 5/106:50 am
PRG
-
DSM
2 stops19h 41m
British Airways
Deal found 1/27$595

Find flight deals from Des Moines to Prague

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Prague (PRG). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$507
(Delta)

One-way from

$267
(Kiwi.com)
Provider with most accurate pricing for Des Moines-Václav Havel Prague flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Václav Havel Prague flights.
Search Deals
From Des Moines to Václav Havel Prague
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One-way flight from Des Moines to Václav Havel Prague
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Prague that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Des Moines to Prague that are best for you.

Fly from

Des Moines

Fly to

Prague

Route

Depart

Return

Price

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 4/12

5:47 pm-9:45 pm

2 stops20h 58m

Václav Havel Prague

Wed 4/22

6:00 am-8:39 pm

2 stops21h 39m

$507

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 4/13

2:44 pm-9:45 pm

2 stops24h 01m

Václav Havel Prague

Mon 4/20

8:50 am-3:41 pm

2 stops37h 51m

$507

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 4/13

5:45 pm-3:00 pm

2 stops14h 15m

Václav Havel Prague

Thu 4/23

6:00 am-8:39 pm

2 stops21h 39m

$507

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Mon 3/9

5:47 pm-5:35 pm

2 stops17h 48m

Václav Havel Prague

Mon 3/16

6:30 pm-4:54 pm

2 stops28h 24m

$508

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 3/10

5:30 am-4:05 pm

2 stops28h 35m

Václav Havel Prague

Tue 3/17

7:25 am-2:18 pm

2 stops36h 53m

$510

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 4/8

3:21 pm-5:55 pm

2 stops19h 34m

Václav Havel Prague

Fri 4/17

6:00 am-9:27 pm

2 stops22h 27m

$510

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 4/8

1:10 pm-5:55 pm

2 stops21h 45m

Václav Havel Prague

Tue 4/21

6:10 am-8:34 pm

2 stops21h 24m

$510

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 4/11

6:59 pm-4:05 pm

2 stops38h 06m

Václav Havel Prague

Wed 4/22

6:10 am-6:15 pm

2 stops19h 05m

$510

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sat 4/11

6:59 pm-4:05 pm

2 stops38h 06m

Václav Havel Prague

Thu 4/23

6:00 am-2:25 pm

2 stops15h 25m

$510

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Tue 4/7

4:25 pm-1:45 pm

2 stops14h 20m

Václav Havel Prague

Mon 4/20

2:30 pm-3:41 pm

2 stops32h 11m

$513

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 20 results
1
2
  • Most accurate provider: When it comes to deals on Des Moines-Prague flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Prague flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Prague flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Prague flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Prague flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Prague

Have a flexible travel schedule? Discover the best time to fly to Prague from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Prague

Get insights into the airlines that provide service to Prague. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Prague. Reviews last updated January 28, 2026.
See what other customers who have flown with United Airlines from Des Moines to Prague have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,209 reviews

Food

6.6

Boarding

7.7

Crew

8.1

Entertainment

7.1

Comfort

7.3

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,209 reviews
United Airlines
7.4
Good
9,209 reviews

Food

6.6

Boarding

7.7

Crew

8.1

Entertainment

7.1

Comfort

7.3

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Prague. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Prague?

    Delta and KLM can get you from Des Moines to Prague in just under 17h 48m. Your travel time can differ by up to 3h 10m. Des Moines and Prague are separated by a distance of 4753 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Des Moines to Prague round-trip?

    Our cheapest airline available from Des Moines to Prague is United Airlines. Our recent data shows that you can find tickets from as low as $597 on this airline.

  • Can I find deals for flights from Des Moines to Prague that include hotel bookings?

    Yes. In addition to deals on Des Moines to Prague flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Prague?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Prague.

  • Can I find deals for business class flights from Des Moines to Prague?

    Yes. Cheapflights offers flight deals from Des Moines to Prague by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top airline flying from Des Moines to Prague

Discover the top airline that operate flights from Des Moines to Prague. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$597Average$903FlexibilityNo cancel feeOn-time69%

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