$399+ Cheap flights from Des Moines (DSM) to the Czech Republic
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/18. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PRG
May 11 — May 181
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to Czech Republic with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Czech Republic
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to Czech RepublicExplore the most affordable flight options available from Des Moines to Czech Republic. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2026.
Explore the most affordable flight options available from Des Moines to Czech Republic. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2026.
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:12 pm
DSM
- PRG
2 stops15h 53m
American Airlines
Wed 8/1910:15 am
PRG
- DSM
1 stop20h 40m
American Airlines
Deal found 4/7![American Airlines logo]()
$721
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:15 pm
DSM
- PRG
2 stops14h 50m
United Airlines
Fri 11/133:10 pm
PRG
- DSM
2 stops14h 51m
United Airlines
Deal found 4/9![United Airlines logo]()
$739
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/108:03 pm
DSM
- PRG
2 stops15h 37m
American Airlines
Tue 5/2610:15 am
PRG
- DSM
1 stop18h 43m
American Airlines
Deal found 4/8![American Airlines logo]()
$830
This Finnair deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1011:11 am
DSM
- PRG
2 stops24h 34m
Multiple Airlines
Tue 5/267:30 pm
PRG
- DSM
2 stops35h 27m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$861
This Air Canada deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:23 am
DSM
- PRG
2 stops16h 27m
Multiple Airlines
Wed 8/199:35 am
PRG
- DSM
3 stops16h 49m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$875
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:05 pm
DSM
- PRG
2 stops39h 50m
United Airlines
Tue 5/266:50 am
PRG
- DSM
2 stops15h 58m
United Airlines
Deal found 4/7![United Airlines logo]()
$905
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:41 pm
DSM
- PRG
2 stops15h 59m
Delta
Mon 5/1811:00 am
PRG
- DSM
2 stops18h 32m
Delta
Deal found 4/9![Delta logo]()
$907
Best flights from Des Moines to Czech RepublicDiscover carefully curated flight deals from Des Moines to Czech Republic that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 11, 2026.
Discover carefully curated flight deals from Des Moines to Czech Republic that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 11, 2026.
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/108:03 pm
DSM
- PRG
2 stops15h 37m
American Airlines
Tue 5/2610:15 am
PRG
- DSM
1 stop18h 43m
American Airlines
Deal found 4/8![American Airlines logo]()
$830
This Finnair deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1011:11 am
DSM
- PRG
2 stops24h 34m
Multiple Airlines
Tue 5/267:30 pm
PRG
- DSM
2 stops35h 27m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$861
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:29 pm
DSM
- PRG
2 stops26h 16m
Delta
Sun 5/176:00 am
PRG
- DSM
2 stops17h 48m
Delta
Deal found 4/9![Delta logo]()
$957
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
DSM
- PRG
2 stops23h 45m
United Airlines
Tue 6/26:50 am
PRG
- DSM
2 stops18h 24m
United Airlines
Deal found 4/11![United Airlines logo]()
$1,039
This Finnair deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:30 am
DSM
- PRG
2 stops29h 15m
Multiple Airlines
Sat 8/157:30 pm
PRG
- DSM
2 stops30h 26m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$940
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:45 pm
DSM
- PRG
2 stops21h 00m
Delta
Sun 5/106:00 am
PRG
- DSM
2 stops21h 36m
Delta
Deal found 4/10![Delta logo]()
$987
This Finnair deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:09 am
DSM
- PRG
2 stops24h 36m
Multiple Airlines
Sun 5/108:40 am
PRG
- DSM
2 stops22h 09m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$991
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:04 pm
DSM
- PRG
2 stops21h 36m
Delta
Thu 5/2811:00 am
PRG
- DSM
2 stops29h 46m
Delta
Deal found 4/7![Delta logo]()
$1,120
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:15 am
DSM
- PRG
2 stops19h 45m
Delta
Tue 6/211:00 am
PRG
- DSM
2 stops29h 46m
Delta
Deal found 4/10![Delta logo]()
$1,166
Last-minute flights from Des Moines to Czech RepublicDiscover last-minute flight deals from Des Moines to Czech Republic. Data last updated April 11, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Czech Republic. Data last updated April 11, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:45 pm
DSM
- PRG
2 stops21h 00m
Delta
Sun 5/106:00 am
PRG
- DSM
2 stops21h 36m
Delta
Deal found 4/10![Delta logo]()
$987
This Finnair deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:09 am
DSM
- PRG
2 stops24h 36m
Multiple Airlines
Sun 5/108:40 am
PRG
- DSM
2 stops22h 09m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$991
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:05 pm
DSM
- PRG
2 stops39h 50m
United Airlines
Tue 5/266:50 am
PRG
- DSM
2 stops15h 58m
United Airlines
Deal found 4/7![United Airlines logo]()
$905
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:25 pm
DSM
- PRG
2 stops22h 20m
Delta
Sat 5/1611:00 am
PRG
- DSM
2 stops31h 08m
Delta
Deal found 4/9![Delta logo]()
$953
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:29 pm
DSM
- PRG
2 stops26h 16m
Delta
Sun 5/176:00 am
PRG
- DSM
2 stops17h 48m
Delta
Deal found 4/9![Delta logo]()
$957
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/108:03 pm
DSM
- PRG
2 stops15h 37m
American Airlines
Tue 5/2610:15 am
PRG
- DSM
1 stop18h 43m
American Airlines
Deal found 4/8![American Airlines logo]()
$830
This Finnair deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1011:11 am
DSM
- PRG
2 stops24h 34m
Multiple Airlines
Tue 5/267:30 pm
PRG
- DSM
2 stops35h 27m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$861
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1011:40 am
DSM
- PRG
2 stops23h 15m
United Airlines
Sun 5/176:10 am
PRG
- DSM
2 stops22h 13m
United Airlines
Deal found 4/9![United Airlines logo]()
$910
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:41 pm
DSM
- PRG
2 stops15h 59m
Delta
Mon 5/1811:00 am
PRG
- DSM
2 stops18h 32m
Delta
Deal found 4/9![Delta logo]()
$907
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:41 pm
DSM
- PRG
2 stops15h 59m
Delta
Sun 5/176:00 am
PRG
- DSM
2 stops17h 48m
Delta
Deal found 4/9![Delta logo]()
$911
One-way flights from Des Moines to Czech RepublicSearch for one-way flight options from Des Moines to Czech Republic. Find affordable one-way fares based on user searches. Data last updated April 11, 2026.
Search for one-way flight options from Des Moines to Czech Republic. Find affordable one-way fares based on user searches. Data last updated April 11, 2026.
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/185:50 am
DSM
- PRG
2 stops46h 00m
United Airlines
Deal found 4/11![United Airlines logo]()
$399
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/181:39 pm
DSM
- PRG
3 stops36h 41m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$633
This Ovago deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:48 pm
DSM
- PRG
2 stops38h 22m
Aer Lingus
Deal found 4/11![Aer Lingus logo]()
$664
This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:02 am
DSM
- PRG
1 stop19h 13m
American Airlines
Deal found 4/11![American Airlines logo]()
$731
This Air France deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2610:56 am
DSM
- PRG
2 stops15h 04m
Air France
Deal found 4/10![Air France logo]()
$845
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
DSM
- PRG
3 stops28h 50m
United Airlines
Deal found 4/11![United Airlines logo]()
$875
This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:02 am
DSM
- PRG
1 stop19h 13m
American Airlines
Deal found 4/11![American Airlines logo]()
$1,165
This Air Canada deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2611:23 am
DSM
- PRG
3 stops16h 27m
Air Canada
Deal found 4/10![Air Canada logo]()
$1,236
Find flight deals from Des Moines to Czech Republic
Keep the following information in mind while searching for Des Moines to Czech Republic flight deals. Data was last updated April 11, 2026.
Round-trip from | $721 (American Airlines) |
|---|---|
One-way from | $399 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Czech Republic that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2026.
Use the filters below to find and compare flights from Des Moines to the Czech Republic that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesPrague
DSM - PRG
DSMPRG
Des Moines
Sun 5/10
8:03 pm-6:40 pm
2 stops15h 37m
Václav Havel Prague
Tue 5/26
10:15 am-9:58 pm
1 stop18h 43m
$830
Des MoinesPrague
DSM - PRG
DSMPRG
Des Moines
Sun 5/10
11:11 am-6:45 pm
2 stops24h 34m
Václav Havel Prague
Tue 5/26
7:30 pm-11:57 pm
2 stops35h 27m
$861
Des MoinesPrague
DSM - PRG
DSMPRG
Des Moines
Sun 8/9
6:30 am-6:45 pm
2 stops29h 15m
Václav Havel Prague
Sat 8/15
7:30 pm-6:56 pm
2 stops30h 26m
$940
Des MoinesPrague
DSM - PRG
DSMPRG
Des Moines
Sat 5/9
12:29 pm-9:45 pm
2 stops26h 16m
Václav Havel Prague
Sun 5/17
6:00 am-4:48 pm
2 stops17h 48m
$957
Des MoinesPrague
DSM - PRG
DSMPRG
Des Moines
Fri 5/1
5:45 pm-9:45 pm
2 stops21h 00m
Václav Havel Prague
Sun 5/10
6:00 am-8:36 pm
2 stops21h 36m
$987
Des MoinesPrague
DSM - PRG
DSMPRG
Des Moines
Fri 5/1
11:09 am-6:45 pm
2 stops24h 36m
Václav Havel Prague
Sun 5/10
8:40 am-11:49 pm
2 stops22h 09m
$991
Des MoinesPrague
DSM - PRG
DSMPRG
Des Moines
Tue 5/26
6:00 am-12:45 pm
2 stops23h 45m
Václav Havel Prague
Tue 6/2
6:50 am-6:14 pm
2 stops18h 24m
$1,039
Des MoinesPrague
DSM - PRG
DSMPRG
Des Moines
Thu 5/21
1:04 pm-5:40 pm
2 stops21h 36m
Václav Havel Prague
Thu 5/28
11:00 am-9:46 am
2 stops29h 46m
$1,120
Des MoinesPrague
DSM - PRG
DSMPRG
Des Moines
Tue 5/26
6:15 am-9:00 am
2 stops19h 45m
Václav Havel Prague
Tue 6/2
11:00 am-9:46 am
2 stops29h 46m
$1,166
Cheapest one-way
Des MoinesPrague
DSM - PRG
DSMPRG
Des Moines
Sat 7/18
5:50 am-10:50 am
2 stops46h 00m
$399
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Czech Republic
Have a flexible travel schedule? Discover the best time to fly to Czech Republic from Des Moines with our price prediction graph.
DSM-PRG
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to the Czech Republic
DSM-CZ0
DSM-PRG
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Czech Republic. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top regions