HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama

$516+ Cheap flights from Roanoke (ROA) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — PTY
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Roanoke to Panama with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Roanoke to Panama

Cheapest flights from Roanoke to Panama
Explore the most affordable flight options available from Roanoke to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:00 amROA - PTY
1 stop7h 56mDelta
Wed 11/53:21 pmPTY - ROA
1 stop8h 48mDelta
Deal found 10/15$516
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/103:00 pmROA - PTY
2 stops23h 45mUnited Airlines
Wed 11/124:41 pmPTY - ROA
2 stops19h 18mUnited Airlines
Deal found 10/15$517
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:00 amROA - PTY
1 stop7h 56mDelta
Tue 11/43:21 pmPTY - ROA
2 stops31h 24mDelta
Deal found 10/15$520
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3110:26 amROA - PTY
2 stops28h 19mUnited Airlines
Wed 11/54:41 pmPTY - ROA
2 stops24h 15mUnited Airlines
Deal found 10/15$522
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:00 amROA - PTY
1 stop7h 56mDelta
Sat 11/83:21 pmPTY - ROA
1 stop8h 48mDelta
Deal found 10/15$536
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/210:26 amROA - PTY
2 stops28h 19mUnited Airlines
Thu 11/68:55 amPTY - ROA
2 stops27h 04mUnited Airlines
Deal found 10/15$537
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/37:50 pmROA - PTY
2 stops18h 55mUnited Airlines
Sat 11/84:41 pmPTY - ROA
2 stops19h 18mUnited Airlines
Deal found 10/15$557
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/210:26 amROA - PTY
2 stops28h 19mUnited Airlines
Sat 11/84:41 pmPTY - ROA
2 stops19h 18mUnited Airlines
Deal found 10/15$572
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:00 amROA - PTY
1 stop8h 12mDelta
Mon 12/83:46 pmPTY - ROA
1 stop8h 25mDelta
Deal found 10/16$602
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2910:00 pmROA - PTY
2 stops21h 38mUnited Airlines
Sat 12/611:35 amPTY - ROA
2 stops22h 31mUnited Airlines
Deal found 10/15$606
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/63:00 pmROA - PTY
2 stops23h 45mUnited Airlines
Sat 11/84:41 pmPTY - ROA
2 stops19h 18mUnited Airlines
Deal found 10/15$646
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:00 amROA - PTY
1 stop7h 56mDelta
Wed 11/53:21 pmPTY - ROA
1 stop8h 48mDelta
Deal found 10/15$647

Cheap flight deals from Roanoke to Panama

Keep the following information in mind while searching for Roanoke to Panama flight deals. Data was last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$516
(Delta)
Provider with most accurate pricing for Roanoke-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Roanoke-Panama City Tocumen Intl flights.
Search Deals
From Roanoke to Panama
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Roanoke to Panama that are best for you.

Fly from

Roanoke

Fly to

Panama

Route

Depart

Return

Price

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 11/3

6:00 am-1:56 pm

1 stop7h 56m

Panama City Tocumen Intl

Wed 11/5

3:21 pm-12:09 am

1 stop8h 48m

$516

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 11/3

6:00 am-1:56 pm

1 stop7h 56m

Panama City Tocumen Intl

Thu 11/6

3:21 pm-12:09 am

1 stop8h 48m

$516

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Tue 11/4

6:20 am-7:38 pm

2 stops13h 18m

Panama City Tocumen Intl

Thu 11/6

8:55 am-11:59 am

2 stops27h 04m

$522

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 12/1

6:00 pm-1:43 pm

2 stops19h 43m

Panama City Tocumen Intl

Mon 12/8

2:50 pm-9:44 am

2 stops18h 54m

$522

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 10/31

3:00 pm-1:45 pm

2 stops23h 45m

Panama City Tocumen Intl

Thu 11/6

4:41 pm-4:56 pm

2 stops24h 15m

$522

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 11/3

6:00 am-1:56 pm

1 stop7h 56m

Panama City Tocumen Intl

Fri 11/7

3:21 pm-12:09 am

1 stop8h 48m

$536

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sun 11/2

10:26 am-2:45 pm

2 stops28h 19m

Panama City Tocumen Intl

Tue 11/4

4:41 pm-11:59 am

2 stops19h 18m

$537

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Wed 11/5

10:28 am-2:45 pm

2 stops28h 17m

Panama City Tocumen Intl

Sat 11/8

4:41 pm-11:59 am

2 stops19h 18m

$557

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sun 11/2

10:26 am-2:45 pm

2 stops28h 19m

Panama City Tocumen Intl

Sat 11/8

4:41 pm-11:59 am

2 stops19h 18m

$572

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 12/1

6:00 am-2:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Mon 12/8

3:46 pm-12:11 am

1 stop8h 25m

$602

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Best time to book a flight from Roanoke to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Panama

What is the cheapest month to book a flight from Roanoke to Panama?

Currently, August is the cheapest month in which you can book a flight from Roanoke to Panama (average of $234). Flying from Roanoke to Panama in June is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ROA to PA?

Find hourly flight availability from Roanoke to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

One of the essential ways to save on airfare from Roanoke to Panama is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 64% on airfare.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to Panama?

    For a flight from Roanoke to Panama, you will be flying from Roanoke. Roanoke (ROA) is just 4.2 mi from the center of the city.

  • How long is the flight from Roanoke to Panama?

    Airlines like Delta and United Airlines fly from Roanoke to Panama in about 7h 56m. The time it takes to get you to your destination can typically vary by up to 5h 22m. Airlines will cover a distance of 1951 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Roanoke to Panama that include hotel bookings?

    Yes. In addition to deals on Roanoke to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Panama.

  • Can I find deals for business class flights from Roanoke to Panama?

    Yes. Cheapflights offers flight deals from Roanoke to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Panama?

    Currently, August is the cheapest month in which you can book a flight from Roanoke to Panama (average of $234). Flying from Roanoke to Panama in June is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Roanoke to Panama

See prices for flight routes from nearby airports that may be better suited for you.
Dulles Intl to San Salvador flights
Dulles Intl to San José flights
Dulles Intl to Panama City flights
Dulles Intl to Guatemala City flights
Reagan-National to San Salvador flights
Reagan-National to San José flights
Dulles Intl to Liberia flights
Reagan-National to Panama City flights
Reagan-National to Guatemala City flights
Reagan-National to Liberia flights
Dulles Intl to Philip S.W.Goldson flights
Dulles Intl to Managua flights
Reagan-National to Philip S.W.Goldson flights
Raleigh to Panama City flights
Raleigh to San José flights
Raleigh to San Salvador flights
Reagan-National to Managua flights
Raleigh to Liberia flights
Raleigh to Philip S.W.Goldson flights
Richmond to San José flights
Raleigh to Guatemala City flights
Dulles Intl to San Pedro Sula flights
Reagan-National to San Pedro Sula flights
Raleigh to San Pedro Sula flights
Richmond to Guatemala City flights
Norfolk to San José flights
Greensboro to Panama City flights
Greensboro to San Salvador flights
Richmond to Panama City flights
Greensboro to Guatemala City flights
Raleigh to Coxen Hole flights
Reagan-National to Coxen Hole flights
Dulles Intl to Coxen Hole flights
Richmond to Liberia flights
Norfolk to Liberia flights
Greensboro to San José flights
Richmond to Philip S.W.Goldson flights
Charlottesville to San José flights
Norfolk to Guatemala City flights
Richmond to San Salvador flights
Norfolk to Panama City flights
Norfolk to San Salvador flights
Norfolk to Philip S.W.Goldson flights
Roanoke to San José flights
Greensboro to Philip S.W.Goldson flights
Raleigh to Managua flights
Greensboro to Coxen Hole flights
Charlottesville to Guatemala City flights
Dulles Intl to David flights
Dulles Intl to Flores flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.