Panama

$205+ Cheap flights from Roanoke (ROA) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — PTY
Jan 11 — Jan 181
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Cheap flight deals from Roanoke to Panama

Cheapest flights from Roanoke to Panama
Explore the most affordable flight options available from Roanoke to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:45 amROA - PTY
2 stops12h 53mUnited Airlines
Mon 12/228:55 amPTY - ROA
2 stops14h 35mUnited Airlines
Deal found 12/9$568
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:33 pmROA - PTY
2 stops22h 21mAmerican Airlines
Thu 12/252:53 pmPTY - ROA
2 stops17h 49mAmerican Airlines
Deal found 12/11$801
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:40 amROA - PTY
2 stops12h 58mUnited Airlines
Sun 12/288:55 amPTY - ROA
2 stops25h 21mUnited Airlines
Deal found 12/9$833
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amROA - PTY
1 stop8h 21mDelta
Thu 12/258:00 amPTY - ROA
1 stop11h 26mDelta
Deal found 12/11$1,168

Find flight deals from Roanoke to Panama

Keep the following information in mind while searching for Roanoke to Panama flight deals. Data was last updated December 12, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$436
(Delta)

One-way from

$205
(Delta)
Provider with most accurate pricing for Roanoke-Panama City Tocumen Intl flight deals.
Provider most trusted by Cheapflights users for Roanoke-Panama City Tocumen Intl flights.
From Roanoke to Panama
One-way flight from Roanoke to Panama

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Roanoke to Panama that are best for you.

Fly from

Roanoke

Fly to

Panama

Route

Depart

Return

Price

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Wed 1/21

6:45 am-7:38 pm

2 stops12h 53m

Panama City Tocumen Intl

Tue 3/3

4:41 pm-10:13 am

2 stops17h 32m

$460

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Thu 1/22

6:45 am-7:38 pm

2 stops12h 53m

Panama City Tocumen Intl

Tue 3/3

4:41 pm-10:13 am

2 stops17h 32m

$460

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sun 1/25

12:40 pm-5:07 pm

2 stops28h 27m

Panama City Tocumen Intl

Wed 3/4

11:35 am-9:43 am

2 stops22h 08m

$460

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Tue 1/20

6:00 am-1:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Wed 3/4

3:20 pm-12:08 am

1 stop8h 48m

$476

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 1/19

7:59 pm-1:55 pm

1 stop17h 56m

Panama City Tocumen Intl

Wed 3/4

3:20 pm-10:49 pm

2 stops31h 29m

$480

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 1/23

12:40 pm-2:45 pm

2 stops26h 05m

Panama City Tocumen Intl

Tue 3/3

4:41 pm-2:12 pm

2 stops21h 31m

$480

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 1/19

3:39 pm-2:45 pm

2 stops23h 06m

Panama City Tocumen Intl

Sun 3/1

8:55 am-10:13 am

2 stops25h 18m

$480

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 1/23

12:40 pm-5:07 pm

2 stops28h 27m

Panama City Tocumen Intl

Mon 3/2

4:41 pm-2:12 pm

2 stops21h 31m

$480

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sat 1/31

12:40 pm-2:45 pm

2 stops26h 05m

Panama City Tocumen Intl

Sun 3/1

4:41 pm-10:13 am

2 stops17h 32m

$480

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 1/23

6:45 am-8:02 pm

2 stops13h 17m

Panama City Tocumen Intl

Thu 3/5

8:55 am-10:13 am

2 stops25h 18m

$480

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 24 results
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Best time to book a flight from Roanoke to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Panama

What is the cheapest time of day to fly from ROA to PA?

Find hourly flight availability from Roanoke to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

One of the essential ways to save on airfare from Roanoke to Panama is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 64% on airfare.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Roanoke to Panama?

    For a flight from Roanoke to Panama, you will be flying from Roanoke. Roanoke (ROA) is just 4.2 mi from the center of the city.

  • How long is the flight from Roanoke to Panama?

    Airlines like United Airlines and Delta fly from Roanoke to Panama in about 7h 55m. The time it takes to get you to your destination can typically vary by up to 4h 58m. Airlines will cover a distance of 1951 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Roanoke to Panama that include hotel bookings?

    Yes. In addition to deals on Roanoke to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Panama.

  • Can I find deals for business class flights from Roanoke to Panama?

    Yes. Cheapflights offers flight deals from Roanoke to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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