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$346+ Cheap flights from Roanoke (ROA) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — PTY
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
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Cheap flight deals from Roanoke to Panama

Cheapest flights from Roanoke to Panama
Explore the most affordable flight options available from Roanoke to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:20 am
ROA
-
PTY
2 stops14h 11m
United Airlines
Wed 10/287:55 am
PTY
-
ROA
2 stops24h 28m
United Airlines
Deal found 2/8$481
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:59 pm
ROA
-
PTY
2 stops19h 15m
United Airlines
Sun 4/193:30 pm
PTY
-
ROA
2 stops21h 43m
United Airlines
Deal found 2/9$501
This Gurufare deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/27:59 pm
ROA
-
PTY
2 stops33h 05m
Multiple Airlines
Mon 4/67:55 am
PTY
-
ROA
2 stops24h 54m
Multiple Airlines
Deal found 2/9$554
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:00 am
ROA
-
PTY
1 stop8h 03m
Delta
Sun 4/192:27 pm
PTY
-
ROA
1 stop8h 58m
Delta
Deal found 2/9$598
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/196:02 pm
ROA
-
PTY
2 stops19h 08m
American Airlines
Sat 7/251:10 pm
PTY
-
ROA
2 stops24h 15m
American Airlines
Deal found 2/9$643
This Gurufare deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/27:59 pm
ROA
-
PTY
2 stops33h 05m
Multiple Airlines
Sun 4/53:30 pm
PTY
-
ROA
2 stops17h 43m
Multiple Airlines
Deal found 2/9$715
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:50 pm
ROA
-
PTY
2 stops23h 48m
United Airlines
Thu 4/29:45 am
PTY
-
ROA
2 stops23h 04m
United Airlines
Deal found 2/9$725
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:00 am
ROA
-
PTY
1 stop8h 03m
Delta
Thu 4/22:28 pm
PTY
-
ROA
1 stop8h 36m
Delta
Deal found 2/9$749
This Gurufare deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:00 am
ROA
-
PTY
1 stop8h 03m
LATAM Airlines
Mon 4/62:28 pm
PTY
-
ROA
1 stop8h 36m
LATAM Airlines
Deal found 2/9$775

Find flight deals from Roanoke to Panama

Keep the following information in mind while searching for Roanoke to Panama flight deals. Data was last updated February 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$501
(United Airlines)

One-way from

$346
(Delta)
Provider with most accurate pricing for Roanoke-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Roanoke-Panama City Tocumen Intl flights.
Search Deals
From Roanoke to Panama
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One-way flight from Roanoke to Panama
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Roanoke to Panama that are best for you.

Fly from

Roanoke

Fly to

Panama

Route

Depart

Return

Price

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sat 4/11

7:59 pm-2:14 pm

2 stops19h 15m

Panama City Tocumen Intl

Sun 4/19

3:30 pm-2:13 pm

2 stops21h 43m

$501

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Thu 4/2

7:59 pm-4:04 am

2 stops33h 05m

Panama City Tocumen Intl

Mon 4/6

7:55 am-9:49 am

2 stops24h 54m

$554

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sat 4/11

6:00 am-1:03 pm

1 stop8h 03m

Panama City Tocumen Intl

Sun 4/19

2:27 pm-12:25 am

1 stop8h 58m

$598

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sun 7/19

6:02 pm-12:10 pm

2 stops19h 08m

Panama City Tocumen Intl

Sat 7/25

1:10 pm-2:25 pm

2 stops24h 15m

$643

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Thu 4/2

7:59 pm-4:04 am

2 stops33h 05m

Panama City Tocumen Intl

Sun 4/5

3:30 pm-10:13 am

2 stops17h 43m

$715

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Thu 3/26

7:50 pm-6:38 pm

2 stops23h 48m

Panama City Tocumen Intl

Thu 4/2

9:45 am-9:49 am

2 stops23h 04m

$725

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Thu 3/26

6:00 am-1:03 pm

1 stop8h 03m

Panama City Tocumen Intl

Thu 4/2

2:28 pm-12:04 am

1 stop8h 36m

$749

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 2/27

6:00 am-1:50 pm

1 stop7h 50m

Panama City Tocumen Intl

Sun 3/8

2:28 pm-12:04 am

1 stop8h 36m

$817

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Thu 3/26

6:00 am-1:03 pm

1 stop8h 03m

$346

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Best time to book a flight from Roanoke to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Panama
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to Panama?

    For a flight from Roanoke to Panama, you will be flying from Roanoke. Roanoke (ROA) is just 4.2 mi from the center of the city.

  • How long is the flight from Roanoke to Panama?

    Airlines like United Airlines and Delta fly from Roanoke to Panama in about 8h 03m. The time it takes to get you to your destination can typically vary by up to 11h 12m. Airlines will cover a distance of 1951 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Roanoke to Panama that include hotel bookings?

    Yes. In addition to deals on Roanoke to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Panama.

  • Can I find deals for business class flights from Roanoke to Panama?

    Yes. Cheapflights offers flight deals from Roanoke to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Roanoke to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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