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$291+ Cheap flights from Myrtle Beach (MYR) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/12. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — PTY
Jul 7 — Jul 141
Mon 7/7
Mon 7/14
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Panama

Keep the following information in mind while searching for Myrtle Beach to Panama flight deals. Data was last updated July 2, 2025.

Round-trip from

$492
(American Airlines)

One-way from

$291
(American Airlines)

Popular in

February

Cheapest in

August

Average price

$631
From Myrtle Beach Intl to Panama
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One-way flight from Myrtle Beach Intl to Panama
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Highest demand for flights based on searches. 7% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Myrtle Beach to Panama

Cheapest flights from Myrtle Beach to Panama
Explore the most affordable flight options available from Myrtle Beach to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/117:26 pmMYR - PTY
2 stops19h 34mAmerican Airlines
Wed 10/153:19 pmPTY - MYR
2 stops18h 07mAmerican Airlines
Deal found 6/30$492
This Avianca Connect deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/156:45 amMYR - PTY
2 stops19h 00mMultiple Airlines
Thu 8/213:20 amPTY - MYR
2 stops15h 25mMultiple Airlines
Deal found 7/1$496
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:00 amMYR - PTY
1 stop7h 47mDelta
Wed 10/152:12 pmPTY - MYR
1 stop8h 24mDelta
Deal found 6/30$658
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1910:23 amMYR - PTY
1 stop10h 08mUnited Airlines
Thu 7/2410:55 pmPTY - MYR
1 stop10h 01mUnited Airlines
Deal found 7/1$677

Cheapflights Fare Finder

Customize your flight search to find flights from Myrtle Beach to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Panama that are best for you.

Fly from

Myrtle Beach

Fly to

Panama

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 10/11

7:26 pm-2:00 pm

2 stops19h 34m

Panama City Tocumen Intl

Wed 10/15

3:19 pm-10:26 am

2 stops18h 07m

$492

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Fri 8/15

6:45 am-12:45 am

2 stops19h 00m

Panama City Tocumen Intl

Thu 8/21

3:20 am-7:45 pm

2 stops15h 25m

$496

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 10/11

6:00 am-12:47 pm

1 stop7h 47m

Panama City Tocumen Intl

Wed 10/15

2:12 pm-11:36 pm

1 stop8h 24m

$658

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 7/19

10:23 am-7:31 pm

1 stop10h 08m

Panama City Tocumen Intl

Thu 7/24

10:55 pm-9:56 am

1 stop10h 01m

$677

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 7/12

7:00 am-2:15 pm

2 stops8h 15m

$291

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 7/12

1:24 pm-10:25 am

3 stops46h 01m

$306

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 7/12

10:23 am-7:31 pm

1 stop10h 08m

$328

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Best time to book a flight from Myrtle Beach to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama

What is the cheapest month to book a flight from Myrtle Beach to Panama?

Currently, October is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $478). Flying from Myrtle Beach to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated July 2, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Panama, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,983 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,983 reviews
Delta
8.0
Very good
7,983 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,861 reviews
Delta
8.0
Very good
7,983 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,983 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to Panama?

    Myrtle Beach Intl (MYR) is the airport you will fly out of if you book a flight from Myrtle Beach to Panama. It is only a 2.1 mi journey to Myrtle Beach Intl (MYR) from Myrtle Beach’s city center.

  • Can I find deals for flights from Myrtle Beach to Panama that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama.

  • Can I find deals for business class flights from Myrtle Beach to Panama?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Panama?

    Currently, October is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $478). Flying from Myrtle Beach to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Augusta to Panama City flights
Greenville to Guatemala City flights
Charleston to San Salvador flights
Savannah to Philip S.W.Goldson flights
Greenville to San Salvador flights
Augusta to Philip S.W.Goldson flights
Myrtle Beach to Guatemala City flights
Columbia to San Pedro Sula flights
Hilton Head Island to San José flights
Savannah to Liberia flights
Myrtle Beach to Panama City flights
Columbia to Liberia flights
Augusta to San Pedro Sula flights
Greenville to San Pedro Sula flights
Savannah to San Pedro Sula flights
Savannah to Coxen Hole flights
Hilton Head Island to Liberia flights

Top 2 airlines flying from Myrtle Beach to Panama

Discover the top 2 airlines that operate flights from Myrtle Beach to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$437Average$570FlexibilityNo cancel feeOn-time71%
DeltaCheapest$457Average$617FlexibilityNo cancel feeOn-timeN/A

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