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$492+ Cheap flights from Myrtle Beach (MYR) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — PTY
Aug 23 — Aug 301
Sat 8/23
Sat 8/30
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Panama

Keep the following information in mind while searching for Myrtle Beach to Panama flight deals. Data was last updated August 18, 2025.

Round-trip from

$492
(American Airlines)
From Myrtle Beach Intl to Panama
Search Deals

Find flight deals from Myrtle Beach to Panama

Cheapest flights from Myrtle Beach to Panama
Explore the most affordable flight options available from Myrtle Beach to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/147:26 pmMYR - PTY
2 stops19h 37mAmerican Airlines
Sat 10/183:15 pmPTY - MYR
2 stops23h 34mAmerican Airlines
Deal found 8/17$492
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/126:00 amMYR - PTY
1 stop7h 55mDelta
Tue 9/162:10 pmPTY - MYR
1 stop8h 39mDelta
Deal found 8/17$515
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/127:36 pmMYR - PTY
2 stops19h 55mAmerican Airlines
Tue 9/161:45 pmPTY - MYR
2 stops20h 03mAmerican Airlines
Deal found 8/17$552
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/127:36 pmMYR - PTY
2 stops25h 39mMultiple Airlines
Tue 9/1612:03 pmPTY - MYR
1 stop7h 03mMultiple Airlines
Deal found 8/17$667
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:00 amMYR - PTY
1 stop7h 56mDelta
Sat 10/182:21 pmPTY - MYR
1 stop8h 38mDelta
Deal found 8/17$794

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Panama that are best for you.

Fly from

Myrtle Beach

Fly to

Panama

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 10/14

7:26 pm-2:03 pm

2 stops19h 37m

Panama City Tocumen Intl

Sat 10/18

3:15 pm-3:49 pm

2 stops23h 34m

$492

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Fri 9/12

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Tue 9/16

2:10 pm-11:49 pm

1 stop8h 39m

$515

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Fri 9/12

7:36 pm-2:31 pm

2 stops19h 55m

Panama City Tocumen Intl

Tue 9/16

1:45 pm-10:48 am

2 stops20h 03m

$552

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Fri 9/12

7:36 pm-8:15 pm

2 stops25h 39m

Panama City Tocumen Intl

Tue 9/16

12:03 pm-8:06 pm

1 stop7h 03m

$667

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 10/14

6:00 am-12:56 pm

1 stop7h 56m

Panama City Tocumen Intl

Sat 10/18

2:21 pm-11:59 pm

1 stop8h 38m

$794

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Best time to book a flight from Myrtle Beach to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama

What is the cheapest month to book a flight from Myrtle Beach to Panama?

Currently, October is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $478). Flying from Myrtle Beach to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated August 18, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Panama, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to Panama?

    Myrtle Beach Intl (MYR) is the airport you will fly out of if you book a flight from Myrtle Beach to Panama. It is only a 2.1 mi journey to Myrtle Beach Intl (MYR) from Myrtle Beach’s city center.

  • How long is the flight from Myrtle Beach to Panama?

    For as low as $515, American Airlines can have you in Panama from Myrtle Beach in 7h 55m. Myrtle Beach and Panama are separated by a distance of 1700 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Myrtle Beach to Panama that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama.

  • Can I find deals for business class flights from Myrtle Beach to Panama?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Panama?

    Currently, October is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $478). Flying from Myrtle Beach to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Augusta to Philip S.W.Goldson flights
Myrtle Beach to Panama City flights
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Hilton Head Island to Liberia flights
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Hilton Head Island to San José flights

Top 2 airlines flying from Myrtle Beach to Panama

Discover the top 2 airlines that operate flights from Myrtle Beach to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$437Average$546FlexibilityNo cancel feeOn-time71%
DeltaCheapest$452Average$663FlexibilityNo cancel feeOn-timeN/A

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