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$440+ Cheap flights from Myrtle Beach (MYR) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/19. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — PTY
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Panama

Keep the following information in mind while searching for Myrtle Beach to Panama flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$440
(American Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
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From Myrtle Beach Intl to Panama
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Find flight deals from Myrtle Beach to Panama

Cheapest flights from Myrtle Beach to Panama
Explore the most affordable flight options available from Myrtle Beach to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:43 pmMYR - PTY
2 stops19h 04mAmerican Airlines
Thu 3/123:50 pmPTY - MYR
2 stops24h 20mAmerican Airlines
Deal found 10/28$480
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/148:11 pmMYR - PTY
2 stops17h 36mAmerican Airlines
Sun 12/214:55 pmPTY - MYR
2 stops17h 37mAmerican Airlines
Deal found 10/30$555
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/148:27 pmMYR - PTY
3 stops28h 13mMultiple Airlines
Sun 12/217:50 pmPTY - MYR
3 stops22h 18mMultiple Airlines
Deal found 10/30$733
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/146:00 amMYR - PTY
1 stop8h 21mDelta
Sun 12/218:00 amPTY - MYR
1 stop12h 30mDelta
Deal found 10/30$788
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:00 amMYR - PTY
1 stop8h 21mDelta
Thu 3/122:20 pmPTY - MYR
1 stop8h 15mDelta
Deal found 10/28$798

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Panama that are best for you.

Fly from

Myrtle Beach

Fly to

Panama

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 3/19

8:41 pm-2:20 pm

2 stops18h 39m

Panama City Tocumen Intl

Thu 3/26

1:50 pm-9:52 am

2 stops19h 02m

$440

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Mon 12/15

6:43 pm-1:47 pm

2 stops19h 04m

Panama City Tocumen Intl

Thu 3/12

3:50 pm-5:10 pm

2 stops24h 20m

$480

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 1/13

5:44 pm-1:27 pm

2 stops19h 43m

Panama City Tocumen Intl

Sat 1/17

2:27 pm-11:35 am

2 stops21h 08m

$500

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sun 12/14

8:27 pm-12:40 am

3 stops28h 13m

Panama City Tocumen Intl

Sun 12/21

7:50 pm-6:08 pm

3 stops22h 18m

$733

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sun 12/14

6:00 am-2:21 pm

1 stop8h 21m

Panama City Tocumen Intl

Sun 12/21

8:00 am-8:30 pm

1 stop12h 30m

$788

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 3/19

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Thu 3/26

2:20 pm-11:35 pm

1 stop8h 15m

$791

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Mon 12/15

6:00 am-2:21 pm

1 stop8h 21m

Panama City Tocumen Intl

Thu 3/12

2:20 pm-11:35 pm

1 stop8h 15m

$798

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Best time to book a flight from Myrtle Beach to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama

What is the cheapest month to book a flight from Myrtle Beach to Panama?

Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $230). Flying from Myrtle Beach to Panama in April is currently the most expensive (average of $548). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Panama, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,034 reviews

Food

6.4

Crew

8.0

Comfort

7.2

Overall

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
11,034 reviews
American Airlines
7.2
Good
11,034 reviews

Food

6.4

Crew

8.0

Comfort

7.2

Overall

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to Panama?

    Myrtle Beach Intl (MYR) is the airport you will fly out of if you book a flight from Myrtle Beach to Panama. It is only a 2.1 mi journey to Myrtle Beach Intl (MYR) from Myrtle Beach’s city center.

  • How long is the flight from Myrtle Beach to Panama?

    For as low as $440, American Airlines can have you in Panama from Myrtle Beach in 18h 39m. Myrtle Beach and Panama are separated by a distance of 1700 mi.

  • Can I find deals for flights from Myrtle Beach to Panama that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama.

  • Can I find deals for business class flights from Myrtle Beach to Panama?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Panama?

    Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $230). Flying from Myrtle Beach to Panama in April is currently the most expensive (average of $548). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Columbia to San José flights
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Greenville to Liberia flights
Savannah to Philip S.W.Goldson flights
Charleston to Guatemala City flights
Charleston to San Salvador flights
Columbia to San Salvador flights
Charleston to Managua flights
Myrtle Beach to Panama City flights
Savannah to San Salvador flights
Columbia to Guatemala City flights
Greenville to San Pedro Sula flights
Savannah to Guatemala City flights
Columbia to Liberia flights
Augusta to San José flights
Greenville to San Salvador flights
Charleston to Coxen Hole flights
Columbia to San Pedro Sula flights
Myrtle Beach to Guatemala City flights
Augusta to Guatemala City flights
Augusta to Philip S.W.Goldson flights
Columbia to Philip S.W.Goldson flights
Augusta to Panama City flights
Charlotte to Tegucigalpa flights

Top airline flying from Myrtle Beach to Panama

Discover the top airline that operate flights from Myrtle Beach to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$437Average$570FlexibilityNo cancel feeOn-time71%

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