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$205+ Cheap flights from Myrtle Beach (MYR) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — PTY
Mar 16 — Mar 231
Mon 3/16
Mon 3/23
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Panama

Cheapest flights from Myrtle Beach to Panama
Explore the most affordable flight options available from Myrtle Beach to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 14, 2026.

This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 pm
MYR
-
PTY
2 stops21h 20m
American Airlines
Sat 9/193:40 pm
PTY
-
MYR
2 stops21h 35m
American Airlines
Deal found 2/11$491
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/193:18 pm
MYR
-
PTY
2 stops22h 22m
American Airlines
Thu 3/261:40 pm
PTY
-
MYR
2 stops19h 26m
American Airlines
Deal found 2/13$511
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:00 am
MYR
-
PTY
1 stop7h 56m
Delta
Sat 10/312:21 pm
PTY
-
MYR
1 stop8h 14m
Delta
Deal found 2/11$583
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am
MYR
-
PTY
1 stop8h 13m
Delta
Sat 9/192:21 pm
PTY
-
MYR
1 stop8h 18m
Delta
Deal found 2/11$588
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/283:29 pm
MYR
-
PTY
2 stops30h 08m
Multiple Airlines
Sat 4/412:03 pm
PTY
-
MYR
1 stop7h 52m
Multiple Airlines
Deal found 2/11$708
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:00 am
MYR
-
PTY
1 stop8h 03m
Delta
Thu 3/262:28 pm
PTY
-
MYR
1 stop8h 36m
Delta
Deal found 2/11$825
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:19 pm
MYR
-
PTY
2 stops20h 21m
American Airlines
Sat 4/43:58 pm
PTY
-
MYR
2 stops24h 54m
American Airlines
Deal found 2/11$1,175
This WestJet deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WestJet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:54 pm
MYR
-
PTY
2 stops38h 26m
WestJet
Tue 4/79:20 am
PTY
-
MYR
2 stops37h 44m
WestJet
Deal found 2/14$1,389
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:10 am
MYR
-
PTY
2 stops7h 50m
American Airlines
Sat 10/313:35 pm
PTY
-
MYR
3 stops17h 04m
American Airlines
Deal found 2/11$2,352

Find flight deals from Myrtle Beach to Panama

Keep the following information in mind while searching for Myrtle Beach to Panama flight deals. Data was last updated February 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$511
(American Airlines)

One-way from

$205
(Trip.com)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
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From Myrtle Beach Intl to Panama
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One-way flight from Myrtle Beach Intl to Panama
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Panama that are best for you.

Fly from

Myrtle Beach

Fly to

Panama

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 3/19

3:18 pm-12:40 pm

2 stops22h 22m

Panama City Tocumen Intl

Thu 3/26

1:40 pm-12:14 pm

2 stops21h 34m

$511

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 3/28

3:29 pm-8:37 pm

2 stops30h 08m

Panama City Tocumen Intl

Sat 4/4

12:03 pm-8:55 pm

1 stop7h 52m

$708

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 3/19

6:00 am-1:03 pm

1 stop8h 03m

Panama City Tocumen Intl

Thu 3/26

2:28 pm-12:04 am

1 stop8h 36m

$825

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 3/28

5:19 pm-12:40 pm

2 stops20h 21m

Panama City Tocumen Intl

Sat 4/4

3:58 pm-5:52 pm

2 stops24h 54m

$1,175

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 3/31

6:54 pm-8:20 am

2 stops38h 26m

Panama City Tocumen Intl

Tue 4/7

9:20 am-12:04 am

2 stops37h 44m

$1,389

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Wed 2/25

9:09 am-12:40 am

2 stops15h 31m

$205

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Wed 2/25

1:00 pm-8:02 pm

1 stop31h 02m

$265

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/11

Best time to book a flight from Myrtle Beach to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama

What is the cheapest month to book a flight from Myrtle Beach to Panama?

Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $230). Flying from Myrtle Beach to Panama in April is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to Panama?

    Myrtle Beach Intl (MYR) is the airport you will fly out of if you book a flight from Myrtle Beach to Panama. It is only a 2.1 mi journey to Myrtle Beach Intl (MYR) from Myrtle Beach’s city center.

  • How long is the flight from Myrtle Beach to Panama?

    For as low as $511, American Airlines can have you in Panama from Myrtle Beach in 22h 22m. Myrtle Beach and Panama are separated by a distance of 1700 mi.

  • Can I find deals for flights from Myrtle Beach to Panama that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama.

  • Can I find deals for business class flights from Myrtle Beach to Panama?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Panama?

    Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $230). Flying from Myrtle Beach to Panama in April is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Greenville to Liberia flights
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Greenville to Philip S.W.Goldson flights
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Augusta to San José flights
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Columbia to Guatemala City flights
Myrtle Beach to San José flights
Myrtle Beach to Guatemala City flights
Columbia to Philip S.W.Goldson flights
Augusta to Panama City flights
Columbia to San Salvador flights
Columbia to Liberia flights
Greenville to San Pedro Sula flights
Savannah to San Pedro Sula flights
Augusta to Philip S.W.Goldson flights
Savannah to Coxen Hole flights
Hilton Head Island to San José flights
Myrtle Beach to Managua flights
Augusta to Guatemala City flights

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