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$220+ Cheap flights from Myrtle Beach (MYR) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/26. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — PTY
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Panama

Keep the following information in mind while searching for Myrtle Beach to Panama flight deals. Data was last updated June 12, 2025.

Round-trip from

$582
(American Airlines)

One-way from

$220
(Mytrip)

Popular in

February

Cheapest in

August

Average price

$651
From Myrtle Beach Intl to Panama
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One-way flight from Myrtle Beach Intl to Panama
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Highest demand for flights based on searches. 7% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Myrtle Beach to Panama

Cheapest flights from Myrtle Beach to Panama
Explore the most affordable flight options available from Myrtle Beach to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/196:16 pmMYR - PTY
2 stops20h 59mAmerican Airlines
Thu 7/241:55 pmPTY - MYR
2 stops22h 42mAmerican Airlines
Deal found 6/11$582
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/196:10 amMYR - PTY
3 stops19h 00mMultiple Airlines
Thu 7/2411:20 amPTY - MYR
2 stops33h 57mMultiple Airlines
Deal found 6/11$597
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/2512:00 pmMYR - PTY
1 stop8h 31mUnited Airlines
Sat 6/2810:55 pmPTY - MYR
1 stop10h 02mUnited Airlines
Deal found 6/11$805

Cheapflights Fare Finder

Customize your flight search to find flights from Myrtle Beach to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Panama that are best for you.

Fly from

Myrtle Beach

Fly to

Panama

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 7/19

6:16 pm-2:15 pm

2 stops20h 59m

Panama City Tocumen Intl

Thu 7/24

1:55 pm-1:37 pm

2 stops22h 42m

$582

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 7/19

6:10 am-12:10 am

3 stops19h 00m

Panama City Tocumen Intl

Thu 7/24

11:20 am-10:17 pm

2 stops33h 57m

$597

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Wed 6/25

12:00 pm-7:31 pm

1 stop8h 31m

Panama City Tocumen Intl

Sat 6/28

10:55 pm-9:57 am

1 stop10h 02m

$805

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 6/26

6:09 am-12:35 pm

2 stops31h 26m

$220

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 6/26

10:58 am-7:31 pm

1 stop9h 33m

$241

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Wed 6/18

4:22 pm-1:00 pm

2 stops21h 38m

$3,043

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Best time to book a flight from Myrtle Beach to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama

What is the cheapest month to book a flight from Myrtle Beach to Panama?

Currently, October is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $478). Flying from Myrtle Beach to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated June 12, 2025.
United Airlines
7.4
Good
8,790 reviews

Overall

7.4

Entertainment

7.0

Food

6.6

Boarding

7.7

Comfort

7.3

Crew

8.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
United Airlines
7.4
Good
8,790 reviews
United Airlines
7.4
Good
8,790 reviews

Overall

7.4

Entertainment

7.0

Food

6.6

Boarding

7.7

Comfort

7.3

Crew

8.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,790 reviews

Overall

7.4

Entertainment

7.0

Food

6.6

Boarding

7.7

Comfort

7.3

Crew

8.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to Panama?

    Myrtle Beach Intl (MYR) is the airport you will fly out of if you book a flight from Myrtle Beach to Panama. It is only a 2.1 mi journey to Myrtle Beach Intl (MYR) from Myrtle Beach’s city center.

  • Can I find deals for flights from Myrtle Beach to Panama that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama.

  • Can I find deals for business class flights from Myrtle Beach to Panama?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Panama?

    Currently, October is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $478). Flying from Myrtle Beach to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Augusta to San José flights
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Greenville to San Pedro Sula flights
Myrtle Beach to Guatemala City flights
Columbia to San Salvador flights
Myrtle Beach to Managua flights
Columbia to Liberia flights
Augusta to Panama City flights
Greenville to Tegucigalpa flights
Myrtle Beach to Panama City flights
Myrtle Beach to Coxen Hole flights
Columbia to Philip S.W.Goldson flights
Augusta to Philip S.W.Goldson flights

Top 2 airlines flying from Myrtle Beach to Panama

Discover the top 2 airlines that operate flights from Myrtle Beach to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$437Average$570FlexibilityNo cancel feeOn-time71%
DeltaCheapest$452Average$617FlexibilityNo cancel feeOn-timeN/A

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