HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama

$205+ Cheap flights from Myrtle Beach (MYR) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/5. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — PTY
Jan 26 — Feb 21
Mon 1/26
Mon 2/2
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to Panama with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to Panama

Best flights from Myrtle Beach to Panama
Discover carefully curated flight deals from Myrtle Beach to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 27, 2025.

This American Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/55:44 pmMYR - PTY
2 stops21h 54mAmerican Airlines
Thu 3/54:05 pmPTY - MYR
2 stops16h 17mAmerican Airlines
Deal found 12/25$460
This Delta deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/56:00 amMYR - PTY
1 stop7h 55mDelta
Thu 3/53:15 pmPTY - MYR
1 stop8h 42mDelta
Deal found 12/25$720
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/29:54 amMYR - PTY
1 stop10h 25mMultiple Airlines
Fri 1/911:25 amPTY - MYR
2 stops31h 55mMultiple Airlines
Deal found 12/26$802
This American Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:35 pmMYR - PTY
2 stops20h 47mAmerican Airlines
Thu 3/261:44 pmPTY - MYR
2 stops17h 47mAmerican Airlines
Deal found 12/25$510
This American Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/203:18 pmMYR - PTY
2 stops22h 32mAmerican Airlines
Mon 3/24:05 pmPTY - MYR
2 stops18h 39mAmerican Airlines
Deal found 12/25$520
This Delta deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:00 amMYR - PTY
1 stop8h 03mDelta
Thu 3/262:28 pmPTY - MYR
1 stop8h 38mDelta
Deal found 12/25$868
This Delta deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:00 amMYR - PTY
1 stop7h 50mDelta
Mon 3/23:15 pmPTY - MYR
1 stop8h 42mDelta
Deal found 12/25$893
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/26:00 amMYR - PTY
1 stop14h 00mDelta
Fri 1/93:20 pmPTY - MYR
1 stop8h 21mDelta
Deal found 12/26$981

Find flight deals from Myrtle Beach to Panama

Keep the following information in mind while searching for Myrtle Beach to Panama flight deals. Data was last updated December 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$460
(American Airlines)

One-way from

$205
(American Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
Search Deals
From Myrtle Beach Intl to Panama
Search Deals
One-way flight from Myrtle Beach Intl to Panama
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 27, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Panama that are best for you.

Fly from

Myrtle Beach

Fly to

Panama

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 2/5

5:44 pm-3:38 pm

2 stops21h 54m

Panama City Tocumen Intl

Thu 3/5

4:05 pm-8:22 am

2 stops16h 17m

$460

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 3/19

6:35 pm-2:22 pm

2 stops20h 47m

Panama City Tocumen Intl

Thu 3/26

1:44 pm-8:31 am

2 stops17h 47m

$510

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Fri 2/20

3:18 pm-1:50 pm

2 stops22h 32m

Panama City Tocumen Intl

Mon 3/2

4:05 pm-10:44 am

2 stops18h 39m

$520

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 2/5

6:00 am-1:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Thu 3/5

3:15 pm-11:57 pm

1 stop8h 42m

$720

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Fri 1/2

9:54 am-8:19 pm

1 stop10h 25m

Panama City Tocumen Intl

Fri 1/9

11:25 am-7:20 pm

2 stops31h 55m

$802

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 3/19

6:00 am-1:03 pm

1 stop8h 03m

Panama City Tocumen Intl

Thu 3/26

2:28 pm-12:06 am

1 stop8h 38m

$868

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Fri 2/20

6:00 am-1:50 pm

1 stop7h 50m

Panama City Tocumen Intl

Mon 3/2

3:15 pm-11:57 pm

1 stop8h 42m

$893

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Fri 1/2

6:00 am-8:00 pm

1 stop14h 00m

Panama City Tocumen Intl

Fri 1/9

3:20 pm-11:41 pm

1 stop8h 21m

$981

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 2/5

5:44 pm-3:38 pm

2 stops21h 54m

$205

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 2/5

6:00 am-1:55 pm

1 stop7h 55m

$327

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/25

Best time to book a flight from Myrtle Beach to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama

What is the cheapest month to book a flight from Myrtle Beach to Panama?

Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $230). Flying from Myrtle Beach to Panama in April is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated December 27, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Panama, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,067 reviews

Entertainment

6.9

Overall

7.2

Food

6.5

Crew

8.0

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,067 reviews
American Airlines
7.2
Good
11,067 reviews

Entertainment

6.9

Overall

7.2

Food

6.5

Crew

8.0

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to Panama?

    Myrtle Beach Intl (MYR) is the airport you will fly out of if you book a flight from Myrtle Beach to Panama. It is only a 2.1 mi journey to Myrtle Beach Intl (MYR) from Myrtle Beach’s city center.

  • How long is the flight from Myrtle Beach to Panama?

    For as low as $460, American Airlines can have you in Panama from Myrtle Beach in 21h 54m. Myrtle Beach and Panama are separated by a distance of 1700 mi.

  • Can I find deals for flights from Myrtle Beach to Panama that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama.

  • Can I find deals for business class flights from Myrtle Beach to Panama?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Panama?

    Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $230). Flying from Myrtle Beach to Panama in April is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to Panama

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to San José flights
Charlotte to Liberia flights
Charlotte to Panama City flights
Charlotte to Philip S.W.Goldson flights
Charlotte to San Salvador flights
Charlotte to Guatemala City flights
Charleston to San José flights
Charleston to Liberia flights
Charlotte to San Pedro Sula flights
Greenville to San José flights
Charleston to Philip S.W.Goldson flights
Charleston to Panama City flights
Savannah to San José flights
Columbia to Panama City flights
Savannah to Liberia flights
Charlotte to Managua flights
Greenville to Panama City flights
Myrtle Beach to Panama City flights
Savannah to Panama City flights
Myrtle Beach to San José flights
Columbia to San José flights
Greenville to Philip S.W.Goldson flights
Greenville to Guatemala City flights
Charlotte to Coxen Hole flights
Greenville to Liberia flights
Savannah to Philip S.W.Goldson flights
Savannah to San Pedro Sula flights
Charleston to San Salvador flights
Charleston to Managua flights
Savannah to San Salvador flights
Augusta to San José flights
Savannah to Guatemala City flights
Columbia to San Salvador flights
Charleston to Guatemala City flights
Myrtle Beach to Coxen Hole flights
Columbia to Guatemala City flights
Savannah to Coxen Hole flights
Augusta to Guatemala City flights
Charleston to Coxen Hole flights
Greenville to San Salvador flights
Augusta to Panama City flights
Columbia to Philip S.W.Goldson flights
Augusta to Philip S.W.Goldson flights
Columbia to San Pedro Sula flights
Columbia to Liberia flights
Myrtle Beach to Guatemala City flights
Greenville to San Pedro Sula flights
Charlotte to Tegucigalpa flights

Top airline flying from Myrtle Beach to Panama

Discover the top airline that operate flights from Myrtle Beach to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$486Average$572FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.