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$450+ Cheap flights from Myrtle Beach (MYR) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/6. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — PTY
ene. 14 — ene. 211
mié. 1/14
mié. 1/21
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Panama

Best flights from Myrtle Beach to Panama
Discover carefully curated flight deals from Myrtle Beach to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated diciembre 15, 2025.

This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/66:58 pmMYR - PTY
1 stop18h 57mDelta
jue. 4/162:20 pmPTY - MYR
1 stop26h 38mDelta
Deal found 12/14$450
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/196:35 pmMYR - PTY
2 stops20h 47mAmerican Airlines
jue. 3/261:44 pmPTY - MYR
2 stops19h 17mAmerican Airlines
Deal found 12/14$480
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/1611:25 amMYR - PTY
1 stop9h 06mUnited Airlines
sáb. 5/2310:55 pmPTY - MYR
1 stop10h 45mUnited Airlines
Deal found 12/15$533
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/197:50 pmMYR - PTY
1 stop18h 05mDelta
vie. 5/222:20 pmPTY - MYR
1 stop20h 59mDelta
Deal found 12/15$470
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/207:56 pmMYR - PTY
2 stops17h 54mAmerican Airlines
lun. 3/24:05 pmPTY - MYR
2 stops19h 44mAmerican Airlines
Deal found 12/13$520
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/1611:25 amMYR - PTY
1 stop9h 06mUnited Airlines
dom. 5/2410:55 pmPTY - MYR
1 stop10h 45mUnited Airlines
Deal found 12/15$553
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/207:56 pmMYR - PTY
2 stops17h 54mAmerican Airlines
dom. 3/14:05 pmPTY - MYR
2 stops22h 23mAmerican Airlines
Deal found 12/13$542
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/186:00 amMYR - PTY
1 stop7h 55mDelta
mié. 5/272:20 pmPTY - MYR
1 stop8h 18mDelta
Deal found 12/15$578
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/66:58 pmMYR - PTY
1 stop18h 57mDelta
mié. 4/152:20 pmPTY - MYR
1 stop8h 18mDelta
Deal found 12/14$585
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/177:50 pmMYR - PTY
1 stop18h 05mDelta
mié. 5/272:20 pmPTY - MYR
1 stop8h 18mDelta
Deal found 12/15$585
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/191:05 pmMYR - PTY
1 stop24h 50mDelta
mié. 5/272:20 pmPTY - MYR
1 stop8h 18mDelta
Deal found 12/15$585

Find flight deals from Myrtle Beach to Panama

Keep the following information in mind while searching for Myrtle Beach to Panama flight deals. Data was last updated diciembre 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$440
(American Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
Search Deals
From Myrtle Beach Intl to Panama
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 15, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Panama that are best for you.

Fly from

Myrtle Beach

Fly to

Panama

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

lun. 4/6

6:58 pm-12:55 pm

1 stop18h 57m

Panama City Tocumen Intl

jue. 4/16

2:20 pm-5:58 pm

1 stop26h 38m

$450

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

mar. 5/19

7:50 pm-12:55 pm

1 stop18h 05m

Panama City Tocumen Intl

vie. 5/22

2:20 pm-12:19 pm

1 stop20h 59m

$470

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

jue. 3/19

6:35 pm-2:22 pm

2 stops20h 47m

Panama City Tocumen Intl

jue. 3/26

1:44 pm-10:01 am

2 stops19h 17m

$480

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

vie. 2/20

7:56 pm-1:50 pm

2 stops17h 54m

Panama City Tocumen Intl

lun. 3/2

4:05 pm-11:49 am

2 stops19h 44m

$520

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

sáb. 5/16

11:25 am-7:31 pm

1 stop9h 06m

Panama City Tocumen Intl

sáb. 5/23

10:55 pm-10:40 am

1 stop10h 45m

$533

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

vie. 2/20

7:56 pm-1:50 pm

2 stops17h 54m

Panama City Tocumen Intl

dom. 3/1

4:05 pm-2:28 pm

2 stops22h 23m

$542

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

sáb. 5/16

11:25 am-7:31 pm

1 stop9h 06m

Panama City Tocumen Intl

dom. 5/24

10:55 pm-10:40 am

1 stop10h 45m

$553

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

lun. 5/18

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

mié. 5/27

2:20 pm-11:38 pm

1 stop8h 18m

$578

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

lun. 4/6

6:58 pm-12:55 pm

1 stop18h 57m

Panama City Tocumen Intl

mié. 4/15

2:20 pm-11:38 pm

1 stop8h 18m

$585

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

dom. 5/17

7:50 pm-12:55 pm

1 stop18h 05m

Panama City Tocumen Intl

mié. 5/27

2:20 pm-11:38 pm

1 stop8h 18m

$585

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 11 results
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Best time to book a flight from Myrtle Beach to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama

What is the cheapest month to book a flight from Myrtle Beach to Panama?

Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $230). Flying from Myrtle Beach to Panama in April is currently the most expensive (average of $548). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated diciembre 15, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Panama, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,052 reviews

Entertainment

6.9

Food

6.5

Crew

8.0

Overall

7.2

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,052 reviews
American Airlines
7.2
Good
11,052 reviews

Entertainment

6.9

Food

6.5

Crew

8.0

Overall

7.2

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to Panama?

    Myrtle Beach Intl (MYR) is the airport you will fly out of if you book a flight from Myrtle Beach to Panama. It is only a 2.1 mi journey to Myrtle Beach Intl (MYR) from Myrtle Beach’s city center.

  • How long is the flight from Myrtle Beach to Panama?

    For as low as $443, American Airlines can have you in Panama from Myrtle Beach in 7h 55m. Myrtle Beach and Panama are separated by a distance of 1700 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Myrtle Beach to Panama that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama.

  • Can I find deals for business class flights from Myrtle Beach to Panama?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Panama?

    Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama (average of $230). Flying from Myrtle Beach to Panama in April is currently the most expensive (average of $548). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Greenville to San Pedro Sula flights
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Columbia to San Salvador flights
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Top airline flying from Myrtle Beach to Panama

Discover the top airline that operate flights from Myrtle Beach to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$486Average$572FlexibilityNo cancel feeOn-time71%

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