HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama

$242+ Cheap flights from Harrisburg (MDT) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — PTY
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Harrisburg to Panama with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Harrisburg to Panama

Cheapest flights from Harrisburg to Panama
Explore the most affordable flight options available from Harrisburg to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/210:35 am
MDT
-
PTY
2 stops9h 56m
United Airlines
Tue 10/610:00 am
PTY
-
MDT
2 stops22h 24m
United Airlines
Deal found 2/8$543
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:37 pm
MDT
-
PTY
2 stops18h 03m
American Airlines
Thu 3/261:40 pm
PTY
-
MDT
2 stops20h 19m
American Airlines
Deal found 2/9$547
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/262:33 pm
MDT
-
PTY
2 stops26h 34m
United Airlines
Thu 4/210:00 am
PTY
-
MDT
2 stops22h 44m
United Airlines
Deal found 2/9$643
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:15 am
MDT
-
PTY
2 stops14h 16m
United Airlines
Sun 4/1210:00 am
PTY
-
MDT
2 stops22h 44m
United Airlines
Deal found 2/10$653
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:06 pm
MDT
-
PTY
2 stops22h 14m
American Airlines
Mon 3/301:40 pm
PTY
-
MDT
2 stops18h 46m
American Airlines
Deal found 2/11$678
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:15 am
MDT
-
PTY
2 stops22h 55m
United Airlines
Sat 4/43:30 pm
PTY
-
MDT
2 stops24h 22m
United Airlines
Deal found 2/11$729
This Gurufare deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/261:24 pm
MDT
-
PTY
1 stop24h 39m
LATAM Airlines
Mon 3/302:28 pm
PTY
-
MDT
1 stop8h 13m
LATAM Airlines
Deal found 2/11$829
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/275:40 pm
MDT
-
PTY
2 stops23h 27m
United Airlines
Fri 4/33:30 pm
PTY
-
MDT
2 stops21h 25m
United Airlines
Deal found 2/10$916
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:00 am
MDT
-
PTY
1 stop8h 03m
Delta
Thu 3/262:28 pm
PTY
-
MDT
1 stop8h 13m
Delta
Deal found 2/9$937
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:00 am
MDT
-
PTY
1 stop8h 03m
Delta
Sun 4/122:28 pm
PTY
-
MDT
1 stop8h 13m
Delta
Deal found 2/10$1,081

Find flight deals from Harrisburg to Panama

Keep the following information in mind while searching for Harrisburg to Panama flight deals. Data was last updated February 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$547
(American Airlines)

One-way from

$242
(American Airlines)
Provider with most accurate pricing for Harrisburg-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Panama City Tocumen Intl flights.
Search Deals
From Harrisburg to Panama
Search Deals
One-way flight from Harrisburg to Panama
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Harrisburg to Panama that are best for you.

Fly from

Harrisburg

Fly to

Panama

Route

Depart

Return

Price

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Mon 3/16

7:37 pm-12:40 pm

2 stops18h 03m

Panama City Tocumen Intl

Thu 3/26

1:40 pm-10:59 am

2 stops20h 19m

$547

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Thu 3/26

2:33 pm-4:07 pm

2 stops26h 34m

Panama City Tocumen Intl

Thu 4/2

10:00 am-9:44 am

2 stops22h 44m

$643

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Tue 4/7

6:15 am-7:31 pm

2 stops14h 16m

Panama City Tocumen Intl

Sun 4/12

10:00 am-9:44 am

2 stops22h 44m

$653

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Thu 3/26

5:06 pm-2:20 pm

2 stops22h 14m

Panama City Tocumen Intl

Mon 3/30

1:40 pm-9:26 am

2 stops18h 46m

$678

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Sat 3/28

6:15 am-4:10 am

2 stops22h 55m

Panama City Tocumen Intl

Sat 4/4

3:30 pm-4:52 pm

2 stops24h 22m

$729

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Thu 3/26

1:24 pm-1:03 pm

1 stop24h 39m

Panama City Tocumen Intl

Mon 3/30

2:28 pm-11:41 pm

1 stop8h 13m

$829

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Fri 3/27

5:40 pm-4:07 pm

2 stops23h 27m

Panama City Tocumen Intl

Fri 4/3

3:30 pm-1:55 pm

2 stops21h 25m

$916

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Mon 3/16

6:00 am-1:03 pm

1 stop8h 03m

Panama City Tocumen Intl

Thu 3/26

2:28 pm-11:41 pm

1 stop8h 13m

$937

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Tue 4/7

6:00 am-1:03 pm

1 stop8h 03m

Panama City Tocumen Intl

Sun 4/12

2:28 pm-11:41 pm

1 stop8h 13m

$1,081

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Tue 4/7

6:45 pm-12:46 pm

3 stops19h 01m

Panama City Tocumen Intl

Sun 4/12

1:49 pm-9:32 am

2 stops18h 43m

$2,213

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/10

Showing 1-10 of 13 results
1
2

Best time to book a flight from Harrisburg to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Panama

What is the cheapest month to book a flight from Harrisburg to Panama?

Currently, December is the cheapest month in which you can book a flight from Harrisburg to Panama (average of $340). Flying from Harrisburg to Panama in January is currently the most expensive (average of $477). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated February 12, 2026.
Peruse reviews from past customers who have flown with Delta from Harrisburg to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,177 reviews

Comfort

7.9

Entertainment

7.8

Crew

8.5

Food

7.2

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,177 reviews
Delta
7.9
Good
8,177 reviews

Comfort

7.9

Entertainment

7.8

Crew

8.5

Food

7.2

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Harrisburg to Panama?

    Harrisburg (MDT), located 8.5 mi from the city center, is the airport you fly out of when you book flights from Harrisburg to Panama.

  • How long is the flight from Harrisburg to Panama?

    Departing from Harrisburg to Panama will take you 18h 03m. There are 2155 mi between Harrisburg and Panama. This flight may include one or multiple stops.

  • Can I find deals for flights from Harrisburg to Panama that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Panama.

  • Can I find deals for business class flights from Harrisburg to Panama?

    Yes. Cheapflights offers flight deals from Harrisburg to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Panama?

    Currently, December is the cheapest month in which you can book a flight from Harrisburg to Panama (average of $340). Flying from Harrisburg to Panama in January is currently the most expensive (average of $477). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Harrisburg to Panama

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to San José flights
Newark to San José flights
John F Kennedy Intl to Panama City flights
John F Kennedy Intl to Guatemala City flights
Newark to Panama City flights
Dulles Intl to San Salvador flights
John F Kennedy Intl to San Salvador flights
Dulles Intl to Panama City flights
John F Kennedy Intl to Liberia flights
LaGuardia to San José flights
Dulles Intl to San José flights
LaGuardia to Panama City flights
Newark to Guatemala City flights
Newark to Liberia flights
Reagan-National to San Salvador flights
Dulles Intl to Guatemala City flights
Reagan-National to San José flights
LaGuardia to Liberia flights
LaGuardia to Guatemala City flights
Newark to San Salvador flights
LaGuardia to San Salvador flights
John F Kennedy Intl to San Pedro Sula flights
Reagan-National to Panama City flights
Dulles Intl to Liberia flights
Reagan-National to Liberia flights
Reagan-National to Guatemala City flights
LaGuardia to Philip S.W.Goldson flights
Dulles Intl to Philip S.W.Goldson flights
John F Kennedy Intl to Philip S.W.Goldson flights
Newark to Philip S.W.Goldson flights
Reagan-National to Philip S.W.Goldson flights
Philadelphia to Liberia flights
Newark to San Pedro Sula flights
LaGuardia to San Pedro Sula flights
John F Kennedy Intl to Managua flights
Philadelphia to San José flights
Philadelphia to Guatemala City flights
Philadelphia to Panama City flights
Newark to Managua flights
LaGuardia to Managua flights
Newark to Coxen Hole flights
Pittsburgh to San José flights
John F Kennedy Intl to Coxen Hole flights
Philadelphia to Philip S.W.Goldson flights
LaGuardia to Coxen Hole flights
Dulles Intl to San Pedro Sula flights
Dulles Intl to Managua flights
Reagan-National to Coxen Hole flights
Dulles Intl to Coxen Hole flights
Philadelphia to San Salvador flights

Top airline flying from Harrisburg to Panama

Discover the top airline that operate flights from Harrisburg to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$544FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.