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$522+ Cheap flights from Harrisburg (MDT) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/7. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — PTY
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from Harrisburg to Panama

Cheapest flights from Harrisburg to Panama
Explore the most affordable flight options available from Harrisburg to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:24 pmMDT - PTY
2 stops23h 43mUnited Airlines
Sat 12/278:55 amPTY - MDT
2 stops15h 12mUnited Airlines
Deal found 12/21$568
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:15 amMDT - PTY
2 stops13h 23mUnited Airlines
Sat 12/2711:35 amPTY - MDT
2 stops22h 01mUnited Airlines
Deal found 12/21$632
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:00 amMDT - PTY
1 stop7h 57mDelta
Sat 12/278:00 amPTY - MDT
1 stop15h 36mDelta
Deal found 12/21$1,068
This Kiwi.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/223:35 pmMDT - PTY
1 stop18h 58mMultiple Airlines
Sat 12/277:50 pmPTY - MDT
2 stops42h 17mMultiple Airlines
Deal found 12/21$1,174
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:00 amMDT - PTY
2 stops10h 54mAmerican Airlines
Sat 12/274:55 pmPTY - MDT
3 stops16h 15mAmerican Airlines
Deal found 12/21$2,530

Find flight deals from Harrisburg to Panama

Keep the following information in mind while searching for Harrisburg to Panama flight deals. Data was last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$522
(United Airlines)

Popular in

December

Cheapest in

August

Average price

$905
Provider with most accurate pricing for Harrisburg-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Panama City Tocumen Intl flights.
Search Deals
From Harrisburg to Panama
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($86 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Harrisburg to Panama that are best for you.

Fly from

Harrisburg

Fly to

Panama

Route

Depart

Return

Price

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Sat 2/7

5:26 pm-2:45 pm

2 stops21h 19m

Panama City Tocumen Intl

Tue 2/10

4:41 pm-4:34 pm

2 stops23h 53m

$522

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Fri 2/6

6:30 am-8:02 pm

2 stops13h 32m

Panama City Tocumen Intl

Fri 2/13

4:41 pm-10:04 am

2 stops17h 23m

$522

HarrisburgPanama City

MDT - PTY

MDTPTY

Harrisburg

Thu 2/5

6:15 am-5:07 pm

2 stops10h 52m

Panama City Tocumen Intl

Thu 2/12

4:41 pm-4:44 pm

2 stops24h 03m

$649

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/20

Best time to book a flight from Harrisburg to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Panama

What is the cheapest month to book a flight from Harrisburg to Panama?

Currently, June is the cheapest month in which you can book a flight from Harrisburg to Panama (average of $265). Flying from Harrisburg to Panama in August is currently the most expensive (average of $471). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated December 23, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Harrisburg to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,014 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,014 reviews
Delta
7.9
Good
8,014 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,014 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Harrisburg to Panama?

    Harrisburg (MDT), located 8.5 mi from the city center, is the airport you fly out of when you book flights from Harrisburg to Panama.

  • How long is the flight from Harrisburg to Panama?

    Departing from Harrisburg to Panama will take you 21h 19m. There are 2155 mi between Harrisburg and Panama.

  • Can I find deals for flights from Harrisburg to Panama that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Panama.

  • Can I find deals for business class flights from Harrisburg to Panama?

    Yes. Cheapflights offers flight deals from Harrisburg to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Panama?

    Currently, June is the cheapest month in which you can book a flight from Harrisburg to Panama (average of $265). Flying from Harrisburg to Panama in August is currently the most expensive (average of $471). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Harrisburg to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Harrisburg to Panama

Discover the top 2 airlines that operate flights from Harrisburg to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$491Average$699FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$501Average$546FlexibilityNo cancel feeOn-time71%

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