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$171+ Cheap flights from Durham, NC to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — PTY
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Durham to Panama

Keep the following information in mind while searching for Durham to Panama flight deals. Data was last updated September 15, 2025.

Round-trip from

$246
(Copa Airlines)

One-way from

$171
(Kiwi.com)

Popular in

December

Cheapest in

November

Average price

$367
From Durham to Panama
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One-way flight from Durham to Panama
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Highest demand for flights based on searches. 9% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($33 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Durham to Panama

Cheapest flights from Durham to Panama
Explore the most affordable flight options available from Durham to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/14:19 pmRDU - PTY
Nonstop4h 27mCopa Airlines
Wed 10/88:57 amPTY - RDU
Nonstop4h 30mCopa Airlines
Deal found 9/14$246
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:00 amRDU - PTY
1 stop13h 37mUnited Airlines
Tue 10/2110:00 amPTY - RDU
1 stop11h 14mUnited Airlines
Deal found 9/15$260
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/78:37 pmRDU - PTY
2 stops18h 26mAmerican Airlines
Tue 10/213:15 pmPTY - RDU
1 stop7h 41mAmerican Airlines
Deal found 9/15$265
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:00 amRDU - PTY
1 stop13h 37mUnited Airlines
Fri 10/243:30 pmPTY - RDU
1 stop29h 44mUnited Airlines
Deal found 9/15$267
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/147:47 pmRDU - PTY
2 stops19h 16mAmerican Airlines
Mon 10/203:15 pmPTY - RDU
2 stops19h 04mAmerican Airlines
Deal found 9/14$275
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/107:51 pmRDU - PTY
1 stop19h 12mAmerican Airlines
Tue 10/143:15 pmPTY - RDU
1 stop7h 41mAmerican Airlines
Deal found 9/14$277
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/174:19 pmRDU - PTY
Nonstop4h 27mCopa Airlines
Fri 10/248:57 amPTY - RDU
Nonstop4h 30mCopa Airlines
Deal found 9/15$286
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:16 pmRDU - PTY
2 stops22h 15mAmerican Airlines
Mon 9/293:31 pmPTY - RDU
2 stops18h 47mAmerican Airlines
Deal found 9/15$328
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:04 amRDU - PTY
1 stop7h 45mAmerican Airlines
Mon 11/242:43 pmPTY - RDU
1 stop7h 25mAmerican Airlines
Deal found 9/15$337
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/195:34 pmRDU - PTY
2 stops20h 09mAmerican Airlines
Wed 12/34:37 pmPTY - RDU
1 stop7h 22mAmerican Airlines
Deal found 9/14$342
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/267:19 pmRDU - PTY
1 stop18h 24mAmerican Airlines
Fri 12/52:50 pmPTY - RDU
1 stop9h 09mAmerican Airlines
Deal found 9/14$345

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Durham to Panama that are best for you.

Fly from

Durham

Fly to

Panama

Route

Depart

Return

Price

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Wed 10/1

4:19 pm-7:46 pm

Nonstop4h 27m

Panama City Tocumen Intl

Wed 10/8

8:57 am-2:27 pm

Nonstop4h 30m

$246

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Fri 10/3

4:19 pm-7:46 pm

Nonstop4h 27m

Panama City Tocumen Intl

Wed 10/8

8:57 am-2:27 pm

Nonstop4h 30m

$246

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Sat 10/18

6:00 am-2:14 pm

1 stop9h 14m

Panama City Tocumen Intl

Wed 10/22

10:00 am-10:14 pm

1 stop11h 14m

$260

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Fri 10/31

8:37 pm-2:03 pm

2 stops18h 26m

Panama City Tocumen Intl

Mon 11/3

2:49 pm-9:23 am

2 stops18h 34m

$342

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Thu 10/16

6:00 am-6:37 pm

1 stop13h 37m

Panama City Tocumen Intl

Thu 10/23

10:00 am-10:14 pm

1 stop11h 14m

$388

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Wed 10/22

6:00 am-6:37 pm

1 stop13h 37m

Panama City Tocumen Intl

Mon 10/27

7:55 am-9:54 pm

1 stop12h 59m

$388

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Wed 11/19

3:14 pm-7:46 pm

Nonstop4h 32m

Panama City Tocumen Intl

Wed 12/3

8:57 am-1:25 pm

Nonstop4h 28m

$441

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Tue 11/18

7:15 am-2:12 pm

1 stop6h 57m

Panama City Tocumen Intl

Sat 12/6

8:05 am-9:10 pm

1 stop13h 05m

$455

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Tue 2/10

6:54 am-1:10 pm

1 stop6h 16m

Panama City Tocumen Intl

Tue 2/24

4:40 pm-12:21 am

1 stop7h 41m

$455

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Mon 11/17

5:15 am-2:12 pm

1 stop8h 57m

Panama City Tocumen Intl

Fri 12/5

3:46 pm-12:19 am

1 stop8h 33m

$455

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 19 results
1
2

Best time to book a flight from Durham to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Panama

What is the cheapest month to book a flight from Durham to Panama?

Currently, October is the cheapest month in which you can book a flight from Durham to Panama (average of $478). Flying from Durham to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to PA?

Find hourly flight availability from Durham to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Durham to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated September 15, 2025.
Read reviews from past customers who have flown Delta, Copa Airlines, and United Airlines from Durham to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.6
Good
1,531 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,929 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Durham to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Durham to Panama flight route?

    The Durham to Panama flight path was viewed by 29 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Durham to Panama?

    Departing from Durham to Panama will take you 4h 27m. There are 1851 mi between Durham and Panama. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest flights from Durham to Panama?

    On average you can expect to pay $319 for a flight from Durham to Panama. The cheapest flight overall is $155 while the most popular route, (Raleigh-Durham - Panama City Tocumen Intl) is currently priced at $246.

  • Can I find deals for flights from Durham to Panama that include hotel bookings?

    Yes. In addition to deals on Durham to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Panama.

  • Can I find deals for business class flights from Durham to Panama?

    Yes. Cheapflights offers flight deals from Durham to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Panama?

    Currently, October is the cheapest month in which you can book a flight from Durham to Panama (average of $478). Flying from Durham to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Durham to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Durham to Panama

Discover the top 4 airlines that operate flights from Durham to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$249Average$582FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$282Average$416FlexibilityNo cancel feeOn-time70%
DeltaCheapest$302Average$548FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$351Average$491FlexibilityNo cancel feeOn-time69%

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