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$170+ Cheap flights from Durham, NC to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — PTY
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Durham to Panama

Cheapest flights from Durham to Panama
Explore the most affordable flight options available from Durham to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2712:13 pmRDU - PTY
1 stop7h 07mMultiple Airlines
Thu 12/410:25 amPTY - RDU
2 stops13h 47mMultiple Airlines
Deal found 10/28$436
This Copa Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/263:14 pmRDU - PTY
Nonstop4h 32mCopa Airlines
Wed 12/38:57 amPTY - RDU
Nonstop4h 28mCopa Airlines
Deal found 10/27$441
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2712:13 pmRDU - PTY
1 stop8h 24mMultiple Airlines
Wed 12/312:33 pmPTY - RDU
2 stops11h 39mMultiple Airlines
Deal found 10/28$447
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/173:55 pmRDU - PTY
1 stop16h 11mMultiple Airlines
Wed 11/196:34 pmPTY - RDU
1 stop16h 44mMultiple Airlines
Deal found 10/29$450
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:07 amRDU - PTY
1 stop13h 31mUnited Airlines
Thu 12/411:55 pmPTY - RDU
1 stop8h 27mUnited Airlines
Deal found 10/28$456
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:07 pmRDU - PTY
2 stops19h 36mAmerican Airlines
Fri 12/192:53 pmPTY - RDU
1 stop9h 40mAmerican Airlines
Deal found 10/28$460
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:07 pmRDU - PTY
2 stops19h 36mAmerican Airlines
Sun 12/72:50 pmPTY - RDU
2 stops18h 39mAmerican Airlines
Deal found 10/28$465
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:50 pmRDU - PTY
1 stop17h 53mAmerican Airlines
Thu 12/42:50 pmPTY - RDU
2 stops18h 39mAmerican Airlines
Deal found 10/28$470
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:07 amRDU - PTY
1 stop13h 31mUnited Airlines
Wed 12/38:55 amPTY - RDU
1 stop13h 20mUnited Airlines
Deal found 10/28$480
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:31 pmRDU - PTY
2 stops19h 12mAmerican Airlines
Wed 12/34:43 pmPTY - RDU
1 stop7h 16mAmerican Airlines
Deal found 10/28$484

Cheap flight deals from Durham to Panama

Keep the following information in mind while searching for Durham to Panama flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$441
(Copa Airlines)

One-way from

$170
(Kiwi.com)

Popular in

December

Cheapest in

November

Average price

$402
Provider with most accurate pricing for Raleigh-Durham-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Raleigh-Durham-Panama City Tocumen Intl flights.
Search Deals
From Durham to Panama
Search Deals
One-way flight from Durham to Panama
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Durham to Panama that are best for you.

Fly from

Durham

Fly to

Panama

Route

Depart

Return

Price

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Wed 2/4

3:12 pm-7:46 pm

Nonstop4h 34m

Panama City Tocumen Intl

Wed 2/18

8:57 am-1:14 pm

Nonstop4h 17m

$441

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Wed 11/26

6:07 am-2:45 pm

1 stop8h 38m

Panama City Tocumen Intl

Fri 12/5

11:35 am-10:15 pm

1 stop10h 40m

$456

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Fri 3/13

6:30 am-6:38 pm

1 stop13h 08m

Panama City Tocumen Intl

Thu 3/19

7:55 am-10:36 pm

1 stop13h 41m

$456

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Sun 2/8

3:12 pm-7:46 pm

Nonstop4h 34m

Panama City Tocumen Intl

Sun 2/22

8:57 am-1:14 pm

Nonstop4h 17m

$456

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Sat 11/29

6:04 am-2:45 pm

1 stop8h 41m

Panama City Tocumen Intl

Wed 12/3

10:00 am-8:55 pm

1 stop10h 55m

$456

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Mon 3/16

11:20 am-7:02 pm

1 stop8h 42m

Panama City Tocumen Intl

Wed 3/18

10:55 pm-9:16 am

1 stop9h 21m

$456

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Sun 2/8

6:15 am-7:38 pm

2 stops13h 23m

Panama City Tocumen Intl

Sun 2/22

8:55 am-10:33 pm

1 stop13h 38m

$456

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Wed 2/4

6:15 am-7:38 pm

2 stops13h 23m

Panama City Tocumen Intl

Wed 2/18

11:35 am-10:33 pm

1 stop10h 58m

$456

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Fri 3/13

6:30 am-6:38 pm

1 stop13h 08m

Panama City Tocumen Intl

Fri 3/20

11:35 am-10:36 pm

1 stop10h 01m

$456

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Sun 3/15

6:30 am-6:38 pm

1 stop13h 08m

Panama City Tocumen Intl

Wed 3/18

7:55 am-10:36 pm

1 stop13h 41m

$456

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 17 results
1
2

Best time to book a flight from Durham to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Panama

What is the cheapest month to book a flight from Durham to Panama?

Currently, August is the cheapest month in which you can book a flight from Durham to Panama (average of $234). Flying from Durham to Panama in December is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to PA?

Find hourly flight availability from Durham to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

It’s typically best to fly out from Durham to Panama at noon. Doing so could potentially save you 41% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 30, 2025.
Read reviews from past customers who have flown Delta, Copa Airlines, and United Airlines from Durham to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,993 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Copa Airlines
7.6
Good
1,563 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,998 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,030 reviews
Delta
7.9
Good
7,993 reviews

Boarding

8.2

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Durham to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Durham to Panama flight route?

    The Durham to Panama flight path was viewed by 21 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Durham to Panama?

    Departing from Durham to Panama will take you 4h 34m. There are 1851 mi between Durham and Panama. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest flights from Durham to Panama?

    On average you can expect to pay $665 for a flight from Durham to Panama. The cheapest flight overall is $105 while the most popular route, (Raleigh-Durham - Panama City Tocumen Intl) is currently priced at $441.

  • Can I find deals for flights from Durham to Panama that include hotel bookings?

    Yes. In addition to deals on Durham to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Panama.

  • Can I find deals for business class flights from Durham to Panama?

    Yes. Cheapflights offers flight deals from Durham to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Panama?

    Currently, August is the cheapest month in which you can book a flight from Durham to Panama (average of $234). Flying from Durham to Panama in December is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Durham to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Durham to Panama

Discover the top 4 airlines that operate flights from Durham to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$249Average$584FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$290Average$457FlexibilityNo cancel feeOn-time70%
DeltaCheapest$367Average$542FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$409Average$498FlexibilityNo cancel feeOn-time69%

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