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$210+ Cheap flights from Detroit (DTT) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — PTY
Mar 26 — Apr 21
Thu 3/26
Thu 4/2
1 adult, Economy
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Cheap flight deals from Detroit to Panama

Cheapest flights from Detroit to Panama
Explore the most affordable flight options available from Detroit to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 24, 2026.

This Trip.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/910:24 am
DTW
-
PTY
3 stops25h 06m
Multiple Airlines
Wed 4/153:05 am
PTY
-
DTW
2 stops14h 39m
Multiple Airlines
Deal found 2/23$476
This Mytrip deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/174:50 pm
DTW
-
PTY
2 stops22h 10m
Multiple Airlines
Tue 3/242:55 am
PTY
-
DTW
2 stops32h 25m
Multiple Airlines
Deal found 2/23$482
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/92:15 pm
DTW
-
PTY
2 stops24h 45m
Multiple Airlines
Tue 4/73:25 am
PTY
-
DTW
3 stops18h 12m
Multiple Airlines
Deal found 2/21$487
This Trip.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2312:36 pm
DTW
-
PTY
2 stops25h 24m
Multiple Airlines
Wed 2/252:55 am
PTY
-
DTW
2 stops18h 44m
Multiple Airlines
Deal found 2/22$494
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/107:15 am
DTW
-
PTY
1 stop14h 04m
Multiple Airlines
Fri 4/1712:03 pm
PTY
-
DTW
1 stop11h 43m
Multiple Airlines
Deal found 2/23$501
This Trip.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:20 am
DTW
-
PTY
2 stops20h 45m
Multiple Airlines
Mon 4/133:05 am
PTY
-
DTW
2 stops19h 54m
Multiple Airlines
Deal found 2/21$506
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/165:20 am
DTW
-
PTY
1 stop15h 00m
Multiple Airlines
Tue 3/1710:25 am
PTY
-
DTW
1 stop12h 34m
Multiple Airlines
Deal found 2/23$509

Find flight deals from Detroit to Panama

Keep the following information in mind while searching for Detroit to Panama flight deals. Data was last updated February 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$476
(Trip.com)

One-way from

$210
(Kiwi.com)
Provider with most accurate pricing for Detroit (DTT)-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Panama City Tocumen Intl flights.
Search Deals
From Detroit (DTT) to Panama
Search Deals
One-way flight from Detroit (DTT) to Panama
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 24, 2026.
Use the filters below to find and compare flights from Detroit to Panama that are best for you.

Fly from

Detroit

Fly to

Panama

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 4/9

8:15 am-1:05 am

2 stops17h 50m

Panama City Tocumen Intl

Wed 4/15

3:05 am-11:59 pm

2 stops19h 54m

$542

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 4/6

4:50 pm-9:15 am

2 stops17h 25m

Panama City Tocumen Intl

Mon 4/13

5:55 pm-12:20 pm

2 stops17h 25m

$547

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 4/10

4:50 pm-9:15 am

2 stops17h 25m

Panama City Tocumen Intl

Thu 4/16

3:25 am-11:59 pm

2 stops19h 34m

$570

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 4/20

6:00 am-10:30 am

2 stops29h 30m

Panama City Tocumen Intl

Mon 5/4

3:50 pm-11:46 pm

2 stops30h 56m

$584

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 4/18

6:00 am-1:31 pm

1 stop8h 31m

Panama City Tocumen Intl

Sun 4/26

8:02 am-10:07 pm

1 stop13h 05m

$693

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 4/20

7:47 pm-6:13 am

1 stop11h 26m

Panama City Tocumen Intl

Mon 5/4

10:29 pm-10:24 am

1 stop10h 55m

$693

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 4/20

6:00 am-4:12 pm

2 stops11h 12m

Panama City Tocumen Intl

Mon 5/4

10:00 am-11:47 pm

1 stop12h 47m

$715

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 4/8

9:00 am-4:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Wed 4/15

10:00 am-11:57 pm

1 stop12h 57m

$760

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 3/1

6:36 pm-8:15 pm

2 stops25h 39m

Panama City Tocumen Intl

Tue 3/31

10:26 am-8:02 am

1 stop20h 36m

$804

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 4/18

6:00 am-6:37 pm

2 stops13h 37m

Panama City Tocumen Intl

Tue 4/21

10:00 am-11:57 pm

1 stop12h 57m

$885

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/23

Showing 1-10 of 19 results
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Best time to book a flight from Detroit to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit to Panama

What is the cheapest month to book a flight from Detroit to Panama?

Currently, June is the cheapest month in which you can book a flight from Detroit to Panama (average of $599). Flying from Detroit to Panama in February is currently the most expensive (average of $792). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to Panama?

    For a flight from Detroit to Panama, you will be flying from All airports. Detroit All airports (DTT) is just 0.6 mi from the center of the city.

  • How long is the flight from Detroit to Panama?

    A quick flight from Detroit to Panama can take about 8h 31m. Copa Airlines provides one of the quickest options available for as low as $693. There are 2302 mi between Detroit and Panama.

  • Can I find deals for flights from Detroit to Panama that include hotel bookings?

    Yes. In addition to deals on Detroit to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Panama.

  • Can I find deals for business class flights from Detroit to Panama?

    Yes. Cheapflights offers flight deals from Detroit to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit to Panama?

    Currently, June is the cheapest month in which you can book a flight from Detroit to Panama (average of $599). Flying from Detroit to Panama in February is currently the most expensive (average of $792). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 4 airlines flying from Detroit to Panama

Discover the top 4 airlines that operate flights from Detroit to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$578Average$819FlexibilityNo cancel feeOn-time71%
DeltaCheapest$608Average$847FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$623Average$753FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$629Average$811FlexibilityNo cancel feeOn-time69%

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