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$290+ Cheap flights from Detroit (DTT) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/13. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — PTY
Dec 12 — Dec 191
Fri 12/12
Fri 12/19
1 adult, Economy
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Cheap flight deals from Detroit to Panama

Keep the following information in mind while searching for Detroit to Panama flight deals. Data was last updated November 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$516
(Avianca Connect)

One-way from

$290
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$993
Provider with most accurate pricing for Detroit (DTT)-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Detroit (DTT)-Panama City Tocumen Intl flights.
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From Detroit (DTT) to Panama
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One-way flight from Detroit (DTT) to Panama
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Highest demand for flights based on searches. 15% potential increase in price ($142 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($33 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Detroit to Panama

Cheapest flights from Detroit to Panama
Explore the most affordable flight options available from Detroit to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/811:07 amDTW - PTY
1 stop9h 30mMultiple Airlines
Wed 12/105:50 pmPTY - DTW
2 stops21h 44mMultiple Airlines
Deal found 11/10$539
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:43 pmDTW - PTY
1 stop17h 23mMultiple Airlines
Sat 12/2710:19 pmPTY - DTW
2 stops42h 52mMultiple Airlines
Deal found 11/12$580
This Avianca Connect deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:15 amDTW - PTY
2 stops18h 25mMultiple Airlines
Tue 12/162:55 amPTY - DTW
2 stops18h 09mMultiple Airlines
Deal found 11/12$589
This Mytrip deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/19:53 pmDTW - PTY
2 stops17h 02mMultiple Airlines
Mon 12/152:55 pmPTY - DTW
3 stops33h 14mMultiple Airlines
Deal found 11/10$591
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/104:39 pmDTW - PTY
1 stop15h 27mMultiple Airlines
Tue 1/611:25 amPTY - DTW
2 stops37h 17mMultiple Airlines
Deal found 11/10$636

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
Use the filters below to find and compare flights from Detroit to Panama that are best for you.

Fly from

Detroit

Fly to

Panama

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 2/2

6:35 am-12:40 am

2 stops18h 05m

Panama City Tocumen Intl

Sun 2/8

9:45 am-10:12 pm

2 stops12h 27m

$516

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 2/6

6:35 am-12:40 am

2 stops18h 05m

Panama City Tocumen Intl

Tue 2/10

2:55 am-10:44 pm

2 stops19h 49m

$530

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 2/1

6:35 am-1:00 am

2 stops18h 25m

Panama City Tocumen Intl

Fri 2/27

2:55 am-9:41 pm

2 stops18h 46m

$545

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 3/7

6:49 pm-5:10 am

1 stop10h 21m

Panama City Tocumen Intl

Tue 3/17

9:30 am-8:17 pm

1 stop9h 47m

$643

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 3/13

4:20 pm-10:30 am

3 stops43h 10m

$290

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 12/14

6:12 pm-2:00 pm

3 stops43h 48m

$303

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 3/29

7:45 pm-12:55 pm

1 stop18h 10m

$334

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 3/30

10:55 am-6:37 pm

1 stop8h 42m

$334

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 3/29

6:05 pm-2:14 pm

2 stops21h 09m

$334

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 4/24

6:30 am-12:55 pm

1 stop7h 25m

$359

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/10

Showing 1-10 of 12 results
1
2

Best time to book a flight from Detroit to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit to Panama

What is the cheapest month to book a flight from Detroit to Panama?

Currently, June is the cheapest month in which you can book a flight from Detroit to Panama (average of $594). Flying from Detroit to Panama in February is currently the most expensive (average of $809). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTT to PA?

Find hourly flight availability from Detroit to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 12, 2025.

It’s optimal to fly from Detroit to Panama at noon. By choosing this option you can save up to 71% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated November 12, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Detroit to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,009 reviews

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,009 reviews
Delta
7.9
Good
8,009 reviews

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,015 reviews
Delta
7.9
Good
8,009 reviews

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,049 reviews
Delta
7.9
Good
8,009 reviews

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to Panama?

    For a flight from Detroit to Panama, you will be flying from All airports. Detroit All airports (DTT) is just 0.6 mi from the center of the city.

  • Can I find deals for flights from Detroit to Panama that include hotel bookings?

    Yes. In addition to deals on Detroit to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Panama.

  • Can I find deals for business class flights from Detroit to Panama?

    Yes. Cheapflights offers flight deals from Detroit to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit to Panama?

    Currently, June is the cheapest month in which you can book a flight from Detroit to Panama (average of $594). Flying from Detroit to Panama in February is currently the most expensive (average of $809). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Detroit to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Detroit to Panama

Discover the top 3 airlines that operate flights from Detroit to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$578Average$800FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$608Average$851FlexibilityNo cancel feeOn-time69%
DeltaCheapest$608Average$937FlexibilityNo cancel feeOn-timeN/A

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