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$198+ Cheap flights from Des Moines (DSM) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Dec 16 — Dec 231
Tue 12/16
Tue 12/23
1 adult, Economy
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Find flight deals from Des Moines to Panama

Cheapest flights from Des Moines to Panama
Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 16, 2025.

This United Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/138:15 amDSM - PTY
1 stop7h 52mUnited Airlines
Fri 12/268:55 amPTY - DSM
1 stop14h 35mUnited Airlines
Deal found 11/16$462
This United Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:05 amDSM - PTY
1 stop7h 40mUnited Airlines
Thu 11/274:41 pmPTY - DSM
1 stop22h 30mUnited Airlines
Deal found 11/16$471
This American Airlines deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:52 pmDSM - PTY
2 stops20h 02mAmerican Airlines
Tue 1/64:31 pmPTY - DSM
2 stops21h 15mAmerican Airlines
Deal found 11/15$517
This United Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/226:05 amDSM - PTY
1 stop12h 33mUnited Airlines
Fri 11/284:41 pmPTY - DSM
2 stops19h 01mUnited Airlines
Deal found 11/16$610
This United Airlines deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/293:00 pmDSM - PTY
1 stop25h 07mUnited Airlines
Mon 3/233:41 pmPTY - DSM
2 stops22h 46mUnited Airlines
Deal found 11/15$623
This American Airlines deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/223:31 pmDSM - PTY
2 stops21h 12mAmerican Airlines
Fri 11/282:43 pmPTY - DSM
1 stop9h 55mAmerican Airlines
Deal found 11/15$671

Cheap flight deals from Des Moines to Panama

Keep the following information in mind while searching for Des Moines to Panama flight deals. Data was last updated November 16, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$462
(United Airlines)

One-way from

$198
(United Airlines)

Popular in

June

Cheapest in

September

Average price

$581
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Des Moines to Panama
Search Deals
One-way flight from Des Moines to Panama
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($103 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($44 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 16, 2025.
Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Fly from

Des Moines

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 2/7

7:50 am-7:38 pm

2 stops10h 48m

Panama City Tocumen Intl

Fri 2/13

8:55 am-10:20 pm

1 stop14h 25m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 5/2

5:45 am-12:55 pm

1 stop7h 10m

Panama City Tocumen Intl

Tue 5/5

2:20 pm-10:29 pm

1 stop8h 09m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 12/13

8:15 am-7:38 pm

1 stop10h 23m

Panama City Tocumen Intl

Fri 12/26

8:55 am-10:30 pm

1 stop14h 35m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 2/24

8:08 am-5:07 pm

1 stop7h 59m

Panama City Tocumen Intl

Fri 3/6

11:35 am-10:44 pm

1 stop12h 09m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 1/13

4:25 pm-1:27 pm

2 stops20h 02m

Panama City Tocumen Intl

Wed 1/21

2:27 pm-10:50 am

2 stops21h 23m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 1/12

8:00 am-7:38 pm

2 stops10h 38m

Panama City Tocumen Intl

Wed 1/21

4:41 pm-10:55 am

2 stops19h 14m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 11/25

6:05 am-7:38 pm

1 stop12h 33m

$198

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 11/25

3:31 pm-1:43 pm

2 stops21h 12m

$198

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 12/15

8:15 am-5:07 pm

1 stop7h 52m

$198

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 3/13

7:15 am-4:07 pm

1 stop8h 52m

$342

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/16

Showing 1-10 of 11 results
1
2

Best time to book a flight from Des Moines to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama

What is the cheapest month to book a flight from Des Moines to Panama?

Currently, December is the cheapest month in which you can book a flight from Des Moines to Panama (average of $401). Flying from Des Moines to Panama in March is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated November 16, 2025.
See what other customers who have flown with Delta and United Airlines from Des Moines to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,015 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Panama?

    For a flight from Des Moines to Panama, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • How long is the flight from Des Moines to Panama?

    Departing from Des Moines to Panama will take you 7h 10m. The distance between Des Moines and Panama is about 2405 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Des Moines to Panama that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama.

  • Can I find deals for business class flights from Des Moines to Panama?

    Yes. Cheapflights offers flight deals from Des Moines to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama?

    Currently, December is the cheapest month in which you can book a flight from Des Moines to Panama (average of $401). Flying from Des Moines to Panama in March is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Moline to San José flights
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Omaha to San Pedro Sula flights
Moline to Liberia flights
La Crosse to Panama City flights
Moline to Guatemala City flights
Des Moines to Tegucigalpa flights

Top 2 airlines flying from Des Moines to Panama

Discover the top 2 airlines that operate flights from Des Moines to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$414Average$489FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$581FlexibilityNo cancel feeOn-timeN/A

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