How long is the flight from Des Moines to Panama?

Departing from Des Moines to Panama will take you 7h 57m. The distance between Des Moines and Panama is about 2405 mi.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What is the cheapest time of day to fly from DSM to PA?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Panama as you normally would.

What airport do you fly from for flights from Des Moines to Panama?

For a flight from Des Moines to Panama, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

Can I find deals for flights from Des Moines to Panama that include hotel bookings?

Yes. In addition to deals on Des Moines to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Panama?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama.

Can I find deals for business class flights from Des Moines to Panama?

Yes. Cheapflights offers flight deals from Des Moines to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$351+ Flights from Des Moines to Panama

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Cheap flight deals from Des Moines to Panama

Cheapest flights from Des Moines to Panama
Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 27, 2025.

Mon 12/296:46 pmDSM - PTY

2 stops18h 59mUnited Airlines

Mon 3/233:41 pmPTY - DSM

2 stops21h 42mUnited Airlines

Deal found 12/25

$466

Mon 12/296:52 pmDSM - PTY

2 stops20h 02mAmerican Airlines

Mon 3/231:39 pmPTY - DSM

2 stops20h 55mAmerican Airlines

Deal found 12/26

$561

Best flights from Des Moines to Panama
Discover carefully curated flight deals from Des Moines to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 27, 2025.

Tue 2/108:10 amDSM - PTY

1 stop7h 57mUnited Airlines

Tue 2/178:55 amPTY - DSM

1 stop14h 25mUnited Airlines

Deal found 12/26

$453

Sun 2/88:10 amDSM - PTY

1 stop10h 28mUnited Airlines

Sun 2/158:55 amPTY - DSM

1 stop14h 25mUnited Airlines

Deal found 12/25

$462

Thu 1/16:00 amDSM - PTY

1 stop10h 07mUnited Airlines

Wed 4/110:00 amPTY - DSM

1 stop12h 43mUnited Airlines

Deal found 12/25

$462

Thu 2/267:52 amDSM - PTY

1 stop8h 15mUnited Airlines

Sat 3/78:55 amPTY - DSM

1 stop14h 49mUnited Airlines

Deal found 12/24

$462

Tue 2/247:52 amDSM - PTY

1 stop8h 15mUnited Airlines

Fri 3/611:35 amPTY - DSM

1 stop12h 09mUnited Airlines

Deal found 12/25

$462

Mon 2/96:48 pmDSM - PTY

2 stops21h 19mUnited Airlines

Fri 2/138:55 amPTY - DSM

1 stop14h 25mUnited Airlines

Deal found 12/24

$466

Last-minute flights from Des Moines to Panama
Discover last-minute flight deals from Des Moines to Panama. Data last updated December 27, 2025 and is based on user searches.

Mon 12/296:46 pmDSM - PTY

2 stops21h 21mUnited Airlines

Mon 3/233:41 pmPTY - DSM

1 stop22h 37mUnited Airlines

Deal found 12/27

$518

Mon 12/296:52 pmDSM - PTY

2 stops20h 02mAmerican Airlines

Mon 3/231:39 pmPTY - DSM

2 stops20h 55mAmerican Airlines

Deal found 12/26

$561

Thu 1/16:00 amDSM - PTY

1 stop7h 45mUnited Airlines

Wed 4/17:55 amPTY - DSM

1 stop14h 48mUnited Airlines

Deal found 12/26

$462

Thu 1/13:27 pmDSM - PTY

2 stops21h 26mAmerican Airlines

Wed 4/11:44 pmPTY - DSM

2 stops23h 33mAmerican Airlines

Deal found 12/26

$466

One-way flights from Des Moines to Panama
Search for one-way flight options from Des Moines to Panama. Find affordable one-way fares based on user searches. Data last updated December 27, 2025.

Fri 3/131:40 pmDSM - PTY

2 stops23h 00mAmerican Airlines

Deal found 12/24

$351

Fri 3/137:15 amDSM - PTY

1 stop8h 52mUnited Airlines

Deal found 12/25

$708

Find flight deals from Des Moines to Panama

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$453 (United Airlines)
One-way from	$351 (American Airlines)
Popular in	June
Cheapest in	September
Average price	$1,033

Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.

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Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.

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From Des Moines to Panama

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One-way flight from Des Moines to Panama

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($70 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 7% potential price decrease ($42 potential savings vs. average RT price).

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Average for round-trip flights in December 2025

Search Deals

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 2/10

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

Tue 2/17

8:55 am-10:20 pm

1 stop14h 25m

$453

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 2/8

8:10 am-7:38 pm

1 stop10h 28m

Panama City Tocumen Intl

Sun 2/15

8:55 am-10:20 pm

1 stop14h 25m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 1/1

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

Wed 4/1

10:00 am-10:43 pm

1 stop12h 43m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 2/26

7:52 am-5:07 pm

1 stop8h 15m

Panama City Tocumen Intl

Sat 3/7

8:55 am-10:44 pm

1 stop14h 49m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 2/24

7:52 am-5:07 pm

1 stop8h 15m

Panama City Tocumen Intl

Fri 3/6

11:35 am-10:44 pm

1 stop12h 09m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 2/9

6:48 pm-5:07 pm

2 stops21h 19m

Panama City Tocumen Intl

Fri 2/13

8:55 am-10:20 pm

1 stop14h 25m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 3/13

1:40 pm-12:40 pm

2 stops23h 00m

$351

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 3/13

7:15 am-4:07 pm

1 stop8h 52m

$708

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/24

Best time to book a flight from Des Moines to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama

What is the cheapest month to book a flight from Des Moines to Panama?

Currently, April is the cheapest month in which you can book a flight from Des Moines to Panama (average of $411). Flying from Des Moines to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

See what other customers who have flown with Delta and United Airlines from Des Moines to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Delta

7.9

Good

8,018 reviews

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

United Airlines

7.4

Good

9,116 reviews

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Related info for your journey

What airport do you fly from for flights from Des Moines to Panama?
For a flight from Des Moines to Panama, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.
How long is the flight from Des Moines to Panama?
Departing from Des Moines to Panama will take you 7h 57m. The distance between Des Moines and Panama is about 2405 mi.
Can I find deals for flights from Des Moines to Panama that include hotel bookings?
Yes. In addition to deals on Des Moines to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Panama?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama.
Can I find deals for business class flights from Des Moines to Panama?
Yes. Cheapflights offers flight deals from Des Moines to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Panama?
Currently, April is the cheapest month in which you can book a flight from Des Moines to Panama (average of $411). Flying from Des Moines to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Des Moines to Panama

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$420	Average$465	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$441	Average$581	FlexibilityNo cancel fee	On-timeN/A

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$351+ Cheap flights from Des Moines (DSM) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/13. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Panama with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Panama

Cheapest flights from Des Moines to PanamaExplore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 27, 2025.

Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 27, 2025.

Find flight deals from Des Moines to Panama

Keep the following information in mind while searching for Des Moines to Panama flight deals. Data was last updated December 27, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Best time to book a flight from Des Moines to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama

What is the cheapest month to book a flight from Des Moines to Panama?

Reviews of airlines servicing Panama

See what other customers who have flown with Delta and United Airlines from Des Moines to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Des Moines to Panama?

How long is the flight from Des Moines to Panama?

Can I find deals for flights from Des Moines to Panama that include hotel bookings?

How can I find direct flights from Des Moines to Panama?

Can I find deals for business class flights from Des Moines to Panama?

What is the cheapest month to book a flight from Des Moines to Panama?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Panama

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Des Moines to Panama

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Des Moines to Panama
Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 27, 2025.