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$198+ Cheap flights from Des Moines (DSM) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
dic. 18 — dic. 251
jue. 12/18
jue. 12/25
1 adult, Economy
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Find flight deals from Des Moines to Panama

Cheapest flights from Des Moines to Panama
Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 18, 2025.

This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/138:15 amDSM - PTY
1 stop7h 52mUnited Airlines
vie. 12/268:55 amPTY - DSM
1 stop14h 35mUnited Airlines
Deal found 11/18$462
This United Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/246:50 pmDSM - PTY
2 stops18h 55mUnited Airlines
jue. 11/274:41 pmPTY - DSM
2 stops20h 33mUnited Airlines
Deal found 11/17$466
This United Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/221:05 pmDSM - PTY
2 stops24h 40mUnited Airlines
vie. 11/284:41 pmPTY - DSM
2 stops19h 01mUnited Airlines
Deal found 11/17$567
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/293:00 pmDSM - PTY
1 stop27h 38mUnited Airlines
lun. 3/233:41 pmPTY - DSM
2 stops18h 49mUnited Airlines
Deal found 11/18$623
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/294:16 pmDSM - PTY
2 stops22h 38mAmerican Airlines
lun. 3/231:50 pmPTY - DSM
2 stops21h 18mAmerican Airlines
Deal found 11/18$636
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/233:31 pmDSM - PTY
2 stops21h 12mAmerican Airlines
dom. 11/302:43 pmPTY - DSM
2 stops23h 46mAmerican Airlines
Deal found 11/17$865

Cheap flight deals from Des Moines to Panama

Keep the following information in mind while searching for Des Moines to Panama flight deals. Data was last updated noviembre 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$462
(United Airlines)

One-way from

$198
(United Airlines)

Popular in

June

Cheapest in

September

Average price

$581
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
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From Des Moines to Panama
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One-way flight from Des Moines to Panama
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Highest demand for flights based on searches. 14% potential increase in price ($103 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($44 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 18, 2025.
Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Fly from

Des Moines

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

sáb. 12/13

8:15 am-5:07 pm

1 stop7h 52m

Panama City Tocumen Intl

vie. 12/26

8:55 am-10:30 pm

1 stop14h 35m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 1/1

6:46 pm-2:45 pm

2 stops18h 59m

Panama City Tocumen Intl

mié. 4/1

7:55 am-10:30 pm

1 stop14h 35m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 1/15

6:48 pm-5:07 pm

2 stops21h 19m

Panama City Tocumen Intl

mié. 1/21

4:41 pm-2:33 pm

2 stops22h 52m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

lun. 11/24

6:05 am-7:38 pm

1 stop12h 33m

Panama City Tocumen Intl

jue. 11/27

4:41 pm-2:19 pm

2 stops22h 38m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mar. 11/25

6:05 am-7:38 pm

1 stop12h 33m

$198

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mar. 11/25

2:15 pm-1:43 pm

2 stops22h 28m

$198

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 1/1

8:00 am-2:45 pm

2 stops29h 45m

$263

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 1/1

5:35 am-8:00 pm

1 stop13h 25m

$273

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mar. 11/25

4:03 pm-7:55 pm

3 stops26h 52m

$384

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/17

Best time to book a flight from Des Moines to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama

What is the cheapest month to book a flight from Des Moines to Panama?

Currently, December is the cheapest month in which you can book a flight from Des Moines to Panama (average of $401). Flying from Des Moines to Panama in March is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated noviembre 18, 2025.
See what other customers who have flown with Delta and United Airlines from Des Moines to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,003 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Food

7.3

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,003 reviews
Delta
7.9
Good
8,003 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Food

7.3

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,019 reviews
Delta
7.9
Good
8,003 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Food

7.3

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Panama?

    For a flight from Des Moines to Panama, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • How long is the flight from Des Moines to Panama?

    Departing from Des Moines to Panama will take you 7h 52m. The distance between Des Moines and Panama is about 2405 mi.

  • What are the cheapest airlines to fly from Des Moines to Panama one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $198. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Des Moines to Panama for a low price.

  • Can I find deals for flights from Des Moines to Panama that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama.

  • Can I find deals for business class flights from Des Moines to Panama?

    Yes. Cheapflights offers flight deals from Des Moines to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama?

    Currently, December is the cheapest month in which you can book a flight from Des Moines to Panama (average of $401). Flying from Des Moines to Panama in March is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Cedar Rapids to San Salvador flights
Omaha to San Pedro Sula flights
Omaha to Managua flights
Moline to San José flights
Cedar Rapids to Philip S.W.Goldson flights
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Cedar Rapids to Panama City flights
Moline to Guatemala City flights
Moline to San Salvador flights
Moline to Liberia flights
Cedar Rapids to Coxen Hole flights
La Crosse to Panama City flights
Moline to Philip S.W.Goldson flights
Des Moines to Tegucigalpa flights

Top 2 airlines flying from Des Moines to Panama

Discover the top 2 airlines that operate flights from Des Moines to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$414Average$489FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$581FlexibilityNo cancel feeOn-timeN/A

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