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$483+ Cheap flights from Des Moines (DSM) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Des Moines to Panama

Cheapest flights from Des Moines to Panama
Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:52 am
DSM
-
PTY
1 stop8h 15m
United Airlines
Sat 3/78:55 am
PTY
-
DSM
1 stop14h 49m
United Airlines
Deal found 1/28$483
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/247:52 am
DSM
-
PTY
1 stop10h 46m
United Airlines
Fri 3/611:55 pm
PTY
-
DSM
2 stops19h 13m
United Airlines
Deal found 1/28$487
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/98:10 am
DSM
-
PTY
1 stop7h 57m
United Airlines
Fri 2/134:41 pm
PTY
-
DSM
1 stop30h 34m
United Airlines
Deal found 1/26$492
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:20 am
DSM
-
PTY
1 stop7h 52m
United Airlines
Sun 4/263:30 pm
PTY
-
DSM
2 stops20h 59m
United Airlines
Deal found 1/27$519
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/265:00 pm
DSM
-
PTY
2 stops19h 36m
American Airlines
Sun 5/31:49 pm
PTY
-
DSM
2 stops21h 39m
American Airlines
Deal found 1/27$524
This KAYAK deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:58 pm
DSM
-
PTY
1 stop25h 14m
Copa Airlines
Thu 5/213:30 pm
PTY
-
DSM
2 stops29h 42m
Copa Airlines
Deal found 1/28$547
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:44 pm
DSM
-
PTY
2 stops18h 36m
American Airlines
Mon 3/231:40 pm
PTY
-
DSM
2 stops19h 21m
American Airlines
Deal found 1/27$562
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/262:02 pm
DSM
-
PTY
2 stops22h 38m
American Airlines
Sat 3/74:05 pm
PTY
-
DSM
2 stops26h 55m
American Airlines
Deal found 1/26$576
This Gurufare deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:02 pm
DSM
-
PTY
2 stops22h 34m
GOL
Thu 5/211:10 pm
PTY
-
DSM
2 stops19h 13m
GOL
Deal found 1/28$593
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:20 am
DSM
-
PTY
1 stop7h 54m
United Airlines
Sun 6/2810:55 pm
PTY
-
DSM
2 stops11h 25m
United Airlines
Deal found 1/27$602
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/94:00 pm
DSM
-
PTY
2 stops20h 27m
American Airlines
Wed 2/252:40 pm
PTY
-
DSM
2 stops23h 38m
American Airlines
Deal found 1/28$608

Find flight deals from Des Moines to Panama

Keep the following information in mind while searching for Des Moines to Panama flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$483
(United Airlines)

Popular in

December

Cheapest in

September

Average price

$453
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Des Moines to Panama
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($117 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($42 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Fly from

Des Moines

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 2/26

7:52 am-5:07 pm

1 stop8h 15m

Panama City Tocumen Intl

Tue 3/3

8:55 am-10:20 pm

1 stop14h 25m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 4/27

8:20 am-4:12 pm

1 stop7h 52m

Panama City Tocumen Intl

Mon 5/4

10:00 am-10:45 pm

1 stop12h 45m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 2/26

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

Sat 3/7

8:55 am-10:44 pm

1 stop14h 49m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 2/24

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

Fri 3/6

8:55 am-10:44 pm

1 stop14h 49m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 2/9

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

Fri 2/13

4:41 pm-2:27 pm

2 stops22h 46m

$487

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 2/9

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

Wed 2/25

4:41 pm-2:27 pm

2 stops22h 46m

$487

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 3/14

6:49 pm-1:45 pm

2 stops18h 56m

$523

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 3/13

7:44 pm-2:20 pm

2 stops18h 36m

$607

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 3/13

7:15 am-6:38 pm

1 stop11h 23m

$719

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Best time to book a flight from Des Moines to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama

What is the cheapest month to book a flight from Des Moines to Panama?

Currently, April is the cheapest month in which you can book a flight from Des Moines to Panama (average of $411). Flying from Des Moines to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated January 29, 2026.
See what other customers who have flown with Delta and United Airlines from Des Moines to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Food

7.2

Overall

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Food

7.2

Overall

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,215 reviews
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Food

7.2

Overall

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Panama?

    For a flight from Des Moines to Panama, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • How long is the flight from Des Moines to Panama?

    Departing from Des Moines to Panama will take you 8h 15m. The distance between Des Moines and Panama is about 2405 mi.

  • Can I find deals for flights from Des Moines to Panama that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama.

  • Can I find deals for business class flights from Des Moines to Panama?

    Yes. Cheapflights offers flight deals from Des Moines to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama?

    Currently, April is the cheapest month in which you can book a flight from Des Moines to Panama (average of $411). Flying from Des Moines to Panama in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Des Moines to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Des Moines to Tegucigalpa flights

Top 2 airlines flying from Des Moines to Panama

Discover the top 2 airlines that operate flights from Des Moines to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$435Average$481FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$557FlexibilityNo cancel feeOn-timeN/A

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