HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama

$194+ Cheap flights from Des Moines (DSM) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Panama with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Panama

Keep the following information in mind while searching for Des Moines to Panama flight deals. Data was last updated June 12, 2025.

Round-trip from

$460
(Trip.com)

One-way from

$194
(United Airlines)

Popular in

June

Cheapest in

September

Average price

$1,069
From Des Moines to Panama
Search Deals
One-way flight from Des Moines to Panama
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($104 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($44 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals

Find flight deals from Des Moines to Panama

Cheapest flights from Des Moines to Panama
Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Trip.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/236:02 amDSM - PTY
1 stop10h 10mUnited Airlines
Wed 7/307:55 amPTY - DSM
1 stop14h 22mUnited Airlines
Deal found 6/11$460
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/294:26 pmDSM - PTY
2 stops19h 54mAmerican Airlines
Sat 12/62:45 pmPTY - DSM
1 stop9h 59mAmerican Airlines
Deal found 6/10$556
This Kissandfly.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/256:24 amDSM - PTY
2 stops12h 13mLufthansa
Fri 8/17:55 amPTY - DSM
2 stops13h 52mLufthansa
Deal found 6/10$609
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2311:00 amDSM - PTY
3 stops29h 39mMultiple Airlines
Wed 7/305:25 pmPTY - DSM
3 stops29h 13mMultiple Airlines
Deal found 6/10$629
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:14 amDSM - PTY
1 stop7h 48mDelta
Wed 12/313:20 pmPTY - DSM
1 stop8h 03mDelta
Deal found 6/10$941
This Gotogate deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/98:00 amDSM - PTY
2 stops37h 10mAvianca
Tue 7/153:20 amPTY - DSM
2 stops18h 27mAvianca
Deal found 6/11$2,312

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Fly from

Des Moines

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 7/23

6:02 am-4:12 pm

1 stop10h 10m

Panama City Tocumen Intl

Wed 7/30

7:55 am-10:17 pm

1 stop14h 22m

$460

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 11/29

4:26 pm-1:20 pm

2 stops19h 54m

Panama City Tocumen Intl

Sat 12/6

2:45 pm-11:44 pm

1 stop9h 59m

$556

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 7/25

6:24 am-6:37 pm

2 stops12h 13m

Panama City Tocumen Intl

Fri 8/1

7:55 am-9:47 pm

2 stops13h 52m

$609

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 7/23

11:00 am-4:39 pm

3 stops29h 39m

Panama City Tocumen Intl

Wed 7/30

5:25 pm-10:38 pm

3 stops29h 13m

$629

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 7/9

8:00 am-9:10 pm

2 stops37h 10m

Panama City Tocumen Intl

Tue 7/15

3:20 am-9:47 pm

2 stops18h 27m

$2,312

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 7/25

6:02 am-4:12 pm

1 stop10h 10m

$194

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 7/25

6:30 am-4:30 pm

3 stops34h 00m

$265

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Des Moines to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama

What is the cheapest month to book a flight from Des Moines to Panama?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama (average of $478). Flying from Des Moines to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to PA?

Find hourly flight availability from Des Moines to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Panama as you normally would.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated June 12, 2025.
United Airlines
7.4
Good
8,790 reviews

Entertainment

7.0

Overall

7.4

Boarding

7.7

Food

6.6

Crew

8.1

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
United Airlines
7.4
Good
8,790 reviews
United Airlines
7.4
Good
8,790 reviews

Entertainment

7.0

Overall

7.4

Boarding

7.7

Food

6.6

Crew

8.1

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,790 reviews

Entertainment

7.0

Overall

7.4

Boarding

7.7

Food

6.6

Crew

8.1

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
Lufthansa
6.8
Okay
7,139 reviews
United Airlines
7.4
Good
8,790 reviews

Entertainment

7.0

Overall

7.4

Boarding

7.7

Food

6.6

Crew

8.1

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
Avianca
6.7
Okay
2,345 reviews
United Airlines
7.4
Good
8,790 reviews

Entertainment

7.0

Overall

7.4

Boarding

7.7

Food

6.6

Crew

8.1

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Panama?

    For a flight from Des Moines to Panama, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • Can I find deals for flights from Des Moines to Panama that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama.

  • Can I find deals for business class flights from Des Moines to Panama?

    Yes. Cheapflights offers flight deals from Des Moines to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama (average of $478). Flying from Des Moines to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Panama

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to Guatemala City flights
Omaha to Liberia flights
Des Moines to San José flights
Omaha to San José flights
Omaha to San Salvador flights
Des Moines to San Salvador flights
Des Moines to Panama City flights
Des Moines to Philip S.W.Goldson flights
Des Moines to Liberia flights
Omaha to Philip S.W.Goldson flights
Omaha to Panama City flights
Cedar Rapids to San José flights
Cedar Rapids to Philip S.W.Goldson flights
Moline to Philip S.W.Goldson flights
Cedar Rapids to Liberia flights
Des Moines to Guatemala City flights
Cedar Rapids to Guatemala City flights
Moline to San José flights
Cedar Rapids to Panama City flights
Omaha to Coxen Hole flights
Cedar Rapids to San Salvador flights
Moline to San Salvador flights
Des Moines to Managua flights
Omaha to Managua flights
Omaha to San Pedro Sula flights
Moline to Liberia flights
Moline to Guatemala City flights
La Crosse to Panama City flights
Des Moines to Tegucigalpa flights
Cedar Rapids to Coxen Hole flights

Top 3 airlines flying from Des Moines to Panama

Discover the top 3 airlines that operate flights from Des Moines to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$349Average$556FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$354Average$544FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$359Average$469FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.