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$198+ Cheap flights from Des Moines (DSM) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
sep. 2 — sep. 91
mar. 9/2
mar. 9/9
1 adult, Economy
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Cheap flight deals from Des Moines to Panama

Keep the following information in mind while searching for Des Moines to Panama flight deals. Data was last updated agosto 28, 2025.

Round-trip from

$461
(United Airlines)

One-way from

$198
(United Airlines)

Popular in

June

Cheapest in

December

Average price

$547
From Des Moines to Panama
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One-way flight from Des Moines to Panama
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Highest demand for flights based on searches. 12% potential increase in price ($90 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($43 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Des Moines to Panama

Cheapest flights from Des Moines to Panama
Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 28, 2025.

This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/136:15 amDSM - PTY
1 stop12h 22mUnited Airlines
lun. 10/2010:00 amPTY - DSM
1 stop12h 28mUnited Airlines
Deal found 8/27$461
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/85:42 pmDSM - PTY
2 stops20h 21mAmerican Airlines
mié. 10/153:15 pmPTY - DSM
2 stops17h 07mAmerican Airlines
Deal found 8/27$465
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/126:15 amDSM - PTY
1 stop12h 22mUnited Airlines
dom. 10/193:30 pmPTY - DSM
2 stops22h 53mUnited Airlines
Deal found 8/28$466
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/126:07 pmDSM - PTY
2 stops19h 56mAmerican Airlines
dom. 10/193:15 pmPTY - DSM
2 stops26h 27mAmerican Airlines
Deal found 8/28$470
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/96:36 pmDSM - PTY
2 stops24h 01mUnited Airlines
jue. 10/1610:00 amPTY - DSM
1 stop12h 22mUnited Airlines
Deal found 8/27$478
This Trip.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/86:15 amDSM - PTY
1 stop12h 22mUnited Airlines
mié. 10/1510:00 amPTY - DSM
1 stop12h 28mUnited Airlines
Deal found 8/27$480
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/278:02 amDSM - PTY
2 stops29h 43mUnited Airlines
dom. 12/711:55 pmPTY - DSM
2 stops15h 25mUnited Airlines
Deal found 8/28$481
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/183:30 pmDSM - PTY
2 stops21h 26mDelta
jue. 10/232:21 pmPTY - DSM
2 stops18h 59mDelta
Deal found 8/28$491
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/166:15 amDSM - PTY
1 stop12h 22mUnited Airlines
dom. 10/263:41 pmPTY - DSM
2 stops18h 49mUnited Airlines
Deal found 8/28$507
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/166:39 pmDSM - PTY
1 stop18h 17mDelta
sáb. 10/252:21 pmPTY - DSM
1 stop8h 09mDelta
Deal found 8/28$513

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 28, 2025.
Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Fly from

Des Moines

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

lun. 10/13

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

lun. 10/20

10:00 am-10:28 pm

1 stop12h 28m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 10/16

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

jue. 10/23

10:00 am-10:22 pm

1 stop12h 22m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

sáb. 10/18

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

vie. 10/24

10:00 am-10:28 pm

1 stop12h 28m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mié. 10/1

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

lun. 10/6

10:00 am-10:28 pm

1 stop12h 28m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

sáb. 10/18

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

jue. 10/23

10:00 am-10:22 pm

1 stop12h 22m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 10/16

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

vie. 10/24

10:00 am-10:28 pm

1 stop12h 28m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mié. 10/8

5:42 pm-2:03 pm

2 stops20h 21m

Panama City Tocumen Intl

mié. 10/15

3:15 pm-8:22 am

2 stops17h 07m

$465

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 10/9

6:22 pm-2:03 pm

2 stops19h 41m

Panama City Tocumen Intl

jue. 10/16

3:15 pm-5:42 pm

2 stops26h 27m

$465

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 1/1

6:46 pm-5:07 pm

2 stops21h 21m

Panama City Tocumen Intl

mié. 4/1

10:00 am-10:30 pm

1 stop12h 30m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

sáb. 10/11

6:15 am-6:37 pm

1 stop12h 22m

$198

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/26

Showing 1-10 of 13 results
1
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Best time to book a flight from Des Moines to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama

What is the cheapest month to book a flight from Des Moines to Panama?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama (average of $478). Flying from Des Moines to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated agosto 28, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,977 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,977 reviews
Delta
8.0
Very good
7,977 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,944 reviews
Delta
8.0
Very good
7,977 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,977 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Panama?

    For a flight from Des Moines to Panama, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • How long is the flight from Des Moines to Panama?

    Departing from Des Moines to Panama will take you 12h 22m. The distance between Des Moines and Panama is about 2405 mi.

  • What are the cheapest airlines to fly from Des Moines to Panama one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $198. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from Des Moines to Panama for a low price.

  • Can I find deals for flights from Des Moines to Panama that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama.

  • Can I find deals for business class flights from Des Moines to Panama?

    Yes. Cheapflights offers flight deals from Des Moines to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama (average of $478). Flying from Des Moines to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Omaha to Panama City flights
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Cedar Rapids to San José flights
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Des Moines to Managua flights
Cedar Rapids to Guatemala City flights
Moline to San José flights
Omaha to San Pedro Sula flights
Cedar Rapids to Philip S.W.Goldson flights
Cedar Rapids to Liberia flights
Moline to San Salvador flights
Omaha to Managua flights
Moline to Liberia flights
Moline to Guatemala City flights
La Crosse to Panama City flights
Des Moines to Tegucigalpa flights
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Top 3 airlines flying from Des Moines to Panama

Discover the top 3 airlines that operate flights from Des Moines to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$410Average$557FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$411Average$484FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$445Average$544FlexibilityNo cancel feeOn-time71%

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