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$198+ Cheap flights from Des Moines (DSM) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Nov 25 — Dec 21
Tue 11/25
Tue 12/2
1 adult, Economy
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Find flight deals from Des Moines to Panama

Cheapest flights from Des Moines to Panama
Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2025.

This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/68:15 amDSM - PTY
1 stop10h 23mUnited Airlines
Sat 12/1311:35 amPTY - DSM
1 stop11h 54mUnited Airlines
Deal found 10/24$452
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:00 amDSM - PTY
1 stop8h 42mAmerican Airlines
Wed 12/172:50 pmPTY - DSM
1 stop9h 39mAmerican Airlines
Deal found 10/26$461
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:50 pmDSM - PTY
2 stops18h 55mUnited Airlines
Mon 12/1511:55 pmPTY - DSM
2 stops15h 25mUnited Airlines
Deal found 10/23$466
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:05 amDSM - PTY
1 stop12h 33mUnited Airlines
Thu 11/274:41 pmPTY - DSM
1 stop22h 30mUnited Airlines
Deal found 10/26$471
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/223:15 pmDSM - PTY
2 stops22h 30mUnited Airlines
Fri 11/284:41 pmPTY - DSM
2 stops19h 01mUnited Airlines
Deal found 10/26$550
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:05 amDSM - PTY
1 stop7h 40mUnited Airlines
Mon 11/248:55 amPTY - DSM
1 stop14h 25mUnited Airlines
Deal found 10/26$576
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:46 pmDSM - PTY
2 stops23h 52mUnited Airlines
Mon 3/233:41 pmPTY - DSM
2 stops22h 46mUnited Airlines
Deal found 10/25$586
This Flysmarter deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flysmarter is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/96:00 amDSM - PTY
1 stop8h 42mBritish Airways
Tue 12/162:50 pmPTY - DSM
1 stop9h 39mBritish Airways
Deal found 10/25$589

Cheap flight deals from Des Moines to Panama

Keep the following information in mind while searching for Des Moines to Panama flight deals. Data was last updated October 26, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$452
(United Airlines)

One-way from

$198
(United Airlines)

Popular in

June

Cheapest in

December

Average price

$583
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
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From Des Moines to Panama
Search Deals
One-way flight from Des Moines to Panama
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Highest demand for flights based on searches. 15% potential increase in price ($106 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($44 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 26, 2025.
Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Fly from

Des Moines

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 12/6

8:15 am-7:38 pm

1 stop10h 23m

Panama City Tocumen Intl

Sat 12/13

11:35 am-10:29 pm

1 stop11h 54m

$452

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 12/10

6:00 am-3:42 pm

1 stop8h 42m

Panama City Tocumen Intl

Wed 12/17

2:50 pm-11:29 pm

1 stop9h 39m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 12/10

8:15 am-7:38 pm

1 stop10h 23m

Panama City Tocumen Intl

Wed 12/17

11:35 am-10:29 pm

1 stop11h 54m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 2/24

8:08 am-7:38 pm

1 stop10h 30m

Panama City Tocumen Intl

Fri 3/6

8:55 am-10:36 pm

1 stop14h 41m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 2/26

8:00 am-7:38 pm

2 stops10h 38m

Panama City Tocumen Intl

Sat 3/7

8:55 am-10:36 pm

1 stop14h 41m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 12/8

8:15 am-5:07 pm

1 stop7h 52m

Panama City Tocumen Intl

Mon 12/15

8:55 am-10:29 pm

1 stop14h 34m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 12/8

6:50 pm-2:45 pm

2 stops18h 55m

$198

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 12/9

5:34 am-2:21 pm

1 stop7h 47m

$198

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 3/13

6:20 pm-12:10 pm

2 stops17h 50m

$348

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 12/9

3:17 pm-7:38 pm

2 stops27h 21m

$490

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/23

Showing 1-10 of 11 results
1
2

Best time to book a flight from Des Moines to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama

What is the cheapest month to book a flight from Des Moines to Panama?

Currently, December is the cheapest month in which you can book a flight from Des Moines to Panama (average of $401). Flying from Des Moines to Panama in March is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 26, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
9,002 reviews
Delta
7.9
Good
7,994 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,994 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Panama?

    For a flight from Des Moines to Panama, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • How long is the flight from Des Moines to Panama?

    Departing from Des Moines to Panama will take you 8h 42m. The distance between Des Moines and Panama is about 2405 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to Panama one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $198. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from Des Moines to Panama for a low price.

  • Can I find deals for flights from Des Moines to Panama that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama.

  • Can I find deals for business class flights from Des Moines to Panama?

    Yes. Cheapflights offers flight deals from Des Moines to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama?

    Currently, December is the cheapest month in which you can book a flight from Des Moines to Panama (average of $401). Flying from Des Moines to Panama in March is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Des Moines to Managua flights
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Des Moines to Tegucigalpa flights

Top 3 airlines flying from Des Moines to Panama

Discover the top 3 airlines that operate flights from Des Moines to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$414Average$486FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$581FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$445Average$572FlexibilityNo cancel feeOn-time71%

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