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$198+ Cheap flights from Des Moines (DSM) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Des Moines to Panama

Keep the following information in mind while searching for Des Moines to Panama flight deals. Data was last updated September 17, 2025.

Round-trip from

$461
(United Airlines)

One-way from

$198
(United Airlines)

Popular in

June

Cheapest in

December

Average price

$441
From Des Moines to Panama
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One-way flight from Des Moines to Panama
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Highest demand for flights based on searches. 15% potential increase in price ($108 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($45 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Panama

Cheapest flights from Des Moines to Panama
Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:05 amDSM - PTY
1 stop7h 40mUnited Airlines
Thu 11/68:55 amPTY - DSM
1 stop14h 25mUnited Airlines
Deal found 9/15$461
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/128:00 amDSM - PTY
2 stops10h 37mUnited Airlines
Sat 10/183:30 pmPTY - DSM
2 stops19h 02mUnited Airlines
Deal found 9/17$466
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:15 amDSM - PTY
1 stop7h 59mUnited Airlines
Mon 10/203:30 pmPTY - DSM
1 stop22h 43mUnited Airlines
Deal found 9/17$470
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/243:15 pmDSM - PTY
2 stops22h 30mUnited Airlines
Thu 11/274:41 pmPTY - DSM
1 stop30h 39mUnited Airlines
Deal found 9/17$475
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:42 pmDSM - PTY
2 stops20h 21mAmerican Airlines
Thu 11/62:49 pmPTY - DSM
2 stops20h 51mAmerican Airlines
Deal found 9/15$509
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:16 pmDSM - PTY
2 stops23h 47mAmerican Airlines
Fri 11/72:49 pmPTY - DSM
2 stops23h 27mAmerican Airlines
Deal found 9/15$510
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2412:54 pmDSM - PTY
2 stops23h 49mAmerican Airlines
Thu 11/272:43 pmPTY - DSM
2 stops22h 53mAmerican Airlines
Deal found 9/17$516
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3111:26 amDSM - PTY
2 stops26h 19mUnited Airlines
Fri 11/78:55 amPTY - DSM
1 stop14h 25mUnited Airlines
Deal found 9/16$541

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Fly from

Des Moines

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 10/30

6:05 am-1:45 pm

1 stop7h 40m

Panama City Tocumen Intl

Thu 11/6

8:55 am-10:20 pm

1 stop14h 25m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 1/1

2:07 pm-1:53 pm

2 stops22h 46m

Panama City Tocumen Intl

Wed 4/1

3:50 pm-12:31 pm

2 stops20h 41m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 1/1

6:46 pm-5:07 pm

2 stops21h 21m

Panama City Tocumen Intl

Wed 4/1

10:00 am-10:30 pm

1 stop12h 30m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 2/8

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

Sat 2/14

11:55 pm-9:51 pm

2 stops22h 56m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/12

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Sat 10/18

3:30 pm-12:19 pm

2 stops20h 49m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 10/30

6:05 am-1:45 pm

1 stop7h 40m

$198

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 1/3

1:59 pm-1:53 pm

2 stops22h 54m

$204

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 11/20

6:05 am-7:38 pm

1 stop12h 33m

$219

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 10/30

5:42 pm-2:03 pm

2 stops20h 21m

$246

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 3/13

6:20 pm-12:10 pm

2 stops17h 50m

$299

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 15 results
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Best time to book a flight from Des Moines to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama

What is the cheapest month to book a flight from Des Moines to Panama?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama (average of $478). Flying from Des Moines to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated September 17, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Panama?

    For a flight from Des Moines to Panama, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • How long is the flight from Des Moines to Panama?

    Departing from Des Moines to Panama will take you 7h 40m. The distance between Des Moines and Panama is about 2405 mi.

  • Can I find deals for flights from Des Moines to Panama that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama.

  • Can I find deals for business class flights from Des Moines to Panama?

    Yes. Cheapflights offers flight deals from Des Moines to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama (average of $478). Flying from Des Moines to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Omaha to Coxen Hole flights
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Cedar Rapids to Philip S.W.Goldson flights
Cedar Rapids to Liberia flights
Omaha to Managua flights
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Moline to San José flights
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Moline to Guatemala City flights
Moline to San Salvador flights
Des Moines to Managua flights
Omaha to San Pedro Sula flights
Moline to Philip S.W.Goldson flights
Moline to Liberia flights
La Crosse to Panama City flights
Des Moines to Tegucigalpa flights

Top 3 airlines flying from Des Moines to Panama

Discover the top 3 airlines that operate flights from Des Moines to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$411Average$484FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$581FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$445Average$544FlexibilityNo cancel feeOn-time71%

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