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$369+ Cheap flights from Charleston (CHS) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
out 17 — out 241
sex 10/17
sex 10/24
1 adult, Economy
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Cheap flight deals from Charleston to Panama

Keep the following information in mind while searching for Charleston to Panama flight deals. Data was last updated setembro 17, 2025.

Round-trip from

$369
(Delta)

Popular in

March

Cheapest in

November

Average price

$444
From Charleston to Panama
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($79 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Charleston to Panama

Cheapest flights from Charleston to Panama
Explore the most affordable flight options available from Charleston to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on setembro 17, 2025.

This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 10/276:30 amCHS - PTY
1 stop13h 08mUnited Airlines
ter 11/258:55 amPTY - CHS
1 stop13h 04mUnited Airlines
Deal found 9/14$369
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 11/35:39 pmCHS - PTY
2 stops20h 10mAmerican Airlines
sex 11/72:49 pmPTY - CHS
2 stops17h 40mAmerican Airlines
Deal found 9/16$374
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 10/268:03 pmCHS - PTY
1 stop17h 53mDelta
seg 11/243:37 pmPTY - CHS
1 stop7h 11mDelta
Deal found 9/14$376
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 10/306:30 amCHS - PTY
1 stop13h 08mUnited Airlines
qui 11/274:41 pmPTY - CHS
1 stop23h 35mUnited Airlines
Deal found 9/14$378
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 10/157:41 pmCHS - PTY
2 stops19h 22mAmerican Airlines
qua 10/223:15 pmPTY - CHS
2 stops16h 01mAmerican Airlines
Deal found 9/16$382
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 10/275:35 amCHS - PTY
1 stop8h 21mDelta
sáb 11/223:37 pmPTY - CHS
1 stop8h 20mDelta
Deal found 9/14$389
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 10/296:30 amCHS - PTY
2 stops8h 33mAmerican Airlines
seg 11/242:43 pmPTY - CHS
2 stops21h 12mAmerican Airlines
Deal found 9/14$394
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 10/268:03 pmCHS - PTY
1 stop17h 53mDelta
sáb 11/228:05 amPTY - CHS
1 stop7h 12mDelta
Deal found 9/14$396
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 11/27:57 pmCHS - PTY
1 stop17h 52mAmerican Airlines
sex 11/72:49 pmPTY - CHS
1 stop9h 10mAmerican Airlines
Deal found 9/16$398
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 10/266:30 amCHS - PTY
1 stop13h 08mUnited Airlines
sex 11/218:55 amPTY - CHS
1 stop13h 04mUnited Airlines
Deal found 9/14$409
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 10/316:30 amCHS - PTY
1 stop13h 08mUnited Airlines
seg 11/248:55 amPTY - CHS
1 stop13h 04mUnited Airlines
Deal found 9/14$442

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated setembro 17, 2025.
Use the filters below to find and compare flights from Charleston to Panama that are best for you.

Fly from

Charleston

Fly to

Panama

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

qua 10/29

6:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

qui 11/27

3:37 pm-10:48 pm

1 stop7h 11m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

qua 10/29

6:00 am-1:55 pm

1 stop8h 55m

Panama City Tocumen Intl

ter 11/25

8:55 am-9:59 pm

1 stop13h 04m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

qua 10/29

6:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

seg 11/24

3:37 pm-11:57 pm

1 stop8h 20m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

seg 10/27

6:30 am-6:38 pm

1 stop13h 08m

Panama City Tocumen Intl

ter 11/25

8:55 am-9:59 pm

1 stop13h 04m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

ter 10/28

5:35 am-12:56 pm

1 stop8h 21m

Panama City Tocumen Intl

qui 11/27

3:37 pm-10:48 pm

1 stop7h 11m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

qui 10/30

6:30 am-6:38 pm

1 stop13h 08m

Panama City Tocumen Intl

ter 11/25

8:55 am-9:59 pm

1 stop13h 04m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

ter 10/28

5:35 am-12:56 pm

1 stop8h 21m

Panama City Tocumen Intl

qua 11/26

3:37 pm-11:57 pm

1 stop8h 20m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

seg 11/3

5:09 pm-1:49 pm

2 stops20h 40m

Panama City Tocumen Intl

sex 11/7

2:49 pm-12:23 pm

2 stops21h 34m

$374

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

ter 10/28

6:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

ter 11/25

3:37 pm-9:31 am

1 stop17h 54m

$376

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

dom 10/26

8:03 pm-12:56 pm

1 stop17h 53m

Panama City Tocumen Intl

qui 11/27

3:37 pm-10:48 pm

1 stop7h 11m

$376

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 12 results
1
2

Best time to book a flight from Charleston to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Panama

What is the cheapest month to book a flight from Charleston to Panama?

Currently, October is the cheapest month in which you can book a flight from Charleston to Panama (average of $478). Flying from Charleston to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to PA?

Find hourly flight availability from Charleston to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated setembro 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Charleston to Panama as you normally would.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated setembro 17, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Charleston to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Charleston to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to Panama?

    For a flight from Charleston to Panama, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to Panama?

    Delta and United Airlines can get you from Charleston to Panama in just under 7h 16m. Your travel time can differ by up to 1h 39m. Airlines will cover a distance of 1645 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Charleston to Panama that include hotel bookings?

    Yes. In addition to deals on Charleston to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Panama.

  • Can I find deals for business class flights from Charleston to Panama?

    Yes. Cheapflights offers flight deals from Charleston to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Panama?

    Currently, October is the cheapest month in which you can book a flight from Charleston to Panama (average of $478). Flying from Charleston to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Charleston to Panama

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to San José flights
Charlotte to San Salvador flights
Charlotte to Liberia flights
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Myrtle Beach to San José flights
Greenville to Guatemala City flights
Charlotte to Managua flights
Greenville to Philip S.W.Goldson flights
Charleston to Guatemala City flights
Charlotte to Coxen Hole flights
Columbia to San José flights
Savannah to Panama City flights
Charleston to Coxen Hole flights
Savannah to Guatemala City flights
Charleston to San Salvador flights
Columbia to Guatemala City flights
Savannah to Philip S.W.Goldson flights
Greenville to Liberia flights
Augusta to Guatemala City flights
Savannah to San Pedro Sula flights
Charleston to Managua flights
Greenville to San Salvador flights
Augusta to Panama City flights
Savannah to San Salvador flights
Myrtle Beach to Guatemala City flights
Columbia to San Pedro Sula flights
Augusta to San José flights
Myrtle Beach to Coxen Hole flights
Myrtle Beach to Philip S.W.Goldson flights
Augusta to San Pedro Sula flights
Columbia to San Salvador flights
Myrtle Beach to Panama City flights
Hilton Head Island to San José flights
Columbia to Philip S.W.Goldson flights
Columbia to Liberia flights
Hilton Head Island to Liberia flights
Augusta to Philip S.W.Goldson flights
Charlotte to Tegucigalpa flights

Top 3 airlines flying from Charleston to Panama

Discover the top 3 airlines that operate flights from Charleston to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated setembro 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$361Average$537FlexibilityNo cancel feeOn-time71%
DeltaCheapest$369Average$476FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$391Average$477FlexibilityNo cancel feeOn-time69%

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