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$194+ Cheap flights from Charleston (CHS) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
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Cheap flight deals from Charleston to Panama

Cheapest flights from Charleston to Panama
Explore the most affordable flight options available from Charleston to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:00 am
CHS
-
PTY
1 stop9h 20m
American Airlines
Thu 3/263:10 pm
PTY
-
CHS
1 stop7h 49m
American Airlines
Deal found 2/12$401
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:09 pm
CHS
-
PTY
1 stop17h 37m
American Airlines
Wed 4/221:49 pm
PTY
-
CHS
1 stop9h 35m
American Airlines
Deal found 2/11$409
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:00 am
CHS
-
PTY
1 stop9h 20m
American Airlines
Wed 3/183:10 pm
PTY
-
CHS
1 stop7h 49m
American Airlines
Deal found 2/11$418
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:13 am
CHS
-
PTY
1 stop8h 47m
American Airlines
Thu 10/153:35 pm
PTY
-
CHS
1 stop7h 24m
American Airlines
Deal found 2/11$421
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:45 pm
CHS
-
PTY
2 stops18h 55m
American Airlines
Tue 3/173:10 pm
PTY
-
CHS
1 stop7h 49m
American Airlines
Deal found 2/12$425
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:00 am
CHS
-
PTY
1 stop12h 37m
United Airlines
Sun 6/147:55 am
PTY
-
CHS
1 stop13h 17m
United Airlines
Deal found 2/9$431
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:45 pm
CHS
-
PTY
2 stops21h 16m
American Airlines
Tue 4/71:49 pm
PTY
-
CHS
2 stops21h 37m
American Airlines
Deal found 2/11$437

Find flight deals from Charleston to Panama

Keep the following information in mind while searching for Charleston to Panama flight deals. Data was last updated February 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$401
(American Airlines)

One-way from

$194
(Kiwi.com)

Popular in

April

Cheapest in

March

Average price

$551
Provider with most accurate pricing for Charleston-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Panama City Tocumen Intl flights.
Search Deals
From Charleston to Panama
Search Deals
One-way flight from Charleston to Panama
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($18 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Charleston to Panama that are best for you.

Fly from

Charleston

Fly to

Panama

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 3/17

6:00 am-12:40 pm

1 stop7h 40m

Panama City Tocumen Intl

Thu 3/26

3:10 pm-11:59 pm

1 stop7h 49m

$401

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 3/24

6:00 am-2:20 pm

1 stop9h 20m

Panama City Tocumen Intl

Tue 3/31

1:40 pm-11:16 am

2 stops20h 36m

$405

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Wed 4/1

6:00 am-3:01 pm

1 stop10h 01m

Panama City Tocumen Intl

Tue 4/7

1:49 pm-8:32 am

2 stops17h 43m

$405

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Wed 3/11

6:45 pm-2:20 pm

2 stops20h 35m

Panama City Tocumen Intl

Wed 3/18

1:40 pm-11:34 am

2 stops20h 54m

$405

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 4/20

8:09 pm-12:46 pm

1 stop17h 37m

Panama City Tocumen Intl

Wed 4/22

1:49 pm-12:24 am

1 stop9h 35m

$409

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 2/23

6:35 pm-8:50 am

2 stops38h 15m

$194

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 2/23

5:10 pm-5:07 pm

1 stop23h 57m

$210

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Best time to book a flight from Charleston to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Panama

What is the cheapest month to book a flight from Charleston to Panama?

Currently, July is the cheapest month in which you can book a flight from Charleston to Panama (average of $230). Flying from Charleston to Panama in April is currently the most expensive (average of $507). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated February 12, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Charleston to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,187 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,187 reviews
Delta
7.9
Good
8,187 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,283 reviews
Delta
7.9
Good
8,187 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,275 reviews
Delta
7.9
Good
8,187 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to Panama?

    For a flight from Charleston to Panama, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to Panama?

    American Airlines can get you from Charleston to Panama in just under 7h 40m. Your travel time can differ by up to . Airlines will cover a distance of 1645 mi.

  • Can I find deals for flights from Charleston to Panama that include hotel bookings?

    Yes. In addition to deals on Charleston to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Panama.

  • Can I find deals for business class flights from Charleston to Panama?

    Yes. Cheapflights offers flight deals from Charleston to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Panama?

    Currently, July is the cheapest month in which you can book a flight from Charleston to Panama (average of $230). Flying from Charleston to Panama in April is currently the most expensive (average of $507). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Charleston to Panama

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to San José flights
Charlotte to Liberia flights
Charlotte to Panama City flights
Charlotte to San Salvador flights
Charlotte to Philip S.W.Goldson flights
Charlotte to Guatemala City flights
Columbia to Panama City flights
Charleston to San José flights
Greenville to Panama City flights
Charlotte to San Pedro Sula flights
Charleston to Liberia flights
Charleston to Panama City flights
Charleston to Philip S.W.Goldson flights
Savannah to San José flights
Charlotte to Coxen Hole flights
Greenville to San José flights
Charlotte to Managua flights
Savannah to Liberia flights
Savannah to Guatemala City flights
Greenville to San Salvador flights
Savannah to Philip S.W.Goldson flights
Greenville to Liberia flights
Myrtle Beach to Panama City flights
Greenville to Guatemala City flights
Columbia to San José flights
Augusta to Panama City flights
Charleston to Coxen Hole flights
Savannah to Panama City flights
Myrtle Beach to San José flights
Greenville to Philip S.W.Goldson flights
Charleston to San Salvador flights
Augusta to San José flights
Savannah to Coxen Hole flights
Charleston to Managua flights
Columbia to Guatemala City flights
Savannah to San Salvador flights
Charleston to Guatemala City flights
Myrtle Beach to Philip S.W.Goldson flights
Hilton Head Island to Liberia flights
Columbia to San Salvador flights
Columbia to Liberia flights
Savannah to San Pedro Sula flights
Columbia to Philip S.W.Goldson flights
Augusta to Guatemala City flights
Augusta to Philip S.W.Goldson flights
Greenville to San Pedro Sula flights
Hilton Head Island to San José flights
Myrtle Beach to Managua flights
Myrtle Beach to Coxen Hole flights

Top 3 airlines flying from Charleston to Panama

Discover the top 3 airlines that operate flights from Charleston to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$309Average$464FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$363Average$546FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$369Average$513FlexibilityNo cancel feeOn-time69%

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