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Panama

$152+ Cheap flights from Charleston (CHS) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/5. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Find flight deals from Charleston to Panama

Cheapest flights from Charleston to Panama
Explore the most affordable flight options available from Charleston to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:00 amCHS - PTY
1 stop9h 42mAmerican Airlines
Thu 1/82:27 pmPTY - CHS
2 stops21h 07mAmerican Airlines
Deal found 11/3$477
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:45 pmCHS - PTY
2 stops19h 08mAmerican Airlines
Thu 12/252:53 pmPTY - CHS
1 stop8h 41mAmerican Airlines
Deal found 11/3$548
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:06 pmCHS - PTY
1 stop19h 48mAmerican Airlines
Tue 1/64:31 pmPTY - CHS
1 stop16h 16mAmerican Airlines
Deal found 11/2$635
This Mytrip deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/228:31 amCHS - PTY
3 stops30h 24mMultiple Airlines
Sun 11/309:45 amPTY - CHS
3 stops36h 20mMultiple Airlines
Deal found 11/3$661
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:39 pmCHS - PTY
2 stops20h 04mAmerican Airlines
Sun 11/302:43 pmPTY - CHS
1 stop18h 00mAmerican Airlines
Deal found 11/3$676

Cheap flight deals from Charleston to Panama

Keep the following information in mind while searching for Charleston to Panama flight deals. Data was last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$390
(United Airlines)

One-way from

$152
(United Airlines)

Popular in

March

Cheapest in

September

Average price

$430
Provider with most accurate pricing for Charleston-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Panama City Tocumen Intl flights.
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From Charleston to Panama
Search Deals
One-way flight from Charleston to Panama
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($75 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Charleston to Panama that are best for you.

Fly from

Charleston

Fly to

Panama

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/16

5:41 pm-3:52 pm

2 stops22h 11m

Panama City Tocumen Intl

Sun 2/1

4:50 pm-11:39 am

2 stops18h 49m

$419

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 12/18

6:45 pm-1:53 pm

2 stops19h 08m

Panama City Tocumen Intl

Thu 12/25

2:53 pm-11:34 pm

1 stop8h 41m

$548

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 12/22

8:06 pm-3:54 pm

1 stop19h 48m

Panama City Tocumen Intl

Tue 1/6

4:31 pm-8:47 am

1 stop16h 16m

$635

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 11/24

5:39 pm-1:43 pm

2 stops20h 04m

Panama City Tocumen Intl

Sun 11/30

2:43 pm-8:43 am

1 stop18h 00m

$676

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 11/22

6:15 pm-2:55 pm

3 stops20h 40m

Panama City Tocumen Intl

Sun 11/30

9:45 am-10:05 pm

3 stops36h 20m

$697

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 1/5

11:05 am-8:02 pm

1 stop8h 57m

$152

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 1/5

6:27 pm-3:31 pm

2 stops21h 04m

$152

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 1/5

10:18 pm-1:00 am

3 stops26h 42m

$258

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 12/18

6:45 pm-1:53 pm

2 stops19h 08m

$335

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 12/18

10:18 pm-8:19 pm

1 stop22h 01m

$398

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Best time to book a flight from Charleston to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Panama

What is the cheapest month to book a flight from Charleston to Panama?

Currently, July is the cheapest month in which you can book a flight from Charleston to Panama (average of $230). Flying from Charleston to Panama in April is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to PA?

Find hourly flight availability from Charleston to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

It’s optimal to fly from Charleston to Panama at noon. By choosing this option you can save up to 42% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated November 3, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Charleston to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,002 reviews

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,002 reviews
Delta
7.9
Good
8,002 reviews

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
United Airlines
7.4
Good
8,997 reviews
Delta
7.9
Good
8,002 reviews

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,038 reviews
Delta
7.9
Good
8,002 reviews

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to Panama?

    For a flight from Charleston to Panama, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to Panama?

    American Airlines can get you from Charleston to Panama in just under 22h 11m. Your travel time can differ by up to . Airlines will cover a distance of 1645 mi.

  • Can I find deals for flights from Charleston to Panama that include hotel bookings?

    Yes. In addition to deals on Charleston to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Panama.

  • Can I find deals for business class flights from Charleston to Panama?

    Yes. Cheapflights offers flight deals from Charleston to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Panama?

    Currently, July is the cheapest month in which you can book a flight from Charleston to Panama (average of $230). Flying from Charleston to Panama in April is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Charleston to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Savannah to Philip S.W.Goldson flights
Myrtle Beach to San José flights
Savannah to San José flights
Charleston to Guatemala City flights
Columbia to San José flights
Charleston to Managua flights
Greenville to Liberia flights
Greenville to Philip S.W.Goldson flights
Savannah to San Pedro Sula flights
Savannah to Panama City flights
Charleston to San Salvador flights
Myrtle Beach to Panama City flights
Columbia to San Salvador flights
Columbia to Guatemala City flights
Greenville to San Pedro Sula flights
Columbia to Liberia flights
Savannah to San Salvador flights
Greenville to San Salvador flights
Columbia to San Pedro Sula flights
Augusta to Panama City flights
Columbia to Philip S.W.Goldson flights
Myrtle Beach to Philip S.W.Goldson flights
Savannah to Guatemala City flights
Charleston to Coxen Hole flights
Augusta to San Pedro Sula flights
Augusta to San José flights
Hilton Head Island to San José flights
Myrtle Beach to Guatemala City flights

Top 3 airlines flying from Charleston to Panama

Discover the top 3 airlines that operate flights from Charleston to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$369Average$476FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$386Average$533FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$391Average$477FlexibilityNo cancel feeOn-time69%

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