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$338+ Cheap flights from Santa Cruz de la Sierra (VVI) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel.
VVI — PTY
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Find cheap flights from Santa Cruz de la Sierra to Panama City with Cheapflights

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Cheapflights Tip: The best prices from Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl are usually found in May or February, booked 50 days in advance, depart on a Saturday or Monday and return on a Wednesday

Cheap flight deals from Santa Cruz de la Sierra to Panama City

Cheapest flights from Santa Cruz de la Sierra to Panama City
Explore the most affordable flight options available from Santa Cruz de la Sierra to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This Avianca deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/83:40 amVVI - PTY
1 stop14h 15mAvianca
Tue 12/162:55 pmPTY - VVI
1 stop10h 40mAvianca
Deal found 12/3$631
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:40 amVVI - PTY
1 stop14h 15mAvianca
Sat 2/212:55 pmPTY - VVI
1 stop10h 40mAvianca
Deal found 12/2$665
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:40 amVVI - PTY
1 stop14h 15mAvianca
Mon 2/232:55 pmPTY - VVI
1 stop10h 40mAvianca
Deal found 12/2$666
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:40 amVVI - PTY
1 stop14h 15mAvianca
Wed 2/182:55 pmPTY - VVI
1 stop10h 40mAvianca
Deal found 12/2$669
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:40 amVVI - PTY
1 stop14h 15mAvianca
Fri 2/205:50 pmPTY - VVI
1 stop7h 45mAvianca
Deal found 12/2$684
This Avianca deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/253:40 amVVI - PTY
1 stop11h 20mAvianca
Wed 12/312:55 pmPTY - VVI
1 stop10h 40mAvianca
Deal found 12/3$691
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:40 amVVI - PTY
1 stop14h 15mMultiple Airlines
Thu 2/195:50 pmPTY - VVI
2 stops12h 35mMultiple Airlines
Deal found 12/2$716
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/253:40 amVVI - PTY
1 stop11h 20mAvianca
Sat 2/212:55 pmPTY - VVI
1 stop10h 40mAvianca
Deal found 12/2$727
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/253:40 amVVI - PTY
1 stop11h 20mAvianca
Tue 2/245:50 pmPTY - VVI
1 stop7h 45mAvianca
Deal found 12/2$728
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/253:40 amVVI - PTY
1 stop11h 20mAvianca
Wed 2/182:55 pmPTY - VVI
1 stop10h 40mAvianca
Deal found 12/2$730
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:40 amVVI - PTY
1 stop14h 15mMultiple Airlines
Fri 2/205:50 pmPTY - VVI
2 stops13h 40mMultiple Airlines
Deal found 12/2$731
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:40 amVVI - PTY
1 stop14h 15mMultiple Airlines
Mon 2/232:55 amPTY - VVI
3 stops17h 20mMultiple Airlines
Deal found 12/2$732

Find flight deals from Santa Cruz de la Sierra to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santa Cruz de la Sierra (VVI) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$600
(Priceline)

One-way from

$338
(Priceline)

Popular in

January

Cheapest in

May

Average price

$651
Provider with most accurate pricing for Santa Cruz de la Sierra Viru Viru Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santa Cruz de la Sierra Viru Viru Intl-Panama City Tocumen Intl flights.
Search Deals
From Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl
Search Deals
One-way flight from Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Cruz de la Sierra to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Santa Cruz de la Sierra to Panama City that are best for you.

Fly from

Santa Cruz de la Sierra

Fly to

Panama City

Route

Depart

Return

Price

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Thu 4/23

11:48 am-3:39 pm

Nonstop4h 51m

Panama City Tocumen Intl

Sun 4/26

9:43 pm-3:40 am

Nonstop4h 57m

$623

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Wed 2/11

1:15 am-5:04 am

Nonstop4h 49m

Panama City Tocumen Intl

Thu 2/19

4:40 pm-10:50 pm

Nonstop5h 10m

$623

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Fri 4/3

1:15 am-5:04 am

Nonstop4h 49m

Panama City Tocumen Intl

Sat 4/25

4:40 pm-10:42 pm

Nonstop5h 02m

$623

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Fri 2/13

1:15 am-5:04 am

Nonstop4h 49m

Panama City Tocumen Intl

Sat 2/28

4:40 pm-10:50 pm

Nonstop5h 10m

$623

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Sat 3/7

11:42 am-3:35 pm

Nonstop4h 53m

Panama City Tocumen Intl

Sat 3/14

4:40 pm-10:50 pm

Nonstop5h 10m

$623

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Sat 1/31

1:15 am-5:04 am

Nonstop4h 49m

Panama City Tocumen Intl

Sat 2/28

4:40 pm-10:50 pm

Nonstop5h 10m

$623

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Tue 1/27

1:15 am-5:04 am

Nonstop4h 49m

Panama City Tocumen Intl

Wed 2/25

9:43 pm-3:44 am

Nonstop5h 01m

$651

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Sun 12/21

3:40 am-4:55 pm

1 stop14h 15m

Panama City Tocumen Intl

Mon 2/23

2:55 pm-2:35 am

1 stop10h 40m

$666

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Tue 3/3

3:40 am-4:55 pm

1 stop14h 15m

$355

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Wed 3/4

3:40 am-2:00 pm

1 stop11h 20m

$355

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/1

Showing 1-10 of 19 results
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Compare providers for flights from Santa Cruz de la Sierra to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Cruz de la Sierra to Panama City in December.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santa Cruz de la Sierra-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santa Cruz de la Sierra-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santa Cruz de la Sierra-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Cruz de la Sierra-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Cruz de la Sierra-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Cruz de la Sierra to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santa Cruz de la Sierra with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Cruz de la Sierra to Panama City

How far ahead should I book a flight from Santa Cruz de la Sierra to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santa Cruz de la Sierra to Panama City. Price data was last updated on November 28, 2025.

Booking 49 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santa Cruz de la Sierra to Panama City. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Santa Cruz de la Sierra to Panama City?

Currently, March is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to Panama City (average of $162). Flying from Santa Cruz de la Sierra to Panama City in January is currently the most expensive (average of $563). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from VVI to PTY?

Find hourly flight availability from Santa Cruz de la Sierra to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

When flying from Santa Cruz de la Sierra to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Santa Cruz de la Sierra to Panama City?

The best insider tips for Santa Cruz de la Sierra to Panama City flights

AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Santa Cruz de la Sierra to Panama City trip
Airlines
United Airlines

United's Economy Plus offers extra legroom and priority boarding for a more comfortable journey.


United's Polaris Business Class features lie-flat seats and upscale amenities for international routes.

Read more about United Airlinesby Harriet Baskas
Copa Airlines

Copa's punctuality is impressive, ranking third globally with 89.46% on-time arrivals in 2023.


Copa's Economy Extra seats offer a 34” pitch and 5” recline for added comfort.

Read more about Copa Airlinesby Paul Rubio
Our travel experts
Harriet Baskas

Harriet Baskas

Expert on United Airlines

Harriet Baskas

Harriet Baskas

Harriet is an award-winning journalist who is happiest in an airport or an unusual museum. Her stories about airports, air travel, and the business of travel have appeared on NBC News, CNBC, USA TODAY, The Points Guy and other outlets. She is the creator of the StuckatTheAirport.com blog and the author of nine books. When not out on the road or exploring the latest airport amenities, she’s home in Seattle getting ready for the next adventure.

Read more
Paul Rubio

Paul Rubio

Expert on Copa Airlines

Paul Rubio

Paul Rubio

Travel journalist and photographer Paul Rubio is a Miami native (and current resident), who has lived in nine countries and traveled to 137. He is an expert in luxury travel, eco-travel, loyalty programs, hotels, airports and airlines. He is a contributing editor at AFAR, Condé Nast Traveler, LUXURY Magazine, and Palm Beach Illustrated.

Read more

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 4, 2025.
See what other customers who have flown with Copa Airlines and Avianca from Santa Cruz de la Sierra to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,554 reviews

Crew

8.1

Food

6.9

Comfort

7.4

Overall

7.6

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Copa Airlines
7.6
Good
1,554 reviews
Copa Airlines
7.6
Good
1,554 reviews

Crew

8.1

Food

6.9

Comfort

7.4

Overall

7.6

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Avianca
6.6
Okay
2,479 reviews
Copa Airlines
7.6
Good
1,554 reviews

Crew

8.1

Food

6.9

Comfort

7.4

Overall

7.6

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

Find useful and relevant information for your journey from Santa Cruz de la Sierra to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santa Cruz de la Sierra to Panama City?

    Panama City Tocumen Intl is the airport most travelers will use when flying to Panama City from Santa Cruz de la Sierra Viru Viru Intl. Booking flights from Viru Viru Intl (VVI) to Tocumen Intl (PTY) should be relatively easy as there are 2 daily flights to Panama City from 2 different airlines. 17h 10m is how long a flight from Santa Cruz de la Sierra to Panama City Tocumen Intl will take if you book a nonstop flight.

  • How popular is this Santa Cruz de la Sierra to Panama City flight route?

    The Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl flight path was viewed by 20 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Santa Cruz de la Sierra to Panama City?

    For as low as $623, Copa Airlines can have you in Panama City from Santa Cruz de la Sierra in 4h 51m. Airlines will cover a distance of 2152 mi. Most flights are nonstop.

  • What are the cheapest airlines flying from Santa Cruz de la Sierra to Panama City round-trip?

    Flying on Avianca is currently your cheapest option to Panama City, with prices starting at $387. Another option worth looking into is Copa Airlines, starting at $443 round trip. Avianca is 32% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Santa Cruz de la Sierra to Panama City?

    No one likes to see their flight delayed. When booking a flight from Santa Cruz de la Sierra to Panama City consider choosing United Airlines (98%), Copa Airlines (95%) or BoA (0%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Santa Cruz de la Sierra to Panama City?

    Looking at all options, your cheapest flight can be booked for $244. While the most popular route (Santa Cruz de la Sierra Viru Viru Intl - Panama City Tocumen Intl) can be booked for $873 on average, our data indicates $914 when flying from Santa Cruz de la Sierra to Panama City.

  • Can I find deals for flights from Santa Cruz de la Sierra to Panama City that include hotel bookings?

    Yes. In addition to deals on Santa Cruz de la Sierra to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Cruz de la Sierra to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Cruz de la Sierra to Panama City.

  • Can I find deals for business class flights from Santa Cruz de la Sierra to Panama City?

    Yes. Cheapflights offers flight deals from Santa Cruz de la Sierra to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Cruz de la Sierra to Panama City?

    Currently, March is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to Panama City (average of $162). Flying from Santa Cruz de la Sierra to Panama City in January is currently the most expensive (average of $563). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Santa Cruz de la Sierra to Panama City

Discover the top 2 airlines that operate flights from Santa Cruz de la Sierra to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$387Average$523FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$443Average$662FlexibilityNo cancel feeOn-time70%

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