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$355+ Cheap flights from Santa Cruz de la Sierra (VVI) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/21. Fares are subject to change and may not be available on all flights or dates of travel.
VVI — PTY
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheapflights Tip: The best prices from Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl are usually found in May or September, booked 47 days in advance, depart on a Monday or Sunday and return on a Wednesday

Cheap flight deals from Santa Cruz de la Sierra to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Santa Cruz de la Sierra (VVI) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$628
(Gotogate)

One-way from

$355
(Avianca)

Popular in

January

Cheapest in

May

Average price

$502
From Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl
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One-way flight from Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl
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Highest demand for flights based on searches. 14% potential increase in price ($88 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Santa Cruz de la Sierra to Panama City

Cheapest flights from Santa Cruz de la Sierra to Panama City
Explore the most affordable flight options available from Santa Cruz de la Sierra to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Gotogate deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/12:55 amVVI - PTY
1 stop19h 15mAvianca
Fri 8/811:05 amPTY - VVI
1 stop13h 45mAvianca
Deal found 6/12$628
This Copa Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/71:09 amVVI - PTY
Nonstop4h 55mCopa Airlines
Thu 7/104:17 pmPTY - VVI
Nonstop5h 02mCopa Airlines
Deal found 6/12$634
This Gotogate deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/410:00 pmVVI - PTY
2 stops11h 55mMultiple Airlines
Mon 8/1111:05 amPTY - VVI
1 stop13h 45mMultiple Airlines
Deal found 6/12$703

Cheapflights Fare Finder

Customize your flight search to find flights from Santa Cruz de la Sierra to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Santa Cruz de la Sierra to Panama City that are best for you.

Fly from

Santa Cruz de la Sierra

Fly to

Panama City

Route

Depart

Return

Price

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Fri 8/1

2:55 am-9:10 pm

1 stop19h 15m

Panama City Tocumen Intl

Fri 8/8

11:05 am-1:50 am

1 stop13h 45m

$628

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Mon 7/7

1:09 am-5:04 am

Nonstop4h 55m

Panama City Tocumen Intl

Thu 7/10

4:17 pm-10:19 pm

Nonstop5h 02m

$634

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Mon 8/4

10:00 pm-8:55 am

2 stops11h 55m

Panama City Tocumen Intl

Mon 8/11

11:05 am-1:50 am

1 stop13h 45m

$703

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Sat 6/21

2:55 am-4:30 pm

1 stop14h 35m

$355

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Wed 7/16

5:20 pm-8:55 am

3 stops16h 35m

$420

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Mon 6/30

1:09 am-5:04 am

Nonstop4h 55m

$803

Santa Cruz de la SierraPanama City

VVI - PTY

VVIPTY

Santa Cruz de la Sierra Viru Viru Intl

Tue 9/16

12:20 pm-6:40 pm

1 stop31h 20m

$4,679

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

The best insider tips for Santa Cruz de la Sierra to Panama City flights

Snippets provided in this section are AI-generated based on a summarization of Cheapflights-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
Cheapflights partnered with top experts to bring you the best recommendations for your Santa Cruz de la Sierra to Panama City trip
Airlines
United Airlines

United's Economy Plus offers extra legroom and priority boarding for a more comfortable journey.


United's Polaris Business Class features lie-flat seats and upscale amenities for international routes.

Read more about United Airlinesby Harriet Baskas
Copa Airlines

Copa's punctuality is impressive, ranking third globally with 89.46% on-time arrivals in 2023.


Copa's Economy Extra seats offer a 34” pitch and 5” recline for added comfort.

Read more about Copa Airlinesby Paul Rubio
Our travel experts
Harriet Baskas

Harriet Baskas

Expert on United Airlines

Harriet Baskas

Harriet Baskas

Harriet is an award-winning journalist who is happiest in an airport or an unusual museum. Her stories about airports, air travel, and the business of travel have appeared on NBC News, CNBC, USA TODAY, The Points Guy and other outlets. She is the creator of the StuckatTheAirport.com blog and the author of nine books. When not out on the road or exploring the latest airport amenities, she’s home in Seattle getting ready for the next adventure.

Read more
Paul Rubio

Paul Rubio

Expert on Copa Airlines

Paul Rubio

Paul Rubio

Travel journalist and photographer Paul Rubio is a Miami native (and current resident), who has lived in nine countries and traveled to 137. He is an expert in luxury travel, eco-travel, loyalty programs, hotels, airports and airlines. He is a contributing editor at AFAR, Condé Nast Traveler, LUXURY Magazine, and Palm Beach Illustrated.

Read more

Best time to book a flight from Santa Cruz de la Sierra to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santa Cruz de la Sierra with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Cruz de la Sierra to Panama City

How far ahead should I book a flight from Santa Cruz de la Sierra to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santa Cruz de la Sierra to Panama City. Price data was last updated on June 9, 2025.

Booking 47 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santa Cruz de la Sierra to Panama City. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Santa Cruz de la Sierra to Panama City?

Currently, October is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to Panama City (average of $478). Flying from Santa Cruz de la Sierra to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from VVI to PTY?

Find hourly flight availability from Santa Cruz de la Sierra to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from Santa Cruz de la Sierra to Panama City, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 54% versus a flight in the afternoon.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated June 12, 2025.
To help decide which airline to fly from Santa Cruz de la Sierra to Panama City, see what other customers have to say about Copa Airlines, Air Europa and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,451 reviews

Overall

7.5

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Crew

8.1

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
Copa Airlines
7.5
Good
1,451 reviews
Copa Airlines
7.5
Good
1,451 reviews

Overall

7.5

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Crew

8.1

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
Air Europa
6.9
Okay
529 reviews
Copa Airlines
7.5
Good
1,451 reviews

Overall

7.5

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Crew

8.1

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
Avianca
6.7
Okay
2,345 reviews
Copa Airlines
7.5
Good
1,451 reviews

Overall

7.5

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Crew

8.1

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.

Related info for your journey

Find useful and relevant information for your journey from Santa Cruz de la Sierra to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Santa Cruz de la Sierra to Panama City?

    Panama City Tocumen Intl is the airport most travelers will use when flying to Panama City from Santa Cruz de la Sierra Viru Viru Intl. Booking flights from Viru Viru Intl (VVI) to Tocumen Intl (PTY) should be relatively easy as there is 1 daily flight to Panama City from 2 different airlines. 13h 36m is how long a flight from Santa Cruz de la Sierra to Panama City Tocumen Intl will take if you book a nonstop flight.

  • How popular is this Santa Cruz de la Sierra to Panama City flight route?

    The Santa Cruz de la Sierra Viru Viru Intl to Panama City Tocumen Intl flight path was viewed by 15 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Santa Cruz de la Sierra to Panama City round-trip?

    Flying on Avianca is currently your cheapest option to Panama City, with prices starting at $628. Another option worth looking into is Copa Airlines, starting at $634 round trip.

  • What are the cheapest airlines to fly from Santa Cruz de la Sierra to Panama City one-way?

    $355 is the cheapest one-way deal found within the past few days, from Avianca. You may also be able to find cheap deals on Copa Airlines and Air Europa, with prices starting from $803 and $4,679, respectively.

  • What are the cheapest flights from Santa Cruz de la Sierra to Panama City?

    Looking at all options, your cheapest flight can be booked for $321. While the most popular route (Santa Cruz de la Sierra Viru Viru Intl - Panama City Tocumen Intl) can be booked for $884 on average our data indicates $631 when flying from Santa Cruz de la Sierra to Panama City.

  • Can I find deals for flights from Santa Cruz de la Sierra to Panama City that include hotel bookings?

    Yes. In addition to deals on Santa Cruz de la Sierra to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Cruz de la Sierra to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Cruz de la Sierra to Panama City.

  • Can I find deals for business class flights from Santa Cruz de la Sierra to Panama City?

    Yes. Cheapflights offers flight deals from Santa Cruz de la Sierra to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Cruz de la Sierra to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Santa Cruz de la Sierra to Panama City (average of $478). Flying from Santa Cruz de la Sierra to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Santa Cruz de la Sierra to Panama City

Discover the top 2 airlines that operate flights from Santa Cruz de la Sierra to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$387Average$486FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$443Average$618FlexibilityNo cancel feeOn-time70%

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