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$205+ Cheap flights from Roanoke (ROA) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/20. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — PTY
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Roanoke to Panama City

Cheapest flights from Roanoke to Panama City
Explore the most affordable flight options available from Roanoke to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:45 amROA - PTY
2 stops12h 53mUnited Airlines
Mon 12/228:55 amPTY - ROA
2 stops14h 35mUnited Airlines
Deal found 12/9$568
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:33 pmROA - PTY
2 stops22h 21mAmerican Airlines
Thu 12/252:53 pmPTY - ROA
2 stops17h 49mAmerican Airlines
Deal found 12/11$801
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:40 amROA - PTY
2 stops12h 58mUnited Airlines
Sun 12/288:55 amPTY - ROA
2 stops25h 21mUnited Airlines
Deal found 12/9$833
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amROA - PTY
1 stop8h 21mDelta
Thu 12/258:00 amPTY - ROA
1 stop11h 26mDelta
Deal found 12/11$1,168

Find flight deals from Roanoke to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Roanoke (ROA) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$436
(Delta)

One-way from

$205
(Delta)
Provider with most accurate pricing for Roanoke-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Roanoke-Panama City Tocumen Intl flights.
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From Roanoke to Panama City Tocumen Intl
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One-way flight from Roanoke to Panama City Tocumen Intl
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Roanoke to Panama City that are best for you.

Fly from

Roanoke

Fly to

Panama City

Route

Depart

Return

Price

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Wed 1/21

6:45 am-7:38 pm

2 stops12h 53m

Panama City Tocumen Intl

Tue 3/3

4:41 pm-10:13 am

2 stops17h 32m

$460

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Thu 1/22

6:45 am-7:38 pm

2 stops12h 53m

Panama City Tocumen Intl

Tue 3/3

4:41 pm-10:13 am

2 stops17h 32m

$460

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sun 1/25

12:40 pm-5:07 pm

2 stops28h 27m

Panama City Tocumen Intl

Wed 3/4

11:35 am-9:43 am

2 stops22h 08m

$460

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Tue 1/20

6:00 am-1:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Wed 3/4

3:20 pm-12:08 am

1 stop8h 48m

$476

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 1/19

7:59 pm-1:55 pm

1 stop17h 56m

Panama City Tocumen Intl

Wed 3/4

3:20 pm-10:49 pm

2 stops31h 29m

$480

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 1/23

12:40 pm-2:45 pm

2 stops26h 05m

Panama City Tocumen Intl

Tue 3/3

4:41 pm-2:12 pm

2 stops21h 31m

$480

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Mon 1/19

3:39 pm-2:45 pm

2 stops23h 06m

Panama City Tocumen Intl

Sun 3/1

8:55 am-10:13 am

2 stops25h 18m

$480

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 1/23

12:40 pm-5:07 pm

2 stops28h 27m

Panama City Tocumen Intl

Mon 3/2

4:41 pm-2:12 pm

2 stops21h 31m

$480

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Sat 1/31

12:40 pm-2:45 pm

2 stops26h 05m

Panama City Tocumen Intl

Sun 3/1

4:41 pm-10:13 am

2 stops17h 32m

$480

RoanokePanama City

ROA - PTY

ROAPTY

Roanoke

Fri 1/23

6:45 am-8:02 pm

2 stops13h 17m

Panama City Tocumen Intl

Thu 3/5

8:55 am-10:13 am

2 stops25h 18m

$480

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 24 results
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Compare providers for flights from Roanoke to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Roanoke to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Roanoke-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Roanoke-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Roanoke-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Roanoke-Panama City flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Roanoke-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Roanoke to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Panama City

What is the cheapest time of day to fly from ROA to PTY?

Find hourly flight availability from Roanoke to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s optimal to fly from Roanoke to Panama City in the evening. By choosing this option you can save up to 64% on the cost of your flight, compared to a flight at noon.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Roanoke to Panama City?

    United Airlines and Delta can get you from Roanoke to Panama City in just under 7h 55m. Your travel time can differ by up to 4h 58m. The distance from Roanoke to Panama City is about 1951 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Roanoke to Panama City that include hotel bookings?

    Yes. In addition to deals on Roanoke to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Panama City.

  • Can I find deals for business class flights from Roanoke to Panama City?

    Yes. Cheapflights offers flight deals from Roanoke to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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