HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$646+ Cheap flights from Madrid, Spain (MAD) to Panama City, FL (ECP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — ECP
Dec 31 — Jan 71
Wed 12/31
Wed 1/7
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Madrid to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Madrid to Panama City

Cheapest flights from Madrid to Panama City
Explore the most affordable flight options available from Madrid to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 1, 2025.

This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/61:15 pmMAD - ECP
2 stops17h 49mAmerican Airlines
Sun 1/47:15 amECP - MAD
2 stops16h 05mAmerican Airlines
Deal found 11/29$1,255
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:15 amMAD - ECP
2 stops17h 34mUnited Airlines
Sun 1/49:52 amECP - MAD
2 stops23h 08mUnited Airlines
Deal found 11/30$1,429
This Delta deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:15 amMAD - ECP
1 stop28h 59mDelta
Sun 1/42:04 pmECP - MAD
2 stops20h 36mDelta
Deal found 11/30$1,583
This United Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1411:15 amMAD - ECP
2 stops29h 33mUnited Airlines
Thu 12/189:52 amECP - MAD
2 stops16h 23mUnited Airlines
Deal found 11/29$1,801
This KLM deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1411:15 amMAD - ECP
1 stop35h 10mMultiple Airlines
Thu 12/185:00 pmECP - MAD
2 stops15h 20mMultiple Airlines
Deal found 11/29$1,807
This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/141:00 pmMAD - ECP
1 stop17h 55mAmerican Airlines
Thu 12/187:15 amECP - MAD
1 stop15h 30mAmerican Airlines
Deal found 11/29$2,021

Cheap flight deals from Madrid to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 1, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$646
(American Airlines)
Provider with most accurate pricing for Madrid Barajas-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Madrid Barajas-Panama City NW Florida Beaches flights.
Search Deals
From Madrid Barajas to Panama City NW Florida Beaches
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Madrid to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 1, 2025.
Use the filters below to find and compare flights from Madrid to Panama City that are best for you.

Fly from

Madrid

Fly to

Panama City

Route

Depart

Return

Price

MadridPanama City

MAD - ECP

MADECP

Madrid Barajas

Tue 1/13

12:40 pm-11:33 am

1 stop29h 53m

Panama City NW Florida Beaches

Tue 1/20

7:02 am-6:15 am

1 stop16h 13m

$646

MadridPanama City

MAD - ECP

MADECP

Madrid Barajas

Tue 1/13

6:00 am-4:12 pm

2 stops41h 12m

Panama City NW Florida Beaches

Tue 1/20

6:30 am-9:15 am

2 stops19h 45m

$696

MadridPanama City

MAD - ECP

MADECP

Madrid Barajas

Fri 1/16

1:35 pm-12:02 pm

2 stops29h 27m

Panama City NW Florida Beaches

Tue 1/20

6:30 am-9:15 am

2 stops19h 45m

$713

MadridPanama City

MAD - ECP

MADECP

Madrid Barajas

Fri 1/16

1:00 pm-9:19 pm

1 stop15h 19m

Panama City NW Florida Beaches

Tue 1/20

7:02 am-5:50 am

2 stops15h 48m

$910

MadridPanama City

MAD - ECP

MADECP

Madrid Barajas

Tue 1/6

7:05 am-7:50 pm

2 stops19h 45m

$1,297

MadridPanama City

MAD - ECP

MADECP

Madrid Barajas

Mon 1/5

6:25 am-9:54 pm

3 stops22h 29m

$1,579

MadridPanama City

MAD - ECP

MADECP

Madrid Barajas

Mon 1/5

6:00 am-10:51 pm

2 stops23h 51m

$1,883

MadridPanama City

MAD - ECP

MADECP

Madrid Barajas

Tue 1/6

1:00 pm-9:19 pm

1 stop15h 19m

$2,207

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/29

Compare providers for flights from Madrid to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Madrid to Panama City in December.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Madrid-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Madrid-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Madrid-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Madrid-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Madrid-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Madrid to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Madrid with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Panama City

What is the cheapest month to book a flight from Madrid to Panama City, Florida?

Currently, November is the cheapest month in which you can book a flight from Madrid to Panama City, Florida (average of $545). Flying from Madrid to Panama City, Florida in July is currently the most expensive (average of $1,160). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Madrid to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Madrid to Panama City, Florida?

    A quick flight from Madrid to Panama City, Florida can take about 29h 53m. American Airlines provides one of the quickest options available for as low as $646. The distance between Madrid and Panama City, Florida is about 4513 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Madrid to Panama City, Florida one-way?

    One-way options have recently been found by users for as low as $1,297 on KLM. Other airlines that offer cheap prices include United Airlines from $1,579 and Delta from $1,883 one-way.

  • Can I find deals for flights from Madrid to Panama City that include hotel bookings?

    Yes. In addition to deals on Madrid to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Madrid to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Panama City.

  • Can I find deals for business class flights from Madrid to Panama City?

    Yes. Cheapflights offers flight deals from Madrid to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Madrid to Panama City, Florida?

    Currently, November is the cheapest month in which you can book a flight from Madrid to Panama City, Florida (average of $545). Flying from Madrid to Panama City, Florida in July is currently the most expensive (average of $1,160). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.