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Panama City

$179+ Cheap flights from Florida Keys to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/25. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — ECP
dic. 21 — dic. 281
dom. 12/21
dom. 12/28
1 adult, Economy
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Cheap flight deals from Florida Keys to Panama City

Keep the following information in mind while searching for Florida Keys to Panama City flight deals. Data was last updated noviembre 21, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$317
(Delta)

One-way from

$179
(Delta)
Provider with most accurate pricing for Key West-Panama City NW Florida Beaches flight deals.
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Provider most trusted by Cheapflights users for Key West-Panama City NW Florida Beaches flights.
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From Florida Keys to Panama City NW Florida Beaches
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One-way flight from Florida Keys to Panama City NW Florida Beaches
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Find flight deals from Florida Keys to Panama City

Cheapest flights from Florida Keys to Panama City
Explore the most affordable flight options available from Florida Keys to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 21, 2025.

This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/256:00 amMIA - ECP
1 stop5h 17mDelta
mié. 12/312:04 pmECP - MIA
1 stop5h 53mDelta
Deal found 11/18$317
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/123:02 pmEYW - ECP
1 stop3h 57mDelta
mié. 12/171:32 pmECP - EYW
1 stop5h 34mDelta
Deal found 11/19$329
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/121:33 pmEYW - ECP
2 stops10h 37mAmerican Airlines
mié. 12/1712:08 pmECP - EYW
1 stop4h 44mAmerican Airlines
Deal found 11/19$334
This Delta deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/63:02 pmEYW - ECP
1 stop4h 58mDelta
mié. 12/1010:00 amECP - EYW
1 stop6h 15mDelta
Deal found 11/20$359
This American Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/68:00 amEYW - ECP
1 stop7h 13mAmerican Airlines
mié. 12/108:30 amECP - EYW
2 stops10h 05mAmerican Airlines
Deal found 11/20$364
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/277:40 amEYW - ECP
1 stop6h 07mDelta
sáb. 11/296:00 amECP - EYW
1 stop7h 03mDelta
Deal found 11/19$399
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/126:00 amMIA - ECP
1 stop4h 14mDelta
lun. 12/156:59 pmECP - MIA
1 stop4h 47mDelta
Deal found 11/19$437
This Southwest deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/306:00 amMIA - ECP
1 stop7h 10mSouthwest
dom. 1/46:35 pmECP - MIA
1 stop4h 30mSouthwest
Deal found 11/19$451
This Southwest deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/147:10 amMIA - ECP
1 stop6h 45mSouthwest
vie. 12/196:35 pmECP - MIA
1 stop4h 30mSouthwest
Deal found 11/20$453
This Southwest deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/127:10 amMIA - ECP
1 stop6h 45mSouthwest
lun. 12/1510:00 amECP - MIA
2 stops10h 50mSouthwest
Deal found 11/19$458
This Delta deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/87:00 amMIA - ECP
1 stop6h 47mDelta
jue. 12/116:59 pmECP - MIA
1 stop4h 47mDelta
Deal found 11/20$467
This Southwest deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/187:10 amMIA - ECP
1 stop6h 45mSouthwest
jue. 12/257:15 amECP - MIA
1 stop4h 35mSouthwest
Deal found 11/18$473

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 21, 2025.
Use the filters below to find and compare flights from Florida Keys to Panama City that are best for you.

Fly from

Florida Keys

Fly to

Panama City

Route

Depart

Return

Price

Key WestPanama City

EYW - ECP

EYWECP

Key West

vie. 1/23

2:45 pm-7:50 pm

1 stop6h 05m

Panama City NW Florida Beaches

mar. 1/27

12:15 pm-7:40 pm

1 stop6h 25m

$317

MiamiPanama City

MIA - ECP

MIAECP

Miami

mié. 1/28

11:13 am-5:33 pm

1 stop7h 20m

Panama City NW Florida Beaches

mar. 4/7

2:53 pm-8:47 pm

1 stop4h 54m

$317

MiamiPanama City

MIA - ECP

MIAECP

Miami

jue. 12/25

6:00 am-10:17 am

1 stop5h 17m

Panama City NW Florida Beaches

mié. 12/31

2:04 pm-8:57 pm

1 stop5h 53m

$317

MiamiPanama City

MIA - ECP

MIAECP

Miami

mié. 1/21

12:00 pm-2:56 pm

1 stop3h 56m

Panama City NW Florida Beaches

sáb. 1/24

4:45 pm-5:28 pm

2 stops23h 43m

$321

Key WestPanama City

EYW - ECP

EYWECP

Key West

vie. 2/6

7:10 am-11:08 am

1 stop4h 58m

Panama City NW Florida Beaches

lun. 2/9

7:20 am-1:48 pm

1 stop5h 28m

$327

Key WestPanama City

EYW - ECP

EYWECP

Key West

vie. 12/12

3:02 pm-5:59 pm

1 stop3h 57m

Panama City NW Florida Beaches

mié. 12/17

1:32 pm-8:06 pm

1 stop5h 34m

$329

Key WestPanama City

EYW - ECP

EYWECP

Key West

vie. 12/12

1:33 pm-11:10 pm

2 stops10h 37m

Panama City NW Florida Beaches

mié. 12/17

12:08 pm-5:52 pm

1 stop4h 44m

$334

MiamiPanama City

MIA - ECP

MIAECP

Miami

mar. 1/27

5:30 pm-10:40 pm

1 stop6h 10m

Panama City NW Florida Beaches

jue. 2/5

6:09 pm-12:51 am

1 stop5h 42m

$337

Key WestPanama City

EYW - ECP

EYWECP

Key West

sáb. 12/6

3:02 pm-7:00 pm

1 stop4h 58m

Panama City NW Florida Beaches

mié. 12/10

10:00 am-5:15 pm

1 stop6h 15m

$359

Key WestPanama City

EYW - ECP

EYWECP

Key West

sáb. 12/6

8:00 am-2:13 pm

1 stop7h 13m

Panama City NW Florida Beaches

mié. 12/10

8:30 am-7:35 pm

2 stops10h 05m

$364

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/20

Showing 1-10 of 26 results
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Best time to book a flight from Florida Keys to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to Panama City
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated noviembre 21, 2025.
See what other customers who have flown with Delta and American Airlines from Florida Keys to Panama City have to say. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,002 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,002 reviews
Delta
7.9
Good
8,002 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,047 reviews
Delta
7.9
Good
8,002 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Florida Keys?

    Most people fly into Panama City NW Florida Beaches (ECP) if they book a flight to Panama City from Florida Keys. NW Florida Beaches is conveniently located just 16.0 mi from Panama City’s city center.

  • How long is the flight from Florida Keys to Panama City, Florida?

    A quick flight from Florida Keys to Panama City, Florida can take about 6h 05m. Delta provides one of the quickest options available for as low as $317. Airlines will cover a distance of 471 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Florida Keys to Panama City that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Panama City.

  • Can I find deals for business class flights from Florida Keys to Panama City?

    Yes. Cheapflights offers flight deals from Florida Keys to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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