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Panama City

$159+ Cheap flights from Florida Keys to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/18. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — ECP
Nov 1 — Nov 81
Sat 11/1
Sat 11/8
1 adult, Economy
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Cheap flight deals from Florida Keys to Panama City

Keep the following information in mind while searching for Florida Keys to Panama City flight deals. Data was last updated October 2, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$317
(Delta)

One-way from

$159
(Delta)
Provider with most accurate pricing for Key West-Panama City NW Florida Beaches flight deals.
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Provider most trusted by Cheapflights users for Key West-Panama City NW Florida Beaches flights.
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From Florida Keys to Panama City NW Florida Beaches
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One-way flight from Florida Keys to Panama City NW Florida Beaches
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Find flight deals from Florida Keys to Panama City

Cheapest flights from Florida Keys to Panama City
Explore the most affordable flight options available from Florida Keys to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 2, 2025.

This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:25 amMIA - ECP
1 stop6h 54mDelta
Wed 12/318:02 amECP - MIA
1 stop3h 54mDelta
Deal found 10/2$317
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/247:00 pmMIA - ECP
1 stop5h 15mAmerican Airlines
Tue 12/28:21 amECP - MIA
1 stop5h 57mAmerican Airlines
Deal found 10/1$318
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:00 amMIA - ECP
1 stop5h 00mAmerican Airlines
Mon 11/2412:00 pmECP - MIA
1 stop4h 31mAmerican Airlines
Deal found 10/2$322
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/166:00 amMIA - ECP
1 stop5h 33mAmerican Airlines
Mon 11/2412:00 pmECP - MIA
1 stop4h 31mAmerican Airlines
Deal found 9/30$323
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:00 amMIA - ECP
1 stop3h 44mDelta
Sun 11/96:40 pmECP - MIA
1 stop5h 06mDelta
Deal found 10/2$327
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/161:57 pmEYW - ECP
1 stop4h 15mDelta
Mon 10/201:35 pmECP - EYW
1 stop5h 31mDelta
Deal found 9/30$339
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:45 pmMIA - ECP
1 stop6h 17mDelta
Sun 1/47:02 pmECP - MIA
1 stop4h 55mDelta
Deal found 10/2$342
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:23 pmMIA - ECP
2 stops19h 37mDelta
Mon 11/241:32 pmECP - MIA
1 stop6h 14mDelta
Deal found 10/2$345
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/205:07 pmMIA - ECP
1 stop7h 06mDelta
Fri 1/27:02 pmECP - MIA
1 stop4h 55mDelta
Deal found 10/2$347
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:00 amMIA - ECP
1 stop5h 19mDelta
Fri 10/246:17 pmECP - MIA
1 stop5h 12mDelta
Deal found 9/30$367
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:17 pmEYW - ECP
1 stop5h 53mDelta
Tue 10/216:00 amECP - EYW
1 stop4h 27mDelta
Deal found 10/2$379
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:00 amMIA - ECP
1 stop10h 24mDelta
Wed 12/318:02 amECP - MIA
1 stop6h 51mDelta
Deal found 10/2$381

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 2, 2025.
Use the filters below to find and compare flights from Florida Keys to Panama City that are best for you.

Fly from

Florida Keys

Fly to

Panama City

Route

Depart

Return

Price

MiamiPanama City

MIA - ECP

MIAECP

Miami

Mon 11/24

7:00 pm-11:15 pm

1 stop5h 15m

Panama City NW Florida Beaches

Tue 12/2

8:21 am-3:18 pm

1 stop5h 57m

$318

MiamiPanama City

MIA - ECP

MIAECP

Miami

Tue 11/25

3:40 pm-8:32 pm

1 stop5h 52m

Panama City NW Florida Beaches

Mon 12/1

6:00 am-1:02 pm

1 stop6h 02m

$322

MiamiPanama City

MIA - ECP

MIAECP

Miami

Thu 11/20

7:00 pm-11:49 pm

1 stop5h 49m

Panama City NW Florida Beaches

Mon 11/24

5:55 pm-11:49 pm

1 stop4h 54m

$322

MiamiPanama City

MIA - ECP

MIAECP

Miami

Fri 12/5

7:30 pm-10:58 pm

1 stop4h 28m

Panama City NW Florida Beaches

Tue 12/9

10:00 am-3:50 pm

1 stop4h 50m

$322

MiamiPanama City

MIA - ECP

MIAECP

Miami

Tue 11/11

12:36 pm-3:55 pm

1 stop4h 19m

Panama City NW Florida Beaches

Fri 11/14

6:40 pm-12:46 am

1 stop5h 06m

$322

MiamiPanama City

MIA - ECP

MIAECP

Miami

Fri 11/7

6:00 am-8:44 am

1 stop3h 44m

Panama City NW Florida Beaches

Mon 11/10

7:02 am-2:35 pm

1 stop6h 33m

$327

MiamiPanama City

MIA - ECP

MIAECP

Miami

Fri 12/5

4:55 pm-10:58 pm

1 stop7h 03m

Panama City NW Florida Beaches

Mon 12/8

1:32 pm-6:25 pm

1 stop3h 53m

$327

Key WestPanama City

EYW - ECP

EYWECP

Key West

Thu 10/16

1:57 pm-5:12 pm

1 stop4h 15m

Panama City NW Florida Beaches

Mon 10/20

1:35 pm-8:06 pm

1 stop5h 31m

$339

MiamiPanama City

MIA - ECP

MIAECP

Miami

Wed 12/24

5:45 pm-11:02 pm

1 stop6h 17m

Panama City NW Florida Beaches

Sat 1/3

7:02 pm-12:54 am

1 stop4h 52m

$342

MiamiPanama City

MIA - ECP

MIAECP

Miami

Wed 12/24

5:45 pm-11:02 pm

1 stop6h 17m

Panama City NW Florida Beaches

Sun 1/4

7:02 pm-12:57 am

1 stop4h 55m

$342

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/2

Showing 1-10 of 35 results
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Best time to book a flight from Florida Keys to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to Panama City
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 2, 2025.
See what other customers who have flown with Delta and American Airlines from Florida Keys to Panama City have to say. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,962 reviews

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,962 reviews
Delta
8.0
Very good
7,962 reviews

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,033 reviews
Delta
8.0
Very good
7,962 reviews

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Florida Keys?

    Most people fly into Panama City NW Florida Beaches (ECP) if they book a flight to Panama City from Florida Keys. NW Florida Beaches is conveniently located just 16.0 mi from Panama City’s city center.

  • How long is the flight from Florida Keys to Panama City, Florida?

    A quick flight from Florida Keys to Panama City, Florida can take about 5h 15m. American Airlines provides one of the quickest options available for as low as $318. Airlines will cover a distance of 460 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Florida Keys to Panama City that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Panama City.

  • Can I find deals for business class flights from Florida Keys to Panama City?

    Yes. Cheapflights offers flight deals from Florida Keys to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from Florida Keys to Panama City, Florida (average of $346). Flying from Florida Keys to Panama City, Florida in March is currently the most expensive (average of $458). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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