HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$158+ Cheap flights from Florida Keys to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — ECP
Feb 6 — Feb 131
Fri 2/6
Fri 2/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Florida Keys to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Florida Keys to Panama City

Keep the following information in mind while searching for Florida Keys to Panama City flight deals. Data was last updated January 7, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$315
(Delta)

One-way from

$158
(Delta)
Provider with most accurate pricing for Key West-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Panama City NW Florida Beaches flights.
Search Deals
From Florida Keys to Panama City NW Florida Beaches
Search Deals
One-way flight from Florida Keys to Panama City NW Florida Beaches
Search Deals

Find flight deals from Florida Keys to Panama City

Cheapest flights from Florida Keys to Panama City
Explore the most affordable flight options available from Florida Keys to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 7, 2026.

This Delta deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:15 amMIA - ECP
1 stop4h 10mDelta
Tue 3/312:10 pmECP - MIA
1 stop5h 11mDelta
Deal found 1/5$315
This Delta deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/38:15 amMIA - ECP
1 stop3h 53mDelta
Tue 2/107:20 amECP - MIA
1 stop5h 58mDelta
Deal found 1/6$316
This Southwest deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/37:15 amMIA - ECP
2 stops11h 55mSouthwest
Tue 2/1010:30 amECP - MIA
1 stop7h 05mSouthwest
Deal found 1/4$322
This Delta deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:15 amMIA - ECP
1 stop4h 10mDelta
Mon 3/22:05 pmECP - MIA
1 stop5h 39mDelta
Deal found 1/5$335
This Delta deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/41:21 pmMIA - ECP
1 stop5h 53mDelta
Mon 2/97:20 amECP - MIA
1 stop5h 58mDelta
Deal found 1/6$336
This Delta deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:00 amMIA - ECP
1 stop6h 38mDelta
Sat 5/97:45 amECP - MIA
1 stop6h 58mDelta
Deal found 1/7$355
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/297:07 amMIA - ECP
1 stop5h 26mAmerican Airlines
Wed 2/412:03 pmECP - MIA
1 stop4h 38mAmerican Airlines
Deal found 1/6$356
This Delta deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/222:45 pmEYW - ECP
1 stop6h 05mDelta
Mon 1/267:20 amECP - EYW
1 stop5h 28mDelta
Deal found 1/6$359
This Delta deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2511:21 amMIA - ECP
2 stops12h 18mDelta
Thu 3/56:06 pmECP - MIA
1 stop5h 47mDelta
Deal found 1/5$360
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2212:00 pmEYW - ECP
2 stops6h 33mAmerican Airlines
Mon 1/2612:03 pmECP - EYW
1 stop4h 58mAmerican Airlines
Deal found 1/6$364
This Southwest deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/56:45 amMIA - ECP
2 stops10h 00mSouthwest
Tue 2/1010:30 amECP - MIA
2 stops10h 30mSouthwest
Deal found 1/5$366
This Delta deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/187:10 amEYW - ECP
1 stop7h 10mDelta
Fri 2/2012:10 pmECP - EYW
1 stop6h 32mDelta
Deal found 1/6$495

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
Use the filters below to find and compare flights from Florida Keys to Panama City that are best for you.

Fly from

Florida Keys

Fly to

Panama City

Route

Depart

Return

Price

MiamiPanama City

MIA - ECP

MIAECP

Miami

Wed 2/25

7:25 pm-10:39 pm

1 stop4h 14m

Panama City NW Florida Beaches

Wed 3/4

9:26 am-2:13 pm

1 stop3h 47m

$315

MiamiPanama City

MIA - ECP

MIAECP

Miami

Wed 2/25

8:15 am-11:25 am

1 stop4h 10m

Panama City NW Florida Beaches

Tue 3/3

12:10 pm-6:21 pm

1 stop5h 11m

$315

MiamiPanama City

MIA - ECP

MIAECP

Miami

Tue 2/3

8:15 am-11:08 am

1 stop3h 53m

Panama City NW Florida Beaches

Tue 2/10

7:20 am-2:18 pm

1 stop5h 58m

$316

MiamiPanama City

MIA - ECP

MIAECP

Miami

Tue 2/3

7:15 am-6:10 pm

2 stops11h 55m

Panama City NW Florida Beaches

Tue 2/10

10:30 am-6:35 pm

1 stop7h 05m

$322

MiamiPanama City

MIA - ECP

MIAECP

Miami

Wed 4/1

12:55 pm-8:00 pm

2 stops8h 05m

Panama City NW Florida Beaches

Wed 4/15

7:55 am-8:40 pm

2 stops11h 45m

$328

MiamiPanama City

MIA - ECP

MIAECP

Miami

Sat 3/7

7:15 am-11:25 am

1 stop5h 10m

Panama City NW Florida Beaches

Tue 3/10

9:25 am-3:37 pm

1 stop5h 12m

$335

MiamiPanama City

MIA - ECP

MIAECP

Miami

Fri 3/6

6:00 am-11:25 am

1 stop6h 25m

Panama City NW Florida Beaches

Wed 3/11

7:05 am-2:10 pm

1 stop6h 05m

$335

MiamiPanama City

MIA - ECP

MIAECP

Miami

Fri 3/6

7:15 am-1:20 pm

1 stop7h 05m

Panama City NW Florida Beaches

Tue 3/10

9:25 am-2:10 pm

1 stop3h 45m

$335

MiamiPanama City

MIA - ECP

MIAECP

Miami

Thu 2/26

8:15 am-1:20 pm

1 stop6h 05m

Panama City NW Florida Beaches

Wed 3/4

9:26 am-2:13 pm

1 stop3h 47m

$335

MiamiPanama City

MIA - ECP

MIAECP

Miami

Thu 3/5

3:20 pm-7:30 pm

1 stop5h 10m

Panama City NW Florida Beaches

Wed 3/11

7:05 am-12:08 pm

1 stop4h 03m

$335

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/7

Showing 1-10 of 29 results
1
2
3

Best time to book a flight from Florida Keys to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to Panama City
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated January 7, 2026.
See what other customers who have flown with Delta and American Airlines from Florida Keys to Panama City have to say. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,025 reviews

Overall

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,025 reviews
Delta
7.9
Good
8,025 reviews

Overall

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,095 reviews
Delta
7.9
Good
8,025 reviews

Overall

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Florida Keys?

    Most people fly into Panama City NW Florida Beaches (ECP) if they book a flight to Panama City from Florida Keys. NW Florida Beaches is conveniently located just 16.0 mi from Panama City’s city center.

  • How long is the flight from Florida Keys to Panama City, Florida?

    A quick flight from Florida Keys to Panama City, Florida can take about 4h 14m. Delta provides one of the quickest options available for as low as $315. Airlines will cover a distance of 460 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Florida Keys to Panama City that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Panama City.

  • Can I find deals for business class flights from Florida Keys to Panama City?

    Yes. Cheapflights offers flight deals from Florida Keys to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florida Keys to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Tampa to Miami flights
Miami to Orlando flights
Orlando to Miami flights
Miami to Tampa flights
Tampa to Fort Lauderdale flights
Fort Lauderdale to Tampa flights
Fort Lauderdale to Jacksonville flights
Pensacola to Miami flights
Jacksonville to Miami flights
Miami to Jacksonville flights
Orlando to Key West flights
Pensacola to Orlando flights
Fort Lauderdale to Orlando flights
Orlando to Fort Lauderdale flights
Tampa to Key West flights
Pensacola to Fort Lauderdale flights
Jacksonville to Fort Lauderdale flights
West Palm Beach to Jacksonville flights
Miami to Key West flights
Tampa to Pensacola flights
Fort Lauderdale to Pensacola flights
Jacksonville to Key West flights
Fort Myers to Jacksonville flights
Orlando to Pensacola flights
Pensacola to Tampa flights
Pensacola to Key West flights
Fort Lauderdale to Tallahassee flights
Miami to Pensacola flights
Tampa to Jacksonville flights
West Palm Beach to Tampa flights
Tallahassee to Miami flights
Panama City to Miami flights
Tallahassee to Fort Lauderdale flights
Sarasota to Key West flights
Miami to Panama City flights
Key West to Tampa flights
Miami to Fort Lauderdale flights
Sarasota to Pensacola flights
Fort Lauderdale to Key West flights
Jacksonville to West Palm Beach flights
Tampa to West Palm Beach flights
Panama City to Orlando flights
Jacksonville to Tampa flights
Fort Myers to Key West flights
West Palm Beach to Tallahassee flights
Orlando to Panama City flights
Fort Myers to Pensacola flights
West Palm Beach to Pensacola flights
Miami to Tallahassee flights
Fort Myers to Orlando flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.