$274+ Cheap flights from Sioux Falls (FSD) to Missouri
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — STL
Nov 11 — Nov 181
Round-trip
1 adult, Economy
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Cheapest flights from Sioux Falls to MissouriExplore the most affordable flight options available from Sioux Falls to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 12, 2026.
Explore the most affordable flight options available from Sioux Falls to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 12, 2026.
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:40 am -
1 stop6h 54m
Sat 11/145:00 am -
1 stop5h 32m
Deal found 10/7![United Airlines logo]()
$301
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:18 pm -
1 stop4h 41m
Sun 11/158:15 pm -
1 stop4h 14m
Deal found 10/8![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:18 pm -
1 stop5h 06m
Sat 11/79:12 am -
1 stop5h 41m
Deal found 10/11![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:31 am -
1 stop3h 50m
Mon 11/3012:28 pm -
1 stop6h 38m
Deal found 10/10![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:50 am -
1 stop4h 25m
Wed 10/288:50 am -
1 stop7h 35m
Deal found 10/8![United Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:42 am -
1 stop6h 40m
Mon 10/265:45 am -
1 stop4h 42m
Deal found 10/7![United Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:08 pm -
2 stops9h 16m
Sat 11/142:54 pm -
1 stop6h 00m
Deal found 10/7![American Airlines logo]()
$351
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:39 pm -
1 stop4h 40m
Wed 10/2811:32 am -
2 stops8h 19m
Deal found 10/8![American Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:50 am -
1 stop6h 27m
Mon 10/266:50 pm -
1 stop4h 39m
Deal found 10/10![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:50 pm -
1 stop4h 54m
Sat 10/175:36 pm -
1 stop5h 35m
Deal found 10/9![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:20 am -
1 stop4h 39m
Tue 10/208:08 pm -
1 stop4h 33m
Deal found 10/10![American Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:54 pm -
1 stop5h 29m
Sat 10/177:16 am -
1 stop7h 02m
Deal found 10/9![American Airlines logo]()
$389
Best flights from Sioux Falls to MissouriDiscover carefully curated flight deals from Sioux Falls to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 12, 2026.
Discover carefully curated flight deals from Sioux Falls to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 12, 2026.
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:40 am -
1 stop6h 54m
Sat 11/145:00 am -
1 stop5h 32m
Deal found 10/7![United Airlines logo]()
$301
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:18 pm -
1 stop4h 41m
Sun 11/158:15 pm -
1 stop4h 14m
Deal found 10/8![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/295:00 am -
1 stop5h 03m
Tue 1/56:30 am -
1 stop5h 41m
Deal found 10/10![Delta logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:50 pm -
2 stops30h 57m
Fri 11/1312:53 pm -
1 stop8h 48m
Deal found 10/8![Multiple Airlines logo]()
$459
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:34 pm -
1 stop20h 59m
Thu 10/298:18 am -
1 stop24h 51m
Deal found 10/10![Allegiant Air logo]()
$573
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:18 pm -
1 stop5h 06m
Sat 11/79:12 am -
1 stop5h 41m
Deal found 10/11![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:31 am -
1 stop3h 50m
Mon 11/3012:28 pm -
1 stop6h 38m
Deal found 10/10![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:50 am -
1 stop4h 25m
Wed 10/288:50 am -
1 stop7h 35m
Deal found 10/8![United Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:08 pm -
2 stops9h 16m
Sat 11/142:54 pm -
1 stop6h 00m
Deal found 10/7![American Airlines logo]()
$351
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:50 am -
1 stop6h 27m
Mon 10/266:50 pm -
1 stop4h 39m
Deal found 10/10![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:50 pm -
1 stop4h 54m
Sat 10/175:36 pm -
1 stop5h 35m
Deal found 10/9![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:20 am -
1 stop4h 39m
Tue 10/208:08 pm -
1 stop4h 33m
Deal found 10/10![American Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:54 pm -
1 stop5h 29m
Sat 10/177:16 am -
1 stop7h 02m
Deal found 10/9![American Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:04 pm -
1 stop6h 40m
Sun 10/185:36 pm -
1 stop5h 35m
Deal found 10/10![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:32 am -
1 stop6h 49m
Tue 11/171:25 pm -
1 stop6h 39m
Deal found 10/11![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:00 am -
1 stop7h 58m
Mon 11/301:14 pm -
1 stop5h 52m
Deal found 10/10![American Airlines logo]()
$424
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/59:45 am -
1 stop6h 34m
Wed 12/911:27 am -
1 stop7h 11m
Deal found 10/8![United Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:32 am -
1 stop6h 39m
Mon 11/161:34 pm -
1 stop6h 30m
Deal found 10/11![United Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:42 am -
1 stop6h 41m
Wed 10/289:00 am -
1 stop7h 25m
Deal found 10/8![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:35 am -
1 stop4h 47m
Tue 10/275:20 pm -
1 stop6h 24m
Deal found 10/8![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
1 stop4h 36m
Sat 11/73:10 pm -
1 stop6h 27m
Deal found 10/7![United Airlines logo]()
$523
Last-minute flights from Sioux Falls to MissouriDiscover last-minute flight deals from Sioux Falls to Missouri. Data last updated October 12, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Missouri. Data last updated October 12, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:50 pm -
1 stop4h 54m
Sat 10/175:36 pm -
1 stop5h 35m
Deal found 10/9![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:54 pm -
1 stop5h 29m
Sat 10/177:16 am -
1 stop7h 02m
Deal found 10/9![American Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:20 am -
1 stop4h 39m
Tue 10/208:08 pm -
1 stop4h 33m
Deal found 10/10![American Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:50 am -
1 stop6h 27m
Mon 10/266:50 pm -
1 stop4h 39m
Deal found 10/10![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:42 am -
1 stop6h 40m
Mon 10/265:45 am -
1 stop4h 42m
Deal found 10/7![United Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:50 am -
1 stop4h 25m
Wed 10/288:50 am -
1 stop7h 35m
Deal found 10/8![United Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:39 pm -
1 stop4h 40m
Wed 10/2811:32 am -
2 stops8h 19m
Deal found 10/8![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:18 pm -
1 stop5h 06m
Sat 11/79:12 am -
1 stop5h 41m
Deal found 10/11![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:40 am -
1 stop6h 54m
Sat 11/145:00 am -
1 stop5h 32m
Deal found 10/7![United Airlines logo]()
$301
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:08 pm -
2 stops9h 16m
Sat 11/142:54 pm -
1 stop6h 00m
Deal found 10/7![American Airlines logo]()
$351
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:18 pm -
1 stop4h 41m
Sun 11/158:15 pm -
1 stop4h 14m
Deal found 10/8![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:31 am -
1 stop3h 50m
Mon 11/3012:28 pm -
1 stop6h 38m
Deal found 10/10![Delta logo]()
$339
One-way flights from Sioux Falls to MissouriSearch for one-way flight options from Sioux Falls to Missouri. Find affordable one-way fares based on user searches. Data last updated October 12, 2026.
Search for one-way flight options from Sioux Falls to Missouri. Find affordable one-way fares based on user searches. Data last updated October 12, 2026.
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:18 pm -
1 stop4h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![American Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:42 pm -
3 stops18h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/10![Multiple Airlines logo]()
$286
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:04 pm -
1 stop6h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![United Airlines logo]()
$333
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:06 pm -
2 stops21h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/11![United Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:06 pm -
2 stops31h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Multiple Airlines logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:50 pm -
3 stops46h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$373
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:55 am -
2 stops17h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![United Airlines logo]()
$486
Find flight deals from Sioux Falls to Missouri
Keep the following information in mind while searching for Sioux Falls to Missouri flight deals. Data was last updated October 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $319 (American Airlines) |
One-way from | $274 (American Airlines) |
Popular in | May |
Cheapest in | December |
Average price | $367 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 12, 2026.
Use the filters below to find and compare flights from Sioux Falls to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Wed 11/11
11:00 am-2:41 pm
1 stop3h 41m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$274
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Fri 11/13
7:18 pm-11:59 pm
1 stop4h 41m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$274
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Sun 10/18
6:42 pm-1:21 pm
3 stops18h 39m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$286
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Sat 11/7
7:40 am-2:34 pm
1 stop6h 54m
Lambert-St Louis
Sat 11/14
5:00 am-10:32 am
1 stop5h 32m
$301
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Fri 11/13
7:18 pm-11:59 pm
1 stop4h 41m
Lambert-St Louis
Sun 11/15
8:15 pm-12:29 am
1 stop4h 14m
$319
Sioux FallsKansas City
FSD Sioux Falls Joe Foss Field - MCI Kansas City
FSDMCI
Sioux Falls Joe Foss Field
Tue 12/29
5:00 am-10:03 am
1 stop5h 03m
Kansas City
Tue 1/5
6:30 am-12:11 pm
1 stop5h 41m
$319
Sioux FallsKansas City
FSD Sioux Falls Joe Foss Field - MCI Kansas City
FSDMCI
Sioux Falls Joe Foss Field
Thu 11/5
7:18 pm-12:24 am
1 stop5h 06m
Kansas City
Sat 11/7
9:12 am-2:53 pm
1 stop5h 41m
$319
Sioux FallsKansas City
FSD Sioux Falls Joe Foss Field - MCI Kansas City
FSDMCI
Sioux Falls Joe Foss Field
Fri 10/23
5:04 pm-11:44 pm
1 stop6h 40m
Kansas City
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$333
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Fri 11/13
5:06 pm-2:34 pm
2 stops21h 28m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$339
Sioux FallsSt. Louis
FSD Sioux Falls Joe Foss Field - STL Lambert-St Louis
FSDSTL
Sioux Falls Joe Foss Field
Mon 11/23
8:31 am-12:21 pm
1 stop3h 50m
Lambert-St Louis
Mon 11/30
12:28 pm-7:06 pm
1 stop6h 38m
$339
Showing 1-10 of 27 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Sioux Falls with our price prediction graph.
FSD-STL
FSD-MCI
FSD-SGF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Missouri
FSD-USMO
FSD-STL
FSD-MCI
FSD-SGF
What is the cheapest month to book a flight from Sioux Falls to Missouri?
Currently, December is the cheapest month in which you can book a flight from Sioux Falls to Missouri (average of $297). Flying from Sioux Falls to Missouri in May is currently the most expensive (average of $696). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated October 12, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Sioux Falls to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Food
7.2
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Overall
7.8
Food
7.2
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Overall
7.8
Food
7.2
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Overall
7.8
Food
7.2
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Sioux Falls to Missouri
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Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Sioux Falls to Missouri by cabin class
Find flights from Sioux Falls to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Sioux Falls and Missouri flights
Browse other Sioux Falls and Missouri flight options. Last updated on October 12, 2026.
Popular flight searches
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Sioux Falls to Missouri flights
Consider these flights traveling from Sioux Falls to Missouri.
Top 3 airlines flying from Sioux Falls to Missouri
Discover the top 3 airlines that operate flights from Sioux Falls to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$192 | Average$367 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$243 | Average$323 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$249 | Average$388 | FlexibilityNo cancel fee | On-timeN/A |