$146+ Cheap flights from Sioux Falls (FSD) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — STL
May 15 — May 221
Round-trip
1 adult, Economy
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Cheapest flights from Sioux Falls to MissouriExplore the most affordable flight options available from Sioux Falls to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2026.
Explore the most affordable flight options available from Sioux Falls to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2026.
This Frontier deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:06 pm
FSD
- STL
1 stop23h 26m
Frontier
Thu 5/78:08 pm
STL
- FSD
1 stop19h 14m
Frontier
Deal found 4/14![Frontier logo]()
$161
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:45 pm
FSD
- STL
1 stop4h 11m
American Airlines
Wed 5/205:20 am
STL
- FSD
1 stop7h 36m
American Airlines
Deal found 4/13![American Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:45 am
FSD
- STL
2 stops30h 51m
Multiple Airlines
Thu 5/78:08 pm
STL
- FSD
1 stop19h 14m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:28 pm
FSD
- STL
1 stop5h 31m
American Airlines
Tue 5/195:20 am
STL
- FSD
1 stop7h 36m
American Airlines
Deal found 4/14![American Airlines logo]()
$281
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:39 pm
FSD
- STL
1 stop4h 17m
American Airlines
Wed 5/135:21 pm
STL
- FSD
1 stop5h 45m
American Airlines
Deal found 4/14![American Airlines logo]()
$291
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:00 am
FSD
- STL
1 stop6h 47m
United Airlines
Sun 5/178:30 pm
STL
- FSD
1 stop4h 19m
United Airlines
Deal found 4/12![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1012:25 pm
FSD
- MCI
1 stop7h 58m
American Airlines
Sat 9/129:49 am
MCI
- FSD
1 stop7h 33m
American Airlines
Deal found 4/14![American Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:45 pm
FSD
- STL
1 stop4h 11m
American Airlines
Mon 5/256:00 am
STL
- FSD
1 stop5h 37m
American Airlines
Deal found 4/15![American Airlines logo]()
$310
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:05 am
FSD
- STL
1 stop6h 24m
Delta
Wed 5/66:20 am
STL
- FSD
1 stop6h 43m
Delta
Deal found 4/14![Delta logo]()
$313
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:05 am
FSD
- STL
1 stop6h 24m
Delta
Sat 5/26:20 am
STL
- FSD
1 stop6h 43m
Delta
Deal found 4/13![Delta logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/39:10 pm
FSD
- STL
2 stops17h 26m
Multiple Airlines
Thu 5/78:08 pm
STL
- FSD
1 stop19h 14m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:06 pm
FSD
- STL
1 stop23h 26m
Multiple Airlines
Thu 5/74:19 pm
STL
- FSD
2 stops25h 29m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$330
Best flights from Sioux Falls to MissouriDiscover carefully curated flight deals from Sioux Falls to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 15, 2026.
Discover carefully curated flight deals from Sioux Falls to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 15, 2026.
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:00 am
FSD
- STL
1 stop6h 47m
United Airlines
Sun 5/178:30 pm
STL
- FSD
1 stop4h 19m
United Airlines
Deal found 4/12![United Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:05 am
FSD
- MCI
1 stop3h 32m
Delta
Wed 5/139:23 am
MCI
- FSD
1 stop3h 26m
Delta
Deal found 4/10![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:35 pm
FSD
- STL
1 stop6h 24m
American Airlines
Sat 6/69:08 am
STL
- FSD
1 stop7h 10m
American Airlines
Deal found 4/11![American Airlines logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:18 pm
FSD
- MCI
1 stop18h 31m
Multiple Airlines
Wed 5/1310:35 am
MCI
- FSD
2 stops55h 13m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$391
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:51 pm
FSD
- STL
1 stop5h 06m
United Airlines
Mon 7/135:33 pm
STL
- FSD
1 stop4h 34m
United Airlines
Deal found 4/12![United Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:05 am
FSD
- STL
1 stop6h 24m
Delta
Wed 5/66:20 am
STL
- FSD
1 stop6h 43m
Delta
Deal found 4/14![Delta logo]()
$313
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:30 am
FSD
- STL
1 stop5h 17m
United Airlines
Sat 5/99:00 am
STL
- FSD
1 stop5h 38m
United Airlines
Deal found 4/10![United Airlines logo]()
$361
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:00 am
FSD
- MCI
1 stop5h 29m
United Airlines
Sun 5/317:55 pm
MCI
- FSD
1 stop4h 56m
United Airlines
Deal found 4/13![United Airlines logo]()
$376
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:35 pm
FSD
- SGF
1 stop6h 09m
American Airlines
Sat 5/303:56 pm
SGF
- FSD
1 stop6h 18m
American Airlines
Deal found 4/14![American Airlines logo]()
$487
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:52 pm
FSD
- MCI
1 stop4h 39m
United Airlines
Sat 5/99:45 am
MCI
- FSD
1 stop4h 53m
United Airlines
Deal found 4/10![United Airlines logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:35 pm
FSD
- STL
1 stop21h 06m
Multiple Airlines
Wed 5/204:50 pm
STL
- FSD
2 stops39h 46m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$513
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:00 am
FSD
- MCI
1 stop4h 33m
United Airlines
Mon 5/256:00 am
MCI
- FSD
1 stop4h 40m
United Airlines
Deal found 4/13![United Airlines logo]()
$383
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:39 am
FSD
- MCI
1 stop6h 46m
United Airlines
Sat 5/23:22 pm
MCI
- FSD
1 stop6h 30m
United Airlines
Deal found 4/13![United Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:52 pm
FSD
- STL
1 stop4h 04m
United Airlines
Sat 5/167:11 pm
STL
- FSD
1 stop4h 18m
United Airlines
Deal found 4/12![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/251:43 pm
FSD
- STL
1 stop7h 11m
United Airlines
Wed 4/296:30 am
STL
- FSD
1 stop4h 12m
United Airlines
Deal found 4/10![United Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:00 am
FSD
- SGF
1 stop4h 38m
United Airlines
Sun 8/233:10 pm
SGF
- FSD
1 stop6h 42m
United Airlines
Deal found 4/11![United Airlines logo]()
$437
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:35 pm
FSD
- STL
1 stop7h 08m
United Airlines
Tue 5/55:28 pm
STL
- FSD
1 stop4h 24m
United Airlines
Deal found 4/14![United Airlines logo]()
$498
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:37 pm
FSD
- SGF
2 stops19h 41m
United Airlines
Fri 5/295:50 am
SGF
- FSD
1 stop4h 50m
United Airlines
Deal found 4/13![United Airlines logo]()
$535
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/169:30 am
FSD
- MCI
1 stop6h 52m
United Airlines
Thu 6/181:50 pm
MCI
- FSD
1 stop6h 18m
United Airlines
Deal found 4/14![United Airlines logo]()
$535
This Delta deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:58 am
FSD
- SGF
2 stops7h 07m
Delta
Sun 8/236:00 am
SGF
- FSD
2 stops9h 28m
Delta
Deal found 4/11![Delta logo]()
$1,467
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:35 pm
FSD
- SGF
2 stops7h 41m
Delta
Fri 5/2912:07 pm
SGF
- FSD
2 stops11h 04m
Delta
Deal found 4/13![Delta logo]()
$1,467
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:00 am
FSD
- MCI
1 stop6h 52m
United Airlines
Thu 4/301:50 pm
MCI
- FSD
1 stop6h 30m
United Airlines
Deal found 4/11![United Airlines logo]()
$635
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/277:39 am
FSD
- MCI
1 stop6h 46m
United Airlines
Fri 5/16:56 pm
MCI
- FSD
1 stop4h 33m
United Airlines
Deal found 4/12![United Airlines logo]()
$635
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:00 am
FSD
- SGF
2 stops18h 56m
United Airlines
Tue 9/86:35 pm
SGF
- FSD
1 stop5h 02m
United Airlines
Deal found 4/15![United Airlines logo]()
$687
Last-minute flights from Sioux Falls to MissouriDiscover last-minute flight deals from Sioux Falls to Missouri. Data last updated April 15, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Missouri. Data last updated April 15, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:05 am
FSD
- STL
1 stop6h 24m
Delta
Sat 5/26:20 am
STL
- FSD
1 stop6h 43m
Delta
Deal found 4/13![Delta logo]()
$319
This Frontier deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:06 pm
FSD
- STL
1 stop23h 26m
Frontier
Thu 5/78:08 pm
STL
- FSD
1 stop19h 14m
Frontier
Deal found 4/14![Frontier logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:06 pm
FSD
- STL
1 stop23h 26m
Multiple Airlines
Thu 5/74:19 pm
STL
- FSD
2 stops25h 29m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/39:10 pm
FSD
- STL
2 stops17h 26m
Multiple Airlines
Thu 5/78:08 pm
STL
- FSD
1 stop19h 14m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:45 am
FSD
- STL
2 stops30h 51m
Multiple Airlines
Thu 5/78:08 pm
STL
- FSD
1 stop19h 14m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:05 am
FSD
- STL
1 stop6h 24m
Delta
Wed 5/66:20 am
STL
- FSD
1 stop6h 43m
Delta
Deal found 4/14![Delta logo]()
$313
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:05 am
FSD
- MCI
1 stop3h 32m
Delta
Wed 5/139:23 am
MCI
- FSD
1 stop3h 26m
Delta
Deal found 4/10![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:00 am
FSD
- STL
1 stop6h 47m
United Airlines
Sun 5/178:30 pm
STL
- FSD
1 stop4h 19m
United Airlines
Deal found 4/12![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:28 pm
FSD
- STL
1 stop5h 31m
American Airlines
Tue 5/195:20 am
STL
- FSD
1 stop7h 36m
American Airlines
Deal found 4/14![American Airlines logo]()
$281
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:39 pm
FSD
- STL
1 stop4h 17m
American Airlines
Wed 5/135:21 pm
STL
- FSD
1 stop5h 45m
American Airlines
Deal found 4/14![American Airlines logo]()
$291
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:45 pm
FSD
- STL
1 stop4h 11m
American Airlines
Wed 5/205:20 am
STL
- FSD
1 stop7h 36m
American Airlines
Deal found 4/13![American Airlines logo]()
$271
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:45 pm
FSD
- STL
1 stop4h 11m
American Airlines
Mon 5/256:00 am
STL
- FSD
1 stop5h 37m
American Airlines
Deal found 4/15![American Airlines logo]()
$310
One-way flights from Sioux Falls to MissouriSearch for one-way flight options from Sioux Falls to Missouri. Find affordable one-way fares based on user searches. Data last updated April 15, 2026.
Search for one-way flight options from Sioux Falls to Missouri. Find affordable one-way fares based on user searches. Data last updated April 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:35 pm
FSD
- STL
1 stop30h 25m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:55 am
FSD
- STL
2 stops8h 41m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$162
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:15 am
FSD
- STL
1 stop6h 15m
Delta
Deal found 4/14![Delta logo]()
$268
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:19 am
FSD
- MCI
1 stop3h 16m
Delta
Deal found 4/15![Delta logo]()
$268
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:05 am
FSD
- STL
1 stop7h 51m
United Airlines
Deal found 4/15![United Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/149:28 pm
FSD
- STL
3 stops45h 23m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$394
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1711:35 am
FSD
- MCI
3 stops29h 54m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:00 am
FSD
- MCI
2 stops8h 26m
United Airlines
Deal found 4/15![United Airlines logo]()
$464
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2010:02 pm
FSD
- STL
3 stops40h 14m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$602
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2012:30 pm
FSD
- STL
2 stops8h 33m
American Airlines
Deal found 4/14![American Airlines logo]()
$608
Find flight deals from Sioux Falls to Missouri
Keep the following information in mind while searching for Sioux Falls to Missouri flight deals. Data was last updated April 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $161 (Frontier) |
One-way from | $146 (Kiwi.com) |
Popular in | July |
Cheapest in | September |
Average price | $374 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2026.
Use the filters below to find and compare flights from Sioux Falls to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsSt. Louis
FSD - STL
FSDSTL
Sioux Falls Joe Foss Field
Sun 5/10
6:00 am-12:47 pm
1 stop6h 47m
Lambert-St Louis
Sun 5/17
8:30 pm-12:49 am
1 stop4h 19m
$309
Quickest round-trip
Sioux FallsKansas City
FSD - MCI
FSDMCI
Sioux Falls Joe Foss Field
Wed 5/6
8:05 am-11:37 am
1 stop3h 32m
Kansas City
Wed 5/13
9:23 am-12:49 pm
1 stop3h 26m
$309
Sioux FallsSt. Louis
FSD - STL
FSDSTL
Sioux Falls Joe Foss Field
Thu 7/9
6:51 pm-11:57 pm
1 stop5h 06m
Lambert-St Louis
Mon 7/13
5:33 pm-10:07 pm
1 stop4h 34m
$309
Sioux FallsSt. Louis
FSD - STL
FSDSTL
Sioux Falls Joe Foss Field
Tue 5/5
8:05 am-2:29 pm
1 stop6h 24m
Lambert-St Louis
Wed 5/6
6:20 am-1:03 pm
1 stop6h 43m
$313
Sioux FallsSt. Louis
FSD - STL
FSDSTL
Sioux Falls Joe Foss Field
Fri 6/5
5:35 pm-11:59 pm
1 stop6h 24m
Lambert-St Louis
Sat 6/6
9:08 am-4:18 pm
1 stop7h 10m
$353
Sioux FallsSt. Louis
FSD - STL
FSDSTL
Sioux Falls Joe Foss Field
Tue 5/5
7:30 am-12:47 pm
1 stop5h 17m
Lambert-St Louis
Sat 5/9
9:00 am-2:38 pm
1 stop5h 38m
$361
Sioux FallsKansas City
FSD - MCI
FSDMCI
Sioux Falls Joe Foss Field
Fri 5/29
5:00 am-10:29 am
1 stop5h 29m
Kansas City
Sun 5/31
7:55 pm-12:51 am
1 stop4h 56m
$376
Sioux FallsKansas City
FSD - MCI
FSDMCI
Sioux Falls Joe Foss Field
Tue 5/5
6:52 pm-11:31 pm
1 stop4h 39m
Kansas City
Sat 5/9
9:45 am-2:38 pm
1 stop4h 53m
$379
Sioux FallsKansas City
FSD - MCI
FSDMCI
Sioux Falls Joe Foss Field
Mon 5/18
6:00 am-10:33 am
1 stop4h 33m
Kansas City
Mon 5/25
6:00 am-10:40 am
1 stop4h 40m
$383
Sioux FallsKansas City
FSD - MCI
FSDMCI
Sioux Falls Joe Foss Field
Tue 4/28
7:39 am-2:25 pm
1 stop6h 46m
Kansas City
Sat 5/2
3:22 pm-9:52 pm
1 stop6h 30m
$389
Showing 1-10 of 35 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Sioux Falls with our price prediction graph.
FSD-STL
FSD-MCI
FSD-SGF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Missouri
FSD-USMO
FSD-STL
FSD-MCI
FSD-SGF
What is the cheapest month to book a flight from Sioux Falls to Missouri?
Currently, August is the cheapest month in which you can book a flight from Sioux Falls to Missouri (average of $228). Flying from Sioux Falls to Missouri in November is currently the most expensive (average of $418). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Sioux Falls to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated April 15, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Sioux Falls to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Overall
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Overall
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Overall
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Overall
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Sioux Falls to Missouri
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Complete your trip
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Sioux Falls and Missouri flights
Browse other Sioux Falls and Missouri flight options. Last updated on April 15, 2026.
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Sioux Falls to Missouri flights
Consider these flights traveling from Sioux Falls to Missouri.
Top 3 airlines flying from Sioux Falls to Missouri
Discover the top 3 airlines that operate flights from Sioux Falls to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$380 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$253 | Average$414 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$337 | FlexibilityNo cancel fee | On-time69% |