$139+ Cheap flights from Missouri to Sioux Falls (FSD)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — FSD
Oct 6 — Oct 131
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Missouri to Sioux Falls with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Sioux Falls
Cheapest
Best
Last-minute
One-way
Cheapest flights from Missouri to Sioux FallsExplore the most affordable flight options available from Missouri to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
Explore the most affordable flight options available from Missouri to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:24 pm -
1 stop6h 20m
Tue 10/135:04 pm -
1 stop6h 40m
Deal found 9/1![United Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:18 pm -
1 stop7h 11m
Sun 9/276:41 pm -
1 stop5h 46m
Deal found 9/1![American Airlines logo]()
$299
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:53 pm -
1 stop4h 19m
Mon 9/146:41 pm -
1 stop4h 18m
Deal found 9/2![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:43 am -
1 stop6h 33m
Sun 9/206:41 pm -
1 stop5h 46m
Deal found 9/1![American Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:01 am -
2 stops9h 44m
Mon 9/146:41 pm -
1 stop5h 46m
Deal found 9/2![American Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:00 am -
1 stop6h 36m
Tue 10/67:39 pm -
1 stop4h 40m
Deal found 9/5![American Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:01 am -
2 stops9h 44m
Wed 9/2312:56 pm -
2 stops11h 31m
Deal found 9/4![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:29 am -
1 stop17h 12m
Sun 10/257:39 pm -
1 stop4h 40m
Deal found 9/3![American Airlines logo]()
$342
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:34 pm -
1 stop6h 30m
Tue 11/39:32 am -
1 stop6h 39m
Deal found 9/1![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:40 pm -
1 stop6h 24m
Mon 11/21:20 pm -
1 stop7h 39m
Deal found 9/2![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:01 am -
2 stops9h 44m
Mon 9/145:59 pm -
1 stop5h 44m
Deal found 9/4![American Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:10 am -
1 stop5h 33m
Sat 9/53:06 pm -
1 stop4h 10m
Deal found 8/31![United Airlines logo]()
$380
Best flights from Missouri to Sioux FallsDiscover carefully curated flight deals from Missouri to Sioux Falls that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
Discover carefully curated flight deals from Missouri to Sioux Falls that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:25 pm -
1 stop5h 04m
Sun 11/87:18 pm -
1 stop5h 06m
Deal found 9/1![American Airlines logo]()
$299
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:24 pm -
1 stop6h 20m
Tue 10/135:04 pm -
1 stop6h 40m
Deal found 9/1![United Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:30 am -
1 stop3h 30m
Tue 10/135:10 am -
2 stops8h 15m
Deal found 9/4![Delta logo]()
$607
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:53 pm -
1 stop4h 19m
Mon 9/146:41 pm -
1 stop4h 18m
Deal found 9/2![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:00 am -
1 stop6h 36m
Tue 10/67:39 pm -
1 stop4h 40m
Deal found 9/5![American Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:01 am -
2 stops9h 44m
Wed 9/2312:56 pm -
1 stop6h 11m
Deal found 9/4![American Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:01 am -
2 stops8h 41m
Sun 9/206:41 pm -
1 stop5h 46m
Deal found 9/1![American Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:39 pm -
1 stop4h 32m
Tue 10/271:20 pm -
1 stop7h 27m
Deal found 8/31![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:34 pm -
1 stop6h 30m
Tue 11/39:32 am -
1 stop6h 39m
Deal found 9/1![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:29 am -
1 stop17h 12m
Sun 10/257:39 pm -
1 stop4h 40m
Deal found 9/3![American Airlines logo]()
$342
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/67:35 am -
1 stop6h 56m
Sat 1/910:00 am -
1 stop4h 34m
Deal found 9/2![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:40 pm -
1 stop6h 24m
Mon 11/21:20 pm -
1 stop7h 39m
Deal found 9/3![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:51 pm -
1 stop4h 38m
Wed 9/2312:56 pm -
1 stop7h 22m
Deal found 9/4![American Airlines logo]()
$413
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:14 pm -
1 stop5h 58m
Tue 9/226:00 am -
1 stop6h 37m
Deal found 9/3![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:30 pm -
1 stop5h 42m
Sun 9/207:40 am -
1 stop4h 22m
Deal found 9/1![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:24 pm -
1 stop6h 20m
Tue 10/67:50 am -
1 stop4h 30m
Deal found 9/4![United Airlines logo]()
$522
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:11 pm -
1 stop4h 33m
Mon 9/286:31 pm -
2 stops15h 35m
Deal found 9/1![United Airlines logo]()
$527
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am -
2 stops10h 00m
Sun 11/81:00 pm -
2 stops9h 19m
Deal found 9/1![Delta logo]()
$1,300
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:30 am -
1 stop5h 14m
Thu 9/246:50 pm -
1 stop4h 52m
Deal found 9/5![United Airlines logo]()
$665
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:39 pm -
1 stop4h 33m
Fri 9/186:50 pm -
1 stop21h 21m
Deal found 9/5![United Airlines logo]()
$694
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:06 am -
2 stops9h 40m
Wed 9/238:23 am -
2 stops8h 31m
Deal found 9/4![Delta logo]()
$3,074
Last-minute flights from Missouri to Sioux FallsDiscover last-minute flight deals from Missouri to Sioux Falls. Data last updated September 6, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Sioux Falls. Data last updated September 6, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:10 am -
1 stop5h 33m
Sat 9/53:06 pm -
1 stop4h 10m
Deal found 8/31![United Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:01 am -
2 stops9h 44m
Mon 9/145:59 pm -
1 stop5h 44m
Deal found 9/4![American Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:53 pm -
1 stop4h 19m
Mon 9/146:41 pm -
1 stop4h 18m
Deal found 9/2![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:01 am -
2 stops9h 44m
Mon 9/146:41 pm -
1 stop5h 46m
Deal found 9/2![American Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:43 am -
1 stop6h 33m
Sun 9/206:41 pm -
1 stop5h 46m
Deal found 9/1![American Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:01 am -
2 stops9h 44m
Wed 9/2312:56 pm -
2 stops11h 31m
Deal found 9/4![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:18 pm -
1 stop7h 11m
Sun 9/276:41 pm -
1 stop5h 46m
Deal found 9/1![American Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:00 am -
1 stop6h 36m
Tue 10/67:39 pm -
1 stop4h 40m
Deal found 9/5![American Airlines logo]()
$333
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:24 pm -
1 stop6h 20m
Tue 10/135:04 pm -
1 stop6h 40m
Deal found 9/1![United Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:29 am -
1 stop17h 12m
Sun 10/257:39 pm -
1 stop4h 40m
Deal found 9/3![American Airlines logo]()
$342
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:40 pm -
1 stop6h 24m
Mon 11/21:20 pm -
1 stop7h 39m
Deal found 9/2![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:34 pm -
1 stop6h 30m
Tue 11/39:32 am -
1 stop6h 39m
Deal found 9/1![United Airlines logo]()
$369
One-way flights from Missouri to Sioux FallsSearch for one-way flight options from Missouri to Sioux Falls. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
Search for one-way flight options from Missouri to Sioux Falls. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
This Trip.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/178:32 pm -
1 stop23h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Frontier logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/248:32 pm -
1 stop23h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Frontier logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2412:27 pm -
2 stops31h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Frontier logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:35 pm -
3 stops48h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2412:27 pm -
1 stop8h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$263
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:25 pm -
1 stop4h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![United Airlines logo]()
$264
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:18 pm -
1 stop7h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![American Airlines logo]()
$264
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2611:01 am -
2 stops9h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![American Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:28 am -
1 stop6h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![American Airlines logo]()
$323
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:30 pm -
1 stop5h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![United Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:26 pm -
3 stops40h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$324
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2410:30 pm -
3 stops37h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$372
Find flight deals from Missouri to Sioux Falls
Keep the following information in mind while searching for Missouri to Sioux Falls flight deals. Data was last updated September 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $299 (United Airlines) |
One-way from | $139 (Trip.com) |
Popular in | July |
Cheapest in | September |
Average price | $297 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
Use the filters below to find and compare flights from Missouri to Sioux Falls that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CitySioux Falls
MCI Kansas City - FSD Sioux Falls Joe Foss Field
MCIFSD
Kansas City
Thu 9/17
8:32 pm-8:07 pm
1 stop23h 35m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$139
St. LouisSioux Falls
STL Lambert-St Louis - FSD Sioux Falls Joe Foss Field
STLFSD
Lambert-St Louis
Thu 9/24
12:27 pm-8:07 pm
2 stops31h 40m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$163
Kansas CitySioux Falls
MCI Kansas City - FSD Sioux Falls Joe Foss Field
MCIFSD
Kansas City
Thu 9/24
10:30 pm-8:07 pm
2 stops21h 37m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$187
St. LouisSioux Falls
STL Lambert-St Louis - FSD Sioux Falls Joe Foss Field
STLFSD
Lambert-St Louis
Fri 10/23
6:35 pm-6:44 pm
3 stops48h 09m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$237
St. LouisSioux Falls
STL Lambert-St Louis - FSD Sioux Falls Joe Foss Field
STLFSD
Lambert-St Louis
Thu 9/24
12:27 pm-9:12 pm
1 stop8h 45m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$263
SpringfieldSioux Falls
SGF Springfield-Branson - FSD Sioux Falls Joe Foss Field
SGFFSD
Springfield-Branson
Wed 10/21
6:25 pm-11:11 pm
1 stop4h 46m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$264
St. LouisSioux Falls
STL Lambert-St Louis - FSD Sioux Falls Joe Foss Field
STLFSD
Lambert-St Louis
Fri 10/23
7:29 am-2:18 pm
1 stop6h 49m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$264
Quickest round-trip
St. LouisSioux Falls
STL Lambert-St Louis - FSD Sioux Falls Joe Foss Field
STLFSD
Lambert-St Louis
Sat 9/26
10:27 am-2:28 pm
1 stop4h 01m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$264
St. LouisSioux Falls
STL Lambert-St Louis - FSD Sioux Falls Joe Foss Field
STLFSD
Lambert-St Louis
Fri 9/25
5:18 pm-12:29 am
1 stop7h 11m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$264
St. LouisSioux Falls
STL Lambert-St Louis - FSD Sioux Falls Joe Foss Field
STLFSD
Lambert-St Louis
Sat 9/26
11:01 am-8:45 pm
2 stops9h 44m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$269
Showing 1-10 of 39 resultsSorted by cheapest first
Best time to book a flight from Missouri to Sioux Falls
Have a flexible travel schedule? Discover the best time to fly to Sioux Falls from Missouri with our price prediction graph.
MCI-FSD
STL-FSD
SGF-FSD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Sioux Falls
USMO-FSD
MCI-FSD
STL-FSD
SGF-FSD
What is the cheapest month to book a flight from Missouri to Sioux Falls?
Currently, September is the cheapest month in which you can book a flight from Missouri to Sioux Falls (average of $297). Flying from Missouri to Sioux Falls in July is currently the most expensive (average of $826). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Sioux Falls?
Airfare is typical for this route at the moment.
Missouri to Sioux Falls flights typically cost between $297 and $417 in September.The cheapest round-trip price found within the last 5 days was $299 on American Airlines (Sep 25-Sep 27).
Related info for your journey
Find useful and relevant information for your journey from Missouri to Sioux Falls. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Sioux Falls?
Book flights to Sioux Falls if you plan to visit one of these locationsMarshall
Yankton
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Sioux Falls flight routes
Top destinations
Alternative routes for Missouri to Sioux Falls
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Sioux Falls by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Sioux Falls by cabin class
Find flights from Missouri to Sioux Falls, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Sioux Falls flights
Browse other Missouri and Sioux Falls flight options. Last updated on September 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Sioux Falls
Explore flights to Sioux Falls departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 6, 2026.
Missouri to Sioux Falls flights
Consider these flights traveling from Missouri to Sioux Falls.
Top 3 airlines flying from Missouri to Sioux Falls
Discover the top 3 airlines that operate flights from Missouri to Sioux Falls. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$249 | Average$368 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$280 | Average$397 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$297 | Average$424 | FlexibilityNo cancel fee | On-time71% |