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$68+ Cheap flights from Panama City, FL (ECP) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — STL
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Panama City to Missouri

Keep the following information in mind while searching for Panama City to Missouri flight deals. Data was last updated September 17, 2025.

Round-trip from

$177
(Delta)

One-way from

$68
(United Airlines)

Popular in

February

Cheapest in

August

Average price

$380

Good round-trip deal

$446 or less

Good one-way deal

$189 or less
From Panama City NW Florida Beaches to Missouri
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One-way flight from Panama City NW Florida Beaches to Missouri
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Highest demand for flights based on searches. 20% potential increase in price ($98 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Panama City NW Florida Beaches to Missouri.
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Price to beat on a one-way flight from Panama City NW Florida Beaches to Missouri.
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Find flight deals from Panama City to Missouri

Cheapest flights from Panama City to Missouri
Explore the most affordable flight options available from Panama City to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:02 amECP - STL
1 stop5h 58mDelta
Sun 12/77:02 pmSTL - ECP
1 stop3h 56mDelta
Deal found 9/15$177
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/141:47 pmECP - STL
1 stop7h 42mAmerican Airlines
Tue 10/216:25 amSTL - ECP
1 stop5h 03mAmerican Airlines
Deal found 9/16$217
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/149:50 amECP - STL
1 stop9h 10mSouthwest
Tue 10/218:40 amSTL - ECP
Nonstop1h 45mSouthwest
Deal found 9/16$269
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/37:20 pmECP - STL
1 stop3h 35mSouthwest
Sun 10/58:05 amSTL - ECP
Nonstop1h 45mSouthwest
Deal found 9/15$287
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/296:54 pmECP - STL
1 stop4h 30mDelta
Thu 10/21:26 pmSTL - ECP
1 stop6h 04mDelta
Deal found 9/15$297
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/112:01 pmECP - STL
2 stops10h 21mAmerican Airlines
Sun 10/59:07 amSTL - ECP
1 stop4h 52mAmerican Airlines
Deal found 9/16$302
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/42:26 pmECP - SGF
1 stop7h 33mUnited Airlines
Tue 10/73:05 pmSGF - ECP
1 stop6h 43mUnited Airlines
Deal found 9/14$324
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:08 pmECP - STL
1 stop5h 00mAmerican Airlines
Sun 12/79:11 amSTL - ECP
1 stop5h 02mAmerican Airlines
Deal found 9/16$333
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/285:00 pmECP - MCI
1 stop4h 08mDelta
Sat 11/19:00 amMCI - ECP
1 stop6h 38mDelta
Deal found 9/17$341
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/283:00 pmECP - MCI
1 stop7h 28mUnited Airlines
Sat 11/18:00 amMCI - ECP
2 stops8h 24mUnited Airlines
Deal found 9/17$346
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/286:49 amECP - MCI
2 stops9h 10mAmerican Airlines
Sat 11/16:02 amMCI - ECP
2 stops8h 08mAmerican Airlines
Deal found 9/17$351
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:17 pmECP - MCI
1 stop5h 35mDelta
Sat 10/256:15 pmMCI - ECP
1 stop4h 26mDelta
Deal found 9/16$352

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Panama City to Missouri that are best for you.

Fly from

Panama City

Fly to

Missouri

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 12/5

7:02 am-1:00 pm

1 stop5h 58m

Lambert-St Louis

Sun 12/7

7:02 pm-10:58 pm

1 stop3h 56m

$177

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 10/14

1:47 pm-9:29 pm

1 stop7h 42m

Lambert-St Louis

Tue 10/21

3:03 pm-10:53 pm

2 stops7h 50m

$222

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 10/14

9:50 am-7:00 pm

1 stop9h 10m

Lambert-St Louis

Tue 10/21

8:40 am-10:25 am

Nonstop1h 45m

$269

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 9/30

6:00 am-9:59 am

1 stop3h 59m

Lambert-St Louis

Sat 10/4

5:11 pm-11:03 pm

1 stop5h 52m

$297

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 10/4

2:20 pm-8:20 pm

1 stop6h 00m

Lambert-St Louis

Sun 10/5

7:00 am-11:40 am

1 stop4h 40m

$297

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 10/3

7:20 pm-10:55 pm

1 stop3h 35m

Lambert-St Louis

Sun 10/5

7:00 am-11:40 am

1 stop4h 40m

$297

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Mon 9/29

6:54 pm-11:24 pm

1 stop4h 30m

Lambert-St Louis

Thu 10/2

1:26 pm-7:30 pm

1 stop6h 04m

$297

Panama CitySpringfield

ECP - SGF

ECPSGF

Panama City NW Florida Beaches

Sat 10/4

2:26 pm-9:59 pm

1 stop7h 33m

Springfield-Branson

Tue 10/7

3:05 pm-9:48 pm

1 stop6h 43m

$324

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 12/5

12:08 pm-5:08 pm

1 stop5h 00m

Lambert-St Louis

Sun 12/7

6:00 am-2:13 pm

2 stops8h 13m

$338

Panama CityKansas City

ECP - MCI

ECPMCI

Panama City NW Florida Beaches

Tue 10/28

5:00 pm-9:08 pm

1 stop4h 08m

Kansas City

Sat 11/1

9:00 am-3:38 pm

1 stop6h 38m

$341

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 44 results
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Best time to book a flight from Panama City to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Missouri

What is the cheapest month to book a flight from Panama City, Florida to Missouri?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Missouri (average of $311). Flying from Panama City, Florida to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to MO?

Find hourly flight availability from Panama City to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City, Florida to Missouri as you normally would.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 17, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Panama City to Missouri by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,961 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,926 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Panama City to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Missouri?

    If you book a flight to Missouri from Panama City, you will be flying from NW Florida Beaches, which is the city’s only airport. Panama City NW Florida Beaches (ECP) is located 16.0 mi from the center of Panama City.

  • How long is the flight from Panama City, Florida to Missouri?

    For as low as $177, Delta can have you in Missouri from Panama City, Florida in 5h 58m. Airlines will cover a distance of 635 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama City, Florida to Missouri?

    Most travelers choose Panama City NW Florida Beaches - Lambert-St Louis, Panama City NW Florida Beaches - Kansas City or Panama City NW Florida Beaches - Springfield-Branson when deciding on the best route from Panama City, Florida to Missouri.

  • What are the cheapest flights from Panama City, Florida to Missouri?

    The cheapest flight price from Panama City, Florida to Missouri is $78. On average you can expect to pay $385. The most popular route, (Panama City NW Florida Beaches - Lambert-St Louis), can usually be booked for $197.

  • Can I find deals for flights from Panama City to Missouri that include hotel bookings?

    Yes. In addition to deals on Panama City to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Missouri.

  • Can I find deals for business class flights from Panama City to Missouri?

    Yes. Cheapflights offers flight deals from Panama City to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Missouri (average of $311). Flying from Panama City, Florida to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Panama City to Missouri

Discover the top 4 airlines that operate flights from Panama City to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$157Average$403FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$158Average$395FlexibilityNo cancel feeOn-time71%
DeltaCheapest$176Average$393FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$401Average$401FlexibilityNo cancel feeOn-time69%

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