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$119+ Cheap flights from Panama City, FL (ECP) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/20. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — STL
feb. 25 — mar. 41
mié. 2/25
mié. 3/4
1 adult, Economy
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Cheap flight deals from Panama City to Missouri

Cheapest flights from Panama City to Missouri
Explore the most affordable flight options available from Panama City to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 26, 2026.

This American Airlines deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 2/141:02 pm
ECP
-
MCI
1 stop6h 25m
American Airlines
sáb. 2/214:08 pm
MCI
-
ECP
2 stops7h 41m
American Airlines
Deal found 1/23$204
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/266:06 pm
ECP
-
MCI
1 stop5h 34m
Delta
dom. 3/15:06 pm
MCI
-
ECP
1 stop5h 33m
Delta
Deal found 1/25$237
This Southwest deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/1412:20 pm
ECP
-
MCI
1 stop11h 35m
Southwest
lun. 5/185:20 am
MCI
-
ECP
1 stop11h 30m
Southwest
Deal found 1/25$248
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/48:20 am
ECP
-
MCI
2 stops8h 48m
American Airlines
dom. 3/89:17 am
MCI
-
ECP
1 stop5h 07m
American Airlines
Deal found 1/24$273
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/264:34 pm
ECP
-
MCI
1 stop7h 25m
American Airlines
dom. 3/15:45 am
MCI
-
ECP
2 stops10h 19m
American Airlines
Deal found 1/25$286
This Southwest deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/113:45 pm
ECP
-
STL
1 stop6h 10m
Southwest
sáb. 2/149:45 am
STL
-
ECP
1 stop6h 45m
Southwest
Deal found 1/25$321
This Southwest deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/237:35 am
ECP
-
STL
2 stops7h 45m
Southwest
lun. 3/25:25 am
STL
-
ECP
1 stop6h 35m
Southwest
Deal found 1/25$349
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 2/11:34 pm
ECP
-
STL
1 stop8h 17m
American Airlines
mié. 2/46:00 am
STL
-
ECP
1 stop7h 04m
American Airlines
Deal found 1/25$351
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/612:03 pm
ECP
-
STL
2 stops10h 41m
American Airlines
lun. 2/96:52 am
STL
-
ECP
1 stop4h 41m
American Airlines
Deal found 1/25$356
This Southwest deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/127:15 am
ECP
-
STL
1 stop5h 35m
Southwest
jue. 5/144:35 pm
STL
-
ECP
Nonstop1h 45m
Southwest
Deal found 1/25$357
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/185:00 pm
ECP
-
STL
1 stop5h 14m
United Airlines
sáb. 2/217:41 am
STL
-
ECP
1 stop5h 46m
United Airlines
Deal found 1/25$359
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/101:10 pm
ECP
-
STL
2 stops9h 48m
United Airlines
sáb. 2/144:28 pm
STL
-
ECP
1 stop5h 28m
United Airlines
Deal found 1/26$364

Find flight deals from Panama City to Missouri

Keep the following information in mind while searching for Panama City to Missouri flight deals. Data was last updated enero 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$204
(American Airlines)

One-way from

$119
(Delta)

Popular in

February

Cheapest in

October

Average price

$460

Good round-trip deal

$572 or less

Good one-way deal

$205 or less
Provider with most accurate pricing for Panama City NW Florida Beaches-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Lambert-St Louis flights.
Search Deals
From Panama City NW Florida Beaches to Missouri
Search Deals
One-way flight from Panama City NW Florida Beaches to Missouri
Search Deals
Highest demand for flights based on searches. 30% potential increase in price ($163 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($35 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Panama City NW Florida Beaches to Missouri.
Search Deals
Price to beat on a one-way flight from Panama City NW Florida Beaches to Missouri.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 26, 2026.
Use the filters below to find and compare flights from Panama City to Missouri that are best for you.

Fly from

Panama City

Fly to

Missouri

Route

Depart

Return

Price

Panama CityKansas City

ECP - MCI

ECPMCI

Panama City NW Florida Beaches

sáb. 2/14

10:31 am-7:27 pm

2 stops8h 56m

Kansas City

sáb. 2/21

1:58 pm-11:49 pm

2 stops9h 51m

$210

Panama CityKansas City

ECP - MCI

ECPMCI

Panama City NW Florida Beaches

jue. 2/26

6:06 pm-11:40 pm

1 stop5h 34m

Kansas City

dom. 3/1

5:06 pm-10:39 pm

1 stop5h 33m

$237

Panama CityKansas City

ECP - MCI

ECPMCI

Panama City NW Florida Beaches

mié. 3/4

6:00 am-12:16 pm

1 stop6h 16m

Kansas City

dom. 3/8

6:41 pm-11:04 pm

1 stop4h 23m

$237

Panama CityKansas City

ECP - MCI

ECPMCI

Panama City NW Florida Beaches

jue. 7/23

6:00 am-11:02 am

1 stop5h 02m

Kansas City

lun. 7/27

6:42 pm-10:46 pm

1 stop4h 04m

$237

Panama CityKansas City

ECP - MCI

ECPMCI

Panama City NW Florida Beaches

jue. 5/14

12:20 pm-11:55 pm

1 stop11h 35m

Kansas City

lun. 5/18

5:20 am-4:50 pm

1 stop11h 30m

$248

Panama CityKansas City

ECP - MCI

ECPMCI

Panama City NW Florida Beaches

jue. 5/14

12:20 pm-11:55 pm

1 stop11h 35m

Kansas City

dom. 5/17

5:25 am-1:25 pm

1 stop8h 00m

$290

Panama CityKansas City

ECP - MCI

ECPMCI

Panama City NW Florida Beaches

mar. 3/24

6:00 am-12:20 pm

1 stop6h 20m

Kansas City

dom. 3/29

6:41 pm-11:04 pm

1 stop4h 23m

$298

Panama CityKansas City

ECP - MCI

ECPMCI

Panama City NW Florida Beaches

mié. 7/15

7:45 am-2:33 pm

1 stop6h 48m

Kansas City

jue. 7/16

5:26 pm-10:46 pm

1 stop5h 20m

$298

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

mié. 2/11

3:45 pm-9:55 pm

1 stop6h 10m

Lambert-St Louis

sáb. 2/14

9:45 am-4:30 pm

1 stop6h 45m

$321

Panama CityKansas City

ECP - MCI

ECPMCI

Panama City NW Florida Beaches

vie. 5/29

7:05 pm-11:55 pm

1 stop4h 50m

Kansas City

vie. 6/5

2:55 pm-7:36 pm

1 stop4h 41m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/23

Showing 1-10 of 35 results
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Best time to book a flight from Panama City to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Missouri

What is the cheapest month to book a flight from Panama City, Florida to Missouri?

Currently, July is the cheapest month in which you can book a flight from Panama City, Florida to Missouri (average of $67). Flying from Panama City, Florida to Missouri in March is currently the most expensive (average of $267). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to MO?

Find hourly flight availability from Panama City to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated enero 26, 2026.

Unlike in the evening, when flights are generally more expensive, you can save up to 3% on flights from Panama City, Florida to Missouri by exploring options for tickets in the afternoon.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated enero 26, 2026.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Panama City to Missouri by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,268 reviews

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,268 reviews
Southwest
8.0
Very good
4,268 reviews

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,111 reviews
Southwest
8.0
Very good
4,268 reviews

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,199 reviews
Southwest
8.0
Very good
4,268 reviews

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,189 reviews
Southwest
8.0
Very good
4,268 reviews

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Panama City to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Missouri?

    If you book a flight to Missouri from Panama City, you will be flying from NW Florida Beaches, which is the city’s only airport. Panama City NW Florida Beaches (ECP) is located 16.0 mi from the center of Panama City.

  • How long is the flight from Panama City, Florida to Missouri?

    For as low as $237, American Airlines can have you in Missouri from Panama City, Florida in 5h 34m. Airlines will cover a distance of 797 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Panama City, Florida to Missouri one-way?

    One-way options have recently been found by users for as low as $83 on American Airlines. Other airlines that offer cheap prices include Southwest from $100 and Delta from $110 one-way.

  • What are the most popular routes from Panama City, Florida to Missouri?

    Most travelers choose Panama City NW Florida Beaches - Kansas City, Panama City NW Florida Beaches - Lambert-St Louis or Panama City NW Florida Beaches - Springfield-Branson when deciding on the best route from Panama City, Florida to Missouri.

  • What are the cheapest flights from Panama City, Florida to Missouri?

    The cheapest flight price from Panama City, Florida to Missouri is $114. On average you can expect to pay $392. The most popular route, (Panama City NW Florida Beaches - Kansas City), can usually be booked for $237.

  • Can I find deals for flights from Panama City to Missouri that include hotel bookings?

    Yes. In addition to deals on Panama City to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Missouri.

  • Can I find deals for business class flights from Panama City to Missouri?

    Yes. Cheapflights offers flight deals from Panama City to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Missouri?

    Currently, July is the cheapest month in which you can book a flight from Panama City, Florida to Missouri (average of $67). Flying from Panama City, Florida to Missouri in March is currently the most expensive (average of $267). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Panama City to Missouri

Discover the top 4 airlines that operate flights from Panama City to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$157Average$383FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$158Average$432FlexibilityNo cancel feeOn-time71%
DeltaCheapest$176Average$385FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$401Average$401FlexibilityNo cancel feeOn-time69%

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