$58+ Cheap flights from Durham, NC to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — STL
Jun 14 — Jun 211
Round-trip
1 adult, Economy
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Cheapest flights from Durham to MissouriExplore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 15, 2026.
Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 15, 2026.
This Priceline deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/137:21 pm
RDU
- STL
1 stop5h 28m
Frontier
Wed 6/175:06 pm
STL
- RDU
1 stop6h 15m
Frontier
Deal found 5/11![Frontier logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:54 pm
RDU
- STL
1 stop5h 36m
Frontier
Sun 6/286:31 pm
STL
- RDU
2 stops19h 02m
Frontier
Deal found 5/13![Frontier logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1710:03 pm
RDU
- STL
2 stops20h 27m
Multiple Airlines
Mon 6/225:06 pm
STL
- RDU
1 stop6h 15m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$206
This Priceline deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:21 pm
RDU
- STL
1 stop6h 36m
Frontier
Wed 5/275:27 pm
STL
- RDU
1 stop6h 06m
Frontier
Deal found 5/12![Frontier logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/1310:03 pm
RDU
- STL
2 stops35h 49m
Multiple Airlines
Wed 6/175:06 pm
STL
- RDU
1 stop6h 15m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/53:18 pm
RDU
- STL
2 stops18h 37m
Frontier
Sat 6/65:27 pm
STL
- RDU
1 stop5h 59m
Frontier
Deal found 5/13![Frontier logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/611:56 am
RDU
- STL
2 stops32h 27m
Frontier
Tue 6/166:31 pm
STL
- RDU
1 stop12h 32m
Frontier
Deal found 5/13![Frontier logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/107:31 pm
RDU
- STL
1 stop29h 28m
Frontier
Sat 8/154:52 pm
STL
- RDU
1 stop6h 33m
Frontier
Deal found 5/13![Frontier logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1110:36 pm
RDU
- STL
2 stops35h 16m
Frontier
Thu 6/186:31 pm
STL
- RDU
1 stop12h 32m
Frontier
Deal found 5/12![Frontier logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1110:36 pm
RDU
- MCI
2 stops19h 45m
Frontier
Sat 6/136:16 pm
MCI
- RDU
1 stop5h 06m
Frontier
Deal found 5/12![Frontier logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:48 pm
RDU
- STL
2 stops16h 07m
Frontier
Sun 6/76:33 pm
STL
- RDU
1 stop4h 51m
Frontier
Deal found 5/14![Frontier logo]()
$217
This Frontier deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/112:33 pm
RDU
- MCI
1 stop5h 56m
Frontier
Mon 6/86:24 pm
MCI
- RDU
1 stop5h 00m
Frontier
Deal found 5/11![Frontier logo]()
$218
Best flights from Durham to MissouriDiscover carefully curated flight deals from Durham to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 15, 2026.
Discover carefully curated flight deals from Durham to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 15, 2026.
This Delta deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:17 am
RDU
- SGF
1 stop4h 39m
Delta
Sat 8/293:53 pm
SGF
- RDU
1 stop4h 22m
Delta
Deal found 5/14![Delta logo]()
$281
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:20 pm
RDU
- STL
2 stops8h 30m
Southwest
Tue 7/148:35 am
STL
- RDU
2 stops9h 10m
Southwest
Deal found 5/10![Southwest logo]()
$306
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:28 pm
RDU
- COU
1 stop7h 18m
American Airlines
Sat 6/276:00 am
COU
- RDU
1 stop4h 29m
American Airlines
Deal found 5/11![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:00 am
RDU
- JLN
2 stops8h 22m
United Airlines
Wed 6/178:54 am
JLN
- RDU
1 stop7h 33m
United Airlines
Deal found 5/13![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2112:53 pm
RDU
- SGF
1 stop6h 20m
Delta
Mon 8/246:06 am
SGF
- RDU
1 stop7h 14m
Delta
Deal found 5/14![Delta logo]()
$323
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:25 am
RDU
- STL
1 stop6h 38m
United Airlines
Sat 9/127:30 am
STL
- RDU
1 stop5h 34m
United Airlines
Deal found 5/11![United Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2112:58 pm
RDU
- TBN
1 stop23h 47m
Multiple Airlines
Mon 5/2512:15 pm
TBN
- RDU
2 stops35h 18m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$712
This Southwest deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:55 pm
RDU
- STL
Nonstop2h 05m
Southwest
Mon 6/85:20 pm
STL
- RDU
1 stop4h 00m
Southwest
Deal found 5/14![Southwest logo]()
$361
This Delta deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:00 am
RDU
- MCI
Nonstop2h 42m
Delta
Wed 6/246:55 pm
MCI
- RDU
Nonstop2h 31m
Delta
Deal found 5/14![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:40 am
RDU
- SGF
2 stops8h 22m
United Airlines
Sat 8/297:30 am
SGF
- RDU
1 stop7h 32m
United Airlines
Deal found 5/14![United Airlines logo]()
$341
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:28 pm
RDU
- COU
1 stop7h 18m
American Airlines
Fri 9/255:17 pm
COU
- RDU
1 stop5h 31m
American Airlines
Deal found 5/14![American Airlines logo]()
$399
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:40 pm
RDU
- MCI
1 stop7h 00m
Southwest
Mon 6/155:15 pm
MCI
- RDU
1 stop6h 25m
Southwest
Deal found 5/11![Southwest logo]()
$369
This Delta deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:55 am
RDU
- MCI
Nonstop3h 01m
Delta
Fri 10/306:55 pm
MCI
- RDU
Nonstop2h 26m
Delta
Deal found 5/14![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:00 am
RDU
- STL
2 stops10h 46m
United Airlines
Tue 7/141:13 pm
STL
- RDU
2 stops9h 31m
United Airlines
Deal found 5/11![United Airlines logo]()
$360
This Delta deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:55 am
RDU
- MCI
Nonstop3h 01m
Delta
Mon 10/196:55 pm
MCI
- RDU
Nonstop2h 26m
Delta
Deal found 5/14![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:55 pm
RDU
- STL
Nonstop2h 05m
Southwest
Thu 6/114:30 pm
STL
- RDU
1 stop6h 25m
Southwest
Deal found 5/10![Southwest logo]()
$385
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/154:28 pm
RDU
- COU
1 stop7h 18m
American Airlines
Fri 6/266:00 am
COU
- RDU
2 stops7h 22m
American Airlines
Deal found 5/12![American Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:00 am
RDU
- STL
2 stops10h 46m
United Airlines
Wed 6/106:00 am
STL
- RDU
1 stop5h 33m
United Airlines
Deal found 5/11![United Airlines logo]()
$366
This Delta deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:45 am
RDU
- MCI
1 stop4h 42m
Delta
Mon 10/126:55 pm
MCI
- RDU
Nonstop2h 26m
Delta
Deal found 5/13![Delta logo]()
$349
This Southwest deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1611:15 am
RDU
- STL
2 stops7h 10m
Southwest
Wed 6/173:15 pm
STL
- RDU
2 stops6h 35m
Southwest
Deal found 5/14![Southwest logo]()
$387
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:23 am
RDU
- MCI
Nonstop2h 52m
Delta
Tue 7/76:55 pm
MCI
- RDU
Nonstop2h 41m
Delta
Deal found 5/11![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:30 pm
RDU
- JLN
1 stop6h 49m
United Airlines
Sat 11/148:52 am
JLN
- RDU
1 stop7h 17m
United Airlines
Deal found 5/12![United Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:10 am
RDU
- MCI
2 stops8h 25m
Southwest
Tue 6/235:20 pm
MCI
- RDU
1 stop3h 40m
Southwest
Deal found 5/12![Southwest logo]()
$388
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:45 am
RDU
- JLN
1 stop6h 33m
United Airlines
Wed 9/307:40 am
JLN
- RDU
1 stop5h 24m
United Airlines
Deal found 5/13![United Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:10 am
RDU
- STL
1 stop5h 40m
Southwest
Sun 6/74:30 pm
STL
- RDU
2 stops6h 10m
Southwest
Deal found 5/11![Southwest logo]()
$399
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:15 pm
RDU
- SGF
1 stop6h 19m
American Airlines
Sun 8/26:53 am
SGF
- RDU
1 stop4h 10m
American Airlines
Deal found 5/15![American Airlines logo]()
$557
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:23 am
RDU
- MCI
Nonstop2h 52m
Delta
Mon 6/86:55 pm
MCI
- RDU
Nonstop2h 31m
Delta
Deal found 5/11![Delta logo]()
$384
This Southwest deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:35 am
RDU
- STL
Nonstop2h 05m
Southwest
Mon 6/159:55 am
STL
- RDU
Nonstop1h 50m
Southwest
Deal found 5/13![Southwest logo]()
$403
This KAYAK deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3112:56 pm
RDU
- COU
2 stops9h 33m
American Airlines
Thu 6/46:00 am
COU
- RDU
2 stops8h 37m
American Airlines
Deal found 5/10![American Airlines logo]()
$609
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:25 am
RDU
- SGF
1 stop5h 23m
United Airlines
Wed 9/303:05 pm
SGF
- RDU
1 stop5h 53m
United Airlines
Deal found 5/14![United Airlines logo]()
$460
Last-minute flights from Durham to MissouriDiscover last-minute flight deals from Durham to Missouri. Data last updated May 15, 2026 and is based on user searches.
Discover last-minute flight deals from Durham to Missouri. Data last updated May 15, 2026 and is based on user searches.
This Priceline deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:21 pm
RDU
- STL
1 stop6h 36m
Frontier
Wed 5/275:27 pm
STL
- RDU
1 stop6h 06m
Frontier
Deal found 5/12![Frontier logo]()
$210
This Frontier deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/112:33 pm
RDU
- MCI
1 stop5h 56m
Frontier
Mon 6/86:24 pm
MCI
- RDU
1 stop5h 00m
Frontier
Deal found 5/11![Frontier logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:48 pm
RDU
- STL
2 stops16h 07m
Frontier
Sun 6/76:33 pm
STL
- RDU
1 stop4h 51m
Frontier
Deal found 5/14![Frontier logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/53:18 pm
RDU
- STL
2 stops18h 37m
Frontier
Mon 6/85:27 pm
STL
- RDU
1 stop17h 32m
Frontier
Deal found 5/14![Frontier logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/611:56 am
RDU
- STL
2 stops32h 27m
Frontier
Tue 6/166:31 pm
STL
- RDU
1 stop12h 32m
Frontier
Deal found 5/13![Frontier logo]()
$213
This Frontier deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/912:26 pm
RDU
- STL
1 stop7h 57m
Frontier
Wed 6/105:06 pm
STL
- RDU
1 stop6h 15m
Frontier
Deal found 5/12![Frontier logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1110:36 pm
RDU
- STL
2 stops35h 16m
Frontier
Thu 6/186:31 pm
STL
- RDU
1 stop12h 32m
Frontier
Deal found 5/12![Frontier logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1110:36 pm
RDU
- MCI
2 stops19h 45m
Frontier
Sat 6/136:16 pm
MCI
- RDU
1 stop5h 06m
Frontier
Deal found 5/12![Frontier logo]()
$217
This Priceline deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/137:21 pm
RDU
- STL
1 stop5h 28m
Frontier
Wed 6/175:06 pm
STL
- RDU
1 stop6h 15m
Frontier
Deal found 5/11![Frontier logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/1310:03 pm
RDU
- STL
2 stops35h 49m
Multiple Airlines
Wed 6/175:06 pm
STL
- RDU
1 stop6h 15m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1710:03 pm
RDU
- STL
2 stops20h 27m
Multiple Airlines
Mon 6/225:06 pm
STL
- RDU
1 stop6h 15m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:54 pm
RDU
- STL
1 stop5h 36m
Frontier
Sun 6/286:31 pm
STL
- RDU
2 stops19h 02m
Frontier
Deal found 5/13![Frontier logo]()
$205
One-way flights from Durham to MissouriSearch for one-way flight options from Durham to Missouri. Find affordable one-way fares based on user searches. Data last updated May 15, 2026.
Search for one-way flight options from Durham to Missouri. Find affordable one-way fares based on user searches. Data last updated May 15, 2026.
This Trip.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/512:14 pm
RDU
- MCI
1 stop6h 07m
Frontier
Deal found 5/10![Frontier logo]()
$58
This Trip.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:10 pm
RDU
- MCI
1 stop6h 11m
Frontier
Deal found 5/12![Frontier logo]()
$59
This Trip.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1712:14 pm
RDU
- MCI
1 stop6h 07m
Frontier
Deal found 5/10![Frontier logo]()
$60
This WAYA deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WAYA is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/412:54 pm
RDU
- STL
1 stop5h 39m
Frontier
Deal found 5/14![Frontier logo]()
$63
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:15 am
RDU
- STL
1 stop27h 42m
Frontier
Deal found 5/12![Frontier logo]()
$64
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:15 am
RDU
- STL
1 stop27h 40m
Frontier
Deal found 5/13![Frontier logo]()
$65
This WAYA deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WAYA is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/512:33 pm
RDU
- MCI
1 stop5h 56m
Frontier
Deal found 5/10![Frontier logo]()
$69
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:15 am
RDU
- MCI
1 stop12h 06m
Frontier
Deal found 5/13![Frontier logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/912:59 pm
RDU
- STL
1 stop5h 38m
Frontier
Deal found 5/12![Frontier logo]()
$94
This Priceline deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/812:14 pm
RDU
- MCI
1 stop6h 07m
Frontier
Deal found 5/13![Frontier logo]()
$95
This Priceline deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:30 pm
RDU
- STL
1 stop7h 29m
Frontier
Deal found 5/12![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:48 pm
RDU
- MCI
2 stops23h 33m
Frontier
Deal found 5/13![Frontier logo]()
$101
Find flight deals from Durham to Missouri
Keep the following information in mind while searching for Durham to Missouri flight deals. Data was last updated May 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $204 (Priceline) |
One-way from | $58 (Trip.com) |
Popular in | September |
Cheapest in | October |
Average price | $373 |
Cheapflights Fare Finder
Customize your flight search to find flights from Durham to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 15, 2026.
Use the filters below to find and compare flights from Durham to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RaleighSpringfield
RDU - SGF
RDUSGF
Raleigh-Durham
Sat 8/22
7:17 am-10:56 am
1 stop4h 39m
Springfield-Branson
Sat 8/29
3:53 pm-9:15 pm
1 stop4h 22m
$281
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Thu 7/9
1:20 pm-8:50 pm
2 stops8h 30m
Lambert-St Louis
Tue 7/14
8:35 am-6:45 pm
2 stops9h 10m
$306
RaleighColumbia
RDU - COU
RDUCOU
Raleigh-Durham
Sat 6/20
4:28 pm-10:46 pm
1 stop7h 18m
Columbia Regional
Sat 6/27
6:00 am-11:29 am
1 stop4h 29m
$308
RaleighSpringfield
RDU - SGF
RDUSGF
Raleigh-Durham
Fri 8/21
12:53 pm-6:13 pm
1 stop6h 20m
Springfield-Branson
Mon 8/24
6:06 am-2:20 pm
1 stop7h 14m
$323
RaleighJoplin
RDU - JLN
RDUJLN
Raleigh-Durham
Thu 6/11
6:00 am-1:22 pm
2 stops8h 22m
Joplin
Wed 6/17
8:54 am-5:27 pm
1 stop7h 33m
$329
RaleighSt. Louis
RDU - STL
RDUSTL
Raleigh-Durham
Sat 9/5
6:25 am-12:03 pm
1 stop6h 38m
Lambert-St Louis
Sat 9/12
7:30 am-2:04 pm
1 stop5h 34m
$335
RaleighKansas City
RDU - MCI
RDUMCI
Raleigh-Durham
Wed 6/10
8:00 am-9:42 am
Nonstop2h 42m
Kansas City
Wed 6/24
6:55 pm-10:26 pm
Nonstop2h 31m
$337
RaleighKansas City
RDU - MCI
RDUMCI
Raleigh-Durham
Thu 10/29
7:55 am-9:56 am
Nonstop3h 01m
Kansas City
Fri 10/30
6:55 pm-10:21 pm
Nonstop2h 26m
$339
RaleighKansas City
RDU - MCI
RDUMCI
Raleigh-Durham
Thu 10/15
7:55 am-9:56 am
Nonstop3h 01m
Kansas City
Mon 10/19
6:55 pm-10:21 pm
Nonstop2h 26m
$339
RaleighSpringfield
RDU - SGF
RDUSGF
Raleigh-Durham
Sat 8/22
10:40 am-6:02 pm
2 stops8h 22m
Springfield-Branson
Sat 8/29
7:30 am-4:02 pm
1 stop7h 32m
$341
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Durham to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Durham with our price prediction graph.
RDU-SGF
RDU-STL
RDU-COU
RDU-JLN
RDU-TBN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Durham to Missouri
DU8-USMO
RDU-SGF
RDU-STL
RDU-COU
RDU-JLN
What is the cheapest time of day to fly from DU8 to MO?
Find hourly flight availability from Durham to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 15, 2026.
One of the essential ways to save on airfare from Durham to Missouri is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 33% on airfare.
How much does it cost to fly round-trip from Durham to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated May 15, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Durham to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Overall
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Durham to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Durham to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Durham to Missouri by cabin class
Find flights from Durham to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Durham and Missouri flights
Browse other Durham and Missouri flight options. Last updated on May 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Durham after your stay in Missouri
Durham to Missouri flights
Consider these flights traveling from Durham to Missouri.
Top 5 airlines flying from Durham to Missouri
Discover the top 5 airlines that operate flights from Durham to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$123 | Average$240 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$177 | Average$332 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$180 | Average$327 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$196 | Average$379 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$382 | FlexibilityNo cancel fee | On-time63% |