$56+ Cheap flights from Durham, NC to Missouri
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — STL
Oct 6 — Oct 131
Round-trip
1 adult, Economy
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Find cheap flights from Durham to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Durham to MissouriExplore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:30 am -
1 stop12h 10m
Wed 10/216:35 pm -
1 stop4h 53m
Deal found 9/2![Frontier logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:35 am -
1 stop7h 35m
Wed 10/146:35 pm -
1 stop4h 53m
Deal found 9/2![Frontier logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:35 am -
1 stop7h 35m
Mon 10/126:35 pm -
1 stop4h 53m
Deal found 9/5![Frontier logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/191:16 pm -
1 stop5h 24m
Wed 10/216:35 pm -
1 stop4h 53m
Deal found 9/2![Frontier logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/134:20 pm -
1 stop26h 20m
Fri 10/166:35 pm -
1 stop4h 53m
Deal found 9/4![Frontier logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:35 am -
1 stop7h 35m
Wed 10/72:29 pm -
1 stop9h 00m
Deal found 9/2![Frontier logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:30 am -
1 stop12h 10m
Fri 10/236:35 pm -
1 stop4h 53m
Deal found 9/2![Frontier logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/161:16 pm -
1 stop5h 24m
Wed 10/216:35 pm -
1 stop27h 13m
Deal found 9/2![Frontier logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:56 pm -
1 stop24h 14m
Wed 10/72:29 pm -
1 stop20h 59m
Deal found 9/2![Frontier logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/191:16 pm -
1 stop5h 24m
Fri 10/236:35 pm -
1 stop4h 53m
Deal found 9/2![Frontier logo]()
$130
This Frontier deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:35 am -
1 stop7h 35m
Mon 10/52:29 pm -
1 stop9h 00m
Deal found 9/2![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:05 am -
1 stop11h 27m
Fri 9/255:31 pm -
1 stop23h 19m
Deal found 9/3![Multiple Airlines logo]()
$232
Best flights from Durham to MissouriDiscover carefully curated flight deals from Durham to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
Discover carefully curated flight deals from Durham to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:50 pm -
1 stop6h 25m
Sat 10/101:50 pm -
1 stop6h 00m
Deal found 9/5![Southwest logo]()
$255
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:15 am -
1 stop4h 54m
Fri 10/167:28 pm -
1 stop4h 00m
Deal found 9/3![Delta logo]()
$290
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
2 stops9h 18m
Mon 11/93:00 pm -
1 stop5h 39m
Deal found 9/2![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:17 am -
2 stops7h 41m
Fri 11/276:28 pm -
1 stop4h 39m
Deal found 9/6![American Airlines logo]()
$493
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:20 am -
Nonstop2h 10m
Wed 10/145:50 am -
1 stop4h 05m
Deal found 9/2![Southwest logo]()
$276
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:14 am -
1 stop6h 33m
Tue 11/36:00 am -
1 stop5h 37m
Deal found 9/3![Delta logo]()
$305
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop2h 10m
Mon 10/192:00 pm -
1 stop6h 45m
Deal found 9/1![Southwest logo]()
$285
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:15 am -
2 stops8h 14m
Mon 11/29:40 am -
1 stop5h 17m
Deal found 9/3![United Airlines logo]()
$340
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:55 pm -
Nonstop2h 05m
Mon 9/282:25 pm -
1 stop5h 30m
Deal found 9/1![Southwest logo]()
$295
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/209:05 am -
Nonstop2h 45m
Fri 10/237:45 pm -
Nonstop2h 33m
Deal found 9/2![Delta logo]()
$342
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/198:52 am -
2 stops10h 10m
Wed 9/236:00 am -
1 stop5h 33m
Deal found 9/4![United Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:50 pm -
Nonstop2h 10m
Wed 10/2110:20 am -
Nonstop1h 50m
Deal found 9/2![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/139:03 am -
Nonstop3h 02m
Mon 11/167:53 pm -
Nonstop2h 33m
Deal found 9/3![Delta logo]()
$342
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
2 stops9h 30m
Mon 10/262:55 pm -
1 stop6h 04m
Deal found 9/1![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
Nonstop2h 10m
Tue 10/2010:20 am -
Nonstop1h 50m
Deal found 9/2![Southwest logo]()
$306
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:20 am -
1 stop5h 55m
Sun 10/47:45 pm -
Nonstop2h 34m
Deal found 9/1![Delta logo]()
$354
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/309:55 am -
1 stop5h 39m
Wed 2/33:10 pm -
1 stop6h 02m
Deal found 9/3![United Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:05 am -
Nonstop2h 15m
Mon 11/234:30 pm -
1 stop6h 00m
Deal found 9/1![Southwest logo]()
$316
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:05 am -
Nonstop2h 45m
Sun 10/257:45 pm -
Nonstop2h 33m
Deal found 9/3![Delta logo]()
$370
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:05 am -
1 stop5h 34m
Tue 9/293:19 pm -
1 stop5h 27m
Deal found 9/1![United Airlines logo]()
$388
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:55 pm -
Nonstop2h 10m
Sat 10/173:40 pm -
1 stop5h 10m
Deal found 9/4![Southwest logo]()
$331
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:15 pm -
1 stop6h 41m
Sun 11/87:45 pm -
Nonstop2h 33m
Deal found 9/1![Delta logo]()
$382
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:24 am -
2 stops11h 31m
Tue 11/32:55 pm -
1 stop6h 04m
Deal found 9/4![United Airlines logo]()
$390
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:50 pm -
Nonstop2h 10m
Mon 10/264:05 pm -
1 stop6h 35m
Deal found 9/6![Southwest logo]()
$331
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:00 am -
1 stop5h 09m
Wed 9/307:32 am -
1 stop7h 31m
Deal found 9/3![United Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/259:03 am -
Nonstop3h 02m
Fri 11/2712:10 pm -
1 stop5h 46m
Deal found 9/3![Delta logo]()
$401
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1611:30 am -
2 stops8h 55m
Wed 11/1810:55 am -
2 stops6h 35m
Deal found 9/2![Southwest logo]()
$342
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:05 am -
1 stop5h 34m
Sat 10/103:19 pm -
2 stops7h 40m
Deal found 9/5![United Airlines logo]()
$414
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:35 am -
1 stop4h 25m
Fri 10/304:10 pm -
1 stop4h 35m
Deal found 9/4![Southwest logo]()
$400
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:05 am -
1 stop7h 33m
Fri 10/911:15 am -
1 stop6h 33m
Deal found 9/3![United Airlines logo]()
$473
Last-minute flights from Durham to MissouriDiscover last-minute flight deals from Durham to Missouri. Data last updated September 6, 2026 and is based on user searches.
Discover last-minute flight deals from Durham to Missouri. Data last updated September 6, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:05 am -
1 stop11h 27m
Fri 9/255:31 pm -
1 stop23h 19m
Deal found 9/3![Multiple Airlines logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:56 pm -
1 stop24h 14m
Wed 10/72:29 pm -
1 stop20h 59m
Deal found 9/2![Frontier logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Fri 10/26:35 am -
1 stop7h 35m
Wed 10/72:29 pm -
1 stop9h 00m
Deal found 9/2![Frontier logo]()
$122
This Frontier deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:35 am -
1 stop7h 35m
Mon 10/52:29 pm -
1 stop9h 00m
Deal found 9/2![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:35 am -
1 stop7h 35m
Wed 10/146:35 pm -
1 stop4h 53m
Deal found 9/2![Frontier logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:35 am -
1 stop7h 35m
Mon 10/126:35 pm -
1 stop4h 53m
Deal found 9/5![Frontier logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/134:20 pm -
1 stop26h 20m
Fri 10/166:35 pm -
1 stop4h 53m
Deal found 9/4![Frontier logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:30 am -
1 stop12h 10m
Wed 10/216:35 pm -
1 stop4h 53m
Deal found 9/2![Frontier logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:30 am -
1 stop12h 10m
Fri 10/236:35 pm -
1 stop4h 53m
Deal found 9/2![Frontier logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/161:16 pm -
1 stop5h 24m
Wed 10/216:35 pm -
1 stop27h 13m
Deal found 9/2![Frontier logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/191:16 pm -
1 stop5h 24m
Wed 10/216:35 pm -
1 stop4h 53m
Deal found 9/2![Frontier logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/191:16 pm -
1 stop5h 24m
Fri 10/236:35 pm -
1 stop4h 53m
Deal found 9/2![Frontier logo]()
$130
One-way flights from Durham to MissouriSearch for one-way flight options from Durham to Missouri. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
Search for one-way flight options from Durham to Missouri. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:35 am -
1 stop7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Frontier logo]()
$56
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:30 am -
1 stop12h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![Frontier logo]()
$57
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:56 pm -
1 stop24h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Frontier logo]()
$58
This Trip.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:30 am -
1 stop12h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Frontier logo]()
$60
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:56 pm -
1 stop24h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Frontier logo]()
$62
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:35 am -
1 stop7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Frontier logo]()
$64
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:35 am -
1 stop7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Frontier logo]()
$65
This Frontier deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:58 pm -
1 stop5h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Frontier logo]()
$66
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:00 am -
1 stop26h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Frontier logo]()
$67
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/41:56 pm -
1 stop24h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![Frontier logo]()
$68
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:35 am -
1 stop7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Frontier logo]()
$69
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:35 am -
1 stop23h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$113
Find flight deals from Durham to Missouri
Keep the following information in mind while searching for Durham to Missouri flight deals. Data was last updated September 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $110 (Kiwi.com) |
One-way from | $56 (Kiwi.com) |
Popular in | September |
Cheapest in | January |
Average price | $490 |
Cheapflights Fare Finder
Customize your flight search to find flights from Durham to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
Use the filters below to find and compare flights from Durham to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RaleighSt. Louis
RDU Raleigh-Durham - STL Lambert-St Louis
RDUSTL
Raleigh-Durham
Sun 9/27
9:35 pm-1:10 pm
2 stops16h 35m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$99
RaleighSt. Louis
RDU Raleigh-Durham - STL Lambert-St Louis
RDUSTL
Raleigh-Durham
Thu 11/5
8:15 pm-12:05 am
1 stop4h 50m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$128
RaleighSt. Louis
RDU Raleigh-Durham - STL Lambert-St Louis
RDUSTL
Raleigh-Durham
Wed 12/2
4:50 pm-9:38 pm
1 stop5h 48m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$128
RaleighSt. Louis
RDU Raleigh-Durham - STL Lambert-St Louis
RDUSTL
Raleigh-Durham
Tue 3/2
2:30 pm-6:01 pm
1 stop4h 31m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$128
RaleighSt. Louis
RDU Raleigh-Durham - STL Lambert-St Louis
RDUSTL
Raleigh-Durham
Wed 12/2
6:00 am-12:10 pm
2 stops7h 10m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$133
RaleighSt. Louis
RDU Raleigh-Durham - STL Lambert-St Louis
RDUSTL
Raleigh-Durham
Tue 9/29
5:15 am-9:00 am
1 stop4h 45m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$138
RaleighSt. Louis
RDU Raleigh-Durham - STL Lambert-St Louis
RDUSTL
Raleigh-Durham
Sat 10/3
5:15 am-9:34 am
1 stop5h 19m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$148
Quickest round-trip
RaleighSt. Louis
RDU Raleigh-Durham - STL Lambert-St Louis
RDUSTL
Raleigh-Durham
Mon 11/2
6:35 am-7:45 am
Nonstop2h 10m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$149
RaleighSt. Louis
RDU Raleigh-Durham - STL Lambert-St Louis
RDUSTL
Raleigh-Durham
Fri 10/23
7:50 pm-9:00 pm
Nonstop2h 10m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$158
RaleighKansas City
RDU Raleigh-Durham - MCI Kansas City
RDUMCI
Raleigh-Durham
Tue 11/3
9:05 am-10:50 am
Nonstop2h 45m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$161
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Durham to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Durham with our price prediction graph.
RDU-STL
RDU-COU
RDU-SGF
RDU-MCI
RDU-JLN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Durham to Missouri
DU8-USMO
RDU-STL
RDU-COU
RDU-SGF
RDU-MCI
What is the cheapest time of day to fly from DU8 to MO?
Find hourly flight availability from Durham to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 6, 2026.
One of the essential ways to save on airfare from Durham to Missouri is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 31% on airfare.
How much does it cost to fly round-trip from Durham to Missouri?
Airfare is below average for this route at the moment.
Durham to Missouri flights typically cost between $347 and $550 in October.The cheapest round-trip price found within the last 5 days was $110 on Frontier (Oct 14-Oct 21).
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 6, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Durham to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Related info for your journey
Find useful and relevant information for your journey from Durham to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Durham to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Durham to Missouri by cabin class
Find flights from Durham to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Durham and Missouri flights
Browse other Durham and Missouri flight options. Last updated on September 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to Durham after your stay in Missouri
Durham to Missouri flights
Consider these flights traveling from Durham to Missouri.
Top 5 airlines flying from Durham to Missouri
Discover the top 5 airlines that operate flights from Durham to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$123 | Average$240 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$180 | Average$386 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$199 | Average$371 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$204 | Average$414 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$432 | FlexibilityNo cancel fee | On-time63% |