$64+ Cheap flights from Chicago (CHI) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — STL
Jan 9 — Jan 161
1 adult, Economy
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Chicago to Missouri
Cheapest flights from Chicago to MissouriExplore the most affordable flight options available from Chicago to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 10, 2025.
Explore the most affordable flight options available from Chicago to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 10, 2025.
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:57 pmORD - STL
Nonstop1h 26mAmerican Airlines
Tue 1/136:00 amSTL - ORD
Nonstop1h 27mAmerican Airlines
Deal found 12/10![American Airlines logo]()
$170
This Frontier deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:23 amORD - STL
1 stop11h 10mFrontier
Thu 1/110:42 amSTL - ORD
1 stop11h 42mFrontier
Deal found 12/9![Frontier logo]()
$188
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:40 pmORD - COU
Nonstop1h 39mUnited Airlines
Tue 12/306:34 pmCOU - ORD
Nonstop1h 36mUnited Airlines
Deal found 12/9![United Airlines logo]()
$194
This United Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:40 pmORD - COU
Nonstop1h 39mUnited Airlines
Sat 12/278:05 amCOU - ORD
Nonstop1h 46mUnited Airlines
Deal found 12/8![United Airlines logo]()
$209
This Delta deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:35 amORD - STL
1 stop4h 37mDelta
Tue 1/133:40 pmSTL - ORD
1 stop6h 03mDelta
Deal found 12/9![Delta logo]()
$213
This Southwest deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:25 amMDW - STL
Nonstop1h 15mSouthwest
Thu 12/254:25 pmSTL - MDW
Nonstop1h 10mSouthwest
Deal found 12/9![Southwest logo]()
$215
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:10 pmORD - STL
Nonstop1h 33mUnited Airlines
Thu 12/256:35 pmSTL - ORD
Nonstop1h 44mUnited Airlines
Deal found 12/9![United Airlines logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2111:50 amORD - CGI
Nonstop1h 35mContour
Thu 1/19:30 amCGI - ORD
Nonstop1h 40mContour
Deal found 12/9![Contour logo]()
$218
This American Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:07 amORD - STL
Nonstop1h 28mAmerican Airlines
Thu 12/256:00 amSTL - ORD
Nonstop1h 30mAmerican Airlines
Deal found 12/8![American Airlines logo]()
$221
This American Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:31 pmORD - SGF
Nonstop1h 57mAmerican Airlines
Thu 1/110:27 amSGF - ORD
Nonstop1h 42mAmerican Airlines
Deal found 12/8![American Airlines logo]()
$223
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:27 pmORD - COU
Nonstop1h 36mAmerican Airlines
Sun 1/1811:56 amCOU - ORD
Nonstop1h 33mAmerican Airlines
Deal found 12/10![American Airlines logo]()
$224
This Mytrip deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1111:50 amORD - CGI
Nonstop1h 35mContour
Sun 12/149:30 amCGI - ORD
Nonstop1h 40mContour
Deal found 12/8![Contour logo]()
$225
Find flight deals from Chicago to Missouri
Keep the following information in mind while searching for Chicago to Missouri flight deals. Data was last updated December 10, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $108 (Contour) |
One-way from | $64 (Booking.com) |
Popular in | October |
Cheapest in | November |
Average price | $257 |
Good round-trip deal | $168 or less |
Good one-way deal | $64 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Chicago to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 10, 2025.
Use the filters below to find and compare flights from Chicago to Missouri that are best for you.
Fly from
Chicago
Fly to
Missouri
Route
Depart
Return
Price
ChicagoCape Girardeau
ORD - CGI
ORDCGI
Chicago O'Hare Intl
Wed 2/18
11:50 am-1:25 pm
Nonstop1h 35m
Cape Girardeau
Thu 2/19
9:30 am-11:10 am
Nonstop1h 40m
$108
ChicagoCape Girardeau
ORD - CGI
ORDCGI
Chicago O'Hare Intl
Fri 2/13
11:50 am-1:25 pm
Nonstop1h 35m
Cape Girardeau
Sun 2/15
9:30 am-11:10 am
Nonstop1h 40m
$122
ChicagoCape Girardeau
ORD - CGI
ORDCGI
Chicago O'Hare Intl
Thu 1/1
11:50 am-1:25 pm
Nonstop1h 35m
Cape Girardeau
Sun 1/4
9:30 am-11:10 am
Nonstop1h 40m
$139
ChicagoSt. Louis
MDW - STL
MDWSTL
Chicago Midway
Tue 2/3
6:10 am-7:35 am
Nonstop1h 25m
Lambert-St Louis
Sat 2/28
6:10 am-7:20 am
Nonstop1h 10m
$144
ChicagoSt. Louis
MDW - STL
MDWSTL
Chicago Midway
Tue 1/20
9:50 am-2:38 pm
1 stop4h 48m
Lambert-St Louis
Tue 1/27
7:10 am-11:59 am
1 stop4h 49m
$157
ChicagoSt. Louis
MDW - STL
MDWSTL
Chicago Midway
Tue 2/3
6:14 pm-11:37 pm
1 stop5h 23m
Lambert-St Louis
Tue 3/3
6:35 am-12:46 pm
1 stop6h 11m
$157
ChicagoSt. Louis
MDW - STL
MDWSTL
Chicago Midway
Tue 1/6
7:16 pm-11:25 pm
1 stop4h 09m
Lambert-St Louis
Tue 1/13
6:00 am-10:27 am
1 stop4h 27m
$157
ChicagoSt. Louis
ORD - STL
ORDSTL
Chicago O'Hare Intl
Tue 1/6
6:45 pm-11:25 pm
1 stop4h 40m
Lambert-St Louis
Tue 1/13
6:35 am-1:08 pm
1 stop6h 33m
$157
ChicagoSt. Louis
ORD - STL
ORDSTL
Chicago O'Hare Intl
Wed 1/28
5:30 am-11:54 am
1 stop6h 24m
Lambert-St Louis
Wed 1/28
5:25 pm-9:43 pm
1 stop4h 18m
$157
ChicagoSt. Louis
MDW - STL
MDWSTL
Chicago Midway
Thu 1/8
6:10 am-2:48 pm
1 stop8h 38m
Lambert-St Louis
Mon 1/12
8:50 am-11:09 pm
1 stop14h 19m
$162
Showing 1-10 of 60 results
Best time to book a flight from Chicago to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Chicago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago to Missouri
What is the cheapest month to book a flight from Chicago to Missouri?
Currently, August is the cheapest month in which you can book a flight from Chicago to Missouri (average of $77). Flying from Chicago to Missouri in February is currently the most expensive (average of $160). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from CHI to MO?
Find hourly flight availability from Chicago to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 10, 2025.
It’s optimal to fly from Chicago to Missouri in the evening. By choosing this option you can save up to 11% on the cost of your flight, compared to a flight in the afternoon.
What is the cheapest day to fly from Chicago to Missouri?
Use this chart to determine the cheapest time to fly round-trip from Chicago to Missouri. Price data was last updated on December 16, 2024.
Travelers seeking maximum savings on their Chicago to Missouri flight should consider departing on Friday afternoons when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
Weekly flight availability from Chicago to Missouri
Explore weekly flight availability from Chicago to Missouri. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 10, 2025.
The most flights from CHI to USMO are scheduled on a Monday (68 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (48 on average).
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated December 10, 2025.
Get a feel of what it's like to fly with Southwest, Contour, and United Airlines from Chicago to Missouri by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
7.9
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
7.9
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
7.9
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
7.9
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
7.9
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
7.9
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Chicago to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Chicago to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Top 5 airlines flying from Chicago to Missouri
Discover the top 5 airlines that operate flights from Chicago to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 10, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$77 | Average$347 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$114 | Average$183 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$115 | Average$326 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$144 | Average$327 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$145 | Average$213 | FlexibilityNo cancel fee | On-timeN/A |