$377+ Cheap flights from La Crosse (LSE) to Mesa, AZ
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — PHX
Oct 13 — Oct 201
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from La Crosse to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from La Crosse to MesaExplore the most affordable flight options available from La Crosse to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
Explore the most affordable flight options available from La Crosse to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:50 pm -
1 stop7h 54m
Sat 10/248:48 am -
1 stop7h 32m
Deal found 9/9![American Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:50 pm -
1 stop7h 54m
Tue 10/271:18 pm -
2 stops8h 41m
Deal found 9/8![American Airlines logo]()
$386
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2712:23 pm -
2 stops10h 28m
Sat 10/3112:15 pm -
2 stops9h 44m
Deal found 9/9![American Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:24 pm -
1 stop6h 50m
Tue 11/178:51 am -
1 stop8h 25m
Deal found 9/11![American Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:23 pm -
1 stop6h 52m
Sat 10/2410:22 am -
1 stop5h 58m
Deal found 9/7![American Airlines logo]()
$413
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:53 pm -
1 stop7h 52m
Sun 12/209:59 am -
1 stop7h 30m
Deal found 9/9![American Airlines logo]()
$425
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:52 pm -
1 stop6h 40m
Mon 11/94:13 pm -
1 stop7h 05m
Deal found 9/9![American Airlines logo]()
$430
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:50 pm -
1 stop7h 54m
Sat 10/177:16 am -
1 stop9h 04m
Deal found 9/9![American Airlines logo]()
$431
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1212:26 pm -
1 stop6h 41m
Mon 9/1412:24 am -
1 stop8h 58m
Deal found 9/11![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:52 pm -
1 stop6h 40m
Thu 11/125:00 am -
1 stop5h 53m
Deal found 9/11![American Airlines logo]()
$450
Best flights from La Crosse to MesaDiscover carefully curated flight deals from La Crosse to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
Discover carefully curated flight deals from La Crosse to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:50 pm -
1 stop7h 54m
Sat 10/248:48 am -
1 stop7h 32m
Deal found 9/9![American Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2712:17 pm -
1 stop6h 45m
Wed 2/173:17 pm -
1 stop7h 42m
Deal found 9/11![American Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:24 pm -
1 stop6h 50m
Tue 11/178:51 am -
1 stop8h 25m
Deal found 9/11![American Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/186:50 pm -
1 stop7h 44m
Tue 3/23:17 pm -
1 stop7h 42m
Deal found 9/9![American Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:50 pm -
1 stop7h 54m
Sat 10/177:16 am -
1 stop9h 04m
Deal found 9/9![American Airlines logo]()
$431
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:50 pm -
1 stop7h 54m
Tue 10/207:16 am -
1 stop9h 04m
Deal found 9/12![American Airlines logo]()
$500
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:24 pm -
2 stops10h 31m
Mon 11/94:13 pm -
1 stop7h 05m
Deal found 9/9![American Airlines logo]()
$501
Last-minute flights from La Crosse to MesaDiscover last-minute flight deals from La Crosse to Mesa. Data last updated September 13, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to Mesa. Data last updated September 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1212:26 pm -
1 stop6h 41m
Mon 9/1412:24 am -
1 stop8h 58m
Deal found 9/11![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:22 pm -
1 stop7h 16m
Fri 4/93:34 pm -
1 stop6h 20m
Deal found 9/12![American Airlines logo]()
$458
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:50 pm -
1 stop7h 54m
Sat 10/177:16 am -
1 stop9h 04m
Deal found 9/9![American Airlines logo]()
$431
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:50 pm -
1 stop7h 54m
Sat 10/248:48 am -
1 stop7h 32m
Deal found 9/9![American Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:50 pm -
1 stop7h 54m
Tue 10/271:18 pm -
2 stops8h 41m
Deal found 9/8![American Airlines logo]()
$386
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:50 pm -
1 stop7h 54m
Wed 10/287:16 am -
1 stop9h 04m
Deal found 9/8![American Airlines logo]()
$480
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2712:23 pm -
2 stops10h 28m
Sat 10/3112:15 pm -
2 stops9h 44m
Deal found 9/9![American Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:23 pm -
1 stop6h 52m
Tue 11/311:27 am -
1 stop5h 49m
Deal found 9/8![American Airlines logo]()
$405
One-way flights from La Crosse to MesaSearch for one-way flight options from La Crosse to Mesa. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
Search for one-way flight options from La Crosse to Mesa. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:22 pm -
1 stop17h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![American Airlines logo]()
$377
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:53 am -
2 stops10h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![American Airlines logo]()
$471
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:00 am -
2 stops11h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![American Airlines logo]()
$534
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1912:23 pm -
2 stops8h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![American Airlines logo]()
$704
Find flight deals from La Crosse to Mesa
Keep the following information in mind while searching for La Crosse to Mesa flight deals. Data was last updated September 13, 2026.
Round-trip from | $380 (American Airlines) |
|---|---|
One-way from | $377 (American Airlines) |
Popular in | September |
Cheapest in | February |
Average price | $790 |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
Use the filters below to find and compare flights from La Crosse to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
La CrossePhoenix
LSE La Crosse - PHX Phoenix Sky Harbor Intl
LSEPHX
La Crosse
Mon 11/23
12:26 pm-12:52 am
1 stop13h 26m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$377
La CrossePhoenix
LSE La Crosse - PHX Phoenix Sky Harbor Intl
LSEPHX
La Crosse
Mon 10/19
6:55 pm-6:50 am
1 stop13h 55m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$377
La CrossePhoenix
LSE La Crosse - PHX Phoenix Sky Harbor Intl
LSEPHX
La Crosse
Sat 10/3
5:53 am-5:07 pm
1 stop13h 14m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$377
La CrossePhoenix
LSE La Crosse - PHX Phoenix Sky Harbor Intl
LSEPHX
La Crosse
Sat 10/17
6:50 pm-12:44 am
1 stop7h 54m
Phoenix Sky Harbor Intl
Sat 10/24
8:48 am-6:20 pm
1 stop7h 32m
$380
La CrossePhoenix
LSE La Crosse - PHX Phoenix Sky Harbor Intl
LSEPHX
La Crosse
Wed 1/27
12:17 pm-6:02 pm
1 stop6h 45m
Phoenix Sky Harbor Intl
Wed 2/17
3:17 pm-11:59 pm
1 stop7h 42m
$380
La CrossePhoenix
LSE La Crosse - PHX Phoenix Sky Harbor Intl
LSEPHX
La Crosse
Fri 11/6
12:24 pm-6:14 pm
1 stop6h 50m
Phoenix Sky Harbor Intl
Tue 11/17
8:51 am-6:16 pm
1 stop8h 25m
$405
La CrossePhoenix
LSE La Crosse - PHX Phoenix Sky Harbor Intl
LSEPHX
La Crosse
Thu 2/18
6:50 pm-1:34 am
1 stop7h 44m
Phoenix Sky Harbor Intl
Tue 3/2
3:17 pm-11:59 pm
1 stop7h 42m
$405
La CrossePhoenix
LSE La Crosse - PHX Phoenix Sky Harbor Intl
LSEPHX
La Crosse
Tue 10/13
6:50 pm-12:44 am
1 stop7h 54m
Phoenix Sky Harbor Intl
Sat 10/17
7:16 am-6:20 pm
1 stop9h 04m
$431
Quickest round-trip
La CrossePhoenix
LSE La Crosse - PHX Phoenix Sky Harbor Intl
LSEPHX
La Crosse
Wed 12/2
12:24 pm-9:35 pm
2 stops10h 11m
Phoenix Sky Harbor Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$471
La CrossePhoenix
LSE La Crosse - PHX Phoenix Sky Harbor Intl
LSEPHX
La Crosse
Sat 10/17
6:50 pm-12:44 am
1 stop7h 54m
Phoenix Sky Harbor Intl
Tue 10/20
7:16 am-6:20 pm
1 stop9h 04m
$500
Showing 1-10 of 11 resultsSorted by cheapest first
Best time to book a flight from La Crosse to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from La Crosse with our price prediction graph.
LSE-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from La Crosse to Mesa
LSE-MS9
LSE-PHX
What is the cheapest time of day to fly from LSE to MS9?
Find hourly flight availability from La Crosse to Mesa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 13, 2026.
When flying from La Crosse to Mesa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 34% versus a flight in the afternoon.
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated September 13, 2026.
Read through reviews of airlines operating flights from La Crosse to Mesa, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Comfort
7.2
Food
6.4
Boarding
7.4
Overall
7.1
Crew
7.9
Reviews
1 / 20
6.0
GoodKristin,Jul 2026
DCA - PHX
Entertainment
6.8
Comfort
7.2
Food
6.4
Boarding
7.4
Overall
7.1
Crew
7.9
Reviews
1 / 20
6.0
GoodKristin,Jul 2026
DCA - PHX
Related info for your journey
Find useful and relevant information for your journey from La Crosse to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from La Crosse
Popular flights
Top destinations
Alternative routes for La Crosse to Mesa
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Mesa by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from La Crosse to Mesa by cabin class
Find flights from La Crosse to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
La Crosse and Mesa flights
Browse other La Crosse and Mesa flight options. Last updated on September 13, 2026.
Other flights from La Crosse
Browse through other flights departing from La Crosse. Flights are based on user searches made on Cheapflights and were last updated on September 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
La Crosse to Mesa flights
Consider these flights traveling from La Crosse to Mesa.
Top 2 airlines flying from La Crosse to Mesa
Discover the top 2 airlines that operate flights from La Crosse to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$109 | Average$140 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$338 | Average$483 | FlexibilityNo cancel fee | On-time71% |