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$131+ Cheap flights from Panama City (PTY) to Medellín

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/8. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MDE
Mar 17 — Mar 241
Tue 3/17
Tue 3/24
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Medellín are usually found in May or July, booked 48 days in advance, depart on a Monday or Wednesday and return on a Friday

Cheap flight deals from Panama City to Medellín

Cheapest flights from Panama City to Medellín
Explore the most affordable flight options available from Panama City to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 15, 2026.

This Copa Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:28 am
PTY
-
MDE
Nonstop1h 23m
Copa Airlines
Mon 3/99:17 am
MDE
-
PTY
Nonstop1h 27m
Copa Airlines
Deal found 2/15$259
This Copa Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:24 pm
PTY
-
MDE
Nonstop1h 24m
Copa Airlines
Sat 4/116:25 am
MDE
-
PTY
Nonstop1h 28m
Copa Airlines
Deal found 2/13$263
This Copa Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:51 pm
PTY
-
MDE
Nonstop1h 24m
Copa Airlines
Wed 11/44:30 pm
MDE
-
PTY
Nonstop1h 27m
Copa Airlines
Deal found 2/13$268
This Copa Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:52 pm
PTY
-
MDE
Nonstop1h 23m
Copa Airlines
Sun 3/296:20 pm
MDE
-
PTY
Nonstop1h 29m
Copa Airlines
Deal found 2/13$270
This Avianca deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/172:55 pm
PTY
-
MDE
1 stop4h 00m
Avianca
Wed 2/259:50 am
MDE
-
PTY
1 stop4h 10m
Avianca
Deal found 2/12$271
This Avianca deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/249:45 am
PTY
-
MDE
1 stop4h 20m
Avianca
Sun 3/294:50 am
MDE
-
PTY
1 stop4h 25m
Avianca
Deal found 2/15$274
This Avianca deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/175:50 pm
PTY
-
MDE
1 stop4h 05m
Avianca
Wed 3/412:40 pm
MDE
-
PTY
1 stop4h 15m
Avianca
Deal found 2/15$275
This Copa Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/66:49 am
PTY
-
MDE
Nonstop1h 26m
Copa Airlines
Sun 7/126:25 am
MDE
-
PTY
Nonstop1h 26m
Copa Airlines
Deal found 2/13$278
This Avianca deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:55 pm
PTY
-
MDE
1 stop4h 30m
Avianca
Sat 8/154:50 am
MDE
-
PTY
1 stop4h 25m
Avianca
Deal found 2/13$279
This Copa Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:19 pm
PTY
-
MDE
Nonstop1h 26m
Copa Airlines
Mon 7/65:00 am
MDE
-
PTY
Nonstop1h 26m
Copa Airlines
Deal found 2/13$289
This Copa Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/209:34 am
PTY
-
MDE
Nonstop1h 22m
Copa Airlines
Fri 3/275:00 am
MDE
-
PTY
Nonstop1h 28m
Copa Airlines
Deal found 2/13$291
This Copa Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/181:20 pm
PTY
-
MDE
Nonstop1h 25m
Copa Airlines
Sun 2/229:44 am
MDE
-
PTY
Nonstop1h 27m
Copa Airlines
Deal found 2/11$295

Find flight deals from Panama City to Medellín

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Medellín (CO1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 15, 2026.

Round-trip from

$259
(Copa Airlines)

One-way from

$131
(Super.com)

Popular in

November

Cheapest in

May

Average price

$187
From Panama City Tocumen Intl to Medellín
Search Deals
One-way flight from Panama City Tocumen Intl to Medellín
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($25 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($3 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Medellín that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 15, 2026.
Use the filters below to find and compare flights from Panama City to Medellín that are best for you.

Fly from

Panama City

Fly to

Medellín

Route

Depart

Return

Price

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 4/3

6:51 am-8:15 am

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Sun 4/5

12:40 pm-2:08 pm

Nonstop1h 28m

$259

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 4/15

8:16 am-9:40 am

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Mon 4/20

8:35 am-10:03 am

Nonstop1h 28m

$259

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 3/26

7:00 am-8:18 am

Nonstop1h 18m

Medellín Jose Maria Cordova Intl

Sat 3/28

6:20 pm-7:48 pm

Nonstop1h 28m

$259

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 5/4

1:21 pm-2:45 pm

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Sun 5/10

9:15 am-10:43 am

Nonstop1h 28m

$259

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 5/1

7:11 pm-8:35 pm

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Mon 5/4

6:25 am-7:53 am

Nonstop1h 28m

$259

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Tue 3/3

7:00 am-8:18 am

Nonstop1h 18m

Medellín Jose Maria Cordova Intl

Tue 3/17

6:25 am-7:49 am

Nonstop1h 24m

$259

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Tue 3/24

8:28 am-9:51 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Tue 3/31

5:00 am-6:28 am

Nonstop1h 28m

$259

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 5/4

9:31 am-10:55 am

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Fri 5/8

6:25 am-7:53 am

Nonstop1h 28m

$259

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 5/6

7:11 pm-8:35 pm

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Sun 5/10

12:40 pm-2:08 pm

Nonstop1h 28m

$259

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 3/12

9:45 am-2:05 pm

1 stop4h 20m

$134

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/11

Showing 1-10 of 17 results
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Best time to book a flight from Panama City to Medellín

Have a flexible travel schedule? Discover the best time to fly to Medellín from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Medellín

How far ahead should I book a flight from Panama City to Medellín?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Medellín. Price data was last updated on February 13, 2026.

Booking 48 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Medellín. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Medellín?

Currently, May is the cheapest month in which you can book a flight from Panama City to Medellín (average of $80). Flying from Panama City to Medellín in February is currently the most expensive (average of $135). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MDE?

Find hourly flight availability from Panama City to Medellín. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 15, 2026.

It’s typically best to fly out from Panama City to Medellín at noon. Doing so could potentially save you 21% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Panama City to Medellín?

Use this chart to determine the cheapest time to fly round-trip from Panama City to Medellín. Price data was last updated on February 7, 2026.

Travelers seeking maximum savings on their Panama City to Medellín flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Panama City to Medellín

Explore weekly flight availability from Panama City to Medellín. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 15, 2026.

The most flights from PTY to CO1 are scheduled on a Sunday (17 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (6 on average).

How often are flights from Panama City to Medellín delayed?

About 5% of weekly flights between Panama City and Medellín have experienced delays in the past year, with the average delay time being 99 minutes.

What is the most punctual flight time for Panama City to Medellín flights?

Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Tuesday tends to have the lowest number of delays on this route, whereas Sunday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Panama City to Medellín flights?

Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 4% of flights being delayed.

Reviews of airlines servicing Medellín

Get insights into the airlines that provide service to Medellín. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Medellín. Reviews last updated February 15, 2026.
Get a feel of what it's like to fly with Copa Airlines and Avianca from Panama City to Medellín by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,558 reviews

Overall

7.5

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.5
Good
1,558 reviews
Copa Airlines
7.5
Good
1,558 reviews

Overall

7.5

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.6
Okay
2,496 reviews
Copa Airlines
7.5
Good
1,558 reviews

Overall

7.5

Entertainment

6.8

Food

6.8

Crew

8.1

Comfort

7.4

Boarding

7.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Panama City to Medellín. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Medellín?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly out of when you book flights from Panama City to Medellín. 3 airlines have flights from Tocumen Intl to Medellín on a regular basis. Booking flights from Panama City Tocumen Intl to Medellín should not be difficult; the airport handles an average of 12 outbound flights to Medellín per day.

  • How long is the flight from Panama City to Medellín?

    A quick flight from Panama City to Medellín can take about 1h 24m. Copa Airlines provides one of the quickest options available for as low as $259. Panama City and Medellín are separated by a distance of 337 mi. All flights are typically nonstop.

  • What are the cheapest airlines flying from Panama City to Medellín round-trip?

    According to our current data, Wingo ($74), Copa Airlines ($123), and Avianca ($147) offers the cheapest pricing from Panama City to Medellín. Wingo is currently priced 59% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Panama City to Medellín one-way?

    The cheapest airlines for a one-way flight from Panama City to Medellín are Wingo ($66), Avianca ($124), and Copa Airlines ($126).

  • What are the most reliable airlines from Panama City to Medellín?

    The top 3 most reliable airlines when flying from Panama City to Medellín are Copa Airlines (95%), KLM (92%) and United Airlines (88%).

  • What are the cheapest flights from Panama City to Medellín?

    On average you can expect to pay $219 for a flight from Panama City to Medellín. The cheapest flight overall is $126 while the most popular route, (Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl) is currently priced at $143.

  • Can I find deals for flights from Panama City to Medellín that include hotel bookings?

    Yes. In addition to deals on Panama City to Medellín flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Medellín?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Medellín.

  • Can I find deals for business class flights from Panama City to Medellín?

    Yes. Cheapflights offers flight deals from Panama City to Medellín by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Medellín?

    Currently, May is the cheapest month in which you can book a flight from Panama City to Medellín (average of $80). Flying from Panama City to Medellín in February is currently the most expensive (average of $135). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Panama City to Medellín

Discover the top 3 airlines that operate flights from Panama City to Medellín. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
WingoCheapest$74Average$160FlexibilityNo cancel feeOn-time83%
Copa AirlinesCheapest$123Average$274FlexibilityNo cancel feeOn-time70%
AviancaCheapest$147Average$290FlexibilityNo cancel feeOn-time71%

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