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$139+ Cheap flights from Panama City (PTY) to Medellín

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MDE
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Medellín are usually found in May or July, booked 57 days in advance, depart on a Monday or Wednesday and return on a Friday

Cheap flight deals from Panama City to Medellín

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Medellín (CO1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$240
(Avianca)

One-way from

$139
(Priceline)

Popular in

October

Cheapest in

May

Average price

$175
From Panama City Tocumen Intl to Medellín
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One-way flight from Panama City Tocumen Intl to Medellín
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Highest demand for flights based on searches. 9% potential increase in price ($19 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($3 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Panama City to Medellín

Cheapest flights from Panama City to Medellín
Explore the most affordable flight options available from Panama City to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/213:20 amPTY - MDE
1 stop5h 41mAvianca
Mon 8/251:25 pmMDE - PTY
Nonstop1h 15mAvianca
Deal found 8/14$235
This Priceline deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/213:20 amPTY - MDE
1 stop5h 41mAvianca
Sun 8/245:55 pmMDE - PTY
Nonstop1h 20mAvianca
Deal found 8/14$240
This Avianca deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/153:40 pmPTY - MDE
Nonstop1h 15mAvianca
Sun 8/177:56 pmMDE - PTY
1 stop4h 14mAvianca
Deal found 8/14$241
This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/203:20 amPTY - MDE
1 stop5h 11mAvianca
Sat 8/231:25 pmMDE - PTY
Nonstop1h 15mAvianca
Deal found 8/14$248
This Mytrip deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/1711:20 amPTY - MDE
Nonstop1h 10mAvianca
Sat 8/231:25 pmMDE - PTY
Nonstop1h 15mAvianca
Deal found 8/13$255
This Avianca deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2011:20 amPTY - MDE
Nonstop1h 10mAvianca
Wed 8/271:25 pmMDE - PTY
Nonstop1h 15mAvianca
Deal found 8/13$258
This Copa Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/11:19 pmPTY - MDE
Nonstop1h 25mCopa Airlines
Thu 11/610:46 amMDE - PTY
Nonstop1h 28mCopa Airlines
Deal found 8/13$260
This Avianca deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1411:20 amPTY - MDE
Nonstop1h 10mAvianca
Sun 8/175:55 pmMDE - PTY
Nonstop1h 20mAvianca
Deal found 8/13$261
This Avianca deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/235:25 pmPTY - MDE
2 stops6h 19mAvianca
Tue 8/261:25 pmMDE - PTY
Nonstop1h 15mAvianca
Deal found 8/14$270
This FlightHub deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1410:05 pmPTY - MDE
1 stop8h 09mAvianca
Mon 8/181:25 pmMDE - PTY
Nonstop1h 15mAvianca
Deal found 8/13$282
This Copa Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3112:51 pmPTY - MDE
Nonstop1h 24mCopa Airlines
Wed 11/510:46 amMDE - PTY
Nonstop1h 28mCopa Airlines
Deal found 8/13$284

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Medellín that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Panama City to Medellín that are best for you.

Fly from

Panama City

Fly to

Medellín

Route

Depart

Return

Price

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 8/28

5:25 pm-10:26 pm

1 stop5h 01m

Medellín Jose Maria Cordova Intl

Fri 8/29

1:25 pm-2:40 pm

Nonstop1h 15m

$240

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 9/4

1:19 pm-2:44 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Thu 9/18

6:18 pm-7:47 pm

Nonstop1h 29m

$260

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Tue 9/30

1:19 pm-2:44 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Tue 10/7

12:45 pm-2:13 pm

Nonstop1h 28m

$260

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sun 10/26

6:53 pm-8:16 pm

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Thu 10/30

10:46 am-12:15 pm

Nonstop1h 29m

$260

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 9/24

1:19 pm-2:44 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Wed 10/1

4:15 pm-5:43 pm

Nonstop1h 28m

$260

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 8/28

1:20 pm-2:45 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Tue 9/2

6:18 pm-7:47 pm

Nonstop1h 29m

$260

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 10/23

12:51 pm-2:15 pm

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Sun 10/26

4:30 pm-5:58 pm

Nonstop1h 28m

$260

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sat 11/1

1:19 pm-2:44 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Thu 11/6

10:46 am-12:14 pm

Nonstop1h 28m

$260

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 9/1

12:51 pm-2:15 pm

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Fri 9/5

12:45 pm-2:14 pm

Nonstop1h 29m

$260

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 8/28

11:20 am-12:30 pm

Nonstop1h 10m

$139

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 18 results
1
2

Best time to book a flight from Panama City to Medellín

Have a flexible travel schedule? Discover the best time to fly to Medellín from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Medellín

How far ahead should I book a flight from Panama City to Medellín?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Medellín. Price data was last updated on August 8, 2025.

Booking 57 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Medellín. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Medellín?

Currently, January is the cheapest month in which you can book a flight from Panama City to Medellín (average of $378). Flying from Panama City to Medellín in December is currently the most expensive (average of $625). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MDE?

Find hourly flight availability from Panama City to Medellín. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

It’s typically best to fly out from Panama City to Medellín in the evening. Doing so could potentially save you 23% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Panama City to Medellín?

Use this chart to determine the cheapest time to fly round-trip from Panama City to Medellín. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Panama City to Medellín flight should consider departing on Wednesday at noon when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Panama City to Medellín

Explore weekly flight availability from Panama City to Medellín. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 14, 2025.

The most flights from PTY to CO1 are scheduled on a Wednesday (15 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (9 on average).

How much does it cost to fly round-trip from Panama City to Medellín?

Reviews of airlines servicing Medellín

Get insights into the airlines that provide service to Medellín. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Medellín. Reviews last updated August 14, 2025.
Get a feel of what it's like to fly with Copa Airlines and Avianca from Panama City to Medellín by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,509 reviews

Overall

7.5

Entertainment

6.8

Comfort

7.4

Boarding

7.8

Crew

8.1

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Copa Airlines
7.5
Good
1,509 reviews
Copa Airlines
7.5
Good
1,509 reviews

Overall

7.5

Entertainment

6.8

Comfort

7.4

Boarding

7.8

Crew

8.1

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Avianca
6.7
Okay
2,401 reviews
Copa Airlines
7.5
Good
1,509 reviews

Overall

7.5

Entertainment

6.8

Comfort

7.4

Boarding

7.8

Crew

8.1

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Medellín. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Medellín?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly out of when you book flights from Panama City to Medellín. 3 airlines have flights from Tocumen Intl to Medellín on a regular basis. Booking flights from Panama City Tocumen Intl to Medellín should not be difficult; the airport handles an average of 11 outbound flights to Medellín per day.

  • What are the cheapest airlines flying from Panama City to Medellín round-trip?

    According to our current data, Copa Airlines ($118), Wingo ($129), and Avianca ($171) offers the cheapest pricing from Panama City to Medellín. Copa Airlines is currently priced 34% below the average price you’ll pay for this route.

  • What are the most reliable airlines from Panama City to Medellín?

    The top 3 most reliable airlines when flying from Panama City to Medellín are Copa Airlines (90%), KLM (82%) and United Airlines (82%).

  • What are the cheapest flights from Panama City to Medellín?

    On average you can expect to pay $211 for a flight from Panama City to Medellín. The cheapest flight overall is $131 while the most popular route, (Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl) is currently priced at $135.

  • Can I find deals for flights from Panama City to Medellín that include hotel bookings?

    Yes. In addition to deals on Panama City to Medellín flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Medellín?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Medellín.

  • Can I find deals for business class flights from Panama City to Medellín?

    Yes. Cheapflights offers flight deals from Panama City to Medellín by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Medellín?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Medellín (average of $378). Flying from Panama City to Medellín in December is currently the most expensive (average of $625). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Panama City to Medellín

Discover the top 3 airlines that operate flights from Panama City to Medellín. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$118Average$267FlexibilityNo cancel feeOn-time70%
WingoCheapest$129Average$160FlexibilityNo cancel feeOn-time83%
AviancaCheapest$171Average$239FlexibilityNo cancel feeOn-time71%

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