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$152+ Cheap flights from Panama City (PTY) to Medellín

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/6. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MDE
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Medellín are usually found in May or July, booked 57 days in advance, depart on a Wednesday or Monday and return on a Friday

Cheap flight deals from Panama City to Medellín

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Medellín (CO1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$286
(Copa Airlines)

One-way from

$152
(Copa Airlines)

Popular in

December

Cheapest in

May

Average price

$169
From Panama City Tocumen Intl to Medellín
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One-way flight from Panama City Tocumen Intl to Medellín
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Highest demand for flights based on searches. 11% potential increase in price ($23 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Panama City to Medellín

Cheapest flights from Panama City to Medellín
Explore the most affordable flight options available from Panama City to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/169:29 pmPTY - MDE
Nonstop1h 22mCopa Airlines
Sun 10/1912:45 pmMDE - PTY
Nonstop1h 28mCopa Airlines
Deal found 9/17$286
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2210:05 pmPTY - MDE
1 stop8h 57mMultiple Airlines
Tue 10/2810:28 pmMDE - PTY
1 stop10h 22mMultiple Airlines
Deal found 9/15$290
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/235:25 pmPTY - MDE
1 stop6h 45mMultiple Airlines
Mon 10/276:35 pmMDE - PTY
1 stop6h 05mMultiple Airlines
Deal found 9/15$293
This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:54 amPTY - MDE
Nonstop1h 24mCopa Airlines
Mon 12/812:42 pmMDE - PTY
Nonstop1h 29mCopa Airlines
Deal found 9/17$297
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/29:45 amPTY - MDE
1 stop4h 25mMultiple Airlines
Wed 11/510:48 pmMDE - PTY
1 stop10h 02mMultiple Airlines
Deal found 9/15$300
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/163:20 amPTY - MDE
1 stop4h 41mMultiple Airlines
Sun 10/198:26 amMDE - PTY
1 stop8h 04mMultiple Airlines
Deal found 9/15$302
This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/207:47 amPTY - MDE
Nonstop1h 23mCopa Airlines
Fri 9/266:37 amMDE - PTY
Nonstop1h 26mCopa Airlines
Deal found 9/17$303
This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1912:51 pmPTY - MDE
Nonstop1h 24mCopa Airlines
Fri 9/266:37 amMDE - PTY
Nonstop1h 26mCopa Airlines
Deal found 9/17$314
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/51:20 pmPTY - MDE
Nonstop1h 25mCopa Airlines
Tue 12/93:15 pmMDE - PTY
Nonstop1h 29mCopa Airlines
Deal found 9/15$318

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Medellín that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Panama City to Medellín that are best for you.

Fly from

Panama City

Fly to

Medellín

Route

Depart

Return

Price

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 2/13

7:10 pm-8:35 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Sat 2/21

12:42 pm-2:10 pm

Nonstop1h 28m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 11/14

12:50 pm-2:15 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Sun 11/16

8:37 am-10:05 am

Nonstop1h 28m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 1/26

9:19 pm-10:40 pm

Nonstop1h 21m

Medellín Jose Maria Cordova Intl

Sun 2/1

9:17 am-10:44 am

Nonstop1h 27m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 10/16

9:29 pm-10:51 pm

Nonstop1h 22m

Medellín Jose Maria Cordova Intl

Sun 10/19

12:45 pm-2:13 pm

Nonstop1h 28m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 10/1

9:32 am-10:55 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Mon 10/20

8:49 am-10:18 am

Nonstop1h 29m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sat 2/14

8:28 am-9:51 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Wed 2/18

9:44 am-11:11 am

Nonstop1h 27m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 1/16

9:33 am-10:56 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Mon 1/19

8:37 am-10:04 am

Nonstop1h 27m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 10/1

1:16 pm-2:41 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Fri 10/31

3:15 pm-4:42 pm

Nonstop1h 27m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 11/13

6:54 am-8:18 am

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Sun 11/16

10:46 am-12:14 pm

Nonstop1h 28m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 10/17

7:47 am-9:10 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Tue 10/21

9:42 am-11:10 am

Nonstop1h 28m

$286

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 22 results
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Best time to book a flight from Panama City to Medellín

Have a flexible travel schedule? Discover the best time to fly to Medellín from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Medellín

How far ahead should I book a flight from Panama City to Medellín?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Medellín. Price data was last updated on September 12, 2025.

Booking 57 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Medellín. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Medellín?

Currently, January is the cheapest month in which you can book a flight from Panama City to Medellín (average of $378). Flying from Panama City to Medellín in December is currently the most expensive (average of $625). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MDE?

Find hourly flight availability from Panama City to Medellín. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

It’s typically best to fly out from Panama City to Medellín in the evening. Doing so could potentially save you 26% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Panama City to Medellín?

Use this chart to determine the cheapest time to fly round-trip from Panama City to Medellín. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Panama City to Medellín flight should consider departing on Tuesday evenings when fares are most often at their lowest. Thursday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Panama City to Medellín

Explore weekly flight availability from Panama City to Medellín. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 17, 2025.

The most flights from PTY to CO1 are scheduled on a Monday (14 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (11 on average).

Reviews of airlines servicing Medellín

Get insights into the airlines that provide service to Medellín. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Medellín. Reviews last updated September 17, 2025.
Get a feel of what it's like to fly with Copa Airlines and Avianca from Panama City to Medellín by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,533 reviews

Comfort

7.4

Boarding

7.8

Food

6.8

Crew

8.1

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,533 reviews
Copa Airlines
7.6
Good
1,533 reviews

Comfort

7.4

Boarding

7.8

Food

6.8

Crew

8.1

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,533 reviews

Comfort

7.4

Boarding

7.8

Food

6.8

Crew

8.1

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Medellín. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Medellín?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly out of when you book flights from Panama City to Medellín. 3 airlines have flights from Tocumen Intl to Medellín on a regular basis. Booking flights from Panama City Tocumen Intl to Medellín should not be difficult; the airport handles an average of 13 outbound flights to Medellín per day.

  • How long is the flight from Panama City to Medellín?

    A quick flight from Panama City to Medellín can take about 1h 25m. Copa Airlines provides one of the quickest options available for as low as $286. Panama City and Medellín are separated by a distance of 337 mi. All flights are typically nonstop.

  • What are the cheapest airlines flying from Panama City to Medellín round-trip?

    According to our current data, Copa Airlines ($123), Wingo ($126), and Avianca ($168) offers the cheapest pricing from Panama City to Medellín. Copa Airlines is currently priced 31% below the average price you’ll pay for this route.

  • What are the most reliable airlines from Panama City to Medellín?

    The top 3 most reliable airlines when flying from Panama City to Medellín are Copa Airlines (91%), United Airlines (90%) and Turkish Airlines (83%).

  • What are the cheapest flights from Panama City to Medellín?

    On average you can expect to pay $235 for a flight from Panama City to Medellín. The cheapest flight overall is $139 while the most popular route, (Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl) is currently priced at $144.

  • Can I find deals for flights from Panama City to Medellín that include hotel bookings?

    Yes. In addition to deals on Panama City to Medellín flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Medellín?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Medellín.

  • Can I find deals for business class flights from Panama City to Medellín?

    Yes. Cheapflights offers flight deals from Panama City to Medellín by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Medellín?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Medellín (average of $378). Flying from Panama City to Medellín in December is currently the most expensive (average of $625). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Panama City to Medellín

Discover the top 3 airlines that operate flights from Panama City to Medellín. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$123Average$272FlexibilityNo cancel feeOn-time70%
WingoCheapest$126Average$159FlexibilityNo cancel feeOn-time83%
AviancaCheapest$168Average$250FlexibilityNo cancel feeOn-time71%

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