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$145+ Cheap flights from Panama City (PTY) to Medellín

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MDE
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Medellín are usually found in May or July, booked 48 days in advance, depart on a Wednesday or Monday and return on a Friday

Cheap flight deals from Panama City to Medellín

Cheapest flights from Panama City to Medellín
Explore the most affordable flight options available from Panama City to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This Super.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/272:55 pmPTY - MDE
1 stop4h 00mAvianca
Sun 12/287:40 pmMDE - PTY
1 stop5h 20mAvianca
Deal found 12/20$270
This Super.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:50 pmPTY - MDE
1 stop5h 45mAvianca
Mon 12/297:00 pmMDE - PTY
1 stop5h 40mAvianca
Deal found 12/21$271
This Copa Airlines deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:28 amPTY - MDE
Nonstop1h 23mCopa Airlines
Wed 12/319:17 amMDE - PTY
Nonstop1h 28mCopa Airlines
Deal found 12/20$286
This Gotogate deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/262:55 pmPTY - MDE
1 stop4h 00mAvianca
Sun 12/289:00 pmMDE - PTY
1 stop4h 00mAvianca
Deal found 12/21$287
This Gotogate deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/252:55 pmPTY - MDE
1 stop4h 00mAvianca
Mon 12/297:40 pmMDE - PTY
1 stop5h 00mAvianca
Deal found 12/21$293
This Mytrip deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:50 pmPTY - MDE
1 stop4h 05mAvianca
Wed 12/318:10 pmMDE - PTY
1 stop4h 30mAvianca
Deal found 12/22$296
This Avianca deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:50 pmPTY - MDE
1 stop4h 05mAvianca
Sat 12/278:10 pmMDE - PTY
1 stop4h 50mAvianca
Deal found 12/23$298
This Copa Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:28 amPTY - MDE
Nonstop1h 23mCopa Airlines
Wed 12/316:20 pmMDE - PTY
Nonstop1h 29mCopa Airlines
Deal found 12/22$303
This Copa Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:52 pmPTY - MDE
Nonstop1h 24mCopa Airlines
Sun 12/283:15 pmMDE - PTY
Nonstop1h 29mCopa Airlines
Deal found 12/21$314
This Copa Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/269:23 pmPTY - MDE
Nonstop1h 25mCopa Airlines
Sun 12/289:17 amMDE - PTY
Nonstop1h 28mCopa Airlines
Deal found 12/22$320
This Copa Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:54 amPTY - MDE
Nonstop1h 24mCopa Airlines
Fri 12/264:30 pmMDE - PTY
Nonstop1h 27mCopa Airlines
Deal found 12/21$331
This Copa Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:05 pmPTY - MDE
Nonstop1h 25mCopa Airlines
Thu 2/1210:46 amMDE - PTY
Nonstop1h 28mCopa Airlines
Deal found 12/22$337

Find flight deals from Panama City to Medellín

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Medellín (CO1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 23, 2025.

Round-trip from

$270
(Super.com)

One-way from

$145
(Super.com)

Popular in

November

Cheapest in

May

Average price

$210
From Panama City Tocumen Intl to Medellín
Search Deals
One-way flight from Panama City Tocumen Intl to Medellín
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($30 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Medellín that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Panama City to Medellín that are best for you.

Fly from

Panama City

Fly to

Medellín

Route

Depart

Return

Price

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sat 1/31

1:20 pm-2:45 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Tue 2/24

10:46 am-12:14 pm

Nonstop1h 28m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sat 1/17

9:33 am-10:56 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Wed 1/21

4:30 pm-5:57 pm

Nonstop1h 27m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sun 2/22

8:28 am-9:51 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Fri 2/27

9:17 am-10:44 am

Nonstop1h 27m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 1/5

9:33 am-10:56 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Fri 1/9

9:17 am-10:43 am

Nonstop1h 26m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 1/7

9:33 am-10:56 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Mon 1/12

10:46 am-12:14 pm

Nonstop1h 28m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Tue 2/17

9:24 pm-10:48 pm

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Wed 2/25

4:30 pm-5:57 pm

Nonstop1h 27m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sat 1/3

9:33 am-10:56 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Fri 1/9

9:17 am-10:43 am

Nonstop1h 26m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 1/26

12:51 pm-2:15 pm

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Sun 2/1

5:00 am-6:28 am

Nonstop1h 28m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 1/8

9:33 am-10:56 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Thu 1/22

12:42 pm-2:09 pm

Nonstop1h 27m

$286

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 1/8

8:28 am-9:51 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Tue 1/13

12:42 pm-2:09 pm

Nonstop1h 27m

$286

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/23

Showing 1-10 of 17 results
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Best time to book a flight from Panama City to Medellín

Have a flexible travel schedule? Discover the best time to fly to Medellín from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Medellín

How far ahead should I book a flight from Panama City to Medellín?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Medellín. Price data was last updated on December 19, 2025.

Booking 48 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Medellín. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Medellín?

Currently, June is the cheapest month in which you can book a flight from Panama City to Medellín (average of $84). Flying from Panama City to Medellín in February is currently the most expensive (average of $132). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MDE?

Find hourly flight availability from Panama City to Medellín. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2025.

It’s typically best to fly out from Panama City to Medellín in the morning. Doing so could potentially save you 30% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Panama City to Medellín?

Use this chart to determine the cheapest time to fly round-trip from Panama City to Medellín. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Panama City to Medellín flight should consider departing on Tuesday evenings when fares are most often at their lowest. Thursday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Panama City to Medellín

Explore weekly flight availability from Panama City to Medellín. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 23, 2025.

The most flights from PTY to CO1 are scheduled on a Monday (14 on average). You will have fewer flight options on Sunday, which is when the least amount of flights are scheduled (2 on average).

How often are flights from Panama City to Medellín delayed?

About 6% of weekly flights between Panama City and Medellín have experienced delays in the past year, with the average delay time being 96 minutes.

What is the most punctual flight time for Panama City to Medellín flights?

Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Tuesday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Panama City to Medellín flights?

Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 5% of flights being delayed.

Reviews of airlines servicing Medellín

Get insights into the airlines that provide service to Medellín. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Medellín. Reviews last updated December 23, 2025.
Get a feel of what it's like to fly with Copa Airlines and Avianca from Panama City to Medellín by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,557 reviews

Entertainment

6.8

Crew

8.1

Overall

7.6

Food

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.6
Good
1,557 reviews
Copa Airlines
7.6
Good
1,557 reviews

Entertainment

6.8

Crew

8.1

Overall

7.6

Food

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.6
Okay
2,491 reviews
Copa Airlines
7.6
Good
1,557 reviews

Entertainment

6.8

Crew

8.1

Overall

7.6

Food

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Panama City to Medellín. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Medellín?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly out of when you book flights from Panama City to Medellín. 3 airlines have flights from Tocumen Intl to Medellín on a regular basis. Booking flights from Panama City Tocumen Intl to Medellín should not be difficult; the airport handles an average of 10 outbound flights to Medellín per day.

  • How long is the flight from Panama City to Medellín?

    A quick flight from Panama City to Medellín can take about 1h 25m. Copa Airlines provides one of the quickest options available for as low as $286. Panama City and Medellín are separated by a distance of 337 mi. All flights are typically nonstop.

  • What are the cheapest airlines flying from Panama City to Medellín round-trip?

    According to our current data, Wingo ($77), Copa Airlines ($120), and Avianca ($152) offers the cheapest pricing from Panama City to Medellín. Wingo is currently priced 57% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Panama City to Medellín one-way?

    The cheapest airlines for a one-way flight from Panama City to Medellín are Wingo ($66), Avianca ($112), and Copa Airlines ($121).

  • What are the most reliable airlines from Panama City to Medellín?

    The top 3 most reliable airlines when flying from Panama City to Medellín are Copa Airlines (93%), Turkish Airlines (90%) and United Airlines (88%).

  • What are the cheapest flights from Panama City to Medellín?

    On average you can expect to pay $227 for a flight from Panama City to Medellín. The cheapest flight overall is $152 while the most popular route, (Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl) is currently priced at $144.

  • Can I find deals for flights from Panama City to Medellín that include hotel bookings?

    Yes. In addition to deals on Panama City to Medellín flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Medellín?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Medellín.

  • Can I find deals for business class flights from Panama City to Medellín?

    Yes. Cheapflights offers flight deals from Panama City to Medellín by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Medellín?

    Currently, June is the cheapest month in which you can book a flight from Panama City to Medellín (average of $84). Flying from Panama City to Medellín in February is currently the most expensive (average of $132). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Panama City to Medellín

Discover the top 3 airlines that operate flights from Panama City to Medellín. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
WingoCheapest$122Average$159FlexibilityNo cancel feeOn-time83%
Copa AirlinesCheapest$135Average$275FlexibilityNo cancel feeOn-time70%
AviancaCheapest$168Average$285FlexibilityNo cancel feeOn-time71%

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