$359+ Cheap flights from Greenville (GSP) to Medellín
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — MDE
Oct 11 — Oct 181
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Greenville to MedellínExplore the most affordable flight options available from Greenville to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
Explore the most affordable flight options available from Greenville to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:33 pm -
2 stops17h 15m
Fri 10/306:00 am -
2 stops15h 39m
Deal found 9/8![American Airlines logo]()
$675
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:37 pm -
2 stops28h 33m
Sun 11/2210:40 am -
2 stops22h 50m
Deal found 9/9![United Airlines logo]()
$695
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:12 pm -
1 stop18h 00m
Mon 11/167:30 am -
1 stop16h 22m
Deal found 9/9![American Airlines logo]()
$701
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:08 pm -
1 stop25h 07m
Wed 10/216:00 am -
1 stop15h 52m
Deal found 9/10![American Airlines logo]()
$702
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/88:12 pm -
1 stop18h 00m
Mon 11/167:30 am -
1 stop16h 22m
Deal found 9/8![American Airlines logo]()
$710
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:39 am -
2 stops12h 55m
Mon 12/147:30 am -
2 stops13h 23m
Deal found 9/8![American Airlines logo]()
$715
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:26 am -
2 stops12h 59m
Mon 11/28:40 pm -
2 stops13h 11m
Deal found 9/10![Multiple Airlines logo]()
$725
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:39 am -
2 stops12h 55m
Tue 1/267:30 am -
1 stop11h 49m
Deal found 9/7![American Airlines logo]()
$728
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:54 am -
2 stops12h 44m
Mon 12/71:30 am -
2 stops13h 20m
Deal found 9/9![American Airlines logo]()
$736
Best flights from Greenville to MedellínDiscover carefully curated flight deals from Greenville to Medellín that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
Discover carefully curated flight deals from Greenville to Medellín that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:37 pm -
2 stops28h 33m
Sun 11/2210:40 am -
2 stops22h 50m
Deal found 9/9![United Airlines logo]()
$695
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:16 pm -
1 stop17h 56m
Sun 12/67:30 am -
1 stop16h 22m
Deal found 9/7![American Airlines logo]()
$702
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:39 am -
2 stops12h 55m
Mon 12/143:12 pm -
1 stop8h 40m
Deal found 9/8![American Airlines logo]()
$715
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2610:26 am -
2 stops35h 44m
Thu 12/1010:40 am -
2 stops23h 12m
Deal found 9/9![United Airlines logo]()
$736
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:39 am -
2 stops12h 55m
Tue 1/267:30 am -
2 stops15h 26m
Deal found 9/7![American Airlines logo]()
$728
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:43 pm -
2 stops26h 27m
Wed 12/910:40 am -
2 stops23h 12m
Deal found 9/9![United Airlines logo]()
$752
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/610:54 am -
2 stops12h 40m
Sat 12/197:30 am -
1 stop17h 25m
Deal found 9/8![American Airlines logo]()
$736
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/207:55 am -
2 stops13h 31m
Sun 1/247:30 am -
1 stop16h 29m
Deal found 9/8![American Airlines logo]()
$889
Last-minute flights from Greenville to MedellínDiscover last-minute flight deals from Greenville to Medellín. Data last updated September 11, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to Medellín. Data last updated September 11, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:08 pm -
1 stop25h 07m
Mon 10/126:00 am -
1 stop15h 52m
Deal found 9/7![American Airlines logo]()
$930
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:08 pm -
1 stop25h 07m
Wed 10/216:00 am -
1 stop15h 52m
Deal found 9/10![American Airlines logo]()
$702
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:01 am -
2 stops13h 14m
Wed 10/216:00 am -
2 stops14h 00m
Deal found 9/10![American Airlines logo]()
$740
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:33 pm -
2 stops17h 15m
Fri 10/306:00 am -
2 stops15h 39m
Deal found 9/8![American Airlines logo]()
$675
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:26 am -
2 stops12h 59m
Mon 11/28:40 pm -
2 stops13h 11m
Deal found 9/10![Multiple Airlines logo]()
$725
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:00 am -
2 stops13h 15m
Mon 11/23:12 pm -
1 stop8h 12m
Deal found 9/10![American Airlines logo]()
$759
One-way flights from Greenville to MedellínSearch for one-way flight options from Greenville to Medellín. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
Search for one-way flight options from Greenville to Medellín. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
This Avianca deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:46 pm -
2 stops17h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Avianca logo]()
$359
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:20 am -
2 stops15h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![United Airlines logo]()
$376
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:00 am -
1 stop14h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![American Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/305:29 pm -
2 stops28h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$386
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/36:30 am -
1 stop15h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![United Airlines logo]()
$397
Find flight deals from Greenville to Medellín
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Medellín (CO1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2026.
Round-trip from | $670 (American Airlines) |
|---|---|
One-way from | $359 (Avianca) |
Popular in | October |
Cheapest in | August |
Average price | $931 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to Medellín that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
Use the filters below to find and compare flights from Greenville to Medellín that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleMedellín
GSP Greenville - MDE Medellín Jose Maria Cordova Intl
GSPMDE
Greenville
Tue 9/29
5:46 pm-10:20 am
2 stops17h 34m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$359
GreenvilleMedellín
GSP Greenville - MDE Medellín Jose Maria Cordova Intl
GSPMDE
Greenville
Tue 9/29
6:20 am-9:10 pm
2 stops15h 50m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$376
Quickest round-trip
GreenvilleMedellín
GSP Greenville - MDE Medellín Jose Maria Cordova Intl
GSPMDE
Greenville
Sun 1/3
6:30 am-10:10 pm
1 stop15h 40m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$397
GreenvilleMedellín
GSP Greenville - MDE Medellín Jose Maria Cordova Intl
GSPMDE
Greenville
Sat 11/14
5:37 pm-10:10 pm
2 stops28h 33m
Medellín Jose Maria Cordova Intl
Sun 11/22
10:40 am-9:30 am
2 stops22h 50m
$695
GreenvilleMedellín
GSP Greenville - MDE Medellín Jose Maria Cordova Intl
GSPMDE
Greenville
Fri 11/27
8:16 pm-2:12 pm
1 stop17h 56m
Medellín Jose Maria Cordova Intl
Sun 12/6
7:30 am-11:52 pm
1 stop16h 22m
$702
GreenvilleMedellín
GSP Greenville - MDE Medellín Jose Maria Cordova Intl
GSPMDE
Greenville
Fri 12/4
10:39 am-11:34 pm
2 stops12h 55m
Medellín Jose Maria Cordova Intl
Mon 12/14
3:12 pm-11:52 pm
1 stop8h 40m
$715
GreenvilleMedellín
GSP Greenville - MDE Medellín Jose Maria Cordova Intl
GSPMDE
Greenville
Fri 12/4
10:39 am-11:34 pm
2 stops12h 55m
Medellín Jose Maria Cordova Intl
Tue 1/26
7:30 am-10:56 pm
2 stops15h 26m
$728
GreenvilleMedellín
GSP Greenville - MDE Medellín Jose Maria Cordova Intl
GSPMDE
Greenville
Thu 11/26
10:26 am-10:10 pm
2 stops35h 44m
Medellín Jose Maria Cordova Intl
Thu 12/10
10:40 am-9:52 am
2 stops23h 12m
$736
GreenvilleMedellín
GSP Greenville - MDE Medellín Jose Maria Cordova Intl
GSPMDE
Greenville
Sun 12/6
10:54 am-11:34 pm
2 stops12h 40m
Medellín Jose Maria Cordova Intl
Sat 12/19
7:30 am-12:55 am
1 stop17h 25m
$736
GreenvilleMedellín
GSP Greenville - MDE Medellín Jose Maria Cordova Intl
GSPMDE
Greenville
Wed 11/25
7:43 pm-10:10 pm
2 stops26h 27m
Medellín Jose Maria Cordova Intl
Wed 12/9
10:40 am-9:52 am
2 stops23h 12m
$752
Showing 1-10 of 11 resultsSorted by cheapest first
Best time to book a flight from Greenville to Medellín
Have a flexible travel schedule? Discover the best time to fly to Medellín from Greenville with our price prediction graph.
GSP-CO1
GSP-MDE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to Medellín
GSP-CO1
GSP-MDE
What is the cheapest month to book a flight from Greenville to Medellín?
Currently, August is the cheapest month in which you can book a flight from Greenville to Medellín (average of $676). Flying from Greenville to Medellín in October is currently the most expensive (average of $939). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Medellín
Get insights into the airlines that provide service to Medellín. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Medellín. Reviews last updated September 11, 2026.
Get a feel of what it's like to fly with American Airlines from Greenville to Medellín by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.2
Entertainment
6.8
Boarding
7.5
Crew
7.9
Overall
7.1
Food
6.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Comfort
7.2
Entertainment
6.8
Boarding
7.5
Crew
7.9
Overall
7.1
Food
6.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Greenville to Medellín. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Greenville and Medellín flights
Browse other Greenville and Medellín flight options. Last updated on September 11, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on September 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Greenville to Medellín
Discover the top airline that operate flights from Greenville to Medellín. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$566 | Average$797 | FlexibilityNo cancel fee | On-time71% |