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$135+ Cheap flights from Greenville (GSP) to Medellín

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — MDE
ene. 11 — ene. 181
dom. 1/11
dom. 1/18
1 adult, Economy
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Cheapflights Tip: The best prices from Greenville to Medellín are usually found in April or March, booked 57 days in advance, depart on a Wednesday or Monday and return on a Tuesday

Cheap flight deals from Greenville to Medellín

Cheapest flights from Greenville to Medellín
Explore the most affordable flight options available from Greenville to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/246:02 amGSP - MDE
1 stop15h 08mAmerican Airlines
mié. 1/147:00 amMDE - GSP
1 stop16h 57mAmerican Airlines
Deal found 12/11$778
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/158:03 pmGSP - MDE
1 stop17h 54mMultiple Airlines
vie. 1/211:50 amMDE - GSP
1 stop7h 33mMultiple Airlines
Deal found 12/10$782
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/275:00 amGSP - MDE
1 stop16h 10mAmerican Airlines
mar. 1/137:00 amMDE - GSP
1 stop16h 57mAmerican Airlines
Deal found 12/11$807
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/246:02 amGSP - MDE
1 stop15h 08mAmerican Airlines
jue. 1/157:00 amMDE - GSP
1 stop16h 57mAmerican Airlines
Deal found 12/11$816
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/238:07 pmGSP - MDE
1 stop17h 59mAmerican Airlines
jue. 1/157:00 amMDE - GSP
1 stop16h 57mAmerican Airlines
Deal found 12/11$826
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/125:28 pmGSP - MDE
2 stops28h 37mUnited Airlines
dom. 12/2810:45 amMDE - GSP
2 stops24h 11mUnited Airlines
Deal found 12/11$834

Find flight deals from Greenville to Medellín

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Medellín (CO1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated diciembre 12, 2025.

Round-trip from

$371
(Kiwi.com)

One-way from

$135
(Kiwi.com)

Popular in

September

Cheapest in

April

Average price

$821
From Greenville to Medellín
Search Deals
One-way flight from Greenville to Medellín
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($83 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Medellín that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
Use the filters below to find and compare flights from Greenville to Medellín that are best for you.

Fly from

Greenville

Fly to

Medellín

Route

Depart

Return

Price

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

jue. 2/5

5:45 pm-2:15 pm

1 stop20h 30m

Medellín Jose Maria Cordova Intl

sáb. 2/21

3:10 pm-4:27 pm

1 stop25h 17m

$371

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

vie. 1/2

8:58 pm-2:14 pm

1 stop17h 16m

Medellín Jose Maria Cordova Intl

mié. 1/14

2:50 pm-3:53 pm

2 stops25h 03m

$472

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

jue. 1/15

4:43 pm-1:55 pm

2 stops21h 12m

Medellín Jose Maria Cordova Intl

lun. 1/26

6:35 am-3:59 pm

1 stop9h 24m

$505

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

jue. 4/23

6:52 am-9:10 pm

1 stop15h 18m

Medellín Jose Maria Cordova Intl

dom. 5/3

9:45 am-10:16 pm

1 stop11h 31m

$516

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

jue. 2/5

6:05 am-9:10 pm

2 stops15h 05m

Medellín Jose Maria Cordova Intl

sáb. 2/21

7:00 am-11:33 pm

2 stops16h 33m

$521

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

vie. 1/23

6:56 pm-2:03 pm

1 stop19h 07m

Medellín Jose Maria Cordova Intl

dom. 2/8

7:00 am-11:57 pm

1 stop16h 57m

$546

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

vie. 1/9

6:56 pm-2:03 pm

1 stop19h 07m

Medellín Jose Maria Cordova Intl

vie. 1/16

7:00 am-11:57 pm

1 stop16h 57m

$556

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

lun. 2/23

6:22 pm-2:13 pm

1 stop19h 51m

$135

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

mar. 12/30

4:43 pm-2:14 pm

2 stops21h 31m

$277

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

mié. 1/7

7:00 am-9:10 pm

1 stop14h 10m

$310

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 12 results
1
2

Best time to book a flight from Greenville to Medellín

Have a flexible travel schedule? Discover the best time to fly to Medellín from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Medellín

How far ahead should I book a flight from Greenville to Medellín?

Use this chart to determine the optimal time to book a round-trip flight from Greenville to Medellín. Price data was last updated on December 5, 2025.

The best time to book flights from Greenville to Medellín is 57 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Greenville to Medellín?

Currently, November is the cheapest month in which you can book a flight from Greenville to Medellín (average of $270). Flying from Greenville to Medellín in June is currently the most expensive (average of $490). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to MDE?

Find hourly flight availability from Greenville to Medellín. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 12, 2025.

One of the essential ways to save on airfare from Greenville to Medellín is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 29% on airfare.

Reviews of airlines servicing Medellín

Get insights into the airlines that provide service to Medellín. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Medellín. Reviews last updated diciembre 12, 2025.
Get a feel of what it's like to fly with American Airlines from Greenville to Medellín by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,050 reviews

Entertainment

6.9

Overall

7.2

Comfort

7.2

Boarding

7.5

Crew

8.0

Food

6.5

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,050 reviews
American Airlines
7.2
Good
11,050 reviews

Entertainment

6.9

Overall

7.2

Comfort

7.2

Boarding

7.5

Crew

8.0

Food

6.5

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Greenville to Medellín. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Medellín?

    If you book a flight to Medellín from Greenville, you will be flying from Greenville, which is the city’s only airport. Greenville (GSP) is located 10.4 mi from the center of Greenville. There are 0 flights from Greenville to Medellín per day from 2 different airlines.

  • What is the cheapest airline to fly from Greenville to Medellín round-trip?

    American Airlines, at $515, was found to be the cheapest airline from Greenville to Medellín.. Users have found that American Airlines is 30% cheaper than the other options available to this destination.

  • Can I find deals for flights from Greenville to Medellín that include hotel bookings?

    Yes. In addition to deals on Greenville to Medellín flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Medellín?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Medellín.

  • Can I find deals for business class flights from Greenville to Medellín?

    Yes. Cheapflights offers flight deals from Greenville to Medellín by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Medellín?

    Currently, November is the cheapest month in which you can book a flight from Greenville to Medellín (average of $270). Flying from Greenville to Medellín in June is currently the most expensive (average of $490). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Greenville to Medellín

Discover the top 2 airlines that operate flights from Greenville to Medellín. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$515Average$732FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$670Average$776FlexibilityNo cancel feeOn-time81%

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