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$220+ Cheap flights from Greenville (GSP) to Medellín

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — MDE
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Greenville to Medellín are usually found in March or April, booked 57 days in advance, depart on a Wednesday or Monday and return on a Tuesday

Cheap flight deals from Greenville to Medellín

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Medellín (CO1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$428
(Kiwi.com)

One-way from

$220
(Kiwi.com)

Popular in

June

Cheapest in

March

Average price

$767
From Greenville to Medellín
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One-way flight from Greenville to Medellín
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Highest demand for flights based on searches. 7% potential increase in price ($54 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Greenville to Medellín

Cheapest flights from Greenville to Medellín
Explore the most affordable flight options available from Greenville to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:00 amGSP - MDE
1 stop9h 09mAmerican Airlines
Thu 11/207:00 amMDE - GSP
1 stop16h 59mAmerican Airlines
Deal found 9/11$506
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:00 amGSP - MDE
1 stop7h 35mAmerican Airlines
Mon 11/107:00 amMDE - GSP
1 stop16h 59mAmerican Airlines
Deal found 9/10$536
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/85:28 pmGSP - MDE
2 stops28h 37mUnited Airlines
Tue 11/1110:45 amMDE - GSP
1 stop11h 14mUnited Airlines
Deal found 9/9$544
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/206:00 amGSP - MDE
1 stop15h 15mAmerican Airlines
Tue 10/281:35 pmMDE - GSP
1 stop8h 46mAmerican Airlines
Deal found 9/11$546
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/18:03 pmGSP - MDE
2 stops25h 37mMultiple Airlines
Sun 12/72:54 pmMDE - GSP
1 stop28h 29mMultiple Airlines
Deal found 9/9$555
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/15:00 amGSP - MDE
1 stop16h 10mAmerican Airlines
Sat 12/61:30 amMDE - GSP
1 stop8h 26mAmerican Airlines
Deal found 9/10$560
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/112:25 pmGSP - MDE
2 stops33h 40mUnited Airlines
Sun 12/710:45 amMDE - GSP
2 stops24h 59mUnited Airlines
Deal found 9/10$561

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Medellín that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Greenville to Medellín that are best for you.

Fly from

Greenville

Fly to

Medellín

Route

Depart

Return

Price

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Thu 11/13

5:00 am-2:09 pm

1 stop9h 09m

Medellín Jose Maria Cordova Intl

Thu 11/20

7:00 am-11:59 pm

1 stop16h 59m

$506

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Fri 1/23

6:20 am-10:05 pm

2 stops15h 45m

Medellín Jose Maria Cordova Intl

Sun 2/8

10:45 am-9:57 pm

1 stop11h 12m

$526

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Fri 1/23

5:38 am-8:52 pm

1 stop15h 14m

Medellín Jose Maria Cordova Intl

Sun 2/8

6:50 am-3:43 pm

1 stop8h 53m

$526

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sat 10/25

8:50 am-8:15 pm

2 stops12h 25m

Medellín Jose Maria Cordova Intl

Sun 11/9

1:30 am-4:54 pm

2 stops15h 24m

$540

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sat 11/8

5:28 pm-10:05 pm

2 stops28h 37m

Medellín Jose Maria Cordova Intl

Tue 11/11

10:45 am-9:59 pm

1 stop11h 14m

$544

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Mon 10/20

6:00 am-8:15 pm

1 stop15h 15m

Medellín Jose Maria Cordova Intl

Tue 10/28

1:35 pm-11:21 pm

1 stop8h 46m

$546

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Thu 10/16

4:47 pm-11:33 pm

2 stops31h 46m

$220

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Wed 10/1

10:05 am-8:44 am

2 stops23h 39m

$244

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Thu 10/16

6:00 am-8:15 pm

1 stop15h 15m

$310

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Wed 10/1

7:00 am-9:10 pm

1 stop15h 10m

$310

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 13 results
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Best time to book a flight from Greenville to Medellín

Have a flexible travel schedule? Discover the best time to fly to Medellín from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Medellín

How far ahead should I book a flight from Greenville to Medellín?

Use this chart to determine the optimal time to book a round-trip flight from Greenville to Medellín. Price data was last updated on August 29, 2025.

The best time to book flights from Greenville to Medellín is 57 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Greenville to Medellín?

Currently, January is the cheapest month in which you can book a flight from Greenville to Medellín (average of $378). Flying from Greenville to Medellín in December is currently the most expensive (average of $625). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to MDE?

Find hourly flight availability from Greenville to Medellín. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

One of the essential ways to save on airfare from Greenville to Medellín is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 24% on airfare.

Reviews of airlines servicing Medellín

Get insights into the airlines that provide service to Medellín. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Medellín. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with American Airlines from Greenville to Medellín by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Food

6.4

Boarding

7.5

Overall

7.2

Entertainment

6.9

Crew

8.0

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Food

6.4

Boarding

7.5

Overall

7.2

Entertainment

6.9

Crew

8.0

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Greenville to Medellín. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Medellín?

    If you book a flight to Medellín from Greenville, you will be flying from Greenville, which is the city’s only airport. Greenville (GSP) is located 10.4 mi from the center of Greenville. There are 0 flights from Greenville to Medellín per day from 2 different airlines.

  • How long is the flight from Greenville to Medellín?

    American Airlines and United Airlines can get you from Greenville to Medellín in just under 9h 09m. Your travel time can differ by up to 6h 36m. Airlines will cover a distance of 2030 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Greenville to Medellín round-trip?

    American Airlines, at $515, was found to be the cheapest airline from Greenville to Medellín.. Users have found that American Airlines is 26% cheaper than the other options available to this destination.

  • Can I find deals for flights from Greenville to Medellín that include hotel bookings?

    Yes. In addition to deals on Greenville to Medellín flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Medellín?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Medellín.

  • Can I find deals for business class flights from Greenville to Medellín?

    Yes. Cheapflights offers flight deals from Greenville to Medellín by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Medellín?

    Currently, January is the cheapest month in which you can book a flight from Greenville to Medellín (average of $378). Flying from Greenville to Medellín in December is currently the most expensive (average of $625). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Greenville to Medellín

Discover the top 2 airlines that operate flights from Greenville to Medellín. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$515Average$741FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$728Average$764FlexibilityNo cancel feeOn-time81%

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