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$186+ Cheap flights from Greenville (GSP) to Medellín

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — MDE
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheap flight deals from Greenville to Medellín

Cheapest flights from Greenville to Medellín
Explore the most affordable flight options available from Greenville to Medellín. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/229:46 pm
GSP
-
MDE
1 stop27h 35m
Multiple Airlines
Wed 4/12:17 pm
MDE
-
GSP
1 stop24h 29m
Multiple Airlines
Deal found 3/8$378
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:28 pm
GSP
-
MDE
1 stop8h 53m
Multiple Airlines
Wed 4/12:17 pm
MDE
-
GSP
1 stop24h 29m
Multiple Airlines
Deal found 3/8$385
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/203:31 pm
GSP
-
MDE
1 stop9h 50m
Multiple Airlines
Wed 4/12:17 pm
MDE
-
GSP
1 stop24h 29m
Multiple Airlines
Deal found 3/8$411
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/229:46 pm
GSP
-
MDE
1 stop27h 35m
Multiple Airlines
Wed 3/251:17 am
MDE
-
GSP
1 stop18h 39m
Multiple Airlines
Deal found 3/8$415
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:28 pm
GSP
-
MDE
1 stop8h 53m
Multiple Airlines
Wed 3/251:17 am
MDE
-
GSP
1 stop18h 39m
Multiple Airlines
Deal found 3/8$422
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/269:46 pm
GSP
-
MDE
1 stop27h 35m
Multiple Airlines
Wed 4/12:17 pm
MDE
-
GSP
1 stop24h 29m
Multiple Airlines
Deal found 3/8$428
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/203:31 pm
GSP
-
MDE
1 stop9h 50m
Multiple Airlines
Wed 3/251:17 am
MDE
-
GSP
1 stop18h 39m
Multiple Airlines
Deal found 3/8$448
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/229:46 pm
GSP
-
MDE
1 stop27h 35m
Multiple Airlines
Sun 3/291:17 am
MDE
-
GSP
1 stop15h 38m
Multiple Airlines
Deal found 3/8$453
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/135:43 pm
GSP
-
MDE
1 stop7h 38m
Multiple Airlines
Sat 4/2510:05 pm
MDE
-
GSP
2 stops41h 48m
Multiple Airlines
Deal found 3/5$455
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:18 pm
GSP
-
MDE
1 stop14h 33m
Multiple Airlines
Sun 4/261:55 pm
MDE
-
GSP
1 stop28h 43m
Multiple Airlines
Deal found 3/5$457

Find flight deals from Greenville to Medellín

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Medellín (CO1). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.

Round-trip from

$378
(Kiwi.com)

One-way from

$186
(Trip.com)

Popular in

September

Cheapest in

July

Average price

$717
From Greenville to Medellín
Search Deals
One-way flight from Greenville to Medellín
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($67 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Medellín that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Greenville to Medellín that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Mon 5/18

6:00 am-8:15 pm

1 stop15h 15m

Medellín Jose Maria Cordova Intl

Tue 6/2

6:00 am-7:45 pm

1 stop12h 45m

$520

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sun 5/10

6:36 am-9:10 pm

2 stops39h 34m

Medellín Jose Maria Cordova Intl

Mon 5/18

9:45 am-9:47 am

2 stops23h 02m

$561

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sun 4/12

7:00 am-9:10 pm

1 stop15h 10m

Medellín Jose Maria Cordova Intl

Sun 4/26

9:45 am-9:45 am

2 stops23h 00m

$585
Quickest round-trip

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sun 4/19

1:08 pm-10:30 pm

2 stops10h 22m

Medellín Jose Maria Cordova Intl

Thu 4/23

7:55 am-11:56 pm

2 stops15h 01m

$605

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sun 5/10

7:52 am-8:15 pm

2 stops13h 23m

Medellín Jose Maria Cordova Intl

Mon 5/18

1:53 pm-9:51 am

2 stops18h 58m

$607

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sun 4/19

6:30 am-9:10 pm

2 stops15h 40m

Medellín Jose Maria Cordova Intl

Thu 4/23

9:45 am-9:46 am

2 stops23h 01m

$619
Cheapest one-way

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Mon 4/20

5:43 pm-9:25 pm

1 stop28h 42m

$186

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Thu 4/30

6:06 pm-1:08 pm

3 stops44h 02m

$277
Quickest one-way

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Thu 4/30

6:00 am-12:48 pm

1 stop7h 48m

$315

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Wed 4/15

6:00 am-8:15 pm

1 stop15h 15m

$318

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/6

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

Best time to book a flight from Greenville to Medellín

Have a flexible travel schedule? Discover the best time to fly to Medellín from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Medellín

How far ahead should I book a flight from Greenville to Medellín?

Use this chart to determine the optimal time to book a round-trip flight from Greenville to Medellín. Price data was last updated on March 6, 2026.

The best time to book flights from Greenville to Medellín is 53 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Greenville to Medellín?

Currently, February is the cheapest month in which you can book a flight from Greenville to Medellín (average of $270). Flying from Greenville to Medellín in June is currently the most expensive (average of $452). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Medellín

Get insights into the airlines that provide service to Medellín. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Medellín. Reviews last updated March 10, 2026.
Get a feel of what it's like to fly with American Airlines from Greenville to Medellín by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,414 reviews

Boarding

7.5

Food

6.4

Entertainment

6.9

Crew

7.9

Overall

7.1

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,414 reviews
American Airlines
7.1
Good
11,414 reviews

Boarding

7.5

Food

6.4

Entertainment

6.9

Crew

7.9

Overall

7.1

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Greenville to Medellín. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Medellín?

    If you book a flight to Medellín from Greenville, you will be flying from Greenville, which is the city’s only airport. Greenville (GSP) is located 10.4 mi from the center of Greenville. There are 0 flights from Greenville to Medellín per day from 1 airline.

  • What is the cheapest airline to fly from Greenville to Medellín round-trip?

    American Airlines, at $515, was found to be the cheapest airline from Greenville to Medellín.. Users have found that American Airlines is 32% cheaper than the other options available to this destination.

  • Can I find deals for flights from Greenville to Medellín that include hotel bookings?

    Yes. In addition to deals on Greenville to Medellín flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Medellín?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Medellín.

  • Can I find deals for business class flights from Greenville to Medellín?

    Yes. Cheapflights offers flight deals from Greenville to Medellín by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Medellín?

    Currently, February is the cheapest month in which you can book a flight from Greenville to Medellín (average of $270). Flying from Greenville to Medellín in June is currently the most expensive (average of $452). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Greenville to Medellín

Discover the top airline that operate flights from Greenville to Medellín. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$515Average$755FlexibilityNo cancel feeOn-time71%

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