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$456+ Cheap flights from Des Moines (DSM) to Lucerne, Switzerland

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ZRH
ago 7 — ago 141
qui 8/7
qui 8/14
1 adult, Economy
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Cheap flight deals from Des Moines to Lucerne

Keep the following information in mind while searching for Des Moines to Lucerne flight deals. Data was last updated agosto 2, 2025.

Round-trip from

$722
(American Airlines)

One-way from

$456
(EaseMyTrip)

Popular in

June

Cheapest in

November

Average price

$937
From Des Moines to Lucerne
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One-way flight from Des Moines to Lucerne
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Highest demand for flights based on searches. 25% potential increase in price ($340 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($65 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Des Moines to Lucerne

Cheapest flights from Des Moines to Lucerne
Explore the most affordable flight options available from Des Moines to Lucerne. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 2, 2025.

This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 8/2212:44 pmDSM - ZRH
1 stop13h 06mAmerican Airlines
sex 8/2911:45 amZRH - DSM
1 stop17h 00mAmerican Airlines
Deal found 8/1$722
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 9/91:10 pmDSM - ZRH
2 stops15h 25mUnited Airlines
dom 9/141:25 pmZRH - DSM
2 stops31h 45mUnited Airlines
Deal found 7/31$741
This Flightnetwork deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 9/148:00 amDSM - ZRH
2 stops15h 10mAir Canada
dom 9/2112:40 pmZRH - DSM
2 stops35h 34mAir Canada
Deal found 7/31$761
This Booking.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 9/153:25 pmDSM - ZRH
2 stops31h 45mMultiple Airlines
seg 9/226:05 pmZRH - DSM
2 stops34h 40mMultiple Airlines
Deal found 8/1$765
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 9/156:00 amDSM - ZRH
2 stops21h 35mDelta
seg 9/2210:10 amZRH - DSM
1 stop19h 27mDelta
Deal found 8/1$807
This Ovago deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 9/164:25 pmDSM - ZRH
2 stops19h 30mBritish Airways
dom 9/287:40 pmZRH - DSM
2 stops34h 48mBritish Airways
Deal found 8/1$849

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Lucerne that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 2, 2025.
Use the filters below to find and compare flights from Des Moines to Lucerne that are best for you.

Fly from

Des Moines

Fly to

Lucerne

Route

Depart

Return

Price

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

sex 8/22

12:44 pm-8:50 am

1 stop13h 06m

Zurich

sex 8/29

11:45 am-9:45 pm

1 stop17h 00m

$722

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

ter 9/9

1:10 pm-11:35 am

2 stops15h 25m

Zurich

dom 9/14

1:25 pm-2:10 pm

2 stops31h 45m

$741

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

dom 9/14

8:00 am-6:10 am

2 stops15h 10m

Zurich

dom 9/21

12:40 pm-5:14 pm

2 stops35h 34m

$761

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

seg 9/15

3:25 pm-6:10 am

2 stops31h 45m

Zurich

seg 9/22

6:05 pm-9:45 pm

2 stops34h 40m

$765

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

seg 9/15

6:00 am-10:35 am

2 stops21h 35m

Zurich

seg 9/22

10:10 am-10:37 pm

1 stop19h 27m

$807

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

ter 9/16

4:25 pm-6:55 pm

2 stops19h 30m

Zurich

dom 9/28

7:40 pm-11:28 pm

2 stops34h 48m

$849

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

dom 9/14

8:00 am-6:10 am

2 stops15h 10m

$456

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

dom 9/14

8:00 am-10:50 am

1 stop19h 50m

$468

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

ter 9/16

6:00 am-8:50 am

1 stop19h 50m

$575

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Best time to book a flight from Des Moines to Lucerne

Have a flexible travel schedule? Discover the best time to fly to Lucerne from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Lucerne

What is the cheapest month to book a flight from Des Moines to Lucerne?

Currently, November is the cheapest month in which you can book a flight from Des Moines to Lucerne (average of $637). Flying from Des Moines to Lucerne in June is currently the most expensive (average of $1,152). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Lucerne

Get insights into the airlines that provide service to Lucerne. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Lucerne. Reviews last updated agosto 2, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Lucerne have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,983 reviews
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,904 reviews
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Air Canada
7.1
Good
9,855 reviews
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
British Airways
6.6
Okay
7,224 reviews
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Lucerne. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Lucerne?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Lucerne from Des Moines. Booking flights from Des Moines (DSM) to Lucerne should be relatively easy as there are 0 daily outbound flights to Lucerne from 1 airline.

  • What are the cheapest airlines to fly from Des Moines to Lucerne one-way?

    To fly one-way, consider booking your trip with Air Canada, which is currently one of the cheapest options available, starting at $456. United Airlines flights start at $468 while deals on American Airlines start at $575 one-way.

  • Can I find deals for flights from Des Moines to Lucerne that include hotel bookings?

    Yes. In addition to deals on Des Moines to Lucerne flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Lucerne?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Lucerne.

  • Can I find deals for business class flights from Des Moines to Lucerne?

    Yes. Cheapflights offers flight deals from Des Moines to Lucerne by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Lucerne?

    Currently, November is the cheapest month in which you can book a flight from Des Moines to Lucerne (average of $637). Flying from Des Moines to Lucerne in June is currently the most expensive (average of $1,152). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Des Moines to Lucerne

Discover the top airline that operate flights from Des Moines to Lucerne. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$594Average$1,001FlexibilityNo cancel feeOn-time69%

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