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$468+ Cheap flights from Des Moines (DSM) to Lucerne, Switzerland

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ZRH
Oct 24 — Oct 311
Fri 10/24
Fri 10/31
1 adult, Economy
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Cheap flight deals from Des Moines to Lucerne

Keep the following information in mind while searching for Des Moines to Lucerne flight deals. Data was last updated September 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$604
(lol.travel)

One-way from

$468
(Flightnetwork)

Popular in

June

Cheapest in

November

Average price

$859
Provider with most accurate pricing for Des Moines-Zurich flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Zurich flights.
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From Des Moines to Lucerne
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One-way flight from Des Moines to Lucerne
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Highest demand for flights based on searches. 28% potential increase in price ($377 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($69 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Lucerne

Cheapest flights from Des Moines to Lucerne
Explore the most affordable flight options available from Des Moines to Lucerne. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2025.

This lol.travel deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/78:02 amDSM - ZRH
2 stops16h 38mUnited Airlines
Fri 11/1411:45 amZRH - DSM
2 stops16h 47mUnited Airlines
Deal found 9/23$604
This Flighttix deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/611:26 amDSM - ZRH
2 stops14h 14mUnited Airlines
Thu 11/1311:45 amZRH - DSM
2 stops16h 47mUnited Airlines
Deal found 9/23$622
This Flighttix deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/72:13 pmDSM - ZRH
2 stops36h 27mScandinavian Airlines
Fri 11/148:25 pmZRH - DSM
2 stops33h 08mScandinavian Airlines
Deal found 9/23$623
This Billigflug deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/611:26 amDSM - ZRH
2 stops14h 14mAir Canada
Thu 11/139:40 amZRH - DSM
1 stop14h 45mAir Canada
Deal found 9/22$624
This Billigflug deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Billigflug is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/61:05 pmDSM - ZRH
1 stop11h 50mMultiple Airlines
Thu 11/131:10 pmZRH - DSM
1 stop28h 20mMultiple Airlines
Deal found 9/22$627

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Lucerne that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 24, 2025.
Use the filters below to find and compare flights from Des Moines to Lucerne that are best for you.

Fly from

Des Moines

Fly to

Lucerne

Route

Depart

Return

Price

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

Thu 11/6

11:26 am-8:40 am

2 stops14h 14m

Zurich

Thu 11/13

9:40 am-8:45 pm

2 stops18h 05m

$622

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

Fri 11/7

5:45 am-10:25 am

2 stops21h 40m

Zurich

Fri 11/14

12:40 pm-9:32 pm

2 stops39h 52m

$635

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

Thu 11/6

1:05 pm-7:55 am

1 stop11h 50m

Zurich

Thu 11/13

1:20 pm-2:19 pm

2 stops31h 59m

$637

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

Fri 11/7

1:35 pm-2:45 pm

2 stops18h 10m

Zurich

Fri 11/14

1:20 pm-4:13 pm

2 stops33h 53m

$640

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

Fri 11/7

6:50 pm-6:15 am

2 stops52h 25m

$468

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

Fri 11/7

1:05 pm-10:40 am

1 stop14h 35m

$518

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

Thu 11/6

5:42 am-8:15 am

2 stops19h 33m

$518

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

Thu 11/6

8:02 am-7:55 am

1 stop16h 53m

$518

Des MoinesZurich

DSM - ZRH

DSMZRH

Des Moines

Thu 11/6

10:50 am-6:25 pm

3 stops24h 35m

$2,919

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/23

Best time to book a flight from Des Moines to Lucerne

Have a flexible travel schedule? Discover the best time to fly to Lucerne from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Lucerne

What is the cheapest month to book a flight from Des Moines to Lucerne?

Currently, November is the cheapest month in which you can book a flight from Des Moines to Lucerne (average of $637). Flying from Des Moines to Lucerne in June is currently the most expensive (average of $1,146). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Lucerne?

Reviews of airlines servicing Lucerne

Get insights into the airlines that provide service to Lucerne. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Lucerne. Reviews last updated September 24, 2025.
See what other customers who have flown with United Airlines from Des Moines to Lucerne have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,928 reviews

Comfort

7.3

Crew

8.1

Boarding

7.7

Food

6.6

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
4.0
Okay

Tim,Sep 2025

IAD - GSP

This was pretty bad. It’s chaos at the Dulles boarding gates for the small regional jets because they use one gate to board 3-4 flights at a time. So, it’s difficult knowing where and when to go. There is little space for any size of carrry-on, so most had to gate check their bags. However, the worst of it was that our single flight attendant fell asleep before we took off and the pilot couldn’t do so until she responded to his messages. My wife had to wake her up! So we were a little late leaving. Not to be thwarted, the flight attendant fell asleep right after take off and there was no sight of her during the flight. When the aircraft touched down, a tray of unsecured canned drinks came crashing onto the aisle up front. I can only assume someone didn’t do what they were supposed to. The pilot was great, but I’m sure he must not be happy with this crew member.
United Airlines
7.4
Good
8,928 reviews
United Airlines
7.4
Good
8,928 reviews

Comfort

7.3

Crew

8.1

Boarding

7.7

Food

6.6

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
4.0
Okay

Tim,Sep 2025

IAD - GSP

This was pretty bad. It’s chaos at the Dulles boarding gates for the small regional jets because they use one gate to board 3-4 flights at a time. So, it’s difficult knowing where and when to go. There is little space for any size of carrry-on, so most had to gate check their bags. However, the worst of it was that our single flight attendant fell asleep before we took off and the pilot couldn’t do so until she responded to his messages. My wife had to wake her up! So we were a little late leaving. Not to be thwarted, the flight attendant fell asleep right after take off and there was no sight of her during the flight. When the aircraft touched down, a tray of unsecured canned drinks came crashing onto the aisle up front. I can only assume someone didn’t do what they were supposed to. The pilot was great, but I’m sure he must not be happy with this crew member.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Lucerne. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Lucerne?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Lucerne from Des Moines. Booking flights from Des Moines (DSM) to Lucerne should be relatively easy as there are 0 daily outbound flights to Lucerne from 1 airline.

  • How long is the flight from Des Moines to Lucerne?

    Airlines like Air Canada and United Airlines fly from Des Moines to Lucerne in about 11h 50m. The time it takes to get you to your destination can typically vary by up to 2h 24m. The distance from Des Moines to Lucerne is about 4666 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to Lucerne one-way?

    To fly one-way, consider booking your trip with Air Canada, which is currently one of the cheapest options available, starting at $468. United Airlines flights start at $518 while deals on American Airlines start at $518 one-way.

  • Can I find deals for flights from Des Moines to Lucerne that include hotel bookings?

    Yes. In addition to deals on Des Moines to Lucerne flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Lucerne?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Lucerne.

  • Can I find deals for business class flights from Des Moines to Lucerne?

    Yes. Cheapflights offers flight deals from Des Moines to Lucerne by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Lucerne?

    Currently, November is the cheapest month in which you can book a flight from Des Moines to Lucerne (average of $637). Flying from Des Moines to Lucerne in June is currently the most expensive (average of $1,146). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Des Moines to Lucerne

Discover the top airline that operate flights from Des Moines to Lucerne. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$607Average$1,030FlexibilityNo cancel feeOn-time69%

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