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$351+ Cheap flights from Panama to Louisville (SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/22. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SDF
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Panama to Louisville

Cheapest flights from Panama to Louisville
Explore the most affordable flight options available from Panama to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:55 pmPTY - SDF
2 stops15h 55mAmerican Airlines
Mon 1/126:00 amSDF - PTY
1 stop9h 38mAmerican Airlines
Deal found 12/15$536
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:55 amPTY - SDF
2 stops13h 35mUnited Airlines
Mon 1/125:35 amSDF - PTY
2 stops14h 03mUnited Airlines
Deal found 12/15$569
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:53 pmPTY - SDF
2 stops22h 37mAmerican Airlines
Thu 1/87:20 pmSDF - PTY
2 stops20h 18mAmerican Airlines
Deal found 12/17$604
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:55 amPTY - SDF
1 stop27h 11mUnited Airlines
Sun 1/43:25 pmSDF - PTY
1 stop25h 42mUnited Airlines
Deal found 12/17$613
This Mytrip deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2211:25 amPTY - SDF
2 stops12h 34mMultiple Airlines
Sun 1/45:05 amSDF - PTY
3 stops19h 55mMultiple Airlines
Deal found 12/17$995
This Mytrip deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:50 pmPTY - SDF
3 stops30h 09mMultiple Airlines
Mon 1/121:55 pmSDF - PTY
3 stops20h 35mMultiple Airlines
Deal found 12/15$1,007

Find flight deals from Panama to Louisville

Keep the following information in mind while searching for Panama to Louisville flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$449
(United Airlines)

One-way from

$351
(United Airlines)

Popular in

January

Cheapest in

December

Average price

$386
Provider with most accurate pricing for Panama City Tocumen Intl-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Louisville Intl flights.
Search Deals
From Panama to Louisville Intl
Search Deals
One-way flight from Panama to Louisville Intl
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($155 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 13% potential price decrease ($70 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Panama to Louisville that are best for you.

Fly from

Panama

Fly to

Louisville

Route

Depart

Return

Price

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Fri 5/1

10:55 pm-8:14 pm

2 stops20h 19m

Louisville Intl

Mon 5/11

6:00 pm-4:12 pm

2 stops23h 12m

$449

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Sat 1/31

4:41 pm-10:23 am

2 stops17h 42m

Louisville Intl

Sat 2/7

2:05 pm-2:45 pm

2 stops24h 40m

$451

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Wed 2/18

4:41 pm-1:23 pm

2 stops20h 42m

Louisville Intl

Sat 2/21

5:35 am-8:02 pm

2 stops14h 27m

$463

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Mon 12/22

8:55 am-10:30 pm

2 stops13h 35m

$351

Panama CityLouisville

PTY - SDF

PTYSDF

Panama City Tocumen Intl

Sun 12/21

2:55 am-11:59 pm

3 stops21h 04m

$519

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Best time to book a flight from Panama to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Louisville

What is the cheapest month to book a flight from Panama to Louisville?

Currently, December is the cheapest month in which you can book a flight from Panama to Louisville (average of $203). Flying from Panama to Louisville in January is currently the most expensive (average of $575). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SDF?

Find hourly flight availability from Panama to Louisville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama to Louisville in the evening. If you’re flexible enough to do this you can expect to save up to 23% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated December 18, 2025.
Peruse reviews from past customers who have flown with United Airlines from Panama to Louisville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,091 reviews

Boarding

7.7

Overall

7.4

Comfort

7.3

Crew

8.1

Entertainment

7.1

Food

6.6

Reviews

1 / 20
4.0
Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability
United Airlines
7.4
Good
9,091 reviews
United Airlines
7.4
Good
9,091 reviews

Boarding

7.7

Overall

7.4

Comfort

7.3

Crew

8.1

Entertainment

7.1

Food

6.6

Reviews

1 / 20
4.0
Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability

Related info for your journey

Find useful and relevant information for your journey from Panama to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Louisville from Panama?

    Located just 5.3 mi from the city center, Louisville Intl (SDF) is the airport most travelers will use when flying to Louisville from Panama.

  • How long is the flight from Panama to Louisville?

    A quick flight from Panama to Louisville can take about 20h 19m. United Airlines provides one of the quickest options available for as low as $449. Panama and Louisville are separated by a distance of 2048 mi.

  • Can I find deals for flights from Panama to Louisville that include hotel bookings?

    Yes. In addition to deals on Panama to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Louisville.

  • Can I find deals for business class flights from Panama to Louisville?

    Yes. Cheapflights offers flight deals from Panama to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Louisville?

    Currently, December is the cheapest month in which you can book a flight from Panama to Louisville (average of $203). Flying from Panama to Louisville in January is currently the most expensive (average of $575). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Alternative routes for Panama to Louisville

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama to Louisville

Discover the top airline that operate flights from Panama to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$366Average$557FlexibilityNo cancel feeOn-time69%

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