HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Louisville

$580+ Cheap flights from La Crosse to Louisville (LSE - SDF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — SDF
Feb 23 — Mar 21
Mon 2/23
Mon 3/2
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from La Crosse to Louisville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from La Crosse to Louisville

Cheapest flights from La Crosse to Louisville
Explore the most affordable flight options available from La Crosse to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 24, 2026.

This American Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:29 pm
LSE
-
SDF
1 stop16h 01m
American Airlines
Fri 2/276:12 pm
SDF
-
LSE
1 stop17h 43m
American Airlines
Deal found 1/22$580

Find flight deals from La Crosse to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$580
(American Airlines)
Provider with most accurate pricing for La Crosse-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for La Crosse-Louisville Intl flights.
Search Deals
From La Crosse to Louisville Intl
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 24, 2026.
Use the filters below to find and compare flights from La Crosse to Louisville that are best for you.

Fly from

La Crosse

Fly to

Louisville

Route

Depart

Return

Price

La CrosseLouisville

LSE - SDF

LSESDF

La Crosse

Mon 2/23

6:29 pm-11:30 am

1 stop16h 01m

Louisville Intl

Fri 2/27

6:12 pm-10:55 am

1 stop17h 43m

$580

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/22

  • Most accurate provider: When it comes to deals on La Crosse-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on La Crosse-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from La Crosse to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from La Crosse to Louisville?

    A quick flight from La Crosse to Louisville can take about 16h 01m. American Airlines provides one of the quickest options available for as low as $580. Airlines will cover a distance of 487 mi.

  • Can I find deals for flights from La Crosse to Louisville that include hotel bookings?

    Yes. In addition to deals on La Crosse to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to Louisville.

  • Can I find deals for business class flights from La Crosse to Louisville?

    Yes. Cheapflights offers flight deals from La Crosse to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for La Crosse to Louisville

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Nashville flights
Minneapolis to Nashville flights
O'Hare Intl to Knoxville flights
Appleton to Nashville flights
Minneapolis to Cincinnati flights
O'Hare Intl to Cincinnati flights
Milwaukee to Nashville flights
O'Hare Intl to Louisville flights
Madison to Nashville flights
Minneapolis to Knoxville flights
Minneapolis to Louisville flights
O'Hare Intl to Lexington flights
Appleton to Knoxville flights
Milwaukee to Knoxville flights
Green Bay to Nashville flights
Minneapolis to Lexington flights
Duluth to Nashville flights
Madison to Lexington flights
Madison to Cincinnati flights
Appleton to Cincinnati flights
Madison to Knoxville flights
Milwaukee to Louisville flights
Eau Claire to Nashville flights
Milwaukee to Lexington flights
Wausau to Nashville flights
Milwaukee to Cincinnati flights
O'Hare Intl to Owensboro flights
Madison to Louisville flights
O'Hare Intl to Evansville flights
O'Hare Intl to Paducah flights
Minneapolis to Evansville flights
Green Bay to Cincinnati flights
O'Hare Intl to Blountville flights
Green Bay to Knoxville flights
Appleton to Lexington flights
Wausau to Cincinnati flights
La Crosse to Nashville flights
Appleton to Louisville flights
Duluth to Knoxville flights
Madison to Blountville flights
Rhinelander to Cincinnati flights
Duluth to Louisville flights
Escanaba to Nashville flights
Wausau to Louisville flights
O'Hare Intl to Huntington flights
Wausau to Knoxville flights
Minneapolis to Huntington flights
Minneapolis to Blountville flights
Wausau to Lexington flights
Milwaukee to Evansville flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.