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$110+ Cheap flights from Knoxville (TYS) to Louisiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Knoxville to Louisiana

Keep the following information in mind while searching for Knoxville to Louisiana flight deals. Data was last updated October 30, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$216
(Kiwi.com)

One-way from

$110
(Trip.com)

Popular in

March

Cheapest in

August

Average price

$408
Provider with most accurate pricing for Knoxville McGhee Tyson-New Orleans Louis Armstrong flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-New Orleans Louis Armstrong flights.
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From Knoxville McGhee Tyson to Louisiana
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One-way flight from Knoxville McGhee Tyson to Louisiana
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Highest demand for flights based on searches. 12% potential increase in price ($53 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Knoxville to Louisiana

Cheapest flights from Knoxville to Louisiana
Explore the most affordable flight options available from Knoxville to Louisiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/139:54 amTYS - MSY
2 stops31h 18mMultiple Airlines
Mon 11/178:59 pmMSY - TYS
1 stop12h 35mMultiple Airlines
Deal found 10/29$216
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/139:54 amTYS - MSY
2 stops31h 18mMultiple Airlines
Sat 11/159:48 pmMSY - TYS
1 stop10h 16mMultiple Airlines
Deal found 10/29$233
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/239:31 amTYS - BTR
1 stop5h 04mDelta
Fri 11/286:55 pmBTR - TYS
1 stop3h 46mDelta
Deal found 10/29$249
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1412:21 pmTYS - MSY
1 stop25h 30mMultiple Airlines
Fri 12/195:56 pmMSY - TYS
1 stop26h 38mMultiple Airlines
Deal found 10/29$249
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:10 amTYS - BTR
1 stop5h 40mAmerican Airlines
Tue 11/187:29 amBTR - TYS
1 stop6h 23mAmerican Airlines
Deal found 10/28$254
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:30 amTYS - MSY
1 stop18h 50mMultiple Airlines
Tue 11/112:30 pmMSY - TYS
1 stop24h 12mMultiple Airlines
Deal found 10/29$254
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:10 amTYS - BTR
1 stop5h 40mAmerican Airlines
Mon 11/176:34 pmBTR - TYS
1 stop4h 34mAmerican Airlines
Deal found 10/28$259
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/158:45 amTYS - BTR
1 stop4h 44mDelta
Tue 11/182:21 pmBTR - TYS
1 stop3h 41mDelta
Deal found 10/28$264
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:38 pmTYS - MSY
1 stop15h 57mMultiple Airlines
Mon 11/108:59 pmMSY - TYS
1 stop12h 35mMultiple Airlines
Deal found 10/28$277
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:18 pmTYS - BTR
1 stop5h 37mAmerican Airlines
Tue 11/185:30 amBTR - TYS
2 stops10h 07mAmerican Airlines
Deal found 10/27$329
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/286:00 amTYS - BTR
1 stop4h 39mDelta
Fri 11/286:55 pmBTR - TYS
1 stop3h 46mDelta
Deal found 10/27$364
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/318:15 amTYS - BTR
1 stop4h 24mAmerican Airlines
Tue 11/46:34 pmBTR - TYS
1 stop4h 34mAmerican Airlines
Deal found 10/29$369

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Louisiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Knoxville to Louisiana that are best for you.

Fly from

Knoxville

Fly to

Louisiana

Route

Depart

Return

Price

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Thu 11/13

9:54 am-4:12 pm

2 stops31h 18m

New Orleans Louis Armstrong

Mon 11/17

8:59 pm-10:34 am

1 stop12h 35m

$216

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Thu 1/22

9:29 am-3:36 pm

1 stop7h 07m

New Orleans Louis Armstrong

Mon 1/26

8:38 pm-12:10 pm

1 stop14h 32m

$226

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Thu 1/22

1:39 pm-7:35 am

2 stops18h 56m

New Orleans Louis Armstrong

Sun 1/25

8:38 pm-5:28 pm

1 stop19h 50m

$231

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Sun 11/23

9:31 am-1:35 pm

1 stop5h 04m

Baton Rouge Ryan

Fri 11/28

6:55 pm-11:41 pm

1 stop3h 46m

$249

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Thu 11/13

5:10 am-9:50 am

1 stop5h 40m

Baton Rouge Ryan

Tue 11/18

7:29 am-2:52 pm

1 stop6h 23m

$254

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Sat 11/15

8:45 am-12:29 pm

1 stop4h 44m

Baton Rouge Ryan

Tue 11/18

6:00 am-10:45 am

1 stop3h 45m

$254

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Sun 11/9

6:30 am-12:20 am

1 stop18h 50m

New Orleans Louis Armstrong

Tue 11/11

2:30 pm-3:42 pm

1 stop24h 12m

$254

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Thu 11/13

5:10 am-9:50 am

1 stop5h 40m

Baton Rouge Ryan

Mon 11/17

6:34 pm-12:08 am

1 stop4h 34m

$259

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Wed 2/18

12:00 pm-4:39 pm

1 stop5h 39m

Lafayette Regional

Sat 2/21

6:00 am-1:26 pm

1 stop6h 26m

$260

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Sun 12/14

5:23 pm-4:27 pm

2 stops24h 04m

New Orleans Louis Armstrong

Fri 12/19

5:56 pm-9:34 pm

1 stop26h 38m

$268

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 24 results
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Best time to book a flight from Knoxville to Louisiana

Have a flexible travel schedule? Discover the best time to fly to Louisiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Louisiana

What is the cheapest month to book a flight from Knoxville to Louisiana?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Louisiana (average of $164). Flying from Knoxville to Louisiana in June is currently the most expensive (average of $238). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to LA?

Find hourly flight availability from Knoxville to Louisiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 31% on flights from Knoxville to Louisiana by exploring options for tickets in the evening.

What is the cheapest day to fly from Knoxville to Louisiana?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Louisiana. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Louisiana flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Louisiana

Get insights into the airlines that provide service to Louisiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisiana. Reviews last updated October 30, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Louisiana have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Louisiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Louisiana?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Louisiana from Knoxville.

  • How long is the flight from Knoxville to Louisiana?

    There are many flights that can get you from Knoxville to Louisiana in 5h 04m. Fly via Delta or American Airlines to get the fastest option. There are 551 mi between Knoxville and Louisiana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to Louisiana?

    The most popular flight routes from Knoxville to Louisiana are Knoxville McGhee Tyson - New Orleans Louis Armstrong, Knoxville McGhee Tyson - Baton Rouge Ryan and Knoxville McGhee Tyson - Lafayette Regional.

  • Can I find deals for flights from Knoxville to Louisiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Louisiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Louisiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Louisiana.

  • Can I find deals for business class flights from Knoxville to Louisiana?

    Yes. Cheapflights offers flight deals from Knoxville to Louisiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Louisiana?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Louisiana (average of $164). Flying from Knoxville to Louisiana in June is currently the most expensive (average of $238). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Louisiana

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Louisiana

Discover the top 3 airlines that operate flights from Knoxville to Louisiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$223Average$438FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$223Average$392FlexibilityNo cancel feeOn-time71%
DeltaCheapest$243Average$369FlexibilityNo cancel feeOn-timeN/A

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