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$97+ Cheap flights from Knoxville (TYS) to Louisiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/1. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Knoxville to Louisiana

Keep the following information in mind while searching for Knoxville to Louisiana flight deals. Data was last updated September 11, 2025.

Round-trip from

$240
(Kiwi.com)

One-way from

$97
(American Airlines)

Popular in

March

Cheapest in

August

Average price

$363
From Knoxville McGhee Tyson to Louisiana
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One-way flight from Knoxville McGhee Tyson to Louisiana
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Highest demand for flights based on searches. 15% potential increase in price ($67 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Louisiana

Cheapest flights from Knoxville to Louisiana
Explore the most affordable flight options available from Knoxville to Louisiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/72:55 pmTYS - MSY
1 stop4h 14mDelta
Tue 10/146:20 amMSY - TYS
1 stop6h 22mDelta
Deal found 9/9$217
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:53 pmTYS - MSY
1 stop10h 12mMultiple Airlines
Thu 12/49:51 pmMSY - TYS
2 stops24h 20mMultiple Airlines
Deal found 9/9$224
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/189:58 pmTYS - MSY
1 stop26h 23mMultiple Airlines
Sun 10/268:00 amMSY - TYS
2 stops34h 32mMultiple Airlines
Deal found 9/10$240
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/224:26 pmTYS - MSY
1 stop8h 27mMultiple Airlines
Sat 11/16:41 amMSY - TYS
1 stop26h 22mMultiple Airlines
Deal found 9/9$248
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/132:50 pmTYS - BTR
1 stop4h 09mDelta
Mon 11/176:50 pmBTR - TYS
1 stop4h 02mDelta
Deal found 9/11$249
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:19 pmTYS - BTR
1 stop6h 47mAmerican Airlines
Tue 9/305:30 amBTR - TYS
1 stop6h 42mAmerican Airlines
Deal found 9/9$254
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:55 pmTYS - MSY
1 stop6h 57mMultiple Airlines
Mon 9/299:57 pmMSY - TYS
2 stops36h 58mMultiple Airlines
Deal found 9/10$256
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/243:26 pmTYS - MSY
1 stop9h 27mMultiple Airlines
Mon 10/276:10 pmMSY - TYS
1 stop15h 23mMultiple Airlines
Deal found 9/10$262
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/224:26 pmTYS - MSY
1 stop8h 27mMultiple Airlines
Sun 10/266:41 amMSY - TYS
1 stop12h 44mMultiple Airlines
Deal found 9/9$269
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:47 pmTYS - BTR
1 stop5h 16mAmerican Airlines
Mon 10/206:36 pmBTR - TYS
1 stop4h 14mAmerican Airlines
Deal found 9/9$274
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:45 amTYS - BTR
1 stop4h 22mDelta
Sun 9/286:20 amBTR - TYS
1 stop3h 36mDelta
Deal found 9/11$284
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/111:34 amTYS - BTR
1 stop5h 15mDelta
Tue 11/41:06 pmBTR - TYS
1 stop6h 04mDelta
Deal found 9/8$289

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Louisiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Knoxville to Louisiana that are best for you.

Fly from

Knoxville

Fly to

Louisiana

Route

Depart

Return

Price

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Tue 10/7

2:55 pm-6:09 pm

1 stop4h 14m

New Orleans Louis Armstrong

Tue 10/14

6:20 am-1:42 pm

1 stop6h 22m

$217

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Wed 12/3

12:53 pm-10:05 pm

1 stop10h 12m

New Orleans Louis Armstrong

Thu 12/4

9:51 pm-11:11 pm

2 stops24h 20m

$224

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Wed 10/22

4:26 pm-11:53 pm

1 stop8h 27m

New Orleans Louis Armstrong

Sat 11/1

6:41 am-10:03 am

1 stop26h 22m

$248

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Wed 2/18

10:05 am-2:33 pm

1 stop5h 28m

Lafayette Regional

Sat 2/21

5:15 pm-9:43 pm

1 stop3h 28m

$249

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Thu 11/13

3:51 pm-7:57 pm

1 stop5h 06m

Baton Rouge Ryan

Tue 11/18

10:35 am-2:46 pm

1 stop3h 11m

$249

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Thu 11/13

3:51 pm-7:57 pm

1 stop5h 06m

Baton Rouge Ryan

Mon 11/17

6:50 pm-11:52 pm

1 stop4h 02m

$249

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Thu 9/25

5:55 pm-11:52 pm

1 stop6h 57m

New Orleans Louis Armstrong

Mon 9/29

9:57 pm-11:55 am

2 stops36h 58m

$256

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Fri 9/26

5:20 pm-10:01 pm

1 stop5h 41m

Baton Rouge Ryan

Tue 9/30

5:30 am-1:12 pm

1 stop6h 42m

$259

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Fri 9/26

7:45 pm-11:06 pm

1 stop4h 21m

Baton Rouge Ryan

Sun 9/28

6:32 pm-12:07 am

1 stop4h 35m

$259

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Fri 10/24

3:26 pm-11:53 pm

1 stop9h 27m

New Orleans Louis Armstrong

Mon 10/27

6:10 pm-10:33 am

1 stop15h 23m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 28 results
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Best time to book a flight from Knoxville to Louisiana

Have a flexible travel schedule? Discover the best time to fly to Louisiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Louisiana

What is the cheapest month to book a flight from Knoxville to Louisiana?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Louisiana (average of $256). Flying from Knoxville to Louisiana in April is currently the most expensive (average of $343). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to LA?

Find hourly flight availability from Knoxville to Louisiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Knoxville to Louisiana, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Louisiana

Get insights into the airlines that provide service to Louisiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisiana. Reviews last updated September 11, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Louisiana have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Louisiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Louisiana?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Louisiana from Knoxville.

  • How long is the flight from Knoxville to Louisiana?

    There are many flights that can get you from Knoxville to Louisiana in 4h 14m. Fly via Delta or American Airlines to get the fastest option. There are 541 mi between Knoxville and Louisiana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to Louisiana?

    The most popular flight routes from Knoxville to Louisiana are Knoxville McGhee Tyson - New Orleans Louis Armstrong, Knoxville McGhee Tyson - Baton Rouge Ryan and Knoxville McGhee Tyson - Lafayette Regional.

  • Can I find deals for flights from Knoxville to Louisiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Louisiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Louisiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Louisiana.

  • Can I find deals for business class flights from Knoxville to Louisiana?

    Yes. Cheapflights offers flight deals from Knoxville to Louisiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Louisiana?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Louisiana (average of $256). Flying from Knoxville to Louisiana in April is currently the most expensive (average of $343). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Louisiana

Discover the top 3 airlines that operate flights from Knoxville to Louisiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$171Average$363FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$223Average$438FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$228Average$396FlexibilityNo cancel feeOn-time71%

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