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$127+ Cheap flights from Knoxville (TYS) to Louisiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/5. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from Knoxville to Louisiana

Cheapest flights from Knoxville to Louisiana
Explore the most affordable flight options available from Knoxville to Louisiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2112:21 pmTYS - MSY
1 stop26h 00mMultiple Airlines
Sat 1/36:40 amMSY - TYS
1 stop24h 38mMultiple Airlines
Deal found 12/14$260
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 amTYS - MSY
1 stop8h 21mAllegiant Air
Mon 12/222:11 pmMSY - TYS
1 stop19h 50mAllegiant Air
Deal found 12/14$333
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 amTYS - MSY
1 stop8h 21mMultiple Airlines
Mon 12/225:00 pmMSY - TYS
2 stops14h 18mMultiple Airlines
Deal found 12/14$387
This American Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:23 amTYS - LFT
1 stop5h 08mAmerican Airlines
Sat 1/107:00 amLFT - TYS
1 stop7h 20mAmerican Airlines
Deal found 12/12$402
This Delta deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:59 pmTYS - MSY
1 stop3h 53mDelta
Thu 1/16:00 amMSY - TYS
1 stop3h 31mDelta
Deal found 12/13$411
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:35 amTYS - MSY
1 stop4h 21mDelta
Sat 1/35:15 amMSY - TYS
1 stop4h 16mDelta
Deal found 12/14$492
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/299:05 amTYS - BTR
1 stop5h 02mUnited Airlines
Fri 1/26:07 pmBTR - TYS
1 stop4h 35mUnited Airlines
Deal found 12/14$533
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:22 pmTYS - MSY
1 stop7h 10mAmerican Airlines
Sat 1/35:30 amMSY - TYS
1 stop4h 58mAmerican Airlines
Deal found 12/14$567
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:15 pmTYS - LFT
1 stop5h 11mUnited Airlines
Fri 1/24:06 pmLFT - TYS
1 stop6h 36mUnited Airlines
Deal found 12/14$568
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/285:35 pmTYS - MSY
1 stop5h 54mUnited Airlines
Thu 1/18:05 amMSY - TYS
1 stop5h 43mUnited Airlines
Deal found 12/13$587
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:35 pmTYS - MSY
1 stop5h 54mUnited Airlines
Fri 1/25:07 pmMSY - TYS
1 stop5h 35mUnited Airlines
Deal found 12/14$607
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:20 pmTYS - LFT
1 stop5h 32mAmerican Airlines
Fri 1/210:01 amLFT - TYS
1 stop4h 38mAmerican Airlines
Deal found 12/13$632

Find flight deals from Knoxville to Louisiana

Keep the following information in mind while searching for Knoxville to Louisiana flight deals. Data was last updated December 15, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$203
(Kiwi.com)

One-way from

$127
(Trip.com)

Popular in

February

Cheapest in

August

Average price

$338
Provider with most accurate pricing for Knoxville McGhee Tyson-New Orleans Louis Armstrong flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-New Orleans Louis Armstrong flights.
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From Knoxville McGhee Tyson to Louisiana
Search Deals
One-way flight from Knoxville McGhee Tyson to Louisiana
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($77 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Louisiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Knoxville to Louisiana that are best for you.

Fly from

Knoxville

Fly to

Louisiana

Route

Depart

Return

Price

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Sun 1/25

9:29 am-8:21 am

1 stop23h 52m

New Orleans Louis Armstrong

Sat 1/31

7:42 pm-8:39 am

1 stop11h 57m

$215

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Wed 1/7

3:53 pm-9:29 pm

2 stops30h 36m

New Orleans Louis Armstrong

Mon 1/12

7:00 am-10:28 pm

1 stop14h 28m

$234

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Mon 1/12

12:55 pm-10:58 pm

1 stop11h 03m

New Orleans Louis Armstrong

Mon 1/19

8:36 pm-12:10 pm

1 stop14h 34m

$236

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Tue 2/17

4:04 pm-8:21 am

1 stop17h 17m

New Orleans Louis Armstrong

Thu 2/19

7:27 pm-12:41 pm

1 stop16h 14m

$242

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Fri 1/30

12:55 pm-10:58 pm

1 stop11h 03m

New Orleans Louis Armstrong

Sun 2/1

8:36 pm-7:56 pm

3 stops22h 20m

$263

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Fri 1/23

8:30 am-9:29 pm

1 stop13h 59m

New Orleans Louis Armstrong

Sun 1/25

8:36 pm-1:40 pm

2 stops16h 04m

$268

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Thu 1/1

12:00 pm-1:16 pm

1 stop26h 16m

New Orleans Louis Armstrong

Sun 1/4

3:10 pm-8:03 am

1 stop15h 53m

$274

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Thu 3/5

7:20 am-8:18 pm

1 stop13h 58m

New Orleans Louis Armstrong

Sun 3/8

8:15 am-10:11 pm

1 stop12h 56m

$316

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Fri 2/27

9:36 pm-8:21 am

1 stop11h 45m

New Orleans Louis Armstrong

Sun 3/1

6:15 am-12:00 pm

3 stops28h 45m

$319

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Sat 1/31

11:40 am-3:31 pm

1 stop4h 51m

Lafayette Regional

Tue 2/3

12:10 pm-6:05 pm

1 stop4h 55m

$339

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 28 results
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Best time to book a flight from Knoxville to Louisiana

Have a flexible travel schedule? Discover the best time to fly to Louisiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Louisiana

What is the cheapest month to book a flight from Knoxville to Louisiana?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Louisiana (average of $164). Flying from Knoxville to Louisiana in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to LA?

Find hourly flight availability from Knoxville to Louisiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 33% on flights from Knoxville to Louisiana by exploring options for tickets in the evening.

What is the cheapest day to fly from Knoxville to Louisiana?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Louisiana. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Louisiana flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Louisiana

Get insights into the airlines that provide service to Louisiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisiana. Reviews last updated December 15, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Louisiana have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,092 reviews
Delta
7.9
Good
8,008 reviews

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,052 reviews
Delta
7.9
Good
8,008 reviews

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Louisiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Louisiana?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Louisiana from Knoxville.

  • How long is the flight from Knoxville to Louisiana?

    There are many flights that can get you from Knoxville to Louisiana in 4h 45m. Fly via United Airlines or American Airlines to get the fastest option. There are 551 mi between Knoxville and Louisiana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Knoxville to Louisiana one-way?

    $99 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $108 and $194, respectively.

  • What are the most popular routes from Knoxville to Louisiana?

    The most popular flight routes from Knoxville to Louisiana are Knoxville McGhee Tyson - New Orleans Louis Armstrong, Knoxville McGhee Tyson - Lafayette Regional and Knoxville McGhee Tyson - Baton Rouge Ryan.

  • Can I find deals for flights from Knoxville to Louisiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Louisiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Louisiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Louisiana.

  • Can I find deals for business class flights from Knoxville to Louisiana?

    Yes. Cheapflights offers flight deals from Knoxville to Louisiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Louisiana?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Louisiana (average of $164). Flying from Knoxville to Louisiana in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Louisiana

Discover the top 3 airlines that operate flights from Knoxville to Louisiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$223Average$402FlexibilityNo cancel feeOn-time71%
DeltaCheapest$244Average$465FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$253Average$438FlexibilityNo cancel feeOn-time69%

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