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$115+ Cheap flights from Knoxville (TYS) to Louisiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Knoxville to Louisiana

Cheapest flights from Knoxville to Louisiana
Explore the most affordable flight options available from Knoxville to Louisiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:36 pm
TYS
-
MSY
1 stop24h 19m
Multiple Airlines
Fri 3/67:27 pm
MSY
-
TYS
1 stop13h 13m
Multiple Airlines
Deal found 1/28$191
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1811:30 am
TYS
-
MSY
1 stop12h 49m
Multiple Airlines
Mon 3/237:20 pm
MSY
-
TYS
1 stop17h 50m
Multiple Airlines
Deal found 1/27$207
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:50 pm
TYS
-
MSY
1 stop6h 05m
Multiple Airlines
Sat 2/286:20 am
MSY
-
TYS
1 stop5h 42m
Multiple Airlines
Deal found 1/29$212
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/75:59 pm
TYS
-
MSY
1 stop15h 23m
Multiple Airlines
Mon 2/911:10 am
MSY
-
TYS
1 stop10h 11m
Multiple Airlines
Deal found 1/27$225
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:40 am
TYS
-
AEX
1 stop4h 53m
American Airlines
Mon 2/166:28 pm
AEX
-
TYS
1 stop5h 00m
American Airlines
Deal found 1/28$228
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:36 pm
TYS
-
MSY
1 stop11h 45m
Multiple Airlines
Mon 3/26:20 am
MSY
-
TYS
2 stops11h 11m
Multiple Airlines
Deal found 1/27$238
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/173:00 pm
TYS
-
MSY
1 stop18h 19m
Multiple Airlines
Wed 3/187:20 pm
MSY
-
TYS
1 stop24h 33m
Multiple Airlines
Deal found 1/28$239
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/59:32 pm
TYS
-
MSY
1 stop17h 18m
Multiple Airlines
Sun 3/88:36 pm
MSY
-
TYS
2 stops13h 25m
Multiple Airlines
Deal found 1/27$262
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/208:58 am
TYS
-
MSY
1 stop15h 21m
Multiple Airlines
Mon 3/237:20 pm
MSY
-
TYS
1 stop17h 50m
Multiple Airlines
Deal found 1/27$264
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/294:55 pm
TYS
-
BTR
1 stop5h 37m
United Airlines
Mon 2/212:00 pm
BTR
-
TYS
1 stop6h 50m
United Airlines
Deal found 1/27$369
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/292:57 pm
TYS
-
BTR
2 stops8h 59m
American Airlines
Mon 2/24:38 pm
BTR
-
TYS
1 stop5h 09m
American Airlines
Deal found 1/27$374
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/205:47 pm
TYS
-
LFT
1 stop5h 12m
American Airlines
Sun 3/225:35 am
LFT
-
TYS
1 stop4h 55m
American Airlines
Deal found 1/28$385

Find flight deals from Knoxville to Louisiana

Keep the following information in mind while searching for Knoxville to Louisiana flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$191
(Kiwi.com)

One-way from

$115
(Kiwi.com)

Popular in

February

Cheapest in

August

Average price

$382
Provider with most accurate pricing for Knoxville McGhee Tyson-New Orleans Louis Armstrong flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-New Orleans Louis Armstrong flights.
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From Knoxville McGhee Tyson to Louisiana
Search Deals
One-way flight from Knoxville McGhee Tyson to Louisiana
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($75 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Louisiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Knoxville to Louisiana that are best for you.

Fly from

Knoxville

Fly to

Louisiana

Route

Depart

Return

Price

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Fri 2/27

9:36 pm-8:55 pm

1 stop24h 19m

New Orleans Louis Armstrong

Fri 3/6

7:27 pm-9:40 am

1 stop13h 13m

$191

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Wed 3/18

11:30 am-11:19 pm

1 stop12h 49m

New Orleans Louis Armstrong

Mon 3/23

7:20 pm-2:10 pm

1 stop17h 50m

$207

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Wed 2/25

3:50 pm-8:55 pm

1 stop6h 05m

New Orleans Louis Armstrong

Sat 2/28

6:20 am-1:02 pm

1 stop5h 42m

$212

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Sat 2/7

5:59 pm-8:22 am

1 stop15h 23m

New Orleans Louis Armstrong

Mon 2/9

11:10 am-10:21 pm

1 stop10h 11m

$225

KnoxvilleAlexandria

TYS - AEX

TYSAEX

Knoxville McGhee Tyson

Thu 2/12

5:40 am-9:33 am

1 stop4h 53m

Alexandria

Mon 2/16

6:28 pm-12:28 am

1 stop5h 00m

$228

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Fri 2/27

9:36 pm-8:21 am

1 stop11h 45m

New Orleans Louis Armstrong

Mon 3/2

6:10 am-6:31 pm

1 stop11h 21m

$250

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Fri 3/20

2:06 pm-11:19 pm

2 stops10h 13m

New Orleans Louis Armstrong

Mon 3/23

7:20 pm-2:10 pm

1 stop17h 50m

$268

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Thu 3/5

9:32 pm-1:50 pm

1 stop17h 18m

New Orleans Louis Armstrong

Sun 3/8

6:10 am-11:26 pm

2 stops16h 16m

$273

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Tue 2/24

2:38 pm-6:21 pm

1 stop4h 43m

New Orleans Louis Armstrong

Tue 3/3

6:30 am-11:08 am

1 stop3h 38m

$277

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Mon 4/13

7:30 am-11:19 pm

1 stop16h 49m

New Orleans Louis Armstrong

Thu 4/16

6:15 am-2:45 pm

1 stop7h 30m

$281

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 38 results
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Best time to book a flight from Knoxville to Louisiana

Have a flexible travel schedule? Discover the best time to fly to Louisiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Louisiana

What is the cheapest month to book a flight from Knoxville to Louisiana?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Louisiana (average of $164). Flying from Knoxville to Louisiana in December is currently the most expensive (average of $251). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisiana

Get insights into the airlines that provide service to Louisiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisiana. Reviews last updated January 29, 2026.
See what other customers who have flown with Delta and American Airlines from Knoxville to Louisiana have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Louisiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Louisiana?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Louisiana from Knoxville.

  • How long is the flight from Knoxville to Louisiana?

    There are many flights that can get you from Knoxville to Louisiana in 4h 53m. Fly via American Airlines, United Airlines, or Delta to get the fastest option. There are 581 mi between Knoxville and Louisiana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Knoxville to Louisiana one-way?

    $99 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $125 and $162, respectively.

  • What are the most popular routes from Knoxville to Louisiana?

    The most popular flight routes from Knoxville to Louisiana are Knoxville McGhee Tyson - New Orleans Louis Armstrong, Knoxville McGhee Tyson - Baton Rouge Ryan and Knoxville McGhee Tyson - Lafayette Regional.

  • Can I find deals for flights from Knoxville to Louisiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Louisiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Louisiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Louisiana.

  • Can I find deals for business class flights from Knoxville to Louisiana?

    Yes. Cheapflights offers flight deals from Knoxville to Louisiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Louisiana?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Louisiana (average of $164). Flying from Knoxville to Louisiana in December is currently the most expensive (average of $251). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Knoxville to Louisiana

Discover the top 2 airlines that operate flights from Knoxville to Louisiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$223Average$394FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$402FlexibilityNo cancel feeOn-timeN/A

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