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$100+ Cheap flights from Knoxville (TYS) to Louisiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
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Cheap flight deals from Knoxville to Louisiana

Keep the following information in mind while searching for Knoxville to Louisiana flight deals. Data was last updated April 29, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$225
(American Airlines)

One-way from

$100
(American Airlines)

Popular in

October

Cheapest in

September

Average price

$408
Provider with most accurate pricing for Knoxville McGhee Tyson-New Orleans Louis Armstrong flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-New Orleans Louis Armstrong flights.
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From Knoxville McGhee Tyson to Louisiana
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One-way flight from Knoxville McGhee Tyson to Louisiana
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Highest demand for flights based on searches. 6% potential increase in price ($26 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Knoxville to Louisiana

Cheapest flights from Knoxville to Louisiana
Explore the most affordable flight options available from Knoxville to Louisiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/217:00 amTYS - MSY
1 stop7h 18mAmerican Airlines
Wed 5/2811:39 amMSY - TYS
1 stop4h 52mAmerican Airlines
Deal found 4/28$225
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/187:05 amTYS - BTR
1 stop5h 30mDelta
Mon 7/213:21 pmBTR - TYS
1 stop3h 44mDelta
Deal found 4/28$249
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/225:30 amTYS - MSY
1 stop4h 23mDelta
Sun 8/247:10 pmMSY - TYS
1 stop3h 37mDelta
Deal found 4/28$249
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/135:58 pmTYS - LFT
1 stop4h 55mAmerican Airlines
Sat 5/177:09 amLFT - TYS
1 stop5h 02mAmerican Airlines
Deal found 4/28$259
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/199:04 pmTYS - MSY
1 stop12h 14mMultiple Airlines
Sun 6/229:07 pmMSY - TYS
1 stop23h 09mMultiple Airlines
Deal found 4/28$303
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/97:15 pmTYS - LFT
1 stop3h 44mDelta
Mon 10/135:15 pmLFT - TYS
1 stop5h 31mDelta
Deal found 4/28$339
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/23:09 pmTYS - BTR
1 stop6h 39mAmerican Airlines
Sun 5/45:20 amBTR - TYS
1 stop5h 14mAmerican Airlines
Deal found 4/28$339
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/15:50 amTYS - MSY
1 stop5h 34mUnited Airlines
Sun 5/45:00 amMSY - TYS
1 stop7h 36mUnited Airlines
Deal found 4/28$339
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/55:15 amTYS - AEX
1 stop5h 49mAmerican Airlines
Fri 6/136:25 pmAEX - TYS
1 stop4h 34mAmerican Airlines
Deal found 4/28$416
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/267:00 amTYS - BTR
1 stop7h 18mUnited Airlines
Sun 6/294:02 pmBTR - TYS
2 stops29h 33mUnited Airlines
Deal found 4/28$528
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/98:52 amTYS - LFT
2 stops27h 35mUnited Airlines
Mon 10/132:00 pmLFT - TYS
2 stops22h 25mUnited Airlines
Deal found 4/28$743

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Louisiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Knoxville to Louisiana that are best for you.

Fly from

Knoxville

Fly to

Louisiana

Route

Depart

Return

Price

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Wed 5/21

7:00 am-1:18 pm

1 stop7h 18m

New Orleans Louis Armstrong

Wed 5/28

11:39 am-5:31 pm

1 stop4h 52m

$225

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Fri 7/18

7:05 am-11:35 am

1 stop5h 30m

Baton Rouge Ryan

Mon 7/21

3:21 pm-8:05 pm

1 stop3h 44m

$249

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Tue 5/13

5:58 pm-9:53 pm

1 stop4h 55m

Lafayette Regional

Sat 5/17

7:09 am-1:11 pm

1 stop5h 02m

$259

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Thu 6/19

9:04 pm-8:18 am

1 stop12h 14m

New Orleans Louis Armstrong

Sun 6/22

9:07 pm-9:16 pm

1 stop23h 09m

$303

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Sat 5/3

5:30 am-9:07 am

1 stop4h 37m

New Orleans Louis Armstrong

Tue 5/6

5:40 pm-11:48 pm

1 stop5h 08m

$324

KnoxvilleNew Orleans

TYS - MSY

TYSMSY

Knoxville McGhee Tyson

Thu 5/1

5:50 am-10:24 am

1 stop5h 34m

New Orleans Louis Armstrong

Sun 5/4

5:00 am-1:36 pm

1 stop7h 36m

$339

KnoxvilleLafayette

TYS - LFT

TYSLFT

Knoxville McGhee Tyson

Thu 10/9

7:15 pm-9:59 pm

1 stop3h 44m

Lafayette Regional

Mon 10/13

5:15 pm-11:46 pm

1 stop5h 31m

$339

KnoxvilleAlexandria

TYS - AEX

TYSAEX

Knoxville McGhee Tyson

Thu 6/5

5:15 am-10:04 am

1 stop5h 49m

Alexandria

Fri 6/13

6:25 pm-11:59 pm

1 stop4h 34m

$416

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Thu 6/26

7:00 am-1:18 pm

1 stop7h 18m

Baton Rouge Ryan

Sun 6/29

4:02 pm-10:35 pm

2 stops29h 33m

$528

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Fri 7/18

6:22 pm-11:11 pm

1 stop5h 49m

Baton Rouge Ryan

Mon 7/21

12:56 pm-10:20 pm

2 stops8h 24m

$565

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 17 results
1
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Best time to book a flight from Knoxville to Louisiana

Have a flexible travel schedule? Discover the best time to fly to Louisiana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Louisiana

What is the cheapest month to book a flight from Knoxville to Louisiana?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Louisiana (average of $256). Flying from Knoxville to Louisiana in April is currently the most expensive (average of $343). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to LA?

Find hourly flight availability from Knoxville to Louisiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2025.

When flying from Knoxville to Louisiana, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Louisiana by month

Plan your trip to Louisiana by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Louisiana ranges from 3.3 - 6.4 inches per month. June is typically the wettest month, when rainfall can reach 6.4 in. October is typically the driest time to visit Louisiana when rainfall is around 3.3 in.

Temperature in Louisiana by month

Plan your trip to Louisiana by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Louisiana, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 82.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing Louisiana

Get insights into the airlines that provide service to Louisiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisiana. Reviews last updated April 29, 2025.
Read through reviews of airlines operating flights from Knoxville to Louisiana, such as Delta, United Airlines and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,929 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Louisiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Louisiana?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Louisiana from Knoxville.

  • What are the cheapest airlines to fly from Knoxville to Louisiana one-way?

    $100 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $126 and $135, respectively.

  • What are the most popular routes from Knoxville to Louisiana?

    The most popular flight routes from Knoxville to Louisiana are Knoxville McGhee Tyson - New Orleans Louis Armstrong, Knoxville McGhee Tyson - Baton Rouge Ryan and Knoxville McGhee Tyson - Lafayette Regional.

  • Can I find deals for flights from Knoxville to Louisiana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Louisiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Louisiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Louisiana.

  • Can I find deals for business class flights from Knoxville to Louisiana?

    Yes. Cheapflights offers flight deals from Knoxville to Louisiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Louisiana?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Louisiana (average of $256). Flying from Knoxville to Louisiana in April is currently the most expensive (average of $343). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Louisiana

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Top 3 airlines flying from Knoxville to Louisiana

Discover the top 3 airlines that operate flights from Knoxville to Louisiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$171Average$330FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$355FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$247Average$378FlexibilityNo cancel feeOn-time69%

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