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Knoxville

$107+ Cheap flights from Louisiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — TYS
Sep 3 — Sep 101
Thu 9/3
Thu 9/10
1 adult, Economy
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Cheap flight deals from Louisiana to Knoxville

Cheapest flights from Louisiana to Knoxville
Explore the most affordable flight options available from Louisiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.

This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/208:03 pm
MSY
-
TYS
1 stop23h 36m
Multiple Airlines
Sun 9/271:19 pm
TYS
-
MSY
2 stops28h 03m
Multiple Airlines
Deal found 7/31$260
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/124:04 pm
LFT
-
TYS
1 stop4h 41m
United Airlines
Sat 9/197:15 am
TYS
-
LFT
1 stop6h 54m
United Airlines
Deal found 7/30$271
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:09 am
SHV
-
TYS
1 stop9h 31m
Allegiant Air
Sat 10/314:50 pm
TYS
-
SHV
1 stop17h 29m
Allegiant Air
Deal found 7/30$275
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:17 pm
MSY
-
TYS
2 stops16h 27m
Multiple Airlines
Fri 9/119:31 am
TYS
-
MSY
1 stop10h 36m
Multiple Airlines
Deal found 7/31$275
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1712:36 pm
MSY
-
TYS
1 stop9h 08m
Multiple Airlines
Fri 8/212:51 pm
TYS
-
MSY
2 stops28h 11m
Multiple Airlines
Deal found 7/30$278
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/179:40 am
MSY
-
TYS
1 stop7h 03m
Multiple Airlines
Sun 12/208:20 am
TYS
-
MSY
1 stop11h 33m
Multiple Airlines
Deal found 8/4$280
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:17 pm
MSY
-
TYS
2 stops38h 18m
Multiple Airlines
Wed 10/710:28 am
TYS
-
MSY
1 stop26h 31m
Multiple Airlines
Deal found 7/30$286
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:00 am
MSY
-
TYS
1 stop5h 37m
United Airlines
Thu 9/33:40 pm
TYS
-
MSY
1 stop5h 23m
United Airlines
Deal found 7/30$287
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/307:11 pm
MSY
-
TYS
2 stops21h 54m
Multiple Airlines
Sun 9/67:00 am
TYS
-
MSY
1 stop14h 36m
Multiple Airlines
Deal found 8/2$291
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:10 am
MSY
-
TYS
2 stops8h 40m
Southwest
Tue 9/88:05 am
TYS
-
MSY
1 stop5h 00m
Southwest
Deal found 8/4$292
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/138:03 pm
MSY
-
TYS
1 stop15h 59m
Multiple Airlines
Wed 9/165:18 pm
TYS
-
MSY
2 stops24h 04m
Multiple Airlines
Deal found 7/30$293
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2912:03 pm
LFT
-
TYS
1 stop5h 14m
United Airlines
Sat 9/52:21 pm
TYS
-
LFT
1 stop6h 11m
United Airlines
Deal found 8/1$295

Find flight deals from Louisiana to Knoxville

Keep the following information in mind while searching for Louisiana to Knoxville flight deals. Data was last updated August 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$260
(Kiwi.com)

One-way from

$107
(Kiwi.com)

Popular in

July

Cheapest in

September

Average price

$380
Provider with most accurate pricing for New Orleans Louis Armstrong-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for New Orleans Louis Armstrong-Knoxville McGhee Tyson flights.
Search Deals
From Louisiana to Knoxville McGhee Tyson
Search Deals
One-way flight from Louisiana to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($41 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
Use the filters below to find and compare flights from Louisiana to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 8/27

7:40 am-12:00 pm

1 stop3h 20m

Knoxville McGhee Tyson

Thu 9/3

5:45 pm-10:30 pm

1 stop5h 45m

$287

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 11/11

6:40 am-2:05 pm

2 stops6h 25m

Knoxville McGhee Tyson

Sat 11/14

3:50 pm-7:50 pm

1 stop5h 00m

$292

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 9/1

10:10 am-7:50 pm

2 stops8h 40m

Knoxville McGhee Tyson

Tue 9/8

8:05 am-12:05 pm

1 stop5h 00m

$292

LafayetteKnoxville

LFT - TYS

LFTTYS

Lafayette Regional

Tue 11/10

11:36 am-5:24 pm

1 stop4h 48m

Knoxville McGhee Tyson

Sun 11/15

7:21 pm-10:42 pm

1 stop4h 21m

$295

LafayetteKnoxville

LFT - TYS

LFTTYS

Lafayette Regional

Sat 8/29

12:03 pm-6:17 pm

1 stop5h 14m

Knoxville McGhee Tyson

Sat 9/5

2:21 pm-7:32 pm

1 stop6h 11m

$295

LafayetteKnoxville

LFT - TYS

LFTTYS

Lafayette Regional

Wed 11/11

3:32 pm-8:09 pm

1 stop3h 37m

Knoxville McGhee Tyson

Sun 11/15

6:00 am-10:45 am

1 stop5h 45m

$295

LafayetteKnoxville

LFT - TYS

LFTTYS

Lafayette Regional

Sat 8/29

6:05 am-12:28 pm

1 stop5h 23m

Knoxville McGhee Tyson

Sat 9/5

6:00 am-11:00 am

1 stop6h 00m

$295

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 8/29

11:31 am-8:24 pm

1 stop7h 53m

Knoxville McGhee Tyson

Mon 8/31

2:21 pm-8:03 pm

1 stop6h 42m

$300
Quickest round-trip

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Wed 9/23

6:03 am-11:18 am

1 stop4h 15m

Knoxville McGhee Tyson

Wed 9/30

12:23 pm-3:01 pm

1 stop3h 38m

$301

ShreveportKnoxville

SHV - TYS

SHVTYS

Shreveport

Tue 10/13

5:09 pm-10:22 pm

1 stop4h 13m

Knoxville McGhee Tyson

Sat 10/17

5:40 am-10:14 am

1 stop5h 34m

$305

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 59 resultsSorted by cheapest first
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Best time to book a flight from Louisiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Louisiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisiana to Knoxville

What is the cheapest month to book a flight from Louisiana to Knoxville?

Currently, February is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $364). Flying from Louisiana to Knoxville in March is currently the most expensive (average of $599). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Louisiana to Knoxville?

Airfare is below average for this route at the moment.
Louisiana to Knoxville flights typically cost between $333 and $413 in September.
The cheapest round-trip price found within the last 5 days was $260 on Multiple Airlines (Sep 20-Sep 27).

How far ahead should I book a flight from Louisiana to Knoxville?

To ensure you get the cheapest price possible for a flight from Louisiana to Knoxville, you should look to book at least 74 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

Related info for your journey

Find useful and relevant information for your journey from Louisiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Louisiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Louisiana to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Louisiana to Knoxville?

    For as low as $287, Southwest can have you in Knoxville from Louisiana in 3h 20m. The distance from Louisiana to Knoxville is about 541 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Louisiana to Knoxville one-way?

    One-way options have recently been found by users for as low as $117 on American Airlines. Other airlines that offer cheap prices include Southwest from $138 and Delta from $151 one-way.

  • What are the most popular routes from Louisiana to Knoxville?

    The most popular route from Louisiana to Knoxville is New Orleans Louis Armstrong - Knoxville McGhee Tyson. You may also consider Lafayette Regional - Knoxville McGhee Tyson or Baton Rouge Ryan - Knoxville McGhee Tyson.

  • Can I find deals for flights from Louisiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Louisiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisiana to Knoxville.

  • Can I find deals for business class flights from Louisiana to Knoxville?

    Yes. Cheapflights offers flight deals from Louisiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisiana to Knoxville?

    Currently, February is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $364). Flying from Louisiana to Knoxville in March is currently the most expensive (average of $599). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

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Alternative routes for Louisiana to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Louisiana to Knoxville

Discover the top 4 airlines that operate flights from Louisiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$381FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$422FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$294Average$458FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$336Average$482FlexibilityNo cancel feeOn-time69%

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