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$552+ Cheap flights from Santiago (SCL) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — TYS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Santiago to Knoxville

Best flights from Santiago to Knoxville
Discover carefully curated flight deals from Santiago to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2110:45 pmSCL - TYS
2 stops18h 04mUnited Airlines
Thu 1/291:59 pmTYS - SCL
2 stops16h 51mUnited Airlines
Deal found 12/11$706
This LATAM Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/264:15 pmSCL - TYS
2 stops18h 49mLATAM Airlines
Mon 3/22:38 pmTYS - SCL
1 stop15h 02mLATAM Airlines
Deal found 12/9$714
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2110:35 pmSCL - TYS
1 stop20h 31mAmerican Airlines
Thu 1/296:20 amTYS - SCL
1 stop24h 40mAmerican Airlines
Deal found 12/11$715
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2610:45 pmSCL - TYS
1 stop23h 10mUnited Airlines
Mon 3/24:55 pmTYS - SCL
1 stop13h 55mUnited Airlines
Deal found 12/9$764

Find flight deals from Santiago to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$706
(United Airlines)

One-way from

$552
(Delta)
Provider with most accurate pricing for Santiago Arturo Merino Benitez-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Knoxville McGhee Tyson flights.
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From Santiago Arturo Merino Benitez to Knoxville McGhee Tyson
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One-way flight from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Santiago to Knoxville that are best for you.

Fly from

Santiago

Fly to

Knoxville

Route

Depart

Return

Price

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 1/21

10:45 pm-2:49 pm

2 stops18h 04m

Knoxville McGhee Tyson

Thu 1/29

1:59 pm-8:50 am

2 stops16h 51m

$706

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 2/26

4:15 pm-9:04 am

2 stops18h 49m

Knoxville McGhee Tyson

Mon 3/2

2:38 pm-7:40 am

1 stop15h 02m

$714

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 1/21

10:35 pm-5:06 pm

1 stop20h 31m

Knoxville McGhee Tyson

Thu 1/29

6:20 am-9:00 am

1 stop24h 40m

$715

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 2/26

10:45 pm-7:55 pm

1 stop23h 10m

Knoxville McGhee Tyson

Mon 3/2

4:55 pm-8:50 am

1 stop13h 55m

$764

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 2/9

11:10 pm-11:08 am

1 stop13h 58m

$552

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 2/9

7:15 am-11:45 pm

3 stops18h 30m

$561

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 1/18

10:30 pm-11:34 am

1 stop15h 04m

$597

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 1/18

10:15 pm-11:45 pm

2 stops27h 30m

$597

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Compare providers for flights from Santiago to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to Knoxville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santiago-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Santiago to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santiago to Knoxville?

    There are many flights that can get you from Santiago to Knoxville in 18h 04m. Fly via United Airlines or LATAM Airlines to get the fastest option. The distance between Santiago and Knoxville is about 4853 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Santiago to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santiago to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Knoxville.

  • Can I find deals for business class flights from Santiago to Knoxville?

    Yes. Cheapflights offers flight deals from Santiago to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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