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$472+ Cheap flights from Santiago (SCL) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — TYS
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
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Cheap flight deals from Santiago to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 30, 2025.

Round-trip from

$743
(United Airlines)

One-way from

$472
(Kiwi.com)
From Santiago Arturo Merino Benitez to Knoxville McGhee Tyson
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One-way flight from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson
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Find flight deals from Santiago to Knoxville

Cheapest flights from Santiago to Knoxville
Explore the most affordable flight options available from Santiago to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2611:15 pmSCL - TYS
1 stop13h 33mDelta
Wed 12/34:00 pmTYS - SCL
1 stop13h 00mDelta
Deal found 7/28$737
This LATAM Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/254:35 amSCL - TYS
2 stops21h 11mLATAM Airlines
Thu 12/44:00 pmTYS - SCL
1 stop13h 00mLATAM Airlines
Deal found 7/29$754
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2610:45 pmSCL - TYS
1 stop23h 24mUnited Airlines
Sat 12/67:05 amTYS - SCL
1 stop23h 45mUnited Airlines
Deal found 7/29$782
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2910:15 pmSCL - TYS
1 stop20h 22mAmerican Airlines
Sat 12/65:46 amTYS - SCL
1 stop24h 04mAmerican Airlines
Deal found 7/28$977

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Santiago to Knoxville that are best for you.

Fly from

Santiago

Fly to

Knoxville

Route

Depart

Return

Price

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 11/26

11:15 pm-10:48 am

1 stop13h 33m

Knoxville McGhee Tyson

Wed 12/3

4:00 pm-7:00 am

1 stop13h 00m

$737

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 11/25

4:35 am-11:46 pm

2 stops21h 11m

Knoxville McGhee Tyson

Thu 12/4

4:00 pm-7:00 am

1 stop13h 00m

$754

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 11/26

10:45 pm-8:09 pm

1 stop23h 24m

Knoxville McGhee Tyson

Sat 12/6

7:05 am-8:50 am

1 stop23h 45m

$782

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sat 11/29

10:15 pm-4:37 pm

1 stop20h 22m

Knoxville McGhee Tyson

Sat 12/6

5:46 am-7:50 am

1 stop24h 04m

$977

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 12/7

11:15 pm-7:14 pm

2 stops21h 59m

$472

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 12/7

10:45 pm-1:49 pm

1 stop17h 04m

$586

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 10/10

10:55 pm-1:39 pm

2 stops15h 44m

$592

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 12/7

7:15 am-11:46 pm

3 stops18h 31m

$595

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Best time to book a flight from Santiago to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 30, 2025.
Get a feel of what it's like to fly with Delta, LATAM Airlines, and United Airlines from Santiago to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
LATAM Airlines
7.5
Good
1,822 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Comfort

7.9

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.

Related info for your journey

Find useful and relevant information for your journey from Santiago to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Santiago to Knoxville round-trip?

    Our cheapest airline available from Santiago to Knoxville is United Airlines. Our recent data shows that you can find tickets from as low as $743 on this airline. Additional options worth looking into are LATAM Airlines and Delta, starting at $754 and $785 round-trip.

  • What are the cheapest airlines to fly from Santiago to Knoxville one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $586. Delta flights start at $592 while deals on LATAM Airlines start at $595 one-way.

  • Can I find deals for flights from Santiago to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santiago to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Knoxville.

  • Can I find deals for business class flights from Santiago to Knoxville?

    Yes. Cheapflights offers flight deals from Santiago to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santiago to Knoxville (average of $294). Flying from Santiago to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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