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$592+ Cheap flights from Santiago (SCL) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/18. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Santiago to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$723
(American Airlines)

One-way from

$592
(Delta)
From Santiago Arturo Merino Benitez to Knoxville McGhee Tyson
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One-way flight from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson
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Find flight deals from Santiago to Knoxville

Cheapest flights from Santiago to Knoxville
Explore the most affordable flight options available from Santiago to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/209:55 pmSCL - TYS
1 stop26h 44mAmerican Airlines
Mon 10/276:00 amTYS - SCL
1 stop25h 05mAmerican Airlines
Deal found 9/10$723
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2010:55 pmSCL - TYS
2 stops16h 48mDelta
Mon 10/278:15 amTYS - SCL
1 stop22h 25mDelta
Deal found 9/11$725
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1912:10 amSCL - TYS
2 stops24h 36mLATAM Airlines
Mon 10/275:16 pmTYS - SCL
1 stop13h 24mLATAM Airlines
Deal found 9/10$733
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/219:55 pmSCL - TYS
1 stop26h 44mAmerican Airlines
Sun 10/267:05 amTYS - SCL
1 stop24h 00mAmerican Airlines
Deal found 9/10$763
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/218:15 amSCL - TYS
2 stops15h 52mDelta
Sun 10/2611:40 amTYS - SCL
2 stops16h 45mDelta
Deal found 9/11$765
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2012:10 amSCL - TYS
2 stops23h 57mLATAM Airlines
Sun 10/265:28 pmTYS - SCL
1 stop13h 12mLATAM Airlines
Deal found 9/10$773

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Santiago to Knoxville that are best for you.

Fly from

Santiago

Fly to

Knoxville

Route

Depart

Return

Price

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 10/20

9:55 pm-11:39 pm

1 stop26h 44m

Knoxville McGhee Tyson

Mon 10/27

6:00 am-8:05 am

1 stop25h 05m

$723

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 10/20

10:55 pm-4:31 pm

2 stops18h 36m

Knoxville McGhee Tyson

Mon 10/27

11:35 am-7:40 am

1 stop19h 05m

$725

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 10/19

12:10 am-11:46 pm

2 stops24h 36m

Knoxville McGhee Tyson

Mon 10/27

5:16 pm-2:05 pm

2 stops19h 49m

$733

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 10/21

9:55 pm-11:39 pm

1 stop26h 44m

Knoxville McGhee Tyson

Sun 10/26

7:05 am-8:05 am

1 stop24h 00m

$763

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 10/21

8:15 am-11:07 pm

2 stops15h 52m

Knoxville McGhee Tyson

Sun 10/26

11:40 am-6:00 am

2 stops17h 20m

$765

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sun 1/18

11:25 pm-1:26 pm

2 stops16h 01m

$592

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Sat 1/17

12:25 am-11:44 pm

2 stops25h 19m

$596

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Santiago to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Santiago to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santiago to Knoxville?

    There are many flights that can get you from Santiago to Knoxville in 18h 36m. Fly via American Airlines or Delta to get the fastest option. The distance between Santiago and Knoxville is about 4853 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Santiago to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santiago to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Knoxville.

  • Can I find deals for business class flights from Santiago to Knoxville?

    Yes. Cheapflights offers flight deals from Santiago to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santiago to Knoxville (average of $294). Flying from Santiago to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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