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$489+ Cheap flights from Santiago (SCL) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — TYS
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Santiago to Knoxville

Cheapest flights from Santiago to Knoxville
Explore the most affordable flight options available from Santiago to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2511:10 pm
SCL
-
TYS
1 stop18h 05m
Delta
Wed 3/411:50 am
TYS
-
SCL
2 stops17h 10m
Delta
Deal found 1/26$811
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/129:45 pm
SCL
-
TYS
2 stops40h 33m
United Airlines
Thu 3/197:00 am
TYS
-
SCL
3 stops23h 50m
United Airlines
Deal found 1/25$817
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:45 pm
SCL
-
TYS
2 stops20h 00m
United Airlines
Sun 3/89:40 am
TYS
-
SCL
2 stops45h 10m
United Airlines
Deal found 1/26$847
This LATAM Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/411:10 pm
SCL
-
TYS
1 stop13h 58m
LATAM Airlines
Sun 3/86:38 pm
TYS
-
SCL
1 stop12h 02m
LATAM Airlines
Deal found 1/26$875
This Orbitz deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:30 pm
SCL
-
TYS
2 stops16h 34m
LATAM Airlines
Wed 3/412:00 pm
TYS
-
SCL
3 stops24h 30m
LATAM Airlines
Deal found 1/26$931

Find flight deals from Santiago to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$811
(Delta)

One-way from

$489
(KAYAK)
Provider with most accurate pricing for Santiago Arturo Merino Benitez-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Knoxville McGhee Tyson flights.
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From Santiago Arturo Merino Benitez to Knoxville McGhee Tyson
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One-way flight from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Santiago to Knoxville that are best for you.

Fly from

Santiago

Fly to

Knoxville

Route

Depart

Return

Price

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 3/12

10:10 pm-9:16 am

1 stop12h 06m

Knoxville McGhee Tyson

Thu 3/19

8:45 am-5:35 am

2 stops19h 50m

$811

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 2/25

11:25 pm-3:15 pm

2 stops17h 50m

Knoxville McGhee Tyson

Wed 3/4

12:00 pm-7:00 am

2 stops17h 00m

$811

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 3/12

9:45 pm-1:18 pm

2 stops40h 33m

Knoxville McGhee Tyson

Thu 3/19

7:00 am-7:50 am

3 stops23h 50m

$817

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 3/4

10:45 pm-8:47 pm

2 stops24h 02m

Knoxville McGhee Tyson

Sun 3/8

2:21 pm-7:50 am

2 stops40h 29m

$847

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 2/9

11:25 pm-6:11 pm

2 stops20h 46m

$489

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Mon 2/9

11:10 pm-9:24 am

1 stop12h 14m

$501

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Compare providers for flights from Santiago to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santiago-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Santiago to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santiago to Knoxville?

    There are many flights that can get you from Santiago to Knoxville in 12h 06m. Fly via Delta to get the fastest option. The distance between Santiago and Knoxville is about 4853 mi.

  • Can I find deals for flights from Santiago to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santiago to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Knoxville.

  • Can I find deals for business class flights from Santiago to Knoxville?

    Yes. Cheapflights offers flight deals from Santiago to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Santiago to Knoxville

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