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$126+ Cheap flights from Columbus (CMH) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — TYS
Aug 21 — Aug 281
Thu 8/21
Thu 8/28
1 adult, Economy
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Cheap flight deals from Columbus to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (CMH) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 16, 2025.

Round-trip from

$214
(American Airlines)

One-way from

$126
(American Airlines)

Popular in

November

Cheapest in

December

Average price

$288
From Columbus to Knoxville McGhee Tyson
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One-way flight from Columbus to Knoxville McGhee Tyson
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High demand for flights, 4% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Columbus to Knoxville

Cheapest flights from Columbus to Knoxville
Explore the most affordable flight options available from Columbus to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2025.

This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/3010:53 amCMH - TYS
1 stop5h 58mAmerican Airlines
Wed 9/35:20 pmTYS - CMH
1 stop6h 24mAmerican Airlines
Deal found 8/15$214
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/37:00 amCMH - TYS
1 stop6h 07mDelta
Mon 10/68:10 pmTYS - CMH
1 stop3h 49mDelta
Deal found 8/14$219
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/309:38 pmCMH - TYS
1 stop14h 17mMultiple Airlines
Fri 10/37:15 amTYS - CMH
1 stop12h 38mMultiple Airlines
Deal found 8/14$222
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/132:37 pmCMH - TYS
2 stops20h 41mMultiple Airlines
Mon 9/221:22 pmTYS - CMH
1 stop7h 11mMultiple Airlines
Deal found 8/15$232
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/118:16 pmCMH - TYS
1 stop3h 51mAmerican Airlines
Thu 9/186:10 pmTYS - CMH
1 stop4h 47mAmerican Airlines
Deal found 8/14$239
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/35:15 amCMH - TYS
1 stop9h 35mMultiple Airlines
Tue 10/711:23 amTYS - CMH
2 stops24h 04mMultiple Airlines
Deal found 8/14$240
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:00 amCMH - TYS
1 stop3h 56mDelta
Wed 10/87:45 amTYS - CMH
1 stop3h 31mDelta
Deal found 8/14$253
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/65:15 amCMH - TYS
1 stop11h 26mMultiple Airlines
Fri 10/109:06 pmTYS - CMH
1 stop14h 44mMultiple Airlines
Deal found 8/14$257
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/56:00 amCMH - TYS
1 stop4h 51mAmerican Airlines
Mon 10/68:37 pmTYS - CMH
1 stop3h 10mAmerican Airlines
Deal found 8/14$259
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/55:15 amCMH - TYS
1 stop9h 27mMultiple Airlines
Fri 10/109:06 pmTYS - CMH
1 stop14h 44mMultiple Airlines
Deal found 8/14$266
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2410:02 amCMH - TYS
1 stop4h 41mDelta
Sun 10/265:44 amTYS - CMH
1 stop3h 13mDelta
Deal found 8/15$273

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
Use the filters below to find and compare flights from Columbus Airport to Knoxville that are best for you.

Fly from

Columbus

Fly to

Knoxville

Route

Depart

Return

Price

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 8/30

10:53 am-4:51 pm

1 stop5h 58m

Knoxville McGhee Tyson

Wed 9/3

5:20 pm-11:44 pm

1 stop6h 24m

$214

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 9/30

8:10 am-11:41 am

1 stop3h 31m

Knoxville McGhee Tyson

Wed 10/8

5:44 am-8:57 am

1 stop3h 13m

$219

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 9/30

6:08 am-11:41 am

1 stop5h 33m

Knoxville McGhee Tyson

Fri 10/10

5:44 am-8:57 am

1 stop3h 13m

$219

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 9/13

6:15 am-10:37 am

1 stop4h 22m

Knoxville McGhee Tyson

Mon 9/22

7:45 pm-11:07 pm

1 stop3h 22m

$219

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Thu 10/2

7:45 pm-11:44 pm

1 stop3h 59m

Knoxville McGhee Tyson

Thu 10/9

2:27 pm-6:54 pm

1 stop4h 27m

$219

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Thu 1/8

6:11 am-10:01 am

1 stop3h 50m

Knoxville McGhee Tyson

Fri 1/16

5:59 am-11:38 am

1 stop5h 39m

$219

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 10/4

6:08 am-10:09 am

1 stop4h 01m

Knoxville McGhee Tyson

Thu 10/9

5:44 am-11:13 am

1 stop5h 29m

$219

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 10/4

3:51 pm-8:05 pm

1 stop4h 14m

Knoxville McGhee Tyson

Mon 10/6

5:16 pm-8:37 pm

1 stop3h 21m

$219

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Thu 10/2

8:10 am-11:41 am

1 stop3h 31m

Knoxville McGhee Tyson

Fri 10/10

5:44 am-8:57 am

1 stop3h 13m

$219

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 10/3

8:00 am-1:07 pm

1 stop5h 07m

Knoxville McGhee Tyson

Tue 10/7

5:44 am-8:57 am

1 stop3h 13m

$219

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 20 results
1
2

Best time to book a flight from Columbus to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus Airport to Knoxville

What is the cheapest month to book a flight from Columbus Airport to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Columbus Airport to Knoxville (average of $294). Flying from Columbus Airport to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CMH to TYS?

Find hourly flight availability from Columbus to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 16, 2025.

One of the essential ways to save on airfare from Columbus Airport to Knoxville is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 34% on airfare.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 16, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Columbus Airport to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,985 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,985 reviews
Delta
8.0
Very good
7,985 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,916 reviews
Delta
8.0
Very good
7,985 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,985 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Columbus to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Columbus?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Columbus. On average, McGhee Tyson has 0 inbound flights from Columbus per day from 3 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the cheapest airlines flying from Columbus Airport to Knoxville round-trip?

    Currently priced at $218, American Airlines will fly you from Columbus Airport to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and United Airlines - these airlines can fly you to your destination from $218 and $258, respectively. These flights start at 26% lower than the current average price 3 months from now.

  • Can I find deals for flights from Columbus to Knoxville that include hotel bookings?

    Yes. In addition to deals on Columbus to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Knoxville.

  • Can I find deals for business class flights from Columbus to Knoxville?

    Yes. Cheapflights offers flight deals from Columbus to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus Airport to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Columbus Airport to Knoxville (average of $294). Flying from Columbus Airport to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Columbus to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Columbus to Nashville flights
Columbus to Memphis flights
Columbus to Chattanooga flights
Columbus to Blountville flights

Top 3 airlines flying from Columbus to Knoxville

Discover the top 3 airlines that operate flights from Columbus to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$293FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$283FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$258Average$380FlexibilityNo cancel feeOn-time69%

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