
Discover tips and strategies to find the most affordable flight options for your journey from Columbus (CMH) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $191 (Kiwi.com) |
One-way from | $153 (American Airlines) |
Popular in | September |
Cheapest in | February |
Average price | $556 |
Fly from
Fly to
Route
Depart
Return
ColumbusKnoxville
CMH Columbus - TYS Knoxville McGhee Tyson
CMHTYS
Columbus
Sat 12/19
6:23 pm-11:53 pm
1 stop5h 30m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
ColumbusKnoxville
CMH Columbus - TYS Knoxville McGhee Tyson
CMHTYS
Columbus
Fri 1/15
5:40 pm-10:20 pm
1 stop4h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
ColumbusKnoxville
CMH Columbus - TYS Knoxville McGhee Tyson
CMHTYS
Columbus
Fri 1/15
8:00 am-12:11 pm
1 stop4h 11m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
ColumbusKnoxville
CMH Columbus - TYS Knoxville McGhee Tyson
CMHTYS
Columbus
Fri 1/15
6:32 pm-10:43 am
2 stops16h 11m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
ColumbusKnoxville
CMH Columbus - TYS Knoxville McGhee Tyson
CMHTYS
Columbus
Tue 12/1
11:28 am-3:13 pm
1 stop3h 45m
Knoxville McGhee Tyson
Wed 12/2
8:30 am-12:05 pm
1 stop3h 35m
ColumbusKnoxville
CMH Columbus - TYS Knoxville McGhee Tyson
CMHTYS
Columbus
Wed 12/9
10:35 am-2:53 pm
1 stop4h 18m
Knoxville McGhee Tyson
Wed 12/16
5:35 pm-10:28 pm
1 stop4h 53m
ColumbusKnoxville
CMH Columbus - TYS Knoxville McGhee Tyson
CMHTYS
Columbus
Mon 12/14
10:35 am-2:53 pm
1 stop4h 18m
Knoxville McGhee Tyson
Wed 12/16
9:45 am-2:21 pm
1 stop4h 36m
ColumbusKnoxville
CMH Columbus - TYS Knoxville McGhee Tyson
CMHTYS
Columbus
Sat 12/12
10:18 am-3:54 pm
1 stop5h 36m
Knoxville McGhee Tyson
Mon 12/14
5:17 pm-11:58 pm
1 stop6h 41m
ColumbusKnoxville
CMH Columbus - TYS Knoxville McGhee Tyson
CMHTYS
Columbus
Tue 12/1
3:45 pm-8:50 pm
1 stop5h 05m
Knoxville McGhee Tyson
Wed 12/2
1:00 pm-9:55 pm
2 stops8h 55m
ColumbusKnoxville
CMH Columbus - TYS Knoxville McGhee Tyson
CMHTYS
Columbus
Mon 12/14
11:25 am-7:50 pm
2 stops8h 25m
Knoxville McGhee Tyson
Wed 12/16
1:00 pm-9:55 pm
2 stops8h 55m
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
Everything you need to know about your flight from Columbus Airport to Knoxville
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Find useful and relevant information for your journey from Columbus to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$236 | Average$386 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$272 | Average$313 | FlexibilityNo cancel fee | On-time69% |