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$112+ Cheap flights from Columbus (CMH) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/20. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — TYS
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from Columbus to Knoxville

Cheapest flights from Columbus to Knoxville
Explore the most affordable flight options available from Columbus to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/229:59 amCMH - TYS
1 stop4h 34mAmerican Airlines
Fri 12/264:12 pmTYS - CMH
1 stop6h 38mAmerican Airlines
Deal found 12/22$547
This United Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/224:45 pmCMH - TYS
1 stop6h 57mUnited Airlines
Fri 12/2611:00 amTYS - CMH
2 stops10h 02mUnited Airlines
Deal found 12/22$552
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:00 amCMH - TYS
1 stop4h 27mAmerican Airlines
Mon 12/295:42 amTYS - CMH
1 stop6h 27mAmerican Airlines
Deal found 12/21$553
This Kiwi.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:13 pmCMH - TYS
2 stops42h 18mMultiple Airlines
Mon 12/296:00 amTYS - CMH
1 stop17h 57mMultiple Airlines
Deal found 12/21$636
This Mytrip deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:28 pmCMH - TYS
2 stops17h 32mMultiple Airlines
Fri 12/266:00 amTYS - CMH
3 stops35h 33mMultiple Airlines
Deal found 12/22$1,359

Find flight deals from Columbus to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (CMH) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$260
(Mytrip)

One-way from

$112
(American Airlines)

Popular in

December

Cheapest in

January

Average price

$506
Provider with most accurate pricing for Columbus-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Columbus-Knoxville McGhee Tyson flights.
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From Columbus to Knoxville McGhee Tyson
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One-way flight from Columbus to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($51 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Columbus Airport to Knoxville that are best for you.

Fly from

Columbus

Fly to

Knoxville

Route

Depart

Return

Price

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 2/14

2:25 pm-8:37 pm

1 stop6h 12m

Knoxville McGhee Tyson

Wed 2/18

7:25 pm-11:44 pm

1 stop4h 19m

$283

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Wed 1/14

5:45 am-3:57 pm

1 stop10h 12m

Knoxville McGhee Tyson

Thu 1/15

9:29 am-11:19 pm

2 stops13h 50m

$286

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 1/16

5:45 am-10:32 am

1 stop4h 47m

Knoxville McGhee Tyson

Mon 1/19

7:20 pm-11:44 pm

1 stop4h 24m

$310

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 1/20

5:36 pm-9:44 pm

1 stop4h 08m

$112

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 1/26

5:45 am-5:28 pm

2 stops11h 43m

$125

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 1/12

6:06 am-5:28 pm

1 stop11h 22m

$129

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sun 1/25

4:11 pm-5:28 pm

1 stop25h 17m

$130

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Wed 1/7

11:14 am-5:53 pm

3 stops30h 39m

$141

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 1/20

6:06 am-3:03 pm

3 stops32h 57m

$160

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 1/6

6:00 am-3:03 pm

2 stops33h 03m

$164

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Compare providers for flights from Columbus to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbus to Knoxville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Columbus Airport-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Columbus Airport-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Columbus Airport-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Columbus Airport-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbus Airport-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Columbus to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus Airport to Knoxville

What is the cheapest month to book a flight from Columbus Airport to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Columbus Airport to Knoxville (average of $194). Flying from Columbus Airport to Knoxville in December is currently the most expensive (average of $260). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CMH to TYS?

Find hourly flight availability from Columbus to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2025.

One of the essential ways to save on airfare from Columbus Airport to Knoxville is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 33% on airfare.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 23, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Columbus Airport to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,014 reviews

Food

7.3

Entertainment

7.9

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,014 reviews
Delta
7.9
Good
8,014 reviews

Food

7.3

Entertainment

7.9

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,014 reviews

Food

7.3

Entertainment

7.9

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Columbus to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Columbus?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Columbus. On average, McGhee Tyson has 0 inbound flights from Columbus per day from 2 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Columbus Airport to Knoxville?

    For as low as $283, United Airlines can have you in Knoxville from Columbus Airport in 6h 12m. There are 296 mi between Columbus Airport and Knoxville.

  • What are the cheapest airlines flying from Columbus Airport to Knoxville round-trip?

    Currently priced at $218, American Airlines will fly you from Columbus Airport to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $218. These flights start at 32% lower than the current average price 3 months from now.

  • Can I find deals for flights from Columbus to Knoxville that include hotel bookings?

    Yes. In addition to deals on Columbus to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Knoxville.

  • Can I find deals for business class flights from Columbus to Knoxville?

    Yes. Cheapflights offers flight deals from Columbus to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus Airport to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Columbus Airport to Knoxville (average of $194). Flying from Columbus Airport to Knoxville in December is currently the most expensive (average of $260). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Columbus to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Columbus to Knoxville

Discover the top 2 airlines that operate flights from Columbus to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$293FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$442FlexibilityNo cancel feeOn-timeN/A

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