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$139+ Cheap flights from Myrtle Beach to Knoxville (MYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — TYS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Knoxville

Cheapest flights from Myrtle Beach to Knoxville
Explore the most affordable flight options available from Myrtle Beach to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:11 amMYR - TYS
1 stop3h 45mAmerican Airlines
Tue 12/308:30 amTYS - MYR
1 stop5h 34mAmerican Airlines
Deal found 12/11$556
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/157:30 amMYR - TYS
1 stop6h 30mAmerican Airlines
Wed 12/178:05 amTYS - MYR
1 stop5h 24mAmerican Airlines
Deal found 12/11$607
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/262:14 pmMYR - TYS
2 stops28h 23mMultiple Airlines
Tue 12/309:08 amTYS - MYR
1 stop9h 00mMultiple Airlines
Deal found 12/11$630
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/261:47 pmMYR - TYS
2 stops21h 09mUnited Airlines
Tue 12/302:00 pmTYS - MYR
2 stops23h 06mUnited Airlines
Deal found 12/11$1,054
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/151:16 pmMYR - TYS
2 stops24h 01mUnited Airlines
Wed 12/175:54 pmTYS - MYR
2 stops19h 12mUnited Airlines
Deal found 12/11$1,355

Find flight deals from Myrtle Beach to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$317
(American Airlines)

One-way from

$139
(Kiwi.com)

Popular in

June

Cheapest in

September

Average price

$316
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
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From Myrtle Beach Intl to Knoxville McGhee Tyson
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One-way flight from Myrtle Beach Intl to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 15% potential increase in price ($65 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

Fly from

Myrtle Beach

Fly to

Knoxville

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 3/2

7:56 pm-11:54 pm

1 stop3h 58m

Knoxville McGhee Tyson

Wed 3/4

5:57 pm-10:56 pm

1 stop4h 59m

$317

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 3/5

3:35 pm-9:15 pm

1 stop5h 40m

Knoxville McGhee Tyson

Sun 3/8

7:25 pm-10:00 am

2 stops14h 35m

$328

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 3/2

9:10 am-8:46 pm

1 stop11h 36m

Knoxville McGhee Tyson

Wed 3/4

3:54 pm-10:05 am

2 stops18h 11m

$402

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 12/26

5:11 am-8:56 am

1 stop3h 45m

Knoxville McGhee Tyson

Tue 12/30

8:30 am-2:04 pm

1 stop5h 34m

$556

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 12/15

7:30 am-2:00 pm

1 stop6h 30m

Knoxville McGhee Tyson

Wed 12/17

8:05 am-1:29 pm

1 stop5h 24m

$607

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 12/26

2:14 pm-6:37 pm

2 stops28h 23m

Knoxville McGhee Tyson

Tue 12/30

9:08 am-6:08 pm

1 stop9h 00m

$630

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 1/8

1:25 pm-1:24 pm

2 stops23h 59m

Knoxville McGhee Tyson

Sun 1/11

1:59 pm-12:41 pm

2 stops22h 42m

$650

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 12/30

9:54 am-11:32 pm

1 stop13h 38m

$139

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Compare providers for flights from Myrtle Beach to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Knoxville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Knoxville

What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

Currently, March is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $208). Flying from Myrtle Beach to Knoxville in November is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to TYS?

Find hourly flight availability from Myrtle Beach to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 29% on flights from Myrtle Beach to Knoxville by exploring options for tickets in the afternoon.

How much does it cost to fly round-trip from Myrtle Beach to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 12, 2025.
Get a feel of what it's like to fly with American Airlines from Myrtle Beach to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,050 reviews

Entertainment

6.9

Overall

7.2

Comfort

7.2

Boarding

7.5

Crew

8.0

Food

6.5

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,050 reviews
American Airlines
7.2
Good
11,050 reviews

Entertainment

6.9

Overall

7.2

Comfort

7.2

Boarding

7.5

Crew

8.0

Food

6.5

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Knoxville?

    For as low as $317, American Airlines can have you in Knoxville from Myrtle Beach in 3h 58m. The distance from Myrtle Beach to Knoxville is about 323 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Myrtle Beach to Knoxville round-trip?

    According to our current data, American Airlines ($228), offers the cheapest pricing from Myrtle Beach to Knoxville. American Airlines is priced at 37% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Myrtle Beach to Knoxville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Knoxville.

  • Can I find deals for business class flights from Myrtle Beach to Knoxville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $208). Flying from Myrtle Beach to Knoxville in November is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top airline flying from Myrtle Beach to Knoxville

Discover the top airline that operate flights from Myrtle Beach to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$316FlexibilityNo cancel feeOn-time71%

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