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$109+ Cheap flights from Myrtle Beach to Knoxville (MYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — TYS
Aug 2 — Aug 91
Sat 8/2
Sat 8/9
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 28, 2025.

Round-trip from

$215
(Mytrip)

One-way from

$109
(Mytrip)

Popular in

June

Cheapest in

March

Average price

$298
From Myrtle Beach Intl to Knoxville McGhee Tyson
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One-way flight from Myrtle Beach Intl to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 11% potential increase in price ($46 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Myrtle Beach to Knoxville

Cheapest flights from Myrtle Beach to Knoxville
Explore the most affordable flight options available from Myrtle Beach to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2025.

This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/209:04 pmMYR - TYS
1 stop15h 58mMultiple Airlines
Mon 8/251:22 pmTYS - MYR
1 stop6h 23mMultiple Airlines
Deal found 7/28$215
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/266:00 amMYR - TYS
1 stop4h 42mDelta
Tue 9/25:45 amTYS - MYR
1 stop4h 24mDelta
Deal found 7/27$229
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/108:20 pmMYR - TYS
1 stop3h 30mAmerican Airlines
Mon 10/138:37 pmTYS - MYR
1 stop3h 22mAmerican Airlines
Deal found 7/26$308
This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/47:56 pmMYR - TYS
2 stops17h 15mAllegiant Air
Thu 8/78:54 pmTYS - MYR
2 stops18h 20mAllegiant Air
Deal found 7/27$384
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/55:12 pmMYR - TYS
2 stops17h 15mUnited Airlines
Sun 8/107:00 amTYS - MYR
1 stop7h 35mUnited Airlines
Deal found 7/28$473

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

Fly from

Myrtle Beach

Fly to

Knoxville

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 8/20

9:04 pm-1:02 pm

1 stop15h 58m

Knoxville McGhee Tyson

Mon 8/25

1:22 pm-7:45 pm

1 stop6h 23m

$215

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 8/26

6:00 am-10:42 am

1 stop4h 42m

Knoxville McGhee Tyson

Tue 9/2

5:45 am-10:09 am

1 stop4h 24m

$229

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 10/10

8:20 pm-11:50 pm

1 stop3h 30m

Knoxville McGhee Tyson

Mon 10/13

8:37 pm-11:59 pm

1 stop3h 22m

$308

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 8/4

7:56 pm-1:11 pm

2 stops17h 15m

Knoxville McGhee Tyson

Thu 8/7

8:54 pm-3:14 pm

2 stops18h 20m

$384

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 8/5

5:12 pm-10:27 am

2 stops17h 15m

Knoxville McGhee Tyson

Sun 8/10

7:00 am-2:35 pm

1 stop7h 35m

$473

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 9/15

9:04 pm-12:55 pm

1 stop15h 51m

$109

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 9/16

2:20 pm-8:02 pm

1 stop5h 42m

$169

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Best time to book a flight from Myrtle Beach to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Knoxville

What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $295). Flying from Myrtle Beach to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to TYS?

Find hourly flight availability from Myrtle Beach to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 28, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 30% on flights from Myrtle Beach to Knoxville by exploring options for tickets in the afternoon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 28, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Myrtle Beach to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,975 reviews

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,975 reviews
Delta
8.0
Very good
7,975 reviews

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,892 reviews
Delta
8.0
Very good
7,975 reviews

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,975 reviews

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
702 reviews
Delta
8.0
Very good
7,975 reviews

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Myrtle Beach to Knoxville round-trip?

    According to our current data, Delta ($229), American Airlines ($308), and Allegiant Air ($384) offers the cheapest pricing from Myrtle Beach to Knoxville. Delta is priced at 39% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Myrtle Beach to Knoxville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Knoxville.

  • Can I find deals for business class flights from Myrtle Beach to Knoxville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $295). Flying from Myrtle Beach to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Corbin
Cherokee
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Myrtle Beach to Knoxville

Discover the top 2 airlines that operate flights from Myrtle Beach to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$358FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$355FlexibilityNo cancel feeOn-time71%

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