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$159+ Cheap flights from Myrtle Beach to Knoxville (MYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/27. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — TYS
Nov 26 — Dec 31
Wed 11/26
Wed 12/3
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 27, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$257
(Kiwi.com)

One-way from

$159
(Delta)

Popular in

June

Cheapest in

September

Average price

$338
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
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From Myrtle Beach Intl to Knoxville McGhee Tyson
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One-way flight from Myrtle Beach Intl to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 14% potential increase in price ($61 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Myrtle Beach to Knoxville

Cheapest flights from Myrtle Beach to Knoxville
Explore the most affordable flight options available from Myrtle Beach to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1811:13 amMYR - TYS
1 stop25h 44mMultiple Airlines
Fri 11/219:45 pmTYS - MYR
1 stop26h 09mMultiple Airlines
Deal found 10/25$257
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/102:46 pmMYR - TYS
1 stop19h 48mMultiple Airlines
Fri 11/143:41 pmTYS - MYR
1 stop6h 45mMultiple Airlines
Deal found 10/25$292
This Mytrip deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/228:58 pmMYR - TYS
1 stop14h 36mMultiple Airlines
Mon 11/249:29 pmTYS - MYR
2 stops22h 34mMultiple Airlines
Deal found 10/25$322
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/119:22 amMYR - TYS
2 stops30h 20mMultiple Airlines
Sat 11/1510:54 amTYS - MYR
1 stop11h 32mMultiple Airlines
Deal found 10/26$325
This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:15 amMYR - TYS
2 stops9h 48mMultiple Airlines
Fri 11/282:59 pmTYS - MYR
1 stop5h 04mMultiple Airlines
Deal found 10/26$329
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/82:46 pmMYR - TYS
1 stop18h 18mMultiple Airlines
Wed 11/124:32 pmTYS - MYR
2 stops21h 22mMultiple Airlines
Deal found 10/26$360

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

Fly from

Myrtle Beach

Fly to

Knoxville

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 11/18

11:13 am-12:57 pm

1 stop25h 44m

Knoxville McGhee Tyson

Fri 11/21

9:45 pm-11:54 pm

1 stop26h 09m

$257

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sun 1/4

7:32 pm-10:15 am

1 stop14h 43m

Knoxville McGhee Tyson

Wed 1/7

3:53 pm-11:43 am

1 stop19h 50m

$260

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 11/10

2:46 pm-10:34 am

1 stop19h 48m

Knoxville McGhee Tyson

Fri 11/14

9:38 pm-10:00 am

2 stops36h 22m

$308

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 3/10

6:00 am-11:07 am

1 stop5h 07m

Knoxville McGhee Tyson

Wed 3/11

5:30 am-10:08 am

1 stop4h 38m

$317

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 11/22

8:58 pm-11:34 am

1 stop14h 36m

Knoxville McGhee Tyson

Mon 11/24

9:29 pm-8:03 pm

2 stops22h 34m

$322

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sun 11/23

6:15 am-4:03 pm

2 stops9h 48m

Knoxville McGhee Tyson

Fri 11/28

2:59 pm-8:03 pm

1 stop5h 04m

$329

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 11/11

9:22 am-3:42 pm

3 stops30h 20m

Knoxville McGhee Tyson

Sat 11/15

10:54 am-10:26 pm

1 stop11h 32m

$335

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 11/27

10:35 am-2:48 pm

1 stop4h 13m

$159

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 11/27

3:56 pm-7:19 pm

2 stops27h 23m

$219

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/25

Compare providers for flights from Myrtle Beach to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Knoxville

What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

Currently, March is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $208). Flying from Myrtle Beach to Knoxville in December is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to TYS?

Find hourly flight availability from Myrtle Beach to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 27, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 29% on flights from Myrtle Beach to Knoxville by exploring options for tickets in the afternoon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 27, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Myrtle Beach to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,996 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,996 reviews
Delta
7.9
Good
7,996 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,033 reviews
Delta
7.9
Good
7,996 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Knoxville?

    For as low as $317, Delta can have you in Knoxville from Myrtle Beach in 5h 07m. The distance from Myrtle Beach to Knoxville is about 323 mi.

  • What are the cheapest airlines flying from Myrtle Beach to Knoxville round-trip?

    According to our current data, Delta ($198), and American Airlines ($228) offers the cheapest pricing from Myrtle Beach to Knoxville. Delta is priced at 45% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Myrtle Beach to Knoxville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Knoxville.

  • Can I find deals for business class flights from Myrtle Beach to Knoxville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $208). Flying from Myrtle Beach to Knoxville in December is currently the most expensive (average of $253). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Myrtle Beach to Knoxville

Discover the top 2 airlines that operate flights from Myrtle Beach to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$443FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$320FlexibilityNo cancel feeOn-time71%

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