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$123+ Cheap flights from Myrtle Beach to Knoxville (MYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — TYS
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Knoxville

Cheapest flights from Myrtle Beach to Knoxville
Explore the most affordable flight options available from Myrtle Beach to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:28 pm
MYR
-
TYS
1 stop16h 12m
Multiple Airlines
Sat 3/289:36 pm
TYS
-
MYR
1 stop19h 57m
Multiple Airlines
Deal found 3/9$276
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:04 am
MYR
-
TYS
1 stop5h 11m
American Airlines
Thu 4/165:00 am
TYS
-
MYR
1 stop3h 24m
American Airlines
Deal found 3/6$279
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:55 pm
MYR
-
TYS
1 stop18h 14m
Multiple Airlines
Thu 5/79:40 pm
TYS
-
MYR
1 stop16h 40m
Multiple Airlines
Deal found 3/9$280
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/410:50 am
MYR
-
TYS
1 stop10h 15m
Southwest
Sat 4/116:40 am
TYS
-
MYR
1 stop5h 30m
Southwest
Deal found 3/7$284
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:43 pm
MYR
-
TYS
1 stop15h 07m
Multiple Airlines
Sun 6/77:30 am
TYS
-
MYR
1 stop7h 07m
Multiple Airlines
Deal found 3/6$290
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:00 am
MYR
-
TYS
1 stop3h 32m
American Airlines
Sun 4/197:00 am
TYS
-
MYR
1 stop3h 26m
American Airlines
Deal found 3/10$298
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:10 pm
MYR
-
TYS
1 stop6h 40m
Southwest
Thu 4/166:35 am
TYS
-
MYR
2 stops14h 15m
Southwest
Deal found 3/6$309
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2010:55 am
MYR
-
TYS
1 stop9h 25m
Southwest
Fri 4/246:35 am
TYS
-
MYR
2 stops14h 15m
Southwest
Deal found 3/6$314
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:45 pm
MYR
-
TYS
1 stop5h 01m
Delta
Sat 10/3110:05 am
TYS
-
MYR
1 stop3h 30m
Delta
Deal found 3/7$317
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:10 am
MYR
-
TYS
1 stop3h 32m
American Airlines
Mon 4/65:00 am
TYS
-
MYR
1 stop3h 32m
American Airlines
Deal found 3/5$323

Find flight deals from Myrtle Beach to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$276
(Kiwi.com)

One-way from

$123
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$646
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
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From Myrtle Beach Intl to Knoxville McGhee Tyson
Search Deals
One-way flight from Myrtle Beach Intl to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($107 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 6/4

8:43 pm-11:50 am

1 stop15h 07m

Knoxville McGhee Tyson

Sun 6/7

7:30 am-2:37 pm

1 stop7h 07m

$290

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 4/4

10:50 am-9:05 pm

1 stop10h 15m

Knoxville McGhee Tyson

Sat 4/11

6:40 am-8:45 pm

2 stops14h 05m

$295

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 4/15

2:10 pm-8:50 pm

1 stop6h 40m

Knoxville McGhee Tyson

Thu 4/16

6:35 am-8:50 pm

2 stops14h 15m

$309

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 4/20

10:55 am-8:20 pm

1 stop9h 25m

Knoxville McGhee Tyson

Fri 4/24

6:35 am-8:50 pm

2 stops14h 15m

$314

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 7/17

11:55 am-10:20 pm

1 stop10h 25m

Knoxville McGhee Tyson

Mon 7/20

7:30 am-6:35 pm

1 stop11h 05m

$328
Quickest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sun 5/3

4:45 pm-10:00 pm

1 stop5h 15m

Knoxville McGhee Tyson

Wed 5/6

7:05 am-1:30 pm

1 stop6h 25m

$340

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 6/4

2:05 pm-9:10 pm

2 stops7h 05m

Knoxville McGhee Tyson

Sun 6/7

7:05 am-5:10 pm

2 stops10h 05m

$368

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 3/24

7:45 am-8:05 pm

2 stops12h 20m

Knoxville McGhee Tyson

Sat 3/28

6:35 am-8:10 pm

2 stops13h 35m

$439

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 3/25

7:45 am-8:05 pm

2 stops12h 20m

Knoxville McGhee Tyson

Sun 3/29

6:35 am-5:10 pm

2 stops10h 35m

$567

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 6/1

10:34 am-11:54 pm

1 stop13h 20m

Knoxville McGhee Tyson

Fri 6/5

7:19 pm-9:59 am

1 stop14h 40m

$579

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/7

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Compare providers for flights from Myrtle Beach to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Knoxville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Knoxville

What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $209). Flying from Myrtle Beach to Knoxville in November is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 10, 2026.
Get a feel of what it's like to fly with American Airlines from Myrtle Beach to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,414 reviews

Entertainment

6.9

Food

6.4

Overall

7.1

Boarding

7.5

Comfort

7.2

Crew

7.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,414 reviews
American Airlines
7.1
Good
11,414 reviews

Entertainment

6.9

Food

6.4

Overall

7.1

Boarding

7.5

Comfort

7.2

Crew

7.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Knoxville?

    For as low as $295, Southwest can have you in Knoxville from Myrtle Beach in 10h 15m. The distance from Myrtle Beach to Knoxville is about 323 mi.

  • What is the cheapest airline to fly from Myrtle Beach to Knoxville round-trip?

    According to our current data, American Airlines ($278), offers the cheapest pricing from Myrtle Beach to Knoxville. American Airlines is priced at 29% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Myrtle Beach to Knoxville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Knoxville.

  • Can I find deals for business class flights from Myrtle Beach to Knoxville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

    Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $209). Flying from Myrtle Beach to Knoxville in November is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Myrtle Beach to Knoxville

Discover the top airline that operate flights from Myrtle Beach to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$278Average$323FlexibilityNo cancel feeOn-time71%

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