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$144+ Cheap flights from Myrtle Beach to Knoxville (MYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$197
(Delta)

One-way from

$144
(Trip.com)

Popular in

June

Cheapest in

March

Average price

$288
From Myrtle Beach Intl to Knoxville McGhee Tyson
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One-way flight from Myrtle Beach Intl to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 11% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Myrtle Beach to Knoxville

Cheapest flights from Myrtle Beach to Knoxville
Explore the most affordable flight options available from Myrtle Beach to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:00 amMYR - TYS
1 stop3h 00mDelta
Wed 10/155:44 amTYS - MYR
1 stop4h 07mDelta
Deal found 9/10$197
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/208:20 pmMYR - TYS
1 stop3h 30mAmerican Airlines
Wed 10/228:15 amTYS - MYR
1 stop3h 13mAmerican Airlines
Deal found 9/10$236
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/37:17 pmMYR - TYS
1 stop12h 33mMultiple Airlines
Fri 10/107:15 amTYS - MYR
1 stop16h 42mMultiple Airlines
Deal found 9/11$273
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/268:06 amMYR - TYS
1 stop3h 44mAmerican Airlines
Tue 9/305:43 pmTYS - MYR
1 stop3h 26mAmerican Airlines
Deal found 9/11$285
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:58 pmMYR - TYS
1 stop4h 48mDelta
Sun 10/198:35 pmTYS - MYR
1 stop3h 24mDelta
Deal found 9/10$289
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/247:36 pmMYR - TYS
1 stop15h 42mMultiple Airlines
Sun 9/2810:09 amTYS - MYR
2 stops32h 02mMultiple Airlines
Deal found 9/8$308
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:00 amMYR - TYS
1 stop5h 55mMultiple Airlines
Sun 10/55:44 pmTYS - MYR
2 stops39h 43mMultiple Airlines
Deal found 9/10$318
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/197:43 pmMYR - TYS
1 stop17h 20mMultiple Airlines
Tue 10/218:00 amTYS - MYR
1 stop11h 11mMultiple Airlines
Deal found 9/10$320
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2612:31 pmMYR - TYS
2 stops31h 01mMultiple Airlines
Thu 10/309:58 amTYS - MYR
1 stop10h 06mMultiple Airlines
Deal found 9/10$330

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

Fly from

Myrtle Beach

Fly to

Knoxville

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 10/8

6:00 am-9:00 am

1 stop3h 00m

Knoxville McGhee Tyson

Wed 10/15

5:44 am-9:51 am

1 stop4h 07m

$197

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 10/20

8:20 pm-11:50 pm

1 stop3h 30m

Knoxville McGhee Tyson

Wed 10/22

8:15 am-11:28 am

1 stop3h 13m

$236

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 10/16

6:58 pm-11:46 pm

1 stop4h 48m

Knoxville McGhee Tyson

Sun 10/19

8:35 pm-11:59 pm

1 stop3h 24m

$289

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 10/3

7:17 pm-7:50 am

1 stop12h 33m

Knoxville McGhee Tyson

Fri 10/10

9:54 pm-3:04 pm

2 stops41h 10m

$292

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 10/3

6:00 am-11:55 am

1 stop5h 55m

Knoxville McGhee Tyson

Sun 10/5

5:44 pm-9:27 am

2 stops39h 43m

$318

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sun 10/19

7:43 pm-1:03 pm

1 stop17h 20m

Knoxville McGhee Tyson

Tue 10/21

8:00 am-7:11 pm

1 stop11h 11m

$320

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sun 10/26

12:31 pm-7:32 pm

2 stops31h 01m

Knoxville McGhee Tyson

Thu 10/30

9:58 am-8:04 pm

1 stop10h 06m

$330

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 9/23

2:45 pm-3:41 pm

1 stop24h 56m

Knoxville McGhee Tyson

Sun 9/28

10:09 am-6:11 pm

2 stops32h 02m

$334

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 10/8

7:00 am-7:23 pm

1 stop12h 23m

Knoxville McGhee Tyson

Wed 10/15

4:26 pm-3:06 pm

2 stops22h 40m

$336

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 9/27

4:23 pm-11:18 am

1 stop18h 55m

$144

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 13 results
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Best time to book a flight from Myrtle Beach to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Knoxville

What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $294). Flying from Myrtle Beach to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to TYS?

Find hourly flight availability from Myrtle Beach to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 30% on flights from Myrtle Beach to Knoxville by exploring options for tickets in the afternoon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Myrtle Beach to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Knoxville?

    For as low as $197, Delta can have you in Knoxville from Myrtle Beach in 3h. The distance from Myrtle Beach to Knoxville is about 323 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Myrtle Beach to Knoxville round-trip?

    According to our current data, Delta ($198), and American Airlines ($228) offers the cheapest pricing from Myrtle Beach to Knoxville. Delta is priced at 47% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Myrtle Beach to Knoxville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Knoxville.

  • Can I find deals for business class flights from Myrtle Beach to Knoxville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $294). Flying from Myrtle Beach to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Myrtle Beach to Knoxville

Discover the top 2 airlines that operate flights from Myrtle Beach to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$358FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$338FlexibilityNo cancel feeOn-time71%

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