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$108+ Cheap flights from Myrtle Beach to Knoxville (MYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — TYS
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$229
(American Airlines)

One-way from

$108
(Mytrip)

Popular in

December

Cheapest in

June

Average price

$276
From Myrtle Beach Intl to Knoxville McGhee Tyson
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One-way flight from Myrtle Beach Intl to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 26% potential increase in price ($134 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Myrtle Beach to Knoxville

Cheapest flights from Myrtle Beach to Knoxville
Explore the most affordable flight options available from Myrtle Beach to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/42:44 pmMYR - TYS
1 stop3h 16mAmerican Airlines
Tue 7/87:52 pmTYS - MYR
1 stop4h 10mAmerican Airlines
Deal found 6/11$229
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/217:56 pmMYR - TYS
2 stops17h 15mMultiple Airlines
Mon 7/286:00 amTYS - MYR
1 stop16h 17mMultiple Airlines
Deal found 6/10$244
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/116:00 amMYR - TYS
1 stop5h 08mDelta
Mon 6/167:44 pmTYS - MYR
1 stop4h 23mDelta
Deal found 6/9$279
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/194:55 pmMYR - TYS
1 stop5h 45mUnited Airlines
Sun 6/227:00 amTYS - MYR
1 stop7h 35mUnited Airlines
Deal found 6/10$329
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/3011:47 amMYR - TYS
2 stops29h 22mAllegiant Air
Sun 7/67:10 amTYS - MYR
2 stops35h 56mAllegiant Air
Deal found 6/11$430

Cheapflights Fare Finder

Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

Fly from

Myrtle Beach

Fly to

Knoxville

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 7/4

2:44 pm-6:00 pm

1 stop3h 16m

Knoxville McGhee Tyson

Tue 7/8

7:52 pm-12:02 am

1 stop4h 10m

$229

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 7/21

7:56 pm-1:11 pm

2 stops17h 15m

Knoxville McGhee Tyson

Mon 7/28

6:00 am-10:17 pm

1 stop16h 17m

$244

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 6/19

4:55 pm-10:40 pm

1 stop5h 45m

Knoxville McGhee Tyson

Sun 6/22

7:00 am-2:35 pm

1 stop7h 35m

$329

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 6/30

11:47 am-5:09 pm

2 stops29h 22m

Knoxville McGhee Tyson

Sun 7/6

7:10 am-7:06 pm

2 stops35h 56m

$430

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 6/16

11:00 am-3:15 pm

1 stop4h 15m

Knoxville McGhee Tyson

Fri 6/20

7:44 pm-12:16 am

1 stop4h 32m

$553

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 7/10

2:31 pm-10:20 pm

1 stop7h 49m

$108

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sun 7/13

10:45 am-10:11 am

1 stop23h 26m

$110

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 7/3

4:22 pm-7:01 pm

1 stop2h 39m

$228

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 7/3

5:12 pm-2:58 pm

2 stops21h 46m

$255

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from Myrtle Beach to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Knoxville

What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $296). Flying from Myrtle Beach to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to TYS?

Find hourly flight availability from Myrtle Beach to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 30% on flights from Myrtle Beach to Knoxville by exploring options for tickets in the afternoon.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 12, 2025.
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.3
Good
725 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Myrtle Beach to Knoxville round-trip?

    According to our current data, American Airlines ($229), United Airlines ($329), and Allegiant Air ($430) offers the cheapest pricing from Myrtle Beach to Knoxville. American Airlines is priced at 37% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Myrtle Beach to Knoxville one-way?

    One-way options have recently been found by users for as low as $108 on Allegiant Air. Other airlines that offer cheap prices include American Airlines from $228 and United Airlines from $255 one-way.

  • Can I find deals for flights from Myrtle Beach to Knoxville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Knoxville.

  • Can I find deals for business class flights from Myrtle Beach to Knoxville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $296). Flying from Myrtle Beach to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top 2 airlines flying from Myrtle Beach to Knoxville

Discover the top 2 airlines that operate flights from Myrtle Beach to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$288FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$355FlexibilityNo cancel feeOn-time71%

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