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Knoxville

$75+ Cheap flights from Indiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/22. Fares are subject to change and may not be available on all flights or dates of travel.
IND — TYS
Jan 2 — Jan 91
Fri 1/2
Fri 1/9
1 adult, Economy
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Cheap flight deals from Indiana to Knoxville

Cheapest flights from Indiana to Knoxville
Explore the most affordable flight options available from Indiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 3, 2025.

This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:25 amORD - TYS
Nonstop1h 52mUnited Airlines
Wed 1/71:59 pmTYS - ORD
Nonstop1h 56mUnited Airlines
Deal found 12/1$189
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/163:08 pmORD - TYS
Nonstop1h 50mAmerican Airlines
Tue 12/237:48 amTYS - ORD
Nonstop2h 02mAmerican Airlines
Deal found 12/2$204
This Frontier deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:00 amORD - TYS
1 stop7h 57mFrontier
Thu 12/114:52 pmTYS - ORD
1 stop8h 20mFrontier
Deal found 12/1$208
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/113:47 pmORD - TYS
1 stop26h 27mMultiple Airlines
Sun 12/144:52 pmTYS - ORD
1 stop8h 20mMultiple Airlines
Deal found 12/2$209
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1610:35 amORD - TYS
Nonstop1h 42mUnited Airlines
Sat 12/206:45 amTYS - ORD
Nonstop2h 07mUnited Airlines
Deal found 12/1$219
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:00 amORD - TYS
Nonstop1h 50mAmerican Airlines
Tue 1/67:54 amTYS - ORD
Nonstop2h 08mAmerican Airlines
Deal found 12/2$223
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:11 amORD - TYS
1 stop15h 26mMultiple Airlines
Wed 12/172:53 pmTYS - ORD
1 stop10h 16mMultiple Airlines
Deal found 12/1$224
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:01 pmORD - TYS
2 stops20h 14mMultiple Airlines
Tue 1/67:22 pmTYS - ORD
1 stop26h 37mMultiple Airlines
Deal found 12/2$226
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amIND - TYS
1 stop16h 42mAllegiant Air
Mon 12/226:30 amTYS - IND
1 stop14h 49mAllegiant Air
Deal found 12/3$229
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:00 amCVG - TYS
1 stop16h 00mAllegiant Air
Wed 1/73:53 pmTYS - CVG
1 stop26h 57mAllegiant Air
Deal found 12/1$232
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/164:53 pmSBN - TYS
1 stop4h 11mUnited Airlines
Sat 12/205:35 pmTYS - SBN
1 stop4h 05mUnited Airlines
Deal found 12/1$239
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:12 amMDW - TYS
2 stops14h 44mMultiple Airlines
Sun 12/2112:50 pmTYS - MDW
1 stop9h 14mMultiple Airlines
Deal found 12/1$252

Find flight deals from Indiana to Knoxville

Keep the following information in mind while searching for Indiana to Knoxville flight deals. Data was last updated December 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$164
(Kiwi.com)

One-way from

$75
(Kiwi.com)

Popular in

March

Cheapest in

June

Average price

$268
Provider with most accurate pricing for Indianapolis-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Indianapolis-Knoxville McGhee Tyson flights.
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From Indiana to Knoxville McGhee Tyson
Search Deals
One-way flight from Indiana to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($66 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 3, 2025.
Use the filters below to find and compare flights from Indiana to Knoxville that are best for you.

Fly from

Indiana

Fly to

Knoxville

Route

Depart

Return

Price

IndianapolisKnoxville

IND - TYS

INDTYS

Indianapolis

Tue 1/27

7:01 am-12:46 pm

1 stop5h 45m

Knoxville McGhee Tyson

Sat 1/31

10:11 am-5:48 pm

2 stops7h 37m

$180

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Sat 1/31

9:38 am-8:39 am

2 stops22h 01m

Knoxville McGhee Tyson

Mon 2/2

12:55 pm-7:58 pm

1 stop8h 03m

$183

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Fri 1/23

7:42 am-10:32 am

Nonstop1h 50m

Knoxville McGhee Tyson

Tue 1/27

11:10 am-12:05 pm

Nonstop1h 55m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Thu 2/5

6:10 pm-8:52 pm

Nonstop1h 42m

Knoxville McGhee Tyson

Sun 2/8

6:45 am-7:48 am

Nonstop2h 03m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Fri 1/30

6:10 pm-8:52 pm

Nonstop1h 42m

Knoxville McGhee Tyson

Mon 2/2

5:29 pm-6:27 pm

Nonstop1h 58m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Fri 2/6

6:10 pm-8:52 pm

Nonstop1h 42m

Knoxville McGhee Tyson

Sun 2/8

6:45 am-7:48 am

Nonstop2h 03m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 2/11

6:10 pm-8:52 pm

Nonstop1h 42m

Knoxville McGhee Tyson

Sun 2/15

6:45 am-7:47 am

Nonstop2h 02m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Thu 1/22

7:42 am-10:32 am

Nonstop1h 50m

Knoxville McGhee Tyson

Sun 1/25

6:45 am-7:48 am

Nonstop2h 03m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Sat 3/7

6:07 pm-8:48 pm

Nonstop1h 41m

Knoxville McGhee Tyson

Wed 3/11

7:00 am-8:01 am

Nonstop2h 01m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Thu 2/19

6:28 pm-9:10 pm

Nonstop1h 42m

Knoxville McGhee Tyson

Sun 2/22

6:45 am-7:47 am

Nonstop2h 02m

$202

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 60 results
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Best time to book a flight from Indiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to Knoxville

What is the cheapest month to book a flight from Indiana to Knoxville?

Currently, July is the cheapest month in which you can book a flight from Indiana to Knoxville (average of $56). Flying from Indiana to Knoxville in March is currently the most expensive (average of $218). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to TYS?

Find hourly flight availability from Indiana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 3, 2025.

A simple way to save on the total cost of your ticket is to fly from Indiana to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 42% on your trip compared to booking a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Indiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Indiana?

    If you book a flight to Knoxville from Indiana, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Indiana to Knoxville?

    Departing from Indiana to Knoxville will take you 1h 50m. Airlines will cover a distance of 475 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Indiana to Knoxville one-way?

    The cheapest airlines for a one-way flight from Indiana to Knoxville are Allegiant Air ($38), Delta ($99), and American Airlines ($99).

  • What are the most popular routes from Indiana to Knoxville?

    Most travelers choose Chicago O'Hare Intl - Knoxville McGhee Tyson, Chicago Midway - Knoxville McGhee Tyson or South Bend/Michiana - Knoxville McGhee Tyson when deciding on the best route from Indiana to Knoxville.

  • Can I find deals for flights from Indiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Indiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to Knoxville.

  • Can I find deals for business class flights from Indiana to Knoxville?

    Yes. Cheapflights offers flight deals from Indiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to Knoxville?

    Currently, July is the cheapest month in which you can book a flight from Indiana to Knoxville (average of $56). Flying from Indiana to Knoxville in March is currently the most expensive (average of $218). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Indiana to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Indiana to Knoxville

Discover the top 4 airlines that operate flights from Indiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$56Average$80FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$107Average$335FlexibilityNo cancel feeOn-time69%
DeltaCheapest$134Average$384FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$208Average$356FlexibilityNo cancel feeOn-time71%

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