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Knoxville

$102+ Cheap flights from Indiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/10. Fares are subject to change and may not be available on all flights or dates of travel.
IND — TYS
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
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Cheap flight deals from Indiana to Knoxville

Keep the following information in mind while searching for Indiana to Knoxville flight deals. Data was last updated January 15, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$189
(United Airlines)

One-way from

$102
(Kiwi.com)

Popular in

March

Cheapest in

November

Average price

$547
Provider with most accurate pricing for Indianapolis-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Indianapolis-Knoxville McGhee Tyson flights.
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From Indiana to Knoxville McGhee Tyson
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One-way flight from Indiana to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 12% potential increase in price ($52 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Indiana to Knoxville

Cheapest flights from Indiana to Knoxville
Explore the most affordable flight options available from Indiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/112:46 pm
MDW
-
TYS
Nonstop1h 28m
Allegiant Air
Sun 6/141:22 pm
TYS
-
MDW
Nonstop1h 34m
Allegiant Air
Deal found 1/12$131
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/66:10 pm
ORD
-
TYS
Nonstop1h 42m
United Airlines
Mon 2/96:45 am
TYS
-
ORD
Nonstop2h 03m
United Airlines
Deal found 1/14$189
This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/298:10 am
ORD
-
TYS
1 stop8h 43m
Multiple Airlines
Sun 2/11:39 pm
TYS
-
ORD
1 stop25h 28m
Multiple Airlines
Deal found 1/13$193
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:45 pm
ORD
-
TYS
Nonstop1h 44m
United Airlines
Sun 4/197:00 am
TYS
-
ORD
Nonstop1h 55m
United Airlines
Deal found 1/14$197
This Kiwi.com deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/45:15 am
ORD
-
TYS
1 stop9h 42m
Multiple Airlines
Sun 2/81:39 pm
TYS
-
ORD
1 stop25h 28m
Multiple Airlines
Deal found 1/15$198
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:06 pm
ORD
-
TYS
Nonstop1h 41m
United Airlines
Mon 3/97:00 am
TYS
-
ORD
Nonstop2h 00m
United Airlines
Deal found 1/15$199
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3110:07 am
ORD
-
TYS
Nonstop1h 39m
American Airlines
Sat 2/74:44 pm
TYS
-
ORD
Nonstop2h 11m
American Airlines
Deal found 1/14$204
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/65:59 pm
ORD
-
TYS
1 stop4h 46m
Delta
Fri 2/132:38 pm
TYS
-
ORD
1 stop5h 11m
Delta
Deal found 1/13$209
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/113:41 pm
SBN
-
TYS
1 stop5h 11m
United Airlines
Sat 2/146:45 am
TYS
-
SBN
1 stop5h 53m
United Airlines
Deal found 1/13$209
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/66:14 pm
MDW
-
TYS
1 stop4h 31m
Delta
Fri 2/136:41 pm
TYS
-
MDW
1 stop4h 50m
Delta
Deal found 1/13$209
This Southwest deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/111:20 pm
MDW
-
TYS
2 stops6h 50m
Southwest
Mon 3/167:25 pm
TYS
-
MDW
1 stop5h 40m
Southwest
Deal found 1/13$214
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/116:02 pm
ORD
-
TYS
2 stops27h 23m
Multiple Airlines
Wed 2/183:52 pm
TYS
-
ORD
1 stop8h 55m
Multiple Airlines
Deal found 1/14$218

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Indiana to Knoxville that are best for you.

Fly from

Indiana

Fly to

Knoxville

Route

Depart

Return

Price

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Sun 4/5

7:15 am-10:08 am

Nonstop1h 53m

Knoxville McGhee Tyson

Sat 4/11

7:00 am-7:55 am

Nonstop1h 55m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Sat 3/28

6:07 pm-8:48 pm

Nonstop1h 41m

Knoxville McGhee Tyson

Sat 4/4

7:00 am-7:55 am

Nonstop1h 55m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Fri 2/20

6:00 pm-8:37 pm

Nonstop1h 37m

Knoxville McGhee Tyson

Sat 2/21

6:45 am-7:47 am

Nonstop2h 02m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Sat 4/4

7:45 pm-10:29 pm

Nonstop1h 44m

Knoxville McGhee Tyson

Mon 4/6

7:00 am-7:55 am

Nonstop1h 55m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 2/4

6:10 pm-8:52 pm

Nonstop1h 42m

Knoxville McGhee Tyson

Sun 2/8

6:45 am-7:48 am

Nonstop2h 03m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 4/15

8:19 pm-11:03 pm

Nonstop1h 44m

Knoxville McGhee Tyson

Sun 4/19

7:00 am-7:55 am

Nonstop1h 55m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Thu 4/16

7:45 pm-10:29 pm

Nonstop1h 44m

Knoxville McGhee Tyson

Sun 4/19

7:00 am-7:55 am

Nonstop1h 55m

$197

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Thu 2/12

7:35 am-10:19 am

Nonstop1h 44m

Knoxville McGhee Tyson

Thu 2/19

6:45 am-7:47 am

Nonstop2h 02m

$198

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Fri 3/6

6:06 pm-8:47 pm

Nonstop1h 41m

Knoxville McGhee Tyson

Mon 3/9

7:00 am-8:00 am

Nonstop2h 00m

$199

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 1/28

10:35 am-1:24 pm

Nonstop1h 49m

Knoxville McGhee Tyson

Mon 2/9

6:45 am-7:48 am

Nonstop2h 03m

$204

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/13

Showing 1-10 of 60 results
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Best time to book a flight from Indiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to Knoxville

What is the cheapest month to book a flight from Indiana to Knoxville?

Currently, July is the cheapest month in which you can book a flight from Indiana to Knoxville (average of $56). Flying from Indiana to Knoxville in December is currently the most expensive (average of $238). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to TYS?

Find hourly flight availability from Indiana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 15, 2026.

A simple way to save on the total cost of your ticket is to fly from Indiana to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 32% on your trip compared to booking a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Indiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Indiana?

    If you book a flight to Knoxville from Indiana, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Indiana to Knoxville?

    Departing from Indiana to Knoxville will take you 1h 53m. Airlines will cover a distance of 475 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Indiana to Knoxville one-way?

    The cheapest airlines for a one-way flight from Indiana to Knoxville are Allegiant Air ($37), Delta ($99), and American Airlines ($99).

  • What are the most popular routes from Indiana to Knoxville?

    Most travelers choose Chicago O'Hare Intl - Knoxville McGhee Tyson, Chicago Midway - Knoxville McGhee Tyson or South Bend/Michiana - Knoxville McGhee Tyson when deciding on the best route from Indiana to Knoxville.

  • Can I find deals for flights from Indiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Indiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to Knoxville.

  • Can I find deals for business class flights from Indiana to Knoxville?

    Yes. Cheapflights offers flight deals from Indiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to Knoxville?

    Currently, July is the cheapest month in which you can book a flight from Indiana to Knoxville (average of $56). Flying from Indiana to Knoxville in December is currently the most expensive (average of $238). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Indiana to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Indiana to Knoxville

Discover the top 4 airlines that operate flights from Indiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$56Average$79FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$107Average$335FlexibilityNo cancel feeOn-time69%
DeltaCheapest$134Average$335FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$208Average$354FlexibilityNo cancel feeOn-time71%

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