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Knoxville

$55+ Cheap flights from Indiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.
IND — TYS
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheap flight deals from Indiana to Knoxville

Keep the following information in mind while searching for Indiana to Knoxville flight deals. Data was last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$136
(Cheapflightsfares)

One-way from

$55
(Cheapflightsfares)

Popular in

March

Cheapest in

December

Average price

$373
Provider with most accurate pricing for Indianapolis-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Indianapolis-Knoxville McGhee Tyson flights.
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From Indiana to Knoxville McGhee Tyson
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One-way flight from Indiana to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 14% potential increase in price ($60 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Indiana to Knoxville

Cheapest flights from Indiana to Knoxville
Explore the most affordable flight options available from Indiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/72:57 pmMDW - TYS
Nonstop1h 25mAllegiant Air
Mon 11/102:47 pmTYS - MDW
Nonstop1h 35mAllegiant Air
Deal found 10/14$136
This Booking.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/242:45 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Mon 10/277:02 pmTYS - MDW
Nonstop1h 32mAllegiant Air
Deal found 10/16$138
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/32:45 pmMDW - TYS
Nonstop1h 24mMultiple Airlines
Sun 11/97:00 amTYS - MDW
1 stop29h 30mMultiple Airlines
Deal found 10/15$147
This Cheapflightsfares deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/143:27 pmMDW - TYS
Nonstop1h 25mAllegiant Air
Mon 11/172:47 pmTYS - MDW
Nonstop1h 35mAllegiant Air
Deal found 10/14$155
This FlightHub deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/104:12 pmMDW - TYS
Nonstop1h 25mMultiple Airlines
Thu 11/137:17 pmTYS - MDW
1 stop17h 13mMultiple Airlines
Deal found 10/16$163
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/143:27 pmMDW - TYS
Nonstop1h 25mMultiple Airlines
Mon 11/172:22 pmTYS - MDW
1 stop7h 09mMultiple Airlines
Deal found 10/14$167
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:05 amMDW - TYS
2 stops14h 58mMultiple Airlines
Fri 11/2112:45 pmTYS - MDW
Nonstop1h 36mMultiple Airlines
Deal found 10/15$170
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/143:27 pmMDW - TYS
Nonstop1h 25mMultiple Airlines
Wed 11/198:15 amTYS - MDW
1 stop28h 27mMultiple Airlines
Deal found 10/14$183
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:32 amMDW - TYS
1 stop12h 34mMultiple Airlines
Mon 11/311:00 amTYS - MDW
1 stop10h 31mMultiple Airlines
Deal found 10/14$185
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/78:04 pmORD - TYS
Nonstop1h 51mUnited Airlines
Mon 11/105:52 pmTYS - ORD
Nonstop2h 01mUnited Airlines
Deal found 10/15$189
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/32:17 pmORD - TYS
Nonstop1h 51mUnited Airlines
Tue 11/188:26 amTYS - ORD
Nonstop2h 04mUnited Airlines
Deal found 10/14$194
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/38:04 pmORD - TYS
Nonstop1h 51mUnited Airlines
Fri 11/148:26 amTYS - ORD
Nonstop2h 04mUnited Airlines
Deal found 10/15$199

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Indiana to Knoxville that are best for you.

Fly from

Indiana

Fly to

Knoxville

Route

Depart

Return

Price

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 11/7

2:57 pm-5:22 pm

Nonstop1h 25m

Knoxville McGhee Tyson

Mon 11/10

2:47 pm-3:22 pm

Nonstop1h 35m

$136

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 10/24

2:45 pm-5:09 pm

Nonstop1h 24m

Knoxville McGhee Tyson

Mon 10/27

7:02 pm-7:34 pm

Nonstop1h 32m

$138

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Thu 11/6

8:04 pm-10:55 pm

Nonstop1h 51m

Knoxville McGhee Tyson

Mon 11/10

5:52 pm-6:53 pm

Nonstop2h 01m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Thu 11/13

7:20 am-10:05 am

Nonstop1h 45m

Knoxville McGhee Tyson

Thu 11/20

8:26 am-9:30 am

Nonstop2h 04m

$189

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Sat 11/1

6:30 am-12:38 pm

1 stop29h 08m

Knoxville McGhee Tyson

Thu 11/6

6:58 pm-10:20 pm

1 stop28h 22m

$193

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Mon 11/3

5:50 pm-8:33 pm

Nonstop1h 43m

Knoxville McGhee Tyson

Fri 11/14

8:26 am-9:30 am

Nonstop2h 04m

$194

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Mon 11/3

5:50 pm-8:33 pm

Nonstop1h 43m

Knoxville McGhee Tyson

Sun 11/9

6:45 am-7:46 am

Nonstop2h 01m

$194

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 11/14

5:57 pm-5:22 pm

1 stop22h 25m

Knoxville McGhee Tyson

Wed 11/19

8:15 am-11:42 am

1 stop28h 27m

$202

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Thu 1/22

7:00 am-4:19 pm

1 stop8h 19m

Knoxville McGhee Tyson

Tue 1/27

7:30 am-12:41 pm

1 stop6h 11m

$209

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Tue 11/11

1:15 pm-8:00 pm

1 stop5h 45m

Knoxville McGhee Tyson

Tue 11/18

5:35 am-9:52 am

1 stop5h 17m

$209

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Showing 1-10 of 60 results
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Best time to book a flight from Indiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to Knoxville

What is the cheapest month to book a flight from Indiana to Knoxville?

Currently, July is the cheapest month in which you can book a flight from Indiana to Knoxville (average of $56). Flying from Indiana to Knoxville in March is currently the most expensive (average of $219). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to TYS?

Find hourly flight availability from Indiana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

A simple way to save on the total cost of your ticket is to fly from Indiana to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 41% on your trip compared to booking a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Indiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Indiana?

    If you book a flight to Knoxville from Indiana, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Indiana to Knoxville?

    Departing from Indiana to Knoxville will take you 1h 25m. Airlines will cover a distance of 460 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Indiana to Knoxville one-way?

    The cheapest airlines for a one-way flight from Indiana to Knoxville are Allegiant Air ($64), Frontier ($95), and American Airlines ($120).

  • What are the most popular routes from Indiana to Knoxville?

    Most travelers choose Chicago O'Hare Intl - Knoxville McGhee Tyson, Chicago Midway - Knoxville McGhee Tyson or Indianapolis - Knoxville McGhee Tyson when deciding on the best route from Indiana to Knoxville.

  • Can I find deals for flights from Indiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Indiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to Knoxville.

  • Can I find deals for business class flights from Indiana to Knoxville?

    Yes. Cheapflights offers flight deals from Indiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to Knoxville?

    Currently, July is the cheapest month in which you can book a flight from Indiana to Knoxville (average of $56). Flying from Indiana to Knoxville in March is currently the most expensive (average of $219). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Indiana to Knoxville

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Top 4 airlines flying from Indiana to Knoxville

Discover the top 4 airlines that operate flights from Indiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$56Average$79FlexibilityNo cancel feeOn-time88%
DeltaCheapest$134Average$298FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$208Average$349FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$208Average$358FlexibilityNo cancel feeOn-time71%

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