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$253+ Cheap flights from Guayaquil (GYE) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — TYS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Guayaquil to Knoxville

Best flights from Guayaquil to Knoxville
Discover carefully curated flight deals from Guayaquil to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 12, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1712:59 amGYE - TYS
1 stop9h 09mMultiple Airlines
Wed 3/188:30 amTYS - GYE
2 stops16h 05mMultiple Airlines
Deal found 12/11$398
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1912:20 pmGYE - TYS
2 stops25h 26mUnited Airlines
Tue 5/197:05 amTYS - GYE
2 stops11h 24mUnited Airlines
Deal found 12/9$647
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1812:59 amGYE - TYS
1 stop19h 43mMultiple Airlines
Tue 5/123:48 pmTYS - GYE
2 stops31h 52mMultiple Airlines
Deal found 12/10$446
This Mytrip deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/71:26 amGYE - TYS
3 stops34h 39mMultiple Airlines
Thu 1/159:29 amTYS - GYE
1 stop14h 52mMultiple Airlines
Deal found 12/9$460
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/81:26 amGYE - TYS
1 stop12h 14mMultiple Airlines
Mon 5/117:10 amTYS - GYE
2 stops35h 10mMultiple Airlines
Deal found 12/11$501
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/162:35 pmGYE - TYS
2 stops47h 11mUnited Airlines
Thu 5/79:00 amTYS - GYE
2 stops33h 29mUnited Airlines
Deal found 12/10$647
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1812:59 amGYE - TYS
1 stop19h 43mMultiple Airlines
Fri 5/155:39 pmTYS - GYE
2 stops30h 01mMultiple Airlines
Deal found 12/9$527
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/192:35 pmGYE - TYS
2 stops51h 30mUnited Airlines
Sun 5/107:05 amTYS - GYE
2 stops14h 46mUnited Airlines
Deal found 12/10$667
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/202:35 pmGYE - TYS
2 stops33h 09mUnited Airlines
Fri 2/209:10 amTYS - GYE
2 stops14h 32mUnited Airlines
Deal found 12/10$693

Find flight deals from Guayaquil to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$398
(Kiwi.com)

One-way from

$253
(Kiwi.com)
Provider with most accurate pricing for Guayaquil Jose Joaquin de Olmedo-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Guayaquil Jose Joaquin de Olmedo-Knoxville McGhee Tyson flights.
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From Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson
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One-way flight from Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Guayaquil to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Guayaquil to Knoxville that are best for you.

Fly from

Guayaquil

Fly to

Knoxville

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 2/17

12:59 am-10:08 am

1 stop9h 09m

Knoxville McGhee Tyson

Wed 3/18

8:30 am-11:35 pm

2 stops16h 05m

$398

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

12:59 am-8:42 pm

1 stop19h 43m

Knoxville McGhee Tyson

Tue 5/12

3:48 pm-10:40 pm

2 stops31h 52m

$446

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 1/7

1:26 am-12:05 pm

3 stops34h 39m

Knoxville McGhee Tyson

Thu 1/15

9:29 am-12:21 am

1 stop14h 52m

$460

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 1/8

1:26 am-1:40 pm

1 stop12h 14m

Knoxville McGhee Tyson

Mon 5/11

7:10 am-5:20 pm

2 stops35h 10m

$501

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

12:59 am-8:42 pm

1 stop19h 43m

Knoxville McGhee Tyson

Fri 5/15

5:39 pm-10:40 pm

2 stops30h 01m

$527

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 2/19

12:20 pm-1:46 pm

2 stops25h 26m

Knoxville McGhee Tyson

Tue 5/19

7:05 am-5:29 pm

2 stops11h 24m

$647

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 2/16

2:35 pm-1:46 pm

2 stops47h 11m

Knoxville McGhee Tyson

Thu 5/7

9:00 am-5:29 pm

2 stops33h 29m

$647

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 1/19

2:35 pm-6:05 pm

2 stops51h 30m

Knoxville McGhee Tyson

Sun 5/10

7:05 am-8:51 pm

2 stops14h 46m

$667

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 1/20

2:35 pm-11:44 pm

2 stops33h 09m

Knoxville McGhee Tyson

Fri 2/20

9:10 am-11:42 pm

2 stops14h 32m

$693

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

12:59 am-8:42 pm

1 stop19h 43m

$253

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 16 results
1
2

Compare providers for flights from Guayaquil to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Guayaquil to Knoxville in December.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Guayaquil-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Guayaquil-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Guayaquil-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Guayaquil-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guayaquil-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Guayaquil to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 12, 2025.
Get a feel of what it's like to fly with Delta and United Airlines from Guayaquil to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Guayaquil to Knoxville round-trip?

    Currently priced at $388, United Airlines will fly you from Guayaquil to Knoxville and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $743.

  • Can I find deals for flights from Guayaquil to Knoxville that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Knoxville.

  • Can I find deals for business class flights from Guayaquil to Knoxville?

    Yes. Cheapflights offers flight deals from Guayaquil to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Guayaquil to Knoxville

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Top 2 airlines flying from Guayaquil to Knoxville

Discover the top 2 airlines that operate flights from Guayaquil to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$388Average$647FlexibilityNo cancel feeOn-time69%
DeltaCheapest$743Average$793FlexibilityNo cancel feeOn-timeN/A

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