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$218+ Cheap flights from Guayaquil (GYE) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — TYS
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Guayaquil to Knoxville

Cheapest flights from Guayaquil to Knoxville
Explore the most affordable flight options available from Guayaquil to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1112:59 am
GYE
-
TYS
1 stop19h 43m
Multiple Airlines
Sun 5/179:40 pm
TYS
-
GYE
1 stop26h 21m
Multiple Airlines
Deal found 1/27$559
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:55 pm
GYE
-
TYS
2 stops23h 37m
Multiple Airlines
Wed 5/271:01 pm
TYS
-
GYE
1 stop11h 00m
Multiple Airlines
Deal found 1/27$564
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/228:34 am
GYE
-
TYS
2 stops28h 07m
Multiple Airlines
Sat 5/911:56 am
TYS
-
GYE
1 stop12h 05m
Multiple Airlines
Deal found 1/25$605
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/212:20 pm
GYE
-
TYS
2 stops25h 26m
United Airlines
Sat 5/169:00 am
TYS
-
GYE
2 stops15h 36m
United Airlines
Deal found 1/26$651
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1112:59 am
GYE
-
TYS
1 stop19h 43m
Multiple Airlines
Wed 5/64:25 pm
TYS
-
GYE
2 stops31h 15m
Multiple Airlines
Deal found 1/27$661
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:31 pm
GYE
-
TYS
1 stop8h 28m
American Airlines
Tue 5/196:00 am
TYS
-
GYE
1 stop16h 02m
American Airlines
Deal found 1/27$706
This Ovago deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/198:34 am
GYE
-
TYS
2 stops29h 12m
Copa Airlines
Wed 5/277:15 am
TYS
-
GYE
2 stops14h 36m
Copa Airlines
Deal found 1/27$726

Find flight deals from Guayaquil to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$559
(Kiwi.com)

One-way from

$218
(Kiwi.com)
Provider with most accurate pricing for Guayaquil Jose Joaquin de Olmedo-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Guayaquil Jose Joaquin de Olmedo-Knoxville McGhee Tyson flights.
Search Deals
From Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson
Search Deals
One-way flight from Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Guayaquil to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Guayaquil to Knoxville that are best for you.

Fly from

Guayaquil

Fly to

Knoxville

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/11

12:59 am-8:42 pm

1 stop19h 43m

Knoxville McGhee Tyson

Sun 5/17

9:40 pm-11:01 pm

1 stop26h 21m

$559

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 3/2

12:20 pm-1:46 pm

2 stops25h 26m

Knoxville McGhee Tyson

Sat 5/16

9:00 am-11:36 pm

2 stops15h 36m

$651

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 5/3

2:37 pm-7:56 pm

2 stops28h 19m

Knoxville McGhee Tyson

Tue 5/19

9:00 am-11:36 pm

2 stops15h 36m

$651

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

12:59 am-8:42 pm

1 stop19h 43m

Knoxville McGhee Tyson

Wed 5/27

1:01 pm-11:01 pm

1 stop11h 00m

$694

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 5/3

2:31 pm-11:59 pm

1 stop8h 28m

Knoxville McGhee Tyson

Tue 5/19

6:00 am-9:02 pm

1 stop16h 02m

$706

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Fri 2/20

12:20 pm-1:46 pm

2 stops25h 26m

Knoxville McGhee Tyson

Thu 5/14

9:00 am-8:51 pm

2 stops12h 51m

$741

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Fri 2/20

12:20 pm-1:46 pm

2 stops25h 26m

Knoxville McGhee Tyson

Wed 5/13

7:00 am-11:36 pm

3 stops17h 36m

$741

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 2/22

3:30 pm-11:11 am

2 stops19h 41m

Knoxville McGhee Tyson

Sat 5/9

5:57 pm-1:31 pm

2 stops20h 34m

$750

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 5/7

11:59 pm-12:25 pm

1 stop11h 26m

$218

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sat 2/21

5:29 am-8:34 pm

2 stops15h 05m

$300

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 12 results
1
2
  • Most accurate provider: When it comes to deals on Guayaquil-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Guayaquil-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Guayaquil-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Guayaquil-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guayaquil-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Guayaquil to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 28, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Guayaquil to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,123 reviews

Food

7.2

Crew

8.5

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,123 reviews
Delta
7.9
Good
8,123 reviews

Food

7.2

Crew

8.5

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,212 reviews
Delta
7.9
Good
8,123 reviews

Food

7.2

Crew

8.5

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,201 reviews
Delta
7.9
Good
8,123 reviews

Food

7.2

Crew

8.5

Boarding

8.1

Comfort

7.9

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Guayaquil to Knoxville?

    Airlines like United Airlines fly from Guayaquil to Knoxville in about 25h 26m. The time it takes to get you to your destination can typically vary by up to . The distance between Guayaquil and Knoxville is about 2635 mi.

  • What are the cheapest airlines flying from Guayaquil to Knoxville round-trip?

    Currently priced at $388, United Airlines will fly you from Guayaquil to Knoxville and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and American Airlines - these airlines can fly you to your destination from $743 and $783, respectively.

  • Can I find deals for flights from Guayaquil to Knoxville that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Knoxville.

  • Can I find deals for business class flights from Guayaquil to Knoxville?

    Yes. Cheapflights offers flight deals from Guayaquil to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Guayaquil to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Guayaquil to Knoxville

Discover the top 3 airlines that operate flights from Guayaquil to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$388Average$636FlexibilityNo cancel feeOn-time69%
DeltaCheapest$743Average$793FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$783Average$880FlexibilityNo cancel feeOn-time71%

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