HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$256+ Cheap flights from Guayaquil (GYE) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — TYS
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Guayaquil to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Guayaquil to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$491
(Kiwi.com)

One-way from

$256
(eDestinos)
Provider with most accurate pricing for Guayaquil Jose Joaquin de Olmedo-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Guayaquil Jose Joaquin de Olmedo-Knoxville McGhee Tyson flights.
Search Deals
From Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson
Search Deals
One-way flight from Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson
Search Deals

Find flight deals from Guayaquil to Knoxville

Cheapest flights from Guayaquil to Knoxville
Explore the most affordable flight options available from Guayaquil to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/88:30 amGYE - TYS
2 stops26h 18mUnited Airlines
Wed 12/107:05 amTYS - GYE
2 stops34h 31mUnited Airlines
Deal found 10/28$901
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/212:21 pmGYE - TYS
2 stops22h 27mUnited Airlines
Sun 12/149:10 amTYS - GYE
2 stops32h 26mUnited Airlines
Deal found 10/29$1,302
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:00 amGYE - TYS
1 stop10h 26mAmerican Airlines
Wed 12/106:00 amTYS - GYE
1 stop17h 06mAmerican Airlines
Deal found 10/29$1,485
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:00 amGYE - TYS
1 stop17h 59mAmerican Airlines
Sun 12/145:05 amTYS - GYE
2 stops18h 01mAmerican Airlines
Deal found 10/27$1,509
This FlightHub deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/13:30 amGYE - TYS
2 stops31h 18mAvianca
Sun 12/147:00 amTYS - GYE
2 stops31h 25mAvianca
Deal found 10/29$1,875
This Avianca deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/74:40 amGYE - TYS
2 stops30h 08mAvianca
Wed 12/107:00 amTYS - GYE
2 stops26h 15mAvianca
Deal found 10/27$3,292

Cheapflights Fare Finder

 
Customize your flight search to find flights from Guayaquil to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Guayaquil to Knoxville that are best for you.

Fly from

Guayaquil

Fly to

Knoxville

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 1/19

4:40 am-3:57 pm

2 stops35h 17m

Knoxville McGhee Tyson

Fri 2/20

7:40 am-11:45 pm

1 stop16h 05m

$491

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 2/26

6:55 pm-7:55 pm

2 stops25h 00m

Knoxville McGhee Tyson

Fri 5/8

7:00 am-8:46 pm

2 stops14h 46m

$625

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 3/2

12:20 pm-7:55 pm

2 stops31h 35m

Knoxville McGhee Tyson

Sat 5/16

10:40 am-5:35 pm

2 stops31h 55m

$626

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 1/20

12:20 pm-7:50 pm

2 stops31h 30m

Knoxville McGhee Tyson

Fri 2/20

9:10 am-11:42 pm

2 stops14h 32m

$626

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 2/17

6:55 pm-6:10 pm

2 stops23h 15m

Knoxville McGhee Tyson

Mon 5/4

9:15 am-11:25 am

2 stops27h 10m

$674

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 2/26

3:31 pm-11:29 am

2 stops19h 58m

Knoxville McGhee Tyson

Fri 5/8

7:15 am-1:33 pm

1 stop7h 18m

$693

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

6:55 pm-8:42 pm

2 stops25h 47m

$256

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 11/5

4:40 am-10:33 pm

2 stops17h 53m

$269

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 2/19

12:59 am-12:41 pm

1 stop11h 42m

$316

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 2/24

7:05 pm-2:35 pm

3 stops43h 30m

$322

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Compare providers for flights from Guayaquil to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Guayaquil to Knoxville in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Guayaquil-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Guayaquil-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Guayaquil-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Guayaquil-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guayaquil-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Guayaquil to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 29, 2025.
Get a feel of what it's like to fly with Delta and United Airlines from Guayaquil to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,992 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!
Delta
7.9
Good
7,992 reviews
Delta
7.9
Good
7,992 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!
United Airlines
7.4
Good
8,999 reviews
Delta
7.9
Good
7,992 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Guayaquil to Knoxville?

    Airlines like United Airlines fly from Guayaquil to Knoxville in about 31h 35m. The time it takes to get you to your destination can typically vary by up to . The distance between Guayaquil and Knoxville is about 2635 mi.

  • What are the cheapest airlines flying from Guayaquil to Knoxville round-trip?

    Currently priced at $388, United Airlines will fly you from Guayaquil to Knoxville and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $743.

  • Can I find deals for flights from Guayaquil to Knoxville that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Knoxville.

  • Can I find deals for business class flights from Guayaquil to Knoxville?

    Yes. Cheapflights offers flight deals from Guayaquil to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Guayaquil to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Guayaquil to Memphis flights
Quito to Knoxville flights
Quito to Nashville flights

Top 2 airlines flying from Guayaquil to Knoxville

Discover the top 2 airlines that operate flights from Guayaquil to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$388Average$647FlexibilityNo cancel feeOn-time69%
DeltaCheapest$743Average$793FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.