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Knoxville

$226+ Cheap flights from Guayaquil (GYE) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/5. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Guayaquil to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$396
(Kiwi.com)

One-way from

$226
(eDestinos)
From Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson
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One-way flight from Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson
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Find flight deals from Guayaquil to Knoxville

Cheapest flights from Guayaquil to Knoxville
Explore the most affordable flight options available from Guayaquil to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/54:40 amGYE - TYS
2 stops17h 53mMultiple Airlines
Thu 12/412:43 pmTYS - GYE
1 stop11h 02mMultiple Airlines
Deal found 9/11$396
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/34:40 amGYE - TYS
2 stops35h 02mMultiple Airlines
Thu 12/412:43 pmTYS - GYE
1 stop11h 02mMultiple Airlines
Deal found 9/11$404
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/274:40 amGYE - TYS
2 stops28h 53mMultiple Airlines
Sun 12/77:11 pmTYS - GYE
1 stop28h 34mMultiple Airlines
Deal found 9/10$428
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/104:40 amGYE - TYS
2 stops35h 02mMultiple Airlines
Thu 12/412:43 pmTYS - GYE
1 stop11h 02mMultiple Airlines
Deal found 9/11$433
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:35 pmGYE - TYS
2 stops38h 29mMultiple Airlines
Thu 12/412:43 pmTYS - GYE
1 stop11h 02mMultiple Airlines
Deal found 9/11$453
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/54:40 amGYE - TYS
2 stops17h 53mMultiple Airlines
Sun 12/77:11 pmTYS - GYE
1 stop28h 34mMultiple Airlines
Deal found 9/11$456
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:55 pmGYE - TYS
2 stops28h 01mMultiple Airlines
Thu 12/412:43 pmTYS - GYE
1 stop11h 02mMultiple Airlines
Deal found 9/11$458
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/94:40 amGYE - TYS
2 stops29h 54mMultiple Airlines
Sun 12/77:11 pmTYS - GYE
1 stop28h 34mMultiple Airlines
Deal found 9/10$460
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/286:55 pmGYE - TYS
2 stops37h 13mMultiple Airlines
Sun 12/77:11 pmTYS - GYE
1 stop28h 34mMultiple Airlines
Deal found 9/10$469

Cheapflights Fare Finder

 
Customize your flight search to find flights from Guayaquil to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Guayaquil to Knoxville that are best for you.

Fly from

Guayaquil

Fly to

Knoxville

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 11/4

6:55 pm-9:04 am

2 stops38h 09m

Knoxville McGhee Tyson

Thu 12/4

12:43 pm-11:45 pm

1 stop11h 02m

$420

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 11/5

4:40 am-10:33 pm

2 stops17h 53m

Knoxville McGhee Tyson

Mon 12/8

9:23 am-11:45 pm

1 stop14h 22m

$484

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 11/2

2:35 pm-12:33 pm

2 stops21h 58m

Knoxville McGhee Tyson

Thu 12/4

12:43 pm-11:45 pm

1 stop11h 02m

$547

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 10/28

8:30 am-11:44 pm

2 stops38h 14m

Knoxville McGhee Tyson

Wed 12/10

9:10 am-11:18 am

2 stops26h 08m

$596

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 10/30

12:18 pm-8:09 pm

2 stops30h 51m

Knoxville McGhee Tyson

Wed 12/10

9:10 am-11:18 am

2 stops26h 08m

$596

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 2/16

2:35 pm-7:34 pm

2 stops52h 59m

Knoxville McGhee Tyson

Thu 5/7

9:15 am-1:45 pm

2 stops29h 30m

$596

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 11/10

6:55 pm-8:09 pm

2 stops25h 14m

Knoxville McGhee Tyson

Wed 12/10

7:05 am-11:18 am

2 stops28h 13m

$603

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 11/4

8:30 am-11:44 pm

2 stops39h 14m

Knoxville McGhee Tyson

Sat 12/6

7:05 am-11:18 am

2 stops28h 13m

$626

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 11/3

12:21 pm-8:09 pm

2 stops31h 48m

Knoxville McGhee Tyson

Sat 12/6

11:42 am-1:34 pm

2 stops25h 52m

$626

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 11/3

8:30 am-8:09 pm

2 stops35h 39m

Knoxville McGhee Tyson

Sun 12/7

9:10 am-11:41 pm

2 stops14h 31m

$626

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 17 results
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Best time to book a flight from Guayaquil to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with United Airlines from Guayaquil to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,937 reviews

Comfort

7.3

Overall

7.4

Boarding

7.7

Food

6.6

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

FRA - SFO

Lufthansa was amazing, I wish United States based airlines operated like them.
United Airlines
7.4
Good
8,937 reviews
United Airlines
7.4
Good
8,937 reviews

Comfort

7.3

Overall

7.4

Boarding

7.7

Food

6.6

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

FRA - SFO

Lufthansa was amazing, I wish United States based airlines operated like them.

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Guayaquil to Knoxville?

    Airlines like United Airlines fly from Guayaquil to Knoxville in about 38h 14m. The time it takes to get you to your destination can typically vary by up to . The distance between Guayaquil and Knoxville is about 2635 mi.

  • What is the cheapest airline to fly from Guayaquil to Knoxville round-trip?

    Currently priced at $388, United Airlines will fly you from Guayaquil to Knoxville and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip.

  • Can I find deals for flights from Guayaquil to Knoxville that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Knoxville.

  • Can I find deals for business class flights from Guayaquil to Knoxville?

    Yes. Cheapflights offers flight deals from Guayaquil to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guayaquil to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Guayaquil to Knoxville (average of $294). Flying from Guayaquil to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Guayaquil to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Guayaquil to Knoxville

Discover the top airline that operate flights from Guayaquil to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$388Average$636FlexibilityNo cancel feeOn-time69%

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