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$367+ Cheap flights from Greenville, NC to Knoxville (PGV - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/27. Fares are subject to change and may not be available on all flights or dates of travel.
PGV — TYS
Mar 28 — Apr 41
Sat 3/28
Sat 4/4
1 adult, Economy
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Cheap flight deals from Greenville to Knoxville

Cheapest flights from Greenville to Knoxville
Explore the most affordable flight options available from Greenville to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 26, 2026.

This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:00 am
PGV
-
TYS
1 stop4h 30m
American Airlines
Sun 8/308:25 pm
TYS
-
PGV
1 stop3h 39m
American Airlines
Deal found 2/25$367
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:00 am
PGV
-
TYS
1 stop5h 45m
American Airlines
Fri 4/108:00 am
TYS
-
PGV
1 stop4h 28m
American Airlines
Deal found 2/25$495

Find flight deals from Greenville to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (PGV) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$495
(American Airlines)
Provider with most accurate pricing for Pitt-Greenville-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Pitt-Greenville-Knoxville McGhee Tyson flights.
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From Pitt-Greenville to Knoxville McGhee Tyson
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Greenville to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Tue 4/7

6:00 am-11:45 am

1 stop5h 45m

Knoxville McGhee Tyson

Fri 4/10

8:00 am-12:28 pm

1 stop4h 28m

$495

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/25

Sorted by cheapest first

Compare providers for flights from Greenville to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Knoxville in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville, North Carolina-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville, North Carolina-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville, North Carolina-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville, North Carolina-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville, North Carolina-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Knoxville

What is the cheapest month to book a flight from Greenville, North Carolina to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Greenville, North Carolina to Knoxville (average of $113). Flying from Greenville, North Carolina to Knoxville in September is currently the most expensive (average of $251). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville, North Carolina to Knoxville?

    For as low as $495, American Airlines can have you in Knoxville from Greenville, North Carolina in 5h 45m. The distance from Greenville, North Carolina to Knoxville is about 371 mi.

  • Can I find deals for flights from Greenville to Knoxville that include hotel bookings?

    Yes. In addition to deals on Greenville to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Knoxville.

  • Can I find deals for business class flights from Greenville to Knoxville?

    Yes. Cheapflights offers flight deals from Greenville to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville, North Carolina to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Greenville, North Carolina to Knoxville (average of $113). Flying from Greenville, North Carolina to Knoxville in September is currently the most expensive (average of $251). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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