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$387+ Cheap flights from Greenville, NC to Knoxville (PGV - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
PGV — TYS
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
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Cheap flight deals from Greenville to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (PGV) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 17, 2025.

Round-trip from

$387
(American Airlines)
From Pitt-Greenville to Knoxville McGhee Tyson
Search Deals

Find flight deals from Greenville to Knoxville

Cheapest flights from Greenville to Knoxville
Explore the most affordable flight options available from Greenville to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/26:00 amPGV - TYS
1 stop4h 32mAmerican Airlines
lun. 10/68:37 pmTYS - PGV
1 stop3h 36mAmerican Airlines
Deal found 9/17$387
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/3012:51 pmPGV - TYS
1 stop5h 59mAmerican Airlines
sáb. 10/47:45 pmTYS - PGV
1 stop3h 41mAmerican Airlines
Deal found 9/14$471
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/95:00 amPGV - TYS
1 stop4h 32mAmerican Airlines
mar. 10/147:43 pmTYS - PGV
1 stop3h 27mAmerican Airlines
Deal found 9/15$516
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/105:00 amPGV - TYS
1 stop4h 32mAmerican Airlines
mar. 10/147:43 pmTYS - PGV
1 stop3h 27mAmerican Airlines
Deal found 9/15$670
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/115:00 amPGV - TYS
1 stop5h 31mAmerican Airlines
mar. 10/147:43 pmTYS - PGV
1 stop3h 27mAmerican Airlines
Deal found 9/15$778

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from Greenville to Knoxville that are best for you.

Fly from

Greenville

Fly to

Knoxville

Route

Depart

Return

Price

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

jue. 10/2

6:00 am-10:32 am

1 stop4h 32m

Knoxville McGhee Tyson

lun. 10/6

8:37 pm-12:13 am

1 stop3h 36m

$387

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

mar. 9/30

12:51 pm-6:50 pm

1 stop5h 59m

Knoxville McGhee Tyson

sáb. 10/4

7:45 pm-11:26 pm

1 stop3h 41m

$471

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

jue. 10/9

5:00 am-9:32 am

1 stop4h 32m

Knoxville McGhee Tyson

mar. 10/14

7:43 pm-11:10 pm

1 stop3h 27m

$516

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

vie. 10/10

5:00 am-9:32 am

1 stop4h 32m

Knoxville McGhee Tyson

mar. 10/14

7:43 pm-11:10 pm

1 stop3h 27m

$670

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

sáb. 10/11

5:00 am-10:31 am

1 stop5h 31m

Knoxville McGhee Tyson

mar. 10/14

7:43 pm-11:10 pm

1 stop3h 27m

$778

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Best time to book a flight from Greenville to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Knoxville

What is the cheapest month to book a flight from Greenville, North Carolina to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Greenville, North Carolina to Knoxville (average of $295). Flying from Greenville, North Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated septiembre 17, 2025.
Get a feel of what it's like to fly with American Airlines from Greenville to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Overall

7.2

Boarding

7.5

Crew

8.0

Comfort

7.2

Food

6.4

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Overall

7.2

Boarding

7.5

Crew

8.0

Comfort

7.2

Food

6.4

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Greenville to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville, North Carolina to Knoxville?

    For as low as $387, American Airlines can have you in Knoxville from Greenville, North Carolina in 4h 32m. The distance from Greenville, North Carolina to Knoxville is about 371 mi.

  • Can I find deals for flights from Greenville to Knoxville that include hotel bookings?

    Yes. In addition to deals on Greenville to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Knoxville.

  • Can I find deals for business class flights from Greenville to Knoxville?

    Yes. Cheapflights offers flight deals from Greenville to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville, North Carolina to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Greenville, North Carolina to Knoxville (average of $295). Flying from Greenville, North Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top airline flying from Greenville to Knoxville

Discover the top airline that operate flights from Greenville to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$418FlexibilityNo cancel feeOn-time71%

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