How long is the flight from Greenville, North Carolina to Knoxville?

For as low as $496, American Airlines can have you in Knoxville from Greenville, North Carolina in 4h 32m. The distance from Greenville, North Carolina to Knoxville is about 371 mi.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What is the cheapest time of day to fly from PGV to TYS?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Greenville, North Carolina to Knoxville as you normally would.

Can I find deals for flights from Greenville to Knoxville that include hotel bookings?

Yes. In addition to deals on Greenville to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Greenville to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Knoxville.

Can I find deals for business class flights from Greenville to Knoxville?

Yes. Cheapflights offers flight deals from Greenville to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$304+ Cheap Flights from Greenville, NC to Knoxville

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Cheap flight deals from Greenville to Knoxville

Round-trip from	$496 (American Airlines)
One-way from	$304 (American Airlines)

From Pitt-Greenville to Knoxville McGhee Tyson

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One-way flight from Pitt-Greenville to Knoxville McGhee Tyson

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Find flight deals from Greenville to Knoxville

Cheapest flights from Greenville to Knoxville
Explore the most affordable flight options available from Greenville to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

Fri 10/105:00 amPGV - TYS

1 stop4h 32mAmerican Airlines

Tue 10/147:43 pmTYS - PGV

1 stop3h 27mAmerican Airlines

Deal found 8/18

$496

Mon 9/16:00 amPGV - TYS

1 stop6h 17mAmerican Airlines

Fri 9/511:18 amTYS - PGV

1 stop5h 24mAmerican Airlines

Deal found 8/17

$529

Best flights from Greenville to Knoxville
Discover carefully curated flight deals from Greenville to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 18, 2025.

Fri 10/105:00 amPGV - TYS

1 stop4h 32mAmerican Airlines

Tue 10/147:43 pmTYS - PGV

1 stop3h 27mAmerican Airlines

Deal found 8/16

$496

Mon 9/16:00 amPGV - TYS

1 stop6h 17mAmerican Airlines

Fri 9/511:18 amTYS - PGV

1 stop5h 24mAmerican Airlines

Deal found 8/17

$529

Last-minute flights from Greenville to Knoxville
Discover last-minute flight deals from Greenville to Knoxville. Data last updated August 18, 2025 and is based on user searches.

Mon 9/16:00 amPGV - TYS

1 stop6h 17mAmerican Airlines

Fri 9/511:18 amTYS - PGV

1 stop5h 24mAmerican Airlines

Deal found 8/17

$529

One-way flights from Greenville to Knoxville
Search for one-way flight options from Greenville to Knoxville. Find affordable one-way fares based on user searches. Data last updated August 18, 2025.

Fri 8/296:00 amPGV - TYS

1 stop3h 09mAmerican Airlines

Deal found 8/16

$304

Cheapflights Fare Finder

Use the filters below to find and compare flights from Greenville to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Fri 10/10

5:00 am-9:32 am

1 stop4h 32m

Knoxville McGhee Tyson

Tue 10/14

7:43 pm-11:10 pm

1 stop3h 27m

$496

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Mon 9/1

6:00 am-12:17 pm

1 stop6h 17m

Knoxville McGhee Tyson

Fri 9/5

11:18 am-4:42 pm

1 stop5h 24m

$529

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Fri 8/29

6:00 am-9:09 am

1 stop3h 09m

$304

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/16

Best time to book a flight from Greenville to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Greenville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Knoxville

What is the cheapest month to book a flight from Greenville, North Carolina to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Greenville, North Carolina to Knoxville (average of $294). Flying from Greenville, North Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

How long is the flight from Greenville, North Carolina to Knoxville?
For as low as $496, American Airlines can have you in Knoxville from Greenville, North Carolina in 4h 32m. The distance from Greenville, North Carolina to Knoxville is about 371 mi.
Can I find deals for flights from Greenville to Knoxville that include hotel bookings?
Yes. In addition to deals on Greenville to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Greenville to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Knoxville.
Can I find deals for business class flights from Greenville to Knoxville?
Yes. Cheapflights offers flight deals from Greenville to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Greenville, North Carolina to Knoxville?
Currently, January is the cheapest month in which you can book a flight from Greenville, North Carolina to Knoxville (average of $294). Flying from Greenville, North Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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$304+ Cheap flights from Greenville, NC to Knoxville (PGV - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/29. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Greenville to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Greenville to Knoxville

Round-trip from

One-way from

Find flight deals from Greenville to Knoxville

Cheapest flights from Greenville to KnoxvilleExplore the most affordable flight options available from Greenville to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

Explore the most affordable flight options available from Greenville to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Greenville to Knoxville that are best for you.

Best time to book a flight from Greenville to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Greenville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Knoxville

What is the cheapest month to book a flight from Greenville, North Carolina to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from Greenville to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Greenville, North Carolina to Knoxville?

Can I find deals for flights from Greenville to Knoxville that include hotel bookings?

How can I find direct flights from Greenville to Knoxville?

Can I find deals for business class flights from Greenville to Knoxville?

What is the cheapest month to book a flight from Greenville, North Carolina to Knoxville?

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Cheapest flights from Greenville to Knoxville
Explore the most affordable flight options available from Greenville to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.