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Knoxville

$48+ Cheap flights from Colorado to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — TYS
Apr 10 — Apr 171
Fri 4/10
Fri 4/17
1 adult, Economy
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Cheap flight deals from Colorado to Knoxville

Cheapest flights from Colorado to Knoxville
Explore the most affordable flight options available from Colorado to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/208:55 am
DEN
-
TYS
Nonstop2h 49m
Allegiant Air
Sun 9/277:00 am
TYS
-
DEN
Nonstop3h 05m
Allegiant Air
Deal found 3/10$162
This Cheapflightsfares deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/49:05 am
DEN
-
TYS
Nonstop2h 47m
Allegiant Air
Sun 6/77:00 am
TYS
-
DEN
Nonstop3h 15m
Allegiant Air
Deal found 3/10$165
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/212:13 am
DEN
-
TYS
1 stop21h 07m
Multiple Airlines
Fri 4/104:20 pm
TYS
-
DEN
Nonstop3h 32m
Multiple Airlines
Deal found 3/6$172
This Super.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:21 pm
DEN
-
TYS
Nonstop2h 52m
Frontier
Mon 6/158:08 pm
TYS
-
DEN
Nonstop3h 34m
Frontier
Deal found 3/9$174
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:21 pm
DEN
-
TYS
Nonstop2h 52m
Multiple Airlines
Sun 5/247:00 am
TYS
-
DEN
Nonstop3h 21m
Multiple Airlines
Deal found 3/7$175
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/610:40 am
DEN
-
TYS
Nonstop2h 48m
Frontier
Mon 4/134:20 pm
TYS
-
DEN
Nonstop3h 32m
Frontier
Deal found 3/7$178
This Frontier deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:21 pm
DEN
-
TYS
Nonstop2h 52m
Frontier
Mon 6/158:08 pm
TYS
-
DEN
Nonstop3h 34m
Frontier
Deal found 3/9$179
This Frontier deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/72:21 pm
DEN
-
TYS
Nonstop2h 52m
Frontier
Fri 8/148:08 pm
TYS
-
DEN
Nonstop3h 34m
Frontier
Deal found 3/9$181
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/309:00 am
DEN
-
TYS
Nonstop2h 49m
Multiple Airlines
Wed 9/28:08 pm
TYS
-
DEN
Nonstop3h 34m
Multiple Airlines
Deal found 3/6$197
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:00 am
COS
-
TYS
1 stop6h 06m
United Airlines
Thu 4/307:00 am
TYS
-
COS
1 stop5h 47m
United Airlines
Deal found 3/8$269
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/21:10 pm
COS
-
TYS
1 stop4h 25m
Southwest
Sat 5/96:40 am
TYS
-
COS
2 stops9h 00m
Southwest
Deal found 3/8$274
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/282:38 pm
MTJ
-
TYS
1 stop7h 13m
American Airlines
Wed 4/15:40 am
TYS
-
MTJ
1 stop7h 54m
American Airlines
Deal found 3/10$280

Find flight deals from Colorado to Knoxville

Keep the following information in mind while searching for Colorado to Knoxville flight deals. Data was last updated March 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$165
(Cheapflightsfares)

One-way from

$48
(Kiwi.com)

Popular in

January

Cheapest in

August

Average price

$339

Good round-trip deal

$210 or less

Good one-way deal

$106 or less
Provider with most accurate pricing for Denver Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Denver Intl-Knoxville McGhee Tyson flights.
Search Deals
From Colorado to Knoxville McGhee Tyson
Search Deals
One-way flight from Colorado to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($49 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a round-trip flight from Colorado to Knoxville McGhee Tyson.
Search Deals
Price to beat on a one-way flight from Colorado to Knoxville McGhee Tyson.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Colorado to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from Colorado to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Colorado SpringsKnoxville

COS - TYS

COSTYS

Colorado Springs

Sat 5/2

6:00 am-3:07 pm

1 stop7h 07m

Knoxville McGhee Tyson

Sat 5/9

7:00 am-10:47 am

1 stop5h 47m

$269

Colorado SpringsKnoxville

COS - TYS

COSTYS

Colorado Springs

Sat 5/2

1:10 pm-7:35 pm

1 stop4h 25m

Knoxville McGhee Tyson

Sat 5/9

6:40 am-1:40 pm

2 stops9h 00m

$274

Colorado SpringsKnoxville

COS - TYS

COSTYS

Colorado Springs

Wed 7/29

12:16 pm-8:56 pm

1 stop6h 40m

Knoxville McGhee Tyson

Wed 9/9

5:57 pm-11:49 pm

2 stops7h 52m

$274

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

Sat 5/16

2:45 pm-7:35 pm

Nonstop2h 50m

Knoxville McGhee Tyson

Tue 5/19

7:05 am-3:00 pm

2 stops9h 55m

$283

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

Wed 6/3

11:20 am-7:40 pm

2 stops6h 20m

Knoxville McGhee Tyson

Sat 6/6

8:00 am-6:25 pm

2 stops12h 25m

$285

Colorado SpringsKnoxville

COS - TYS

COSTYS

Colorado Springs

Tue 5/5

3:25 pm-10:23 pm

1 stop4h 58m

Knoxville McGhee Tyson

Mon 5/11

6:01 pm-11:59 pm

2 stops7h 58m

$292

MontroseKnoxville

MTJ - TYS

MTJTYS

Montrose County

Thu 3/26

1:33 pm-11:44 pm

1 stop8h 11m

Knoxville McGhee Tyson

Tue 3/31

8:30 am-12:41 pm

1 stop6h 11m

$307

MontroseKnoxville

MTJ - TYS

MTJTYS

Montrose County

Sat 3/28

1:42 pm-11:44 pm

2 stops8h 02m

Knoxville McGhee Tyson

Wed 4/1

7:05 am-2:31 pm

2 stops9h 26m

$317

Colorado SpringsKnoxville

COS - TYS

COSTYS

Colorado Springs

Wed 7/29

5:35 am-2:05 pm

2 stops6h 30m

Knoxville McGhee Tyson

Wed 9/9

1:55 pm-9:45 pm

2 stops9h 50m

$319
Quickest round-trip

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

Sat 8/22

5:45 pm-10:38 pm

Nonstop2h 53m

Knoxville McGhee Tyson

Fri 8/28

4:56 pm-6:17 pm

Nonstop3h 21m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/9

Showing 1-10 of 54 resultsSorted by cheapest first
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Best time to book a flight from Colorado to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Colorado with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Colorado to Knoxville

What is the cheapest month to book a flight from Colorado to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Colorado to Knoxville (average of $58). Flying from Colorado to Knoxville in January is currently the most expensive (average of $151). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CO to TYS?

Find hourly flight availability from Colorado to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 11, 2026.

When flying from Colorado to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Weekly flight availability from Colorado to Knoxville

Explore weekly flight availability from Colorado to Knoxville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated March 11, 2026.

The most flights from USCO to TYS are scheduled on a Monday (2 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).

Related info for your journey

Find useful and relevant information for your journey from Colorado to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Colorado?

    For a flight from Colorado to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How popular is this Colorado to Knoxville flight route?

    The Colorado to Knoxville McGhee Tyson flight path was viewed by 8 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Colorado to Knoxville?

    There are many flights that can get you from Colorado to Knoxville in 4h 25m. Fly via United Airlines, Southwest, or American Airlines to get the fastest option. The distance from Colorado to Knoxville is about 1153 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Colorado to Knoxville one-way?

    One-way options have recently been found by users for as low as $58 on Frontier. Other airlines that offer cheap prices include Allegiant Air from $59 and Delta from $124 one-way.

  • What are the most popular routes from Colorado to Knoxville?

    Most travelers choose Denver Intl - Knoxville McGhee Tyson, Aspen Pitkin County - Knoxville McGhee Tyson or Durango La Plata County - Knoxville McGhee Tyson when deciding on the best route from Colorado to Knoxville.

  • What are the most reliable airlines from Colorado to Knoxville?

    Before booking your flight to Knoxville from Colorado, check out the most reliable airlines to get you to your destination on time: Allegiant Air (100%), United Airlines (90%), SkyWest Airlines( 88%).

  • What are the cheapest flights from Colorado to Knoxville?

    Looking for the cheapest flight from Colorado to Knoxville? While on average our users pay $491, our data indicates the cheapest price to be $74. The most popular route (Denver Intl - Knoxville McGhee Tyson), is priced around $144.

  • Can I find deals for flights from Colorado to Knoxville that include hotel bookings?

    Yes. In addition to deals on Colorado to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Colorado to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Colorado to Knoxville.

  • Can I find deals for business class flights from Colorado to Knoxville?

    Yes. Cheapflights offers flight deals from Colorado to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Colorado to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Colorado to Knoxville (average of $58). Flying from Colorado to Knoxville in January is currently the most expensive (average of $151). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Alternative routes for Colorado to Knoxville

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Top 6 airlines flying from Colorado to Knoxville

Discover the top 6 airlines that operate flights from Colorado to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$58Average$132FlexibilityNo cancel feeOn-time88%
FrontierCheapest$72Average$191FlexibilityNo cancel feeOn-time62%
DeltaCheapest$124Average$273FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$382FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$228Average$358FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$248Average$323FlexibilityNo cancel feeOn-time63%

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