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Knoxville

$42+ Cheap flights from Colorado to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — TYS
oct. 16 — oct. 231
jue. 10/16
jue. 10/23
1 adult, Economy
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Cheap flight deals from Colorado to Knoxville

Keep the following information in mind while searching for Colorado to Knoxville flight deals. Data was last updated septiembre 16, 2025.

Round-trip from

$101
(Cheapflightsfares)

One-way from

$42
(Cheapflightsfares)

Popular in

March

Cheapest in

August

Average price

$226

Good round-trip deal

$133 or less

Good one-way deal

$106 or less
From Colorado to Knoxville McGhee Tyson
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One-way flight from Colorado to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 2% potential increase in price ($5 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Colorado to Knoxville McGhee Tyson.
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Price to beat on a one-way flight from Colorado to Knoxville McGhee Tyson.
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Find flight deals from Colorado to Knoxville

Cheapest flights from Colorado to Knoxville
Explore the most affordable flight options available from Colorado to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 16, 2025.

This Frontier deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/222:59 pmDEN - TYS
Nonstop2h 46mFrontier
lun. 9/298:35 pmTYS - DEN
Nonstop3h 09mFrontier
Deal found 9/13$94
This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/69:05 amDEN - TYS
Nonstop2h 39mAllegiant Air
dom. 11/97:00 amTYS - DEN
Nonstop3h 15mAllegiant Air
Deal found 9/16$101
This Cheapflightsfares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/258:56 amDEN - TYS
Nonstop2h 47mAllegiant Air
dom. 9/287:00 amTYS - DEN
Nonstop3h 06mAllegiant Air
Deal found 9/14$107
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/69:05 amDEN - TYS
Nonstop2h 39mMultiple Airlines
jue. 11/67:17 pmTYS - DEN
Nonstop3h 17mMultiple Airlines
Deal found 9/13$110
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/118:33 amDEN - TYS
Nonstop2h 38mAllegiant Air
dom. 12/146:30 amTYS - DEN
Nonstop3h 13mAllegiant Air
Deal found 9/15$114
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/61:36 pmDEN - TYS
Nonstop2h 46mMultiple Airlines
dom. 11/97:00 amTYS - DEN
Nonstop3h 15mMultiple Airlines
Deal found 9/15$119
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/28:54 amDEN - TYS
Nonstop2h 39mMultiple Airlines
jue. 10/98:17 pmTYS - DEN
Nonstop3h 22mMultiple Airlines
Deal found 9/15$124
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/222:59 pmDEN - TYS
Nonstop2h 46mMultiple Airlines
dom. 9/287:00 amTYS - DEN
Nonstop3h 06mMultiple Airlines
Deal found 9/13$129
This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/131:36 pmDEN - TYS
Nonstop2h 46mMultiple Airlines
dom. 11/167:00 amTYS - DEN
Nonstop3h 15mMultiple Airlines
Deal found 9/16$131
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/511:29 amDEN - TYS
Nonstop2h 49mFrontier
jue. 10/98:17 pmTYS - DEN
Nonstop3h 22mFrontier
Deal found 9/15$132
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/2812:13 pmDRO - TYS
1 stop7h 30mAmerican Airlines
mar. 11/45:10 amTYS - DRO
1 stop6h 41mAmerican Airlines
Deal found 9/14$278
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/176:02 amCOS - TYS
1 stop5h 11mAmerican Airlines
sáb. 9/206:00 amTYS - COS
1 stop6h 11mAmerican Airlines
Deal found 9/13$343

Cheapflights Fare Finder

 
Customize your flight search to find flights from Colorado to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 16, 2025.
Use the filters below to find and compare flights from Colorado to Knoxville that are best for you.

Fly from

Colorado

Fly to

Knoxville

Route

Depart

Return

Price

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

dom. 10/19

12:50 am-9:00 am

1 stop6h 10m

Knoxville McGhee Tyson

lun. 10/27

6:04 pm-11:04 pm

1 stop7h 00m

$237

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

lun. 10/13

12:55 am-11:04 am

1 stop8h 09m

Knoxville McGhee Tyson

mar. 10/21

3:48 pm-9:41 pm

1 stop7h 53m

$243

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

sáb. 10/4

1:26 pm-11:43 pm

1 stop8h 17m

Knoxville McGhee Tyson

mar. 10/7

4:40 pm-5:53 pm

Nonstop3h 13m

$254

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

vie. 10/3

12:59 am-10:25 am

1 stop7h 26m

Knoxville McGhee Tyson

mar. 10/7

2:55 pm-8:15 pm

1 stop7h 20m

$264

DurangoKnoxville

DRO - TYS

DROTYS

Durango La Plata County

mar. 10/28

12:13 pm-9:43 pm

1 stop7h 30m

Knoxville McGhee Tyson

mar. 11/4

5:10 am-9:51 am

1 stop6h 41m

$278

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

vie. 10/31

5:30 pm-10:30 pm

Nonstop3h 00m

Knoxville McGhee Tyson

dom. 11/2

8:50 am-10:31 am

Nonstop3h 41m

$279

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

mar. 10/14

5:25 pm-10:28 pm

Nonstop3h 03m

Knoxville McGhee Tyson

mar. 10/21

4:40 pm-5:53 pm

Nonstop3h 13m

$279

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

mié. 10/29

5:30 pm-10:30 pm

Nonstop3h 00m

Knoxville McGhee Tyson

mié. 11/5

4:55 pm-6:22 pm

Nonstop3h 27m

$279

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

jue. 10/2

11:05 am-8:39 pm

1 stop7h 34m

Knoxville McGhee Tyson

lun. 10/6

8:10 pm-11:59 pm

1 stop5h 49m

$293

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

vie. 11/14

6:00 am-2:46 pm

1 stop6h 46m

Knoxville McGhee Tyson

dom. 11/16

8:05 pm-12:13 am

1 stop6h 08m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 45 results
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Best time to book a flight from Colorado to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Colorado with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Colorado to Knoxville

What is the cheapest month to book a flight from Colorado to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Colorado to Knoxville (average of $295). Flying from Colorado to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CO to TYS?

Find hourly flight availability from Colorado to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 16, 2025.

When flying from Colorado to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Weekly flight availability from Colorado to Knoxville

Explore weekly flight availability from Colorado to Knoxville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated septiembre 16, 2025.

The most flights from USCO to TYS are scheduled on a Monday (2 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (1 on average).

Related info for your journey

Find useful and relevant information for your journey from Colorado to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Colorado?

    For a flight from Colorado to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How popular is this Colorado to Knoxville flight route?

    The Colorado to Knoxville McGhee Tyson flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Colorado to Knoxville?

    There are many flights that can get you from Colorado to Knoxville in 6h 10m. Fly via Delta, United Airlines, or American Airlines to get the fastest option. The distance from Colorado to Knoxville is about 1159 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Colorado to Knoxville?

    Most travelers choose Denver Intl - Knoxville McGhee Tyson, Grand Junction Regnl - Knoxville McGhee Tyson or Montrose County - Knoxville McGhee Tyson when deciding on the best route from Colorado to Knoxville.

  • What are the most reliable airlines from Colorado to Knoxville?

    Before booking your flight to Knoxville from Colorado, check out the most reliable airlines to get you to your destination on time: Frontier (67%), United Airlines (64%), Allegiant Air( 55%).

  • What are the cheapest flights from Colorado to Knoxville?

    Looking for the cheapest flight from Colorado to Knoxville? While on average our users pay $206, our data indicates the cheapest price to be $50. The most popular route (Denver Intl - Knoxville McGhee Tyson), is priced around $105.

  • Can I find deals for flights from Colorado to Knoxville that include hotel bookings?

    Yes. In addition to deals on Colorado to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Colorado to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Colorado to Knoxville.

  • Can I find deals for business class flights from Colorado to Knoxville?

    Yes. Cheapflights offers flight deals from Colorado to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Colorado to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Colorado to Knoxville (average of $295). Flying from Colorado to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Colorado to Knoxville

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Top 5 airlines flying from Colorado to Knoxville

Discover the top 5 airlines that operate flights from Colorado to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$70Average$134FlexibilityNo cancel feeOn-time88%
FrontierCheapest$78Average$174FlexibilityNo cancel feeOn-time62%
DeltaCheapest$197Average$368FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$208Average$383FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$233Average$534FlexibilityNo cancel feeOn-time69%

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