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Knoxville

$48+ Cheap flights from Colorado to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/28. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — TYS
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find flight deals from Colorado to Knoxville

Cheapest flights from Colorado to Knoxville
Explore the most affordable flight options available from Colorado to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:33 amDEN - TYS
Nonstop2h 38mAllegiant Air
Sun 12/76:30 amTYS - DEN
Nonstop3h 13mAllegiant Air
Deal found 11/5$92
This Cheapflightsfares deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/208:45 amDEN - TYS
Nonstop2h 39mAllegiant Air
Sun 11/236:30 amTYS - DEN
Nonstop3h 25mAllegiant Air
Deal found 11/6$96
This Cheapflightsfares deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:33 amDEN - TYS
Nonstop2h 38mAllegiant Air
Thu 12/116:30 amTYS - DEN
Nonstop3h 13mAllegiant Air
Deal found 11/6$99
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2111:07 amDEN - TYS
Nonstop2h 46mFrontier
Sat 11/228:05 pmTYS - DEN
Nonstop3h 21mFrontier
Deal found 11/6$102
This Cheapflightsfares deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/139:05 amDEN - TYS
Nonstop2h 39mAllegiant Air
Sun 11/167:00 amTYS - DEN
Nonstop3h 15mAllegiant Air
Deal found 11/5$104
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/811:12 amDEN - TYS
Nonstop2h 45mFrontier
Thu 12/114:52 pmTYS - DEN
Nonstop3h 31mFrontier
Deal found 11/6$105
This Mytrip deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:33 amDEN - TYS
Nonstop2h 38mMultiple Airlines
Thu 12/114:52 pmTYS - DEN
Nonstop3h 31mMultiple Airlines
Deal found 11/6$106
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/208:45 amDEN - TYS
Nonstop2h 39mMultiple Airlines
Sat 11/228:05 pmTYS - DEN
Nonstop3h 21mMultiple Airlines
Deal found 11/6$114
This Mytrip deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/131:36 pmDEN - TYS
Nonstop2h 46mMultiple Airlines
Thu 11/206:30 amTYS - DEN
Nonstop3h 25mMultiple Airlines
Deal found 11/6$116
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2111:07 amDEN - TYS
Nonstop2h 46mMultiple Airlines
Sun 11/236:30 amTYS - DEN
Nonstop3h 25mMultiple Airlines
Deal found 11/6$124
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:36 pmCOS - TYS
1 stop7h 04mAmerican Airlines
Wed 12/104:22 pmTYS - COS
1 stop6h 08mAmerican Airlines
Deal found 11/5$249
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:00 pmCOS - TYS
2 stops13h 38mDelta
Wed 12/107:39 amTYS - COS
2 stops11h 40mDelta
Deal found 11/5$377

Cheap flight deals from Colorado to Knoxville

Keep the following information in mind while searching for Colorado to Knoxville flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$92
(Cheapflightsfares)

One-way from

$48
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$209

Good round-trip deal

$187 or less

Good one-way deal

$124 or less
Provider with most accurate pricing for Denver Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Denver Intl-Knoxville McGhee Tyson flights.
Search Deals
From Colorado to Knoxville McGhee Tyson
Search Deals
One-way flight from Colorado to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($11 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Colorado to Knoxville McGhee Tyson.
Search Deals
Price to beat on a one-way flight from Colorado to Knoxville McGhee Tyson.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Colorado to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Colorado to Knoxville that are best for you.

Fly from

Colorado

Fly to

Knoxville

Route

Depart

Return

Price

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

Thu 11/20

8:45 am-1:24 pm

Nonstop2h 39m

Knoxville McGhee Tyson

Sun 11/23

12:24 pm-9:41 pm

1 stop11h 17m

$181

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

Fri 12/12

1:59 pm-11:18 pm

1 stop7h 19m

Knoxville McGhee Tyson

Sun 12/14

7:59 pm-12:07 am

1 stop6h 08m

$219

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

Fri 12/5

1:16 pm-8:05 pm

1 stop4h 49m

Knoxville McGhee Tyson

Mon 12/8

7:59 pm-12:07 am

1 stop6h 08m

$219

Colorado SpringsKnoxville

COS - TYS

COSTYS

Colorado Springs

Wed 12/3

5:33 am-3:32 pm

1 stop7h 59m

Knoxville McGhee Tyson

Wed 12/10

4:22 pm-8:30 pm

1 stop6h 08m

$249

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

Wed 12/3

6:46 am-4:44 pm

1 stop7h 58m

Knoxville McGhee Tyson

Tue 12/9

6:29 am-10:07 am

1 stop5h 38m

$249

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

Thu 11/20

4:05 pm-11:59 pm

1 stop5h 54m

Knoxville McGhee Tyson

Thu 11/27

2:25 pm-7:29 pm

1 stop7h 04m

$274

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

Thu 11/13

11:15 pm-10:56 pm

3 stops21h 41m

Knoxville McGhee Tyson

Sun 11/16

7:00 am-8:15 am

Nonstop3h 15m

$290

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

Wed 12/3

5:30 pm-10:30 pm

Nonstop3h 00m

Knoxville McGhee Tyson

Tue 12/9

9:40 am-2:52 pm

1 stop7h 12m

$319

DenverKnoxville

DEN - TYS

DENTYS

Denver Intl

Wed 11/19

10:18 am-8:00 pm

1 stop7h 42m

Knoxville McGhee Tyson

Thu 11/27

2:49 pm-5:51 pm

1 stop5h 02m

$319

Colorado SpringsKnoxville

COS - TYS

COSTYS

Colorado Springs

Wed 4/15

8:32 am-5:26 pm

1 stop6h 54m

Knoxville McGhee Tyson

Sat 4/18

12:18 pm-3:37 pm

1 stop5h 19m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 40 results
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Best time to book a flight from Colorado to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Colorado with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Colorado to Knoxville

What is the cheapest month to book a flight from Colorado to Knoxville?

Currently, February is the cheapest month in which you can book a flight from Colorado to Knoxville (average of $57). Flying from Colorado to Knoxville in October is currently the most expensive (average of $96). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CO to TYS?

Find hourly flight availability from Colorado to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

It’s optimal to fly from Colorado to Knoxville in the evening. By choosing this option you can save up to 43% on the cost of your flight, compared to a flight in the afternoon.

What is the cheapest day to fly from Colorado to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Colorado to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Colorado to Knoxville flight should consider departing on Tuesday at noon when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Colorado to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Colorado?

    For a flight from Colorado to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How popular is this Colorado to Knoxville flight route?

    The Colorado to Knoxville McGhee Tyson flight path was viewed by 5 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Colorado to Knoxville?

    There are many flights that can get you from Colorado to Knoxville in 5h 54m. Fly via Delta, American Airlines, or United Airlines to get the fastest option. The distance from Colorado to Knoxville is about 1159 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Colorado to Knoxville?

    Most travelers choose Denver Intl - Knoxville McGhee Tyson, Grand Junction Regnl - Knoxville McGhee Tyson or Colorado Springs - Knoxville McGhee Tyson when deciding on the best route from Colorado to Knoxville.

  • What are the most reliable airlines from Colorado to Knoxville?

    Before booking your flight to Knoxville from Colorado, check out the most reliable airlines to get you to your destination on time: Allegiant Air (92%), United Airlines (90%), Frontier( 86%).

  • What are the cheapest flights from Colorado to Knoxville?

    Looking for the cheapest flight from Colorado to Knoxville? While on average our users pay $230, our data indicates the cheapest price to be $54. The most popular route (Denver Intl - Knoxville McGhee Tyson), is priced around $88.

  • Can I find deals for flights from Colorado to Knoxville that include hotel bookings?

    Yes. In addition to deals on Colorado to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Colorado to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Colorado to Knoxville.

  • Can I find deals for business class flights from Colorado to Knoxville?

    Yes. Cheapflights offers flight deals from Colorado to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Colorado to Knoxville?

    Currently, February is the cheapest month in which you can book a flight from Colorado to Knoxville (average of $57). Flying from Colorado to Knoxville in October is currently the most expensive (average of $96). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Colorado to Knoxville

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Top 5 airlines flying from Colorado to Knoxville

Discover the top 5 airlines that operate flights from Colorado to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$64Average$132FlexibilityNo cancel feeOn-time88%
FrontierCheapest$81Average$186FlexibilityNo cancel feeOn-time62%
DeltaCheapest$133Average$273FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$387FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$233Average$532FlexibilityNo cancel feeOn-time69%

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