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$87+ Cheap flights from Charleston to Knoxville (CHS - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Sep 8 — Sep 151
Mon 9/8
Mon 9/15
1 adult, Economy
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Cheap flight deals from Charleston to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 3, 2025.

Round-trip from

$226
(Kiwi.com)

One-way from

$146
(Kiwi.com)

Popular in

August

Cheapest in

June

Average price

$508
From Charleston to Knoxville McGhee Tyson
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One-way flight from Charleston to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 3% potential increase in price ($21 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Charleston to Knoxville

Cheapest flights from Charleston to Knoxville
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 3, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2010:11 amCHS - TYS
1 stop24h 22mMultiple Airlines
Thu 10/239:15 pmTYS - CHS
1 stop11h 51mMultiple Airlines
Deal found 9/1$226
This Mytrip deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1610:11 amCHS - TYS
1 stop10h 00mMultiple Airlines
Thu 10/239:15 pmTYS - CHS
1 stop11h 51mMultiple Airlines
Deal found 9/1$254
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/310:10 amCHS - TYS
1 stop6h 56mMultiple Airlines
Mon 10/68:10 pmTYS - CHS
2 stops22h 31mMultiple Airlines
Deal found 9/2$280
This Mytrip deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/212:08 pmCHS - TYS
1 stop8h 17mMultiple Airlines
Sun 10/57:20 amTYS - CHS
2 stops25h 46mMultiple Airlines
Deal found 9/1$283
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2610:10 amCHS - TYS
1 stop24h 08mMultiple Airlines
Sun 9/285:55 pmTYS - CHS
1 stop15h 10mMultiple Airlines
Deal found 9/3$293
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1210:10 amCHS - TYS
1 stop9h 49mMultiple Airlines
Sat 9/138:55 pmTYS - CHS
2 stops13h 50mMultiple Airlines
Deal found 8/31$304
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1510:10 amCHS - TYS
2 stops24h 25mMultiple Airlines
Wed 9/174:31 pmTYS - CHS
1 stop18h 14mMultiple Airlines
Deal found 9/2$317
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2512:08 pmCHS - TYS
1 stop22h 25mMultiple Airlines
Sun 9/285:55 pmTYS - CHS
1 stop15h 10mMultiple Airlines
Deal found 9/2$325

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 3, 2025.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Charleston

Fly to

Knoxville

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 10/20

10:11 am-10:33 am

1 stop24h 22m

Knoxville McGhee Tyson

Thu 10/23

9:15 pm-9:06 am

1 stop11h 51m

$226

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 10/16

10:11 am-8:11 pm

1 stop10h 00m

Knoxville McGhee Tyson

Thu 10/23

9:15 pm-9:06 am

1 stop11h 51m

$254

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 10/3

10:10 am-5:06 pm

1 stop6h 56m

Knoxville McGhee Tyson

Mon 10/6

8:10 pm-6:41 pm

2 stops22h 31m

$280

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 10/2

12:08 pm-8:25 pm

1 stop8h 17m

Knoxville McGhee Tyson

Sun 10/5

7:20 am-9:06 am

2 stops25h 46m

$283

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 9/26

10:10 am-10:18 am

1 stop24h 08m

Knoxville McGhee Tyson

Sun 9/28

5:55 pm-9:05 am

1 stop15h 10m

$293

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 9/15

10:10 am-10:35 am

2 stops24h 25m

Knoxville McGhee Tyson

Wed 9/17

4:31 pm-10:45 am

1 stop18h 14m

$317

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 9/25

12:08 pm-10:33 am

1 stop22h 25m

Knoxville McGhee Tyson

Sun 9/28

5:55 pm-9:05 am

1 stop15h 10m

$325

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 9/26

10:10 am-10:18 am

1 stop24h 08m

$87

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 10/17

10:11 am-10:18 am

1 stop24h 07m

$146

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 10/16

10:11 am-8:11 pm

1 stop10h 00m

$150

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/3

Showing 1-10 of 13 results
1
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Best time to book a flight from Charleston to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Knoxville

What is the cheapest month to book a flight from Charleston to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $294). Flying from Charleston to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to TYS?

Find hourly flight availability from Charleston to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 3, 2025.

When flying from Charleston to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 25% versus a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 3, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,972 reviews

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,972 reviews
Delta
8.0
Very good
7,972 reviews

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,972 reviews

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Charleston to Knoxville round-trip?

    Flying on American Airlines is currently your cheapest option to Knoxville, with prices starting at $326. Another option worth looking into is Delta, starting at $326 round trip. You may be able to fly from Charleston to Knoxville for 36% less than the average price by searching for these airlines.

  • Can I find deals for flights from Charleston to Knoxville that include hotel bookings?

    Yes. In addition to deals on Charleston to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Knoxville.

  • Can I find deals for business class flights from Charleston to Knoxville?

    Yes. Cheapflights offers flight deals from Charleston to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $294). Flying from Charleston to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Charleston to Knoxville

Discover the top 2 airlines that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$326Average$503FlexibilityNo cancel feeOn-time71%
DeltaCheapest$326Average$560FlexibilityNo cancel feeOn-timeN/A

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