$109+ Cheap flights from Charleston (CHS) to Key Largo, FL
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — MIA
Sep 13 — Sep 201
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to Key Largo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Charleston to Key Largo are usually found in September or October, booked 76 days in advance, depart on a Friday or Thursday and return on a Tuesday
Cheap flight deals from Charleston to Key Largo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Charleston to Key LargoExplore the most affordable flight options available from Charleston to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2026.
Explore the most affordable flight options available from Charleston to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2026.
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:10 am -
1 stop5h 25m
Tue 9/2911:50 am -
1 stop7h 30m
Deal found 8/12![Southwest logo]()
$240
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/294:45 pm -
1 stop5h 50m
Tue 11/36:30 am -
1 stop6h 15m
Deal found 8/13![Southwest logo]()
$261
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:00 pm -
1 stop7h 05m
Sat 11/76:20 am -
1 stop11h 45m
Deal found 8/13![Southwest logo]()
$267
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:10 am -
1 stop5h 25m
Wed 9/169:15 am -
1 stop10h 35m
Deal found 8/12![Southwest logo]()
$270
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:35 am -
1 stop4h 45m
Tue 11/106:30 am -
1 stop6h 15m
Deal found 8/10![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/14:45 pm -
1 stop5h 50m
Mon 10/56:25 am -
1 stop7h 35m
Deal found 8/12![Southwest logo]()
$282
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:00 am -
1 stop7h 50m
Sat 9/197:45 am -
1 stop8h 55m
Deal found 8/13![Southwest logo]()
$284
Best flights from Charleston to Key LargoDiscover carefully curated flight deals from Charleston to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2026.
Discover carefully curated flight deals from Charleston to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2026.
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:15 pm -
1 stop7h 50m
Mon 9/146:20 am -
1 stop9h 05m
Deal found 8/11![Southwest logo]()
$305
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:30 am -
1 stop3h 56m
Mon 4/194:40 pm -
1 stop6h 15m
Deal found 8/9![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:05 am -
2 stops11h 15m
Sat 10/36:10 am -
1 stop7h 15m
Deal found 8/9![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:26 pm -
1 stop6h 29m
Sun 9/206:00 am -
1 stop5h 38m
Deal found 8/12![Delta logo]()
$322
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:35 am -
2 stops9h 35m
Mon 8/317:00 am -
2 stops8h 25m
Deal found 8/9![Southwest logo]()
$327
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:35 am -
2 stops11h 25m
Mon 10/57:10 am -
2 stops6h 50m
Deal found 8/12![Southwest logo]()
$333
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:35 am -
1 stop4h 45m
Mon 11/237:05 am -
2 stops11h 25m
Deal found 8/12![Southwest logo]()
$344
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:20 am -
1 stop10h 15m
Wed 9/169:15 am -
1 stop10h 35m
Deal found 8/12![Southwest logo]()
$350
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:35 am -
2 stops9h 35m
Sun 9/206:45 am -
2 stops6h 20m
Deal found 8/11![Southwest logo]()
$370
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:10 am -
2 stops11h 30m
Wed 11/116:30 am -
1 stop6h 15m
Deal found 8/13![Southwest logo]()
$371
Last-minute flights from Charleston to Key LargoDiscover last-minute flight deals from Charleston to Key Largo. Data last updated August 14, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Key Largo. Data last updated August 14, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:45 am -
2 stops9h 20m
Wed 9/27:30 am -
1 stop5h 05m
Deal found 8/10![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:10 am -
1 stop5h 25m
Wed 9/1611:50 am -
2 stops8h 00m
Deal found 8/12![Southwest logo]()
$270
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:30 pm -
Nonstop1h 44m
Mon 9/149:50 pm -
Nonstop1h 53m
Deal found 8/11![American Airlines logo]()
$297
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:35 am -
2 stops9h 35m
Sat 9/127:45 am -
2 stops11h 40m
Deal found 8/10![Southwest logo]()
$287
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:00 am -
1 stop7h 50m
Sat 9/197:45 am -
2 stops11h 40m
Deal found 8/13![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:10 am -
1 stop5h 25m
Tue 9/2911:50 am -
1 stop7h 30m
Deal found 8/12![Southwest logo]()
$240
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:00 am -
Nonstop1h 44m
Fri 10/23:44 pm -
Nonstop1h 49m
Deal found 8/11![American Airlines logo]()
$298
One-way flights from Charleston to Key LargoSearch for one-way flight options from Charleston to Key Largo. Find affordable one-way fares based on user searches. Data last updated August 14, 2026.
Search for one-way flight options from Charleston to Key Largo. Find affordable one-way fares based on user searches. Data last updated August 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:13 pm -
2 stops25h 08m
Deal found 8/11![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/159:18 am -
2 stops11h 20m
Deal found 8/14![Multiple Airlines logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
2 stops33h 24m
Deal found 8/9![Multiple Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:16 pm -
2 stops26h 05m
Deal found 8/11![Multiple Airlines logo]()
$119
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:55 pm -
1 stop7h 40m
Deal found 8/11![Southwest logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:27 pm -
2 stops29h 11m
Deal found 8/14![Multiple Airlines logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:32 pm -
2 stops31h 01m
Deal found 8/12![Multiple Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:00 am -
2 stops33h 24m
Deal found 8/12![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:00 pm -
2 stops27h 12m
Deal found 8/11![Multiple Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:00 pm -
2 stops30h 29m
Deal found 8/12![Multiple Airlines logo]()
$128
Find flight deals from Charleston to Key Largo
Keep the following information in mind while searching for Charleston to Key Largo flight deals. Data was last updated August 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $240 (Southwest) |
One-way from | $109 (Kiwi.com) |
Popular in | April |
Cheapest in | September |
Average price | $302 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Charleston to Key Largo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Thu 9/10
1:15 pm-9:05 pm
1 stop7h 50m
Miami
Mon 9/14
6:20 am-3:25 pm
1 stop9h 05m
$305
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Sat 9/26
8:05 am-7:20 pm
2 stops11h 15m
Miami
Sat 10/3
6:10 am-1:25 pm
1 stop7h 15m
$309
Quickest round-trip
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Thu 10/15
5:30 am-9:26 am
1 stop3h 56m
Miami
Mon 4/19
4:40 pm-10:55 pm
1 stop6h 15m
$317
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Sat 9/12
6:26 pm-12:55 am
1 stop6h 29m
Miami
Sun 9/20
6:00 am-11:38 am
1 stop5h 38m
$322
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Fri 8/28
6:35 am-4:10 pm
2 stops9h 35m
Miami
Mon 8/31
7:00 am-3:25 pm
2 stops8h 25m
$327
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Thu 10/1
6:35 am-6:00 pm
2 stops11h 25m
Miami
Mon 10/5
7:10 am-2:00 pm
2 stops6h 50m
$333
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Tue 11/3
6:35 am-11:20 am
1 stop4h 45m
Miami
Mon 11/23
7:05 am-6:30 pm
2 stops11h 25m
$344
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Sun 9/13
7:20 am-5:35 pm
1 stop10h 15m
Miami
Wed 9/16
9:15 am-7:50 pm
1 stop10h 35m
$350
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Thu 9/17
6:35 am-4:10 pm
2 stops9h 35m
Miami
Sun 9/20
6:45 am-1:05 pm
2 stops6h 20m
$370
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Sat 10/31
6:10 am-5:40 pm
2 stops11h 30m
Miami
Wed 11/11
6:30 am-12:45 pm
1 stop6h 15m
$371
Showing 1-10 of 21 resultsSorted by cheapest first
Best time to book a flight from Charleston to Key Largo
Have a flexible travel schedule? Discover the best time to fly to Key Largo from Charleston with our price prediction graph.
CHS-MIA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Key Largo
CHS-KE9
CHS-MIA
What is the cheapest time of day to fly from CHS to KE9?
Find hourly flight availability from Charleston to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2026.
A simple way to save on the total cost of your ticket is to fly from Charleston to Key Largo in the afternoon. If you’re flexible enough to do this you can expect to save up to 30% on your trip compared to booking a flight in the morning.
How much does it cost to fly round-trip from Charleston to Key Largo?
Airfare is below average for this route at the moment.
Charleston to Key Largo flights typically cost between $265 and $404 in September.The cheapest round-trip price found within the last 5 days was $240 on Southwest (Sep 22-Sep 29).
Reviews of airlines servicing Key Largo
Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated August 14, 2026.
Read reviews from past customers who have flown Delta,American Airlines, andJetBlue from Charleston to Key Largo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Overall
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Overall
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Overall
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from Charleston to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Find flights from Charleston to Key Largo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Charleston and Key Largo flights
Browse other Charleston and Key Largo flight options. Last updated on August 14, 2026.
Other flights from Charleston
Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on August 14, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Charleston to Key Largo flights
Consider these flights traveling from Charleston to Key Largo.
Top 4 airlines flying from Charleston to Key Largo
Discover the top 4 airlines that operate flights from Charleston to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$78 | Average$218 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$106 | Average$187 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$157 | Average$361 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$157 | Average$362 | FlexibilityNo cancel fee | On-time71% |