$105+ Cheap flights from Charleston (CHS) to Key Largo, FL
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — MIA
Oct 5 — Oct 121
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to Key Largo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Charleston to Key Largo are usually found in November or January, booked 76 days in advance, depart on a Friday or Thursday and return on a Tuesday
Cheap flight deals from Charleston to Key Largo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Charleston to Key LargoExplore the most affordable flight options available from Charleston to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
Explore the most affordable flight options available from Charleston to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:26 pm -
1 stop6h 29m
Tue 10/612:05 pm -
1 stop4h 30m
Deal found 9/3![Delta logo]()
$229
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:00 am -
Nonstop1h 44m
Wed 10/710:14 pm -
Nonstop1h 45m
Deal found 9/2![American Airlines logo]()
$287
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:00 am -
Nonstop1h 44m
Sat 10/38:15 am -
1 stop5h 21m
Deal found 9/2![American Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
Nonstop1h 40m
Fri 10/235:08 pm -
Nonstop1h 50m
Deal found 9/2![American Airlines logo]()
$302
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:40 am -
1 stop6h 25m
Wed 10/76:04 am -
1 stop4h 06m
Deal found 8/31![Delta logo]()
$307
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:30 pm -
Nonstop1h 44m
Fri 10/95:08 pm -
Nonstop1h 50m
Deal found 9/1![American Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
Nonstop1h 44m
Mon 10/510:14 pm -
Nonstop1h 45m
Deal found 8/31![American Airlines logo]()
$316
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:38 pm -
Nonstop1h 46m
Mon 10/128:45 am -
Nonstop1h 47m
Deal found 9/2![American Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1611:12 am -
Nonstop1h 43m
Fri 10/235:08 pm -
Nonstop1h 50m
Deal found 9/1![American Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:00 am -
2 stops35h 05m
Tue 12/221:25 pm -
1 stop9h 11m
Deal found 9/2![Multiple Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:15 am -
1 stop4h 04m
Fri 10/165:50 pm -
1 stop6h 09m
Deal found 9/3![Delta logo]()
$322
Best flights from Charleston to Key LargoDiscover carefully curated flight deals from Charleston to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
Discover carefully curated flight deals from Charleston to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/292:12 pm -
1 stop6h 58m
Tue 10/66:04 am -
1 stop4h 06m
Deal found 9/1![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:35 am -
1 stop5h 50m
Tue 10/66:45 am -
2 stops10h 50m
Deal found 9/1![Southwest logo]()
$312
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1111:19 am -
1 stop4h 41m
Fri 11/135:05 pm -
1 stop6h 54m
Deal found 9/3![Delta logo]()
$322
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:35 am -
2 stops10h 10m
Fri 11/136:50 am -
1 stop9h 00m
Deal found 9/3![Southwest logo]()
$327
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:20 pm -
1 stop6h 21m
Fri 10/167:36 pm -
1 stop4h 23m
Deal found 8/31![Delta logo]()
$322
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:40 am -
2 stops10h 15m
Fri 10/167:10 am -
2 stops10h 50m
Deal found 9/1![Southwest logo]()
$332
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:10 am -
2 stops11h 55m
Fri 10/27:10 am -
2 stops10h 50m
Deal found 9/1![Southwest logo]()
$332
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/234:11 pm -
1 stop4h 48m
Fri 11/276:00 am -
1 stop4h 47m
Deal found 8/31![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:35 am -
1 stop5h 15m
Sat 9/267:45 am -
2 stops11h 40m
Deal found 9/3![Southwest logo]()
$336
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:35 am -
2 stops10h 10m
Sat 12/56:45 am -
2 stops9h 55m
Deal found 9/2![Southwest logo]()
$342
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:12 pm -
1 stop4h 53m
Thu 10/86:04 am -
1 stop4h 06m
Deal found 9/1![Delta logo]()
$383
Last-minute flights from Charleston to Key LargoDiscover last-minute flight deals from Charleston to Key Largo. Data last updated September 5, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Key Largo. Data last updated September 5, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:00 am -
Nonstop1h 44m
Sat 10/39:50 pm -
Nonstop1h 53m
Deal found 9/2![American Airlines logo]()
$287
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:40 am -
1 stop6h 25m
Wed 10/76:04 am -
1 stop4h 06m
Deal found 8/31![Delta logo]()
$307
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
Nonstop1h 44m
Mon 10/510:14 pm -
Nonstop1h 45m
Deal found 8/31![American Airlines logo]()
$316
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:26 pm -
1 stop6h 29m
Tue 10/612:05 pm -
1 stop4h 30m
Deal found 9/3![Delta logo]()
$229
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:30 pm -
Nonstop1h 44m
Fri 10/95:08 pm -
Nonstop1h 50m
Deal found 9/1![American Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:38 pm -
Nonstop1h 46m
Mon 10/128:45 am -
Nonstop1h 47m
Deal found 9/2![American Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
Nonstop1h 40m
Fri 10/235:08 pm -
Nonstop1h 50m
Deal found 9/2![American Airlines logo]()
$302
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:15 am -
1 stop4h 04m
Fri 10/165:50 pm -
1 stop6h 09m
Deal found 9/3![Delta logo]()
$322
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1611:12 am -
Nonstop1h 43m
Fri 10/235:08 pm -
Nonstop1h 50m
Deal found 9/1![American Airlines logo]()
$318
One-way flights from Charleston to Key LargoSearch for one-way flight options from Charleston to Key Largo. Find affordable one-way fares based on user searches. Data last updated September 5, 2026.
Search for one-way flight options from Charleston to Key Largo. Find affordable one-way fares based on user searches. Data last updated September 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/293:00 pm -
2 stops29h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
2 stops28h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:00 pm -
2 stops30h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Multiple Airlines logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:18 am -
2 stops25h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Multiple Airlines logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:00 am -
2 stops28h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/223:00 pm -
2 stops29h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Multiple Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/33:00 pm -
2 stops30h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:58 pm -
2 stops23h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$123
Find flight deals from Charleston to Key Largo
Keep the following information in mind while searching for Charleston to Key Largo flight deals. Data was last updated September 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $229 (Delta) |
One-way from | $105 (Kiwi.com) |
Popular in | April |
Cheapest in | November |
Average price | $297 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
Use the filters below to find and compare flights from Charleston to Key Largo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Tue 11/17
4:17 pm-8:59 pm
1 stop4h 42m
Miami
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$154
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Sat 9/26
4:27 pm-9:09 pm
1 stop4h 42m
Miami
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$154
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Tue 11/3
10:30 am-3:04 pm
1 stop4h 34m
Miami
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$154
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Wed 3/3
2:25 pm-8:54 pm
1 stop6h 29m
Miami
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$154
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Tue 9/29
6:40 am-1:05 pm
1 stop6h 25m
Miami
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$154
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Tue 12/1
4:17 pm-8:55 pm
1 stop4h 38m
Miami
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$164
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Sat 11/7
6:29 pm-12:53 am
1 stop6h 24m
Miami
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$164
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Wed 12/2
5:10 am-10:27 am
1 stop5h 17m
Miami
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$164
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Thu 9/24
6:00 am-11:20 am
1 stop5h 20m
Miami
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$169
CharlestonMiami
CHS Charleston - MIA Miami
CHSMIA
Charleston
Thu 11/12
12:58 pm-6:40 pm
1 stop5h 42m
Miami
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$169
Showing 1-10 of 22 resultsSorted by cheapest first
Best time to book a flight from Charleston to Key Largo
Have a flexible travel schedule? Discover the best time to fly to Key Largo from Charleston with our price prediction graph.
CHS-MIA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Key Largo
CHS-KE9
CHS-MIA
What is the cheapest time of day to fly from CHS to KE9?
Find hourly flight availability from Charleston to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 5, 2026.
A simple way to save on the total cost of your ticket is to fly from Charleston to Key Largo in the afternoon. If you’re flexible enough to do this you can expect to save up to 34% on your trip compared to booking a flight in the morning.
How much does it cost to fly round-trip from Charleston to Key Largo?
Airfare is below average for this route at the moment.
Charleston to Key Largo flights typically cost between $244 and $366 in October.The cheapest round-trip price found within the last 5 days was $229 on Delta (Oct 3-Oct 6).
Reviews of airlines servicing Key Largo
Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated September 5, 2026.
Read reviews from past customers who have flown Delta,American Airlines, andJetBlue from Charleston to Key Largo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Entertainment
7.8
Overall
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Crew
8.5
Entertainment
7.8
Overall
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Crew
8.5
Entertainment
7.8
Overall
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Crew
8.5
Entertainment
7.8
Overall
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from Charleston to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Charleston to Key Largo
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Complete your trip
Complete your trip to Key Largo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Charleston to Key Largo by cabin class
Find flights from Charleston to Key Largo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Charleston and Key Largo flights
Browse other Charleston and Key Largo flight options. Last updated on September 5, 2026.
Other flights from Charleston
Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on September 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Charleston to Key Largo flights
Consider these flights traveling from Charleston to Key Largo.
Top 4 airlines flying from Charleston to Key Largo
Discover the top 4 airlines that operate flights from Charleston to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$78 | Average$225 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$104 | Average$191 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$157 | Average$361 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$158 | Average$369 | FlexibilityNo cancel fee | On-time71% |