Key Largo

$54+ Cheap flights from Charleston (CHS) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/14. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — MIA
Jan 17 — Jan 241
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Cheapflights Tip: The best prices from Charleston to Key Largo are usually found in August or September, booked 70 days in advance, depart on a Thursday or Friday and return on a Saturday

Cheap flight deals from Charleston to Key Largo

Cheapest flights from Charleston to Key Largo
Explore the most affordable flight options available from Charleston to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:30 amCHS - MIA
Nonstop1h 49mAmerican Airlines
Wed 12/315:35 pmMIA - CHS
Nonstop1h 52mAmerican Airlines
Deal found 12/16$167
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:30 amCHS - MIA
Nonstop1h 49mAmerican Airlines
Fri 12/2610:56 pmMIA - CHS
Nonstop1h 49mAmerican Airlines
Deal found 12/16$197
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:15 pmCHS - MIA
1 stop19h 20mMultiple Airlines
Tue 1/68:00 amMIA - CHS
2 stops29h 10mMultiple Airlines
Deal found 12/17$217
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:07 pmCHS - MIA
Nonstop1h 53mAmerican Airlines
Wed 12/315:35 pmMIA - CHS
Nonstop1h 52mAmerican Airlines
Deal found 12/17$269
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:27 pmCHS - MIA
1 stop6h 20mAmerican Airlines
Thu 1/110:56 pmMIA - CHS
Nonstop1h 49mAmerican Airlines
Deal found 12/17$279
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/288:07 pmCHS - MIA
Nonstop1h 53mAmerican Airlines
Sat 1/37:00 amMIA - CHS
Nonstop1h 47mAmerican Airlines
Deal found 12/17$284
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:15 pmCHS - MIA
1 stop19h 20mSpirit Airlines
Tue 1/67:14 pmMIA - CHS
1 stop17h 56mSpirit Airlines
Deal found 12/17$285
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:16 pmCHS - MIA
1 stop20h 22mMultiple Airlines
Sun 1/45:30 amMIA - CHS
2 stops39h 53mMultiple Airlines
Deal found 12/16$292
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amCHS - MIA
1 stop4h 23mDelta
Wed 12/314:01 pmMIA - CHS
1 stop4h 38mDelta
Deal found 12/16$293
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:15 pmCHS - MIA
1 stop9h 02mMultiple Airlines
Sun 1/45:30 amMIA - CHS
2 stops39h 53mMultiple Airlines
Deal found 12/16$302
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:30 amCHS - MIA
1 stop3h 58mDelta
Thu 1/16:00 amMIA - CHS
1 stop5h 36mDelta
Deal found 12/17$308

Find flight deals from Charleston to Key Largo

Keep the following information in mind while searching for Charleston to Key Largo flight deals. Data was last updated December 18, 2025.

Most accurate provider

CheapOair
3 stars

Most trusted provider

CheapOair
3 stars

Round-trip from

$142
(American Airlines)

One-way from

$54
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$342
Provider with most accurate pricing for Charleston-Miami flight deals.
Provider most trusted by Cheapflights users for Charleston-Miami flights.
From Charleston to Key Largo
One-way flight from Charleston to Key Largo
Highest demand for flights based on searches. 3% potential increase in price ($9 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Average for round-trip flights in December 2025

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Charleston to Key Largo that are best for you.

Fly from

Charleston

Fly to

Key Largo

Route

Depart

Return

Price

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Mon 1/19

7:00 pm-12:51 am

1 stop5h 51m

Miami

Sat 1/24

7:15 am-2:06 pm

1 stop6h 51m

$157

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Thu 1/8

12:53 pm-5:15 pm

1 stop4h 22m

Miami

Mon 1/12

5:50 am-11:48 am

1 stop5h 58m

$157

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Sat 1/17

2:06 pm-9:10 pm

1 stop7h 04m

Miami

Sun 1/25

7:00 am-8:47 am

Nonstop1h 47m

$192

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Wed 4/22

9:35 am-7:25 pm

1 stop9h 50m

Miami

Tue 4/28

11:55 am-8:40 am

1 stop20h 45m

$218

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Fri 2/6

7:00 pm-12:51 am

1 stop5h 51m

Miami

Tue 2/10

1:21 pm-5:53 pm

1 stop4h 32m

$218

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Fri 1/9

12:53 pm-5:15 pm

1 stop4h 22m

Miami

Sun 1/18

7:15 am-11:48 am

1 stop4h 33m

$218

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Fri 2/20

5:00 pm-12:14 am

1 stop7h 14m

Miami

Sun 3/1

7:09 pm-4:05 pm

2 stops20h 56m

$223

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Wed 2/25

5:27 am-10:40 am

1 stop5h 13m

Miami

Sat 2/28

6:00 am-12:21 pm

1 stop6h 21m

$223

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Fri 1/23

6:35 pm-8:13 pm

3 stops25h 38m

Miami

Sun 1/25

8:51 pm-5:36 pm

2 stops20h 45m

$226

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Thu 1/29

11:40 am-10:00 pm

2 stops10h 20m

Miami

Sat 1/31

7:50 am-1:15 pm

1 stop5h 25m

$238

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 22 results
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Best time to book a flight from Charleston to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Key Largo

How far ahead should I book a flight from Charleston to Key Largo?

Use this chart to determine the optimal time to book a round-trip flight from Charleston to Key Largo. Price data was last updated on December 12, 2025.

The best time to book flights from Charleston to Key Largo is 70 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Charleston to Key Largo?

Currently, March is the cheapest month in which you can book a flight from Charleston to Key Largo (average of $33). Flying from Charleston to Key Largo in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to KE9?

Find hourly flight availability from Charleston to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

A simple way to save on the total cost of your ticket is to fly from Charleston to Key Largo in the morning. If you’re flexible enough to do this you can expect to save up to 37% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from Charleston to Key Largo?

Use this chart to determine the cheapest time to fly round-trip from Charleston to Key Largo. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Charleston to Key Largo flight should consider departing on Monday mornings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Charleston to Key Largo?

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated December 18, 2025.
Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Charleston to Key Largo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Food

7.0

Overall

7.9

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Food

7.0

Overall

7.9

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Food

7.0

Overall

7.9

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Food

7.0

Overall

7.9

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Food

7.0

Overall

7.9

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Food

7.0

Overall

7.9

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Charleston to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Charleston to Key Largo?

    Located just 10.2 mi from the city center, Charleston is the airport most travelers will use when flying to Key Largo from Charleston. Booking flights from Charleston (CHS) to Key Largo should be relatively easy as there is 1 daily outbound flight to Key Largo from 6 different airlines.

  • How popular is this Charleston to Key Largo flight route?

  • How long is the flight from Charleston to Key Largo?

    Airlines like Delta and American Airlines fly from Charleston to Key Largo in about 5h 51m. The time it takes to get you to your destination can typically vary by up to 1h 13m. There are 490 mi between Charleston and Key Largo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Charleston to Key Largo one-way?

    One-way options have recently been found by users for as low as $39 on Spirit Airlines. Other airlines that offer cheap prices include American Airlines from $78 and JetBlue from $78 one-way.

  • What are the most reliable airlines from Charleston to Key Largo?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Charleston to Key Largo on time: Envoy Air (75%), Qatar Airways (72%), American Airlines (71%).

  • What are the cheapest flights from Charleston to Key Largo?

    While on average a flight from Charleston to Key Largo is generally $426, our data shows the cheapest flight currently is $78. When looking at the most popular route, (Charleston - Miami), you can expect to pay $135 for that flight.

  • Can I find deals for flights from Charleston to Key Largo that include hotel bookings?

    Yes. In addition to deals on Charleston to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Key Largo.

  • Can I find deals for business class flights from Charleston to Key Largo?

    Yes. Cheapflights offers flight deals from Charleston to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Key Largo?

    Currently, March is the cheapest month in which you can book a flight from Charleston to Key Largo (average of $33). Flying from Charleston to Key Largo in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Charleston to Key Largo

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from Charleston to Key Largo

Discover the top 6 airlines that operate flights from Charleston to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$39Average$107FlexibilityNo cancel feeOn-time65%
JetBlueCheapest$86Average$199FlexibilityNo cancel feeOn-time62%
Breeze AirwaysCheapest$110Average$220FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$179Average$362FlexibilityNo cancel feeOn-time71%
DeltaCheapest$181Average$369FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$245Average$339FlexibilityNo cancel feeOn-time63%

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