$70+ Cheap flights from Missouri to Jacksonville (JAX)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/26. Fares are subject to change and may not be available on all flights or dates of travel.
STL — JAX
May 2 — May 91
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Missouri to JacksonvilleExplore the most affordable flight options available from Missouri to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2026.
Explore the most affordable flight options available from Missouri to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2026.
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:15 am
STL
- JAX
Nonstop2h 00m
Southwest
Tue 5/128:20 am
JAX
- STL
Nonstop2h 15m
Southwest
Deal found 4/1![Southwest logo]()
$263
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2911:35 am
STL
- JAX
1 stop4h 45m
Southwest
Wed 5/67:20 am
JAX
- STL
1 stop5h 10m
Southwest
Deal found 4/1![Southwest logo]()
$273
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:10 am
STL
- JAX
2 stops9h 52m
United Airlines
Tue 5/126:46 pm
JAX
- STL
1 stop5h 10m
United Airlines
Deal found 4/1![United Airlines logo]()
$278
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:24 pm
SGF
- JAX
1 stop4h 57m
American Airlines
Sat 5/26:00 am
JAX
- SGF
1 stop6h 04m
American Airlines
Deal found 3/29![American Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:41 pm
STL
- JAX
1 stop21h 54m
Frontier
Tue 5/126:30 pm
JAX
- STL
1 stop15h 25m
Frontier
Deal found 3/28![Frontier logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:23 pm
STL
- JAX
1 stop20h 07m
Frontier
Mon 5/49:49 pm
JAX
- STL
2 stops20h 47m
Frontier
Deal found 3/29![Frontier logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:27 pm
STL
- JAX
2 stops14h 11m
Multiple Airlines
Wed 5/136:30 pm
JAX
- STL
1 stop23h 24m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$286
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/303:43 pm
STL
- JAX
1 stop7h 25m
American Airlines
Tue 5/126:00 am
JAX
- STL
1 stop5h 16m
American Airlines
Deal found 4/1![American Airlines logo]()
$287
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1310:15 am
STL
- JAX
Nonstop2h 00m
Southwest
Tue 5/198:20 am
JAX
- STL
Nonstop2h 15m
Southwest
Deal found 3/30![Southwest logo]()
$291
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/274:25 pm
STL
- JAX
1 stop4h 50m
Southwest
Mon 6/16:55 am
JAX
- STL
1 stop4h 55m
Southwest
Deal found 3/30![Southwest logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/36:19 pm
MCI
- JAX
2 stops13h 19m
Multiple Airlines
Thu 8/136:28 pm
JAX
- MCI
1 stop23h 56m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:19 pm
MCI
- JAX
1 stop22h 18m
Multiple Airlines
Tue 8/119:03 pm
JAX
- MCI
2 stops21h 21m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$299
Best flights from Missouri to JacksonvilleDiscover carefully curated flight deals from Missouri to Jacksonville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 2, 2026.
Discover carefully curated flight deals from Missouri to Jacksonville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 2, 2026.
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:24 pm
SGF
- JAX
1 stop4h 57m
American Airlines
Sat 5/26:00 am
JAX
- SGF
1 stop6h 04m
American Airlines
Deal found 3/29![American Airlines logo]()
$281
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:15 am
STL
- JAX
Nonstop2h 00m
Southwest
Wed 5/134:30 pm
JAX
- STL
1 stop7h 40m
Southwest
Deal found 3/28![Southwest logo]()
$296
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:15 am
STL
- JAX
1 stop3h 30m
Delta
Wed 5/137:05 am
JAX
- STL
1 stop3h 39m
Delta
Deal found 3/28![Delta logo]()
$301
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2511:30 am
COU
- JAX
1 stop7h 04m
United Airlines
Sat 5/28:00 am
JAX
- COU
1 stop7h 32m
United Airlines
Deal found 3/28![United Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/131:15 pm
STL
- JAX
1 stop6h 30m
Southwest
Tue 5/198:20 am
JAX
- STL
Nonstop2h 15m
Southwest
Deal found 3/30![Southwest logo]()
$296
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/33:42 pm
STL
- JAX
1 stop5h 00m
Delta
Mon 9/72:30 pm
JAX
- STL
1 stop4h 32m
Delta
Deal found 3/28![Delta logo]()
$325
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:00 am
STL
- JAX
1 stop7h 27m
United Airlines
Fri 7/177:09 pm
JAX
- STL
1 stop5h 36m
United Airlines
Deal found 3/28![United Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:25 am
STL
- JAX
1 stop6h 00m
Southwest
Sun 5/107:15 am
JAX
- STL
1 stop4h 50m
Southwest
Deal found 3/29![Southwest logo]()
$308
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:58 pm
SGF
- JAX
1 stop4h 12m
Delta
Mon 7/136:58 pm
JAX
- SGF
1 stop4h 12m
Delta
Deal found 3/29![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:30 am
COU
- JAX
1 stop7h 04m
United Airlines
Mon 4/204:32 pm
JAX
- COU
2 stops9h 01m
United Airlines
Deal found 4/1![United Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:45 am
STL
- JAX
2 stops8h 00m
Southwest
Wed 5/136:30 am
JAX
- STL
2 stops7h 30m
Southwest
Deal found 3/28![Southwest logo]()
$311
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/148:00 am
COU
- JAX
2 stops13h 45m
United Airlines
Sat 4/1812:24 pm
JAX
- COU
2 stops10h 37m
United Airlines
Deal found 3/30![United Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/251:45 pm
STL
- JAX
1 stop7h 20m
Southwest
Mon 6/16:55 am
JAX
- STL
1 stop4h 55m
Southwest
Deal found 3/29![Southwest logo]()
$313
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/126:55 pm
SGF
- JAX
1 stop4h 07m
Delta
Sat 4/187:30 am
JAX
- SGF
1 stop4h 31m
Delta
Deal found 3/29![Delta logo]()
$374
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:55 pm
STL
- JAX
Nonstop2h 00m
Southwest
Mon 5/113:35 pm
JAX
- STL
Nonstop2h 15m
Southwest
Deal found 4/1![Southwest logo]()
$324
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:23 am
SGF
- JAX
1 stop7h 11m
United Airlines
Wed 4/299:20 am
JAX
- SGF
2 stops9h 04m
United Airlines
Deal found 3/31![United Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:47 pm
MCI
- JAX
1 stop4h 12m
Delta
Mon 5/46:59 pm
JAX
- MCI
1 stop5h 51m
Delta
Deal found 3/29![Delta logo]()
$403
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/275:15 pm
MCI
- JAX
1 stop4h 40m
Southwest
Sat 5/27:10 pm
JAX
- MCI
1 stop4h 30m
Southwest
Deal found 3/30![Southwest logo]()
$351
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:10 pm
COU
- JAX
1 stop5h 36m
United Airlines
Sat 5/98:00 am
JAX
- COU
1 stop7h 32m
United Airlines
Deal found 3/28![United Airlines logo]()
$398
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:39 am
MCI
- JAX
1 stop7h 15m
Delta
Thu 8/135:30 am
JAX
- MCI
1 stop7h 51m
Delta
Deal found 3/30![Delta logo]()
$427
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:00 am
COU
- JAX
1 stop9h 39m
United Airlines
Sat 5/95:00 pm
JAX
- COU
1 stop6h 03m
United Airlines
Deal found 3/30![United Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:20 am
MCI
- JAX
1 stop7h 00m
Southwest
Sun 5/36:25 am
JAX
- MCI
1 stop4h 10m
Southwest
Deal found 3/31![Southwest logo]()
$371
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:50 pm
MCI
- JAX
1 stop5h 49m
United Airlines
Thu 8/2011:37 am
JAX
- MCI
1 stop6h 04m
United Airlines
Deal found 3/28![United Airlines logo]()
$407
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/912:25 pm
MCI
- JAX
2 stops7h 40m
Southwest
Sat 6/135:25 am
JAX
- MCI
1 stop6h 00m
Southwest
Deal found 3/29![Southwest logo]()
$391
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/188:56 am
JLN
- JAX
2 stops10h 06m
United Airlines
Wed 4/228:00 am
JAX
- JLN
1 stop6h 12m
United Airlines
Deal found 3/28![United Airlines logo]()
$410
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/252:05 pm
MCI
- JAX
2 stops7h 40m
Southwest
Mon 6/18:15 pm
JAX
- MCI
1 stop4h 20m
Southwest
Deal found 3/29![Southwest logo]()
$391
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/161:58 pm
JLN
- JAX
1 stop6h 48m
United Airlines
Mon 4/208:00 am
JAX
- JLN
1 stop6h 12m
United Airlines
Deal found 4/1![United Airlines logo]()
$414
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:50 am
MCI
- JAX
1 stop6h 20m
Southwest
Sun 6/219:10 pm
JAX
- MCI
1 stop4h 00m
Southwest
Deal found 4/1![Southwest logo]()
$407
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/188:00 am
SGF
- JAX
2 stops11h 02m
United Airlines
Wed 4/223:10 pm
JAX
- SGF
1 stop7h 54m
United Airlines
Deal found 3/28![United Airlines logo]()
$414
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1312:15 pm
MCI
- JAX
2 stops7h 50m
Southwest
Thu 8/207:50 am
JAX
- MCI
2 stops8h 35m
Southwest
Deal found 3/28![Southwest logo]()
$417
Last-minute flights from Missouri to JacksonvilleDiscover last-minute flight deals from Missouri to Jacksonville. Data last updated April 2, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Jacksonville. Data last updated April 2, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/149:02 am
COU
- JAX
1 stop9h 40m
United Airlines
Sat 4/183:10 pm
JAX
- COU
1 stop7h 51m
United Airlines
Deal found 3/30![United Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:24 pm
SGF
- JAX
1 stop4h 57m
American Airlines
Wed 4/293:56 pm
JAX
- SGF
1 stop6h 58m
American Airlines
Deal found 3/31![American Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2511:30 am
COU
- JAX
1 stop7h 04m
United Airlines
Sat 5/28:00 am
JAX
- COU
1 stop7h 32m
United Airlines
Deal found 3/28![United Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:15 am
STL
- JAX
Nonstop2h 00m
Southwest
Wed 5/68:20 am
JAX
- STL
Nonstop2h 15m
Southwest
Deal found 4/1![Southwest logo]()
$263
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:24 pm
SGF
- JAX
1 stop4h 57m
American Airlines
Sat 5/26:00 am
JAX
- SGF
1 stop6h 04m
American Airlines
Deal found 3/29![American Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:23 pm
STL
- JAX
1 stop20h 07m
Frontier
Mon 5/49:49 pm
JAX
- STL
2 stops20h 47m
Frontier
Deal found 3/29![Frontier logo]()
$285
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/303:43 pm
STL
- JAX
1 stop7h 25m
American Airlines
Tue 5/126:00 am
JAX
- STL
1 stop5h 16m
American Airlines
Deal found 4/1![American Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:41 pm
STL
- JAX
1 stop21h 54m
Frontier
Tue 5/126:30 pm
JAX
- STL
1 stop15h 25m
Frontier
Deal found 3/28![Frontier logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:34 pm
MCI
- JAX
2 stops26h 01m
Frontier
Tue 5/126:30 pm
JAX
- MCI
1 stop23h 59m
Frontier
Deal found 3/30![Frontier logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:27 pm
STL
- JAX
2 stops14h 11m
Multiple Airlines
Wed 5/136:30 pm
JAX
- STL
1 stop23h 24m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$286
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1310:15 am
STL
- JAX
Nonstop2h 00m
Southwest
Tue 5/198:20 am
JAX
- STL
Nonstop2h 15m
Southwest
Deal found 3/30![Southwest logo]()
$291
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/274:25 pm
STL
- JAX
1 stop4h 50m
Southwest
Mon 6/16:55 am
JAX
- STL
1 stop4h 55m
Southwest
Deal found 3/30![Southwest logo]()
$292
One-way flights from Missouri to JacksonvilleSearch for one-way flight options from Missouri to Jacksonville. Find affordable one-way fares based on user searches. Data last updated April 2, 2026.
Search for one-way flight options from Missouri to Jacksonville. Find affordable one-way fares based on user searches. Data last updated April 2, 2026.
This Frontier deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2611:53 am
MCI
- JAX
1 stop4h 37m
Frontier
Deal found 3/31![Frontier logo]()
$70
This Frontier deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2611:44 am
STL
- JAX
1 stop4h 46m
Frontier
Deal found 3/30![Frontier logo]()
$70
This Frontier deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:21 am
STL
- JAX
1 stop5h 09m
Frontier
Deal found 3/31![Frontier logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:24 pm
MCI
- JAX
1 stop22h 13m
Frontier
Deal found 3/31![Frontier logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:33 pm
STL
- JAX
1 stop22h 02m
Frontier
Deal found 4/1![Frontier logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/258:23 pm
STL
- JAX
2 stops16h 06m
Frontier
Deal found 3/28![Frontier logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:27 pm
STL
- JAX
1 stop23h 08m
Frontier
Deal found 3/31![Frontier logo]()
$136
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:25 am
STL
- JAX
1 stop7h 49m
Delta
Deal found 3/31![Delta logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:33 pm
STL
- JAX
2 stops38h 26m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- JAX
1 stop22h 02m
Frontier
Deal found 3/29![Frontier logo]()
$141
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:13 pm
STL
- JAX
2 stops9h 46m
United Airlines
Deal found 3/31![United Airlines logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:23 pm
STL
- JAX
2 stops36h 38m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$143
Find flight deals from Missouri to Jacksonville
Keep the following information in mind while searching for Missouri to Jacksonville flight deals. Data was last updated April 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $263 (Southwest) |
One-way from | $70 (Frontier) |
Popular in | November |
Cheapest in | September |
Average price | $334 |
Good round-trip deal | $347 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Jacksonville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
Use the filters below to find and compare flights from Missouri to Jacksonville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SpringfieldJacksonville
SGF - JAX
SGFJAX
Springfield-Branson
Wed 4/29
6:24 pm-12:21 am
1 stop4h 57m
Jacksonville
Sat 5/2
6:00 am-11:04 am
1 stop6h 04m
$281
St. LouisJacksonville
STL - JAX
STLJAX
Lambert-St Louis
Tue 5/12
10:15 am-1:15 pm
Nonstop2h 00m
Jacksonville
Wed 5/13
4:30 pm-11:10 pm
1 stop7h 40m
$296
St. LouisJacksonville
STL - JAX
STLJAX
Lambert-St Louis
Wed 5/13
1:15 pm-8:45 pm
1 stop6h 30m
Jacksonville
Tue 5/19
8:20 am-9:35 am
Nonstop2h 15m
$296
St. LouisJacksonville
STL - JAX
STLJAX
Lambert-St Louis
Tue 5/12
7:15 am-11:45 am
1 stop3h 30m
Jacksonville
Wed 5/13
7:05 am-9:44 am
1 stop3h 39m
$301
St. LouisJacksonville
STL - JAX
STLJAX
Lambert-St Louis
Tue 4/28
8:25 am-3:25 pm
1 stop6h 00m
Jacksonville
Sun 5/10
7:15 am-11:05 am
1 stop4h 50m
$308
St. LouisJacksonville
STL - JAX
STLJAX
Lambert-St Louis
Mon 5/11
5:45 am-2:45 pm
2 stops8h 00m
Jacksonville
Wed 5/13
6:30 am-1:00 pm
2 stops7h 30m
$311
St. LouisJacksonville
STL - JAX
STLJAX
Lambert-St Louis
Mon 5/25
1:45 pm-10:05 pm
1 stop7h 20m
Jacksonville
Mon 6/1
6:55 am-10:50 am
1 stop4h 55m
$313
ColumbiaJacksonville
COU - JAX
COUJAX
Columbia Regional
Sat 4/25
11:30 am-7:34 pm
1 stop7h 04m
Jacksonville
Sat 5/2
8:00 am-2:32 pm
1 stop7h 32m
$318
Quickest round-trip
St. LouisJacksonville
STL - JAX
STLJAX
Lambert-St Louis
Fri 5/8
1:55 pm-4:55 pm
Nonstop2h 00m
Jacksonville
Mon 5/11
3:35 pm-4:50 pm
Nonstop2h 15m
$324
St. LouisJacksonville
STL - JAX
STLJAX
Lambert-St Louis
Thu 9/3
3:42 pm-9:42 pm
1 stop5h 00m
Jacksonville
Mon 9/7
2:30 pm-6:02 pm
1 stop4h 32m
$325
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to Jacksonville
Have a flexible travel schedule? Discover the best time to fly to Jacksonville from Missouri with our price prediction graph.
STL-JAX
SGF-JAX
MCI-JAX
COU-JAX
JLN-JAX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Jacksonville
USMO-JAX
STL-JAX
SGF-JAX
MCI-JAX
COU-JAX
What is the cheapest month to book a flight from Missouri to Jacksonville?
Currently, October is the cheapest month in which you can book a flight from Missouri to Jacksonville (average of $171). Flying from Missouri to Jacksonville in December is currently the most expensive (average of $239). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to JAX?
Find hourly flight availability from Missouri to Jacksonville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 2, 2026.
It’s optimal to fly from Missouri to Jacksonville in the evening. By choosing this option you can save up to 20% on the cost of your flight, compared to a flight in the afternoon.
How much does it cost to fly round-trip from Missouri to Jacksonville?
Related info for your journey
Find useful and relevant information for your journey from Missouri to Jacksonville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Jacksonville?
Book flights to Jacksonville if you plan to visit one of these locationsJacksonville Beach
Orange Park
Fernandina Beach
Kingsland
Waycross
Yulee
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Missouri to Jacksonville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Jacksonville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Jacksonville by cabin class
Find flights from Missouri to Jacksonville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Jacksonville
Explore flights to Jacksonville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 2, 2026.
Missouri and Jacksonville flights
Browse other Missouri and Jacksonville flight options. Last updated on April 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Jacksonville flights
Consider these flights traveling from Missouri to Jacksonville.
Top 5 airlines flying from Missouri to Jacksonville
Discover the top 5 airlines that operate flights from Missouri to Jacksonville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$176 | Average$354 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$186 | Average$340 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$214 | Average$353 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$238 | Average$359 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$251 | Average$390 | FlexibilityNo cancel fee | On-time62% |