How long is the flight from Missouri to Italy?

For as low as $433, Lufthansa can have you in Italy from Missouri in 16h 20m. Airlines will cover a distance of 4752 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines to fly from Missouri to Italy one-way?

$265 is the cheapest one-way deal found within the past few days, from Lufthansa. You may also be able to find cheap deals on United Airlines and American Airlines, with prices starting from $322 and $418, respectively.

In terms of precipitation, rainfall in Italy ranges from 0.6 - 4.4 inches per month. November is typically the wettest month, when rainfall can reach 4.4 in. June is typically the driest time to visit Italy when rainfall is around 0.6 in.

If weather is an important factor for your trip to Italy, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 46.4 F).

Can I find deals for flights from Missouri to Italy that include hotel bookings?

Yes. In addition to deals on Missouri to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Italy?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Italy.

Can I find deals for business class flights from Missouri to Italy?

Yes. Cheapflights offers flight deals from Missouri to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$258+ Flights from Missouri to Italy

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Cheap flight deals from Missouri to Italy

Cheapest flights from Missouri to Italy
Explore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Wed 12/105:27 pmSTL - MXP

2 stops33h 28mAir Canada

Tue 12/161:05 pmMXP - STL

2 stops33h 35mAir Canada

Deal found 12/7

$551

Wed 12/106:42 pmSTL - MXP

2 stops32h 13mUnited Airlines

Tue 12/169:45 amMXP - STL

1 stop14h 45mUnited Airlines

Deal found 12/7

$570

Wed 12/109:30 amSTL - MXP

1 stop16h 35mKLM

Tue 12/1611:05 amMXP - STL

1 stop17h 52mKLM

Deal found 12/7

$592

Wed 12/1012:49 pmSTL - LIN

2 stops16h 11mDelta

Tue 12/166:30 amLIN - STL

2 stops21h 17mDelta

Deal found 12/7

$610

Sat 12/611:36 amMCI - FCO

1 stop13h 09mLufthansa

Sat 12/137:05 amFCO - MCI

2 stops23h 44mLufthansa

Deal found 12/5

$665

Wed 12/1012:45 pmMCI - FCO

1 stop12h 45mBrussels Airlines

Thu 12/2511:00 amFCO - MCI

1 stop16h 31mBrussels Airlines

Deal found 12/6

$669

Tue 12/306:35 pmSTL - FCO

2 stops16h 40mUnited Airlines

Wed 1/1411:15 amFCO - STL

2 stops34h 15mUnited Airlines

Deal found 12/7

$686

Thu 12/115:12 pmMCI - FCO

1 stop31h 43mKLM

Thu 12/2510:05 amFCO - MCI

1 stop16h 36mKLM

Deal found 12/6

$689

Tue 12/3011:41 amSTL - FCO

1 stop16h 04mBritish Airways

Tue 1/61:10 pmFCO - STL

1 stop16h 49mBritish Airways

Deal found 12/6

$693

Tue 12/306:35 pmSTL - FCO

2 stops16h 40mLufthansa

Wed 1/1410:30 amFCO - STL

1 stop20h 29mLufthansa

Deal found 12/7

$697

Tue 12/309:09 amSTL - FCO

2 stops16h 51mAmerican Airlines

Tue 1/61:10 pmFCO - STL

1 stop16h 49mAmerican Airlines

Deal found 12/6

$699

Tue 12/307:00 amSTL - FCO

1 stop20h 30mKLM

Wed 1/1412:45 pmFCO - STL

2 stops17h 54mKLM

Deal found 12/5

$700

Best flights from Missouri to Italy
Discover carefully curated flight deals from Missouri to Italy that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 8, 2025.

Mon 1/191:15 pmSTL - MXP

2 stops16h 20mLufthansa

Mon 2/29:45 amMXP - STL

1 stop21h 14mLufthansa

Deal found 12/7

$433

Wed 2/116:30 pmMCI - MXP

2 stops19h 15mMultiple Airlines

Wed 2/251:05 pmMXP - MCI

2 stops39h 54mMultiple Airlines

Deal found 12/7

$469

Wed 1/219:57 amSTL - MXP

2 stops16h 58mUnited Airlines

Wed 1/281:05 pmMXP - STL

2 stops32h 25mUnited Airlines

Deal found 12/7

$474

Thu 3/56:00 amMCI - MXP

2 stops20h 55mAir Canada

Thu 3/1212:05 pmMXP - MCI

2 stops39h 54mAir Canada

Deal found 12/6

$474

Mon 1/191:18 pmSTL - MXP

1 stop13h 27mDelta

Mon 2/211:05 amMXP - STL

1 stop19h 32mDelta

Deal found 12/7

$481

Mon 1/195:04 pmSTL - FLR

2 stops35h 16mBritish Airways

Mon 1/2611:40 amFLR - STL

2 stops42h 04mBritish Airways

Deal found 12/4

$488

Thu 3/197:10 amSTL - MXP

1 stop18h 55mKLM

Tue 3/3111:40 amMXP - STL

1 stop19h 02mKLM

Deal found 12/6

$490

Sat 2/2111:46 amSTL - NAP

2 stops16h 59mAmerican Airlines

Sun 3/16:20 amNAP - STL

2 stops18h 42mAmerican Airlines

Deal found 12/7

$572

Mon 2/29:57 amMCI - VCE

2 stops17h 33mScandinavian Airlines

Sat 2/79:50 amVCE - MCI

2 stops21h 01mScandinavian Airlines

Deal found 12/6

$790

Wed 1/2111:22 amSTL - MXP

1 stop13h 08mLufthansa

Wed 1/286:55 amMXP - STL

1 stop14h 00mLufthansa

Deal found 12/7

$435

Thu 3/58:00 amMCI - MXP

2 stops18h 55mUnited Airlines

Thu 3/1212:05 pmMXP - MCI

2 stops32h 23mUnited Airlines

Deal found 12/6

$474

Wed 1/218:00 amMCI - MXP

2 stops18h 55mMultiple Airlines

Wed 1/281:05 pmMXP - MCI

2 stops28h 27mMultiple Airlines

Deal found 12/7

$474

Sun 3/17:10 amSTL - MXP

1 stop18h 55mKLM

Mon 3/910:05 amMXP - STL

1 stop19h 37mKLM

Deal found 12/7

$490

Tue 2/1010:50 amMCI - MXP

2 stops25h 55mBritish Airways

Sun 2/1512:15 pmMXP - MCI

2 stops17h 20mBritish Airways

Deal found 12/7

$491

Thu 3/56:13 pmMCI - MXP

2 stops16h 12mDelta

Thu 3/128:25 amMXP - MCI

1 stop16h 54mDelta

Deal found 12/6

$494

Wed 1/213:50 pmSTL - LIN

1 stop11h 15mLufthansa

Wed 1/2810:45 amLIN - STL

2 stops20h 14mLufthansa

Deal found 12/7

$450

Mon 1/197:00 amSTL - MXP

1 stop17h 30mUnited Airlines

Mon 2/29:45 amMXP - STL

1 stop21h 14mUnited Airlines

Deal found 12/8

$481

Wed 1/211:22 pmMCI - MXP

1 stop12h 43mKLM

Wed 1/2812:00 pmMXP - MCI

1 stop14h 19mKLM

Deal found 12/7

$490

Wed 2/410:50 amMCI - MXP

2 stops26h 10mBritish Airways

Tue 2/1711:45 amMXP - MCI

2 stops18h 06mBritish Airways

Deal found 12/6

$491

Thu 3/56:13 pmMCI - MXP

2 stops16h 12mMultiple Airlines

Thu 3/1211:00 amMXP - MCI

1 stop14h 19mMultiple Airlines

Deal found 12/6

$494

Mon 1/196:25 amSTL - LIN

2 stops19h 20mDelta

Sun 2/11:00 pmLIN - STL

2 stops17h 37mDelta

Deal found 12/6

$494

Wed 1/2111:22 amSTL - FCO

1 stop13h 33mLufthansa

Wed 1/287:05 amFCO - STL

1 stop13h 50mLufthansa

Deal found 12/6

$474

Mon 1/196:30 amSTL - MXP

2 stops18h 00mUnited Airlines

Sun 2/19:45 amMXP - STL

1 stop21h 14mUnited Airlines

Deal found 12/6

$481

Wed 2/116:06 amMCI - MXP

2 stops30h 54mBritish Airways

Mon 2/238:50 pmMXP - MCI

2 stops31h 52mBritish Airways

Deal found 12/7

$491

Mon 1/199:45 amSTL - LIN

2 stops16h 00mDelta

Mon 2/26:30 amLIN - STL

2 stops18h 20mDelta

Deal found 12/8

$494

Wed 1/289:57 amMCI - VCE

1 stop18h 23mKLM

Sun 2/16:30 amVCE - MCI

2 stops19h 49mKLM

Deal found 12/7

$497

Thu 1/224:05 pmSTL - VCE

2 stops19h 10mMultiple Airlines

Thu 1/297:00 pmVCE - STL

1 stop25h 55mMultiple Airlines

Deal found 12/7

$500

Sun 3/16:45 pmSTL - MXP

2 stops14h 55mLufthansa

Mon 3/99:10 amMXP - STL

2 stops20h 41mLufthansa

Deal found 12/7

$483

Mon 1/194:05 pmSTL - FCO

1 stop11h 50mUnited Airlines

Mon 1/2611:15 amFCO - STL

2 stops34h 15mUnited Airlines

Deal found 12/4

$489

Thu 1/222:54 pmSTL - VCE

2 stops18h 46mBritish Airways

Thu 1/296:55 amVCE - STL

2 stops18h 19mBritish Airways

Deal found 12/7

$493

Last-minute flights from Missouri to Italy
Discover last-minute flight deals from Missouri to Italy. Data last updated December 8, 2025 and is based on user searches.

Sat 1/174:05 pmSTL - FCO

2 stops34h 20mAir Canada

Fri 1/307:05 amFCO - STL

2 stops39h 24mAir Canada

Deal found 12/4

$479

Mon 1/191:15 pmSTL - MXP

2 stops16h 20mLufthansa

Mon 2/29:45 amMXP - STL

1 stop21h 14mLufthansa

Deal found 12/7

$433

Mon 1/194:05 pmSTL - MXP

2 stops34h 50mAir Canada

Mon 2/26:05 amMXP - STL

2 stops40h 24mAir Canada

Deal found 12/8

$464

Mon 1/194:05 pmSTL - MXP

2 stops34h 50mAir Canada

Sun 2/11:05 pmMXP - STL

2 stops33h 24mAir Canada

Deal found 12/6

$466

Mon 1/1911:55 amSTL - MXP

2 stops24h 55mMultiple Airlines

Mon 2/210:25 amMXP - STL

2 stops19h 47mMultiple Airlines

Deal found 12/7

$478

Mon 1/196:30 amSTL - MXP

2 stops18h 00mUnited Airlines

Sun 2/19:45 amMXP - STL

1 stop21h 14mUnited Airlines

Deal found 12/6

$481

Tue 1/2011:22 amSTL - FCO

1 stop13h 33mLufthansa

Tue 1/2712:20 pmFCO - STL

2 stops18h 39mLufthansa

Deal found 12/6

$439

Wed 1/2111:22 amSTL - MXP

1 stop13h 08mLufthansa

Wed 1/281:20 pmMXP - STL

2 stops16h 38mLufthansa

Deal found 12/7

$428

Wed 1/213:50 pmSTL - LIN

1 stop11h 15mLufthansa

Wed 1/2810:45 amLIN - STL

2 stops20h 14mLufthansa

Deal found 12/7

$450

Wed 1/2111:22 amSTL - FCO

1 stop13h 33mLufthansa

Wed 1/287:05 amFCO - STL

1 stop13h 50mLufthansa

Deal found 12/6

$474

Wed 1/219:57 amSTL - MXP

2 stops16h 58mUnited Airlines

Wed 1/281:05 pmMXP - STL

2 stops32h 25mUnited Airlines

Deal found 12/7

$474

Wed 1/218:00 amMCI - MXP

2 stops18h 55mMultiple Airlines

Wed 1/281:05 pmMXP - MCI

2 stops28h 27mMultiple Airlines

Deal found 12/7

$474

One-way flights from Missouri to Italy
Search for one-way flight options from Missouri to Italy. Find affordable one-way fares based on user searches. Data last updated December 8, 2025.

Mon 4/2011:14 amSTL - MXP

2 stops23h 46mBritish Airways

Deal found 12/6

$258

Mon 4/207:50 amSTL - LIN

2 stops21h 40mBritish Airways

Deal found 12/6

$258

Mon 4/206:35 pmSTL - MXP

1 stop11h 45mLufthansa

Deal found 12/6

$263

Mon 4/202:34 pmSTL - LIN

2 stops16h 01mAmerican Airlines

Deal found 12/6

$264

Tue 5/191:30 pmSTL - MXP

1 stop13h 50mUnited Airlines

Deal found 12/7

$267

Mon 4/207:45 amSTL - MXP

3 stops19h 15mAir Canada

Deal found 12/6

$270

Tue 5/1911:14 amSTL - MXP

2 stops17h 06mMultiple Airlines

Deal found 12/7

$273

Tue 3/107:57 pmMCI - FCO

2 stops14h 58mBritish Airways

Deal found 12/5

$285

Tue 3/1012:50 pmMCI - FCO

1 stop14h 10mMultiple Airlines

Deal found 12/5

$287

Sat 3/74:08 pmMCI - FCO

2 stops17h 47mBritish Airways

Deal found 12/5

$328

Thu 2/1910:42 amSTL - FCO

3 stops49h 48mMultiple Airlines

Deal found 12/5

$337

Sun 1/185:04 pmMCI - FCO

3 stops45h 01mMultiple Airlines

Deal found 12/5

$339

Find flight deals from Missouri to Italy

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$428 (Kiwi.com)
One-way from	$258 (oojo)
Popular in	June
Cheapest in	November
Average price	$820

Provider with most accurate pricing for Lambert-St Louis-Rome (ROM) flight deals.

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Provider most trusted by Cheapflights users for Lambert-St Louis-Rome (ROM) flights.

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From Missouri to Italy

Search Deals

One-way flight from Missouri to Italy

Search Deals

Highest demand for flights based on searches. 25% potential increase in price ($346 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($53 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Fly from

Fly to

Route

Depart

Return

Price

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Mon 1/19

1:15 pm-12:35 pm

2 stops16h 20m

Milan Malpensa

Mon 2/2

9:45 am-11:59 pm

1 stop21h 14m

$433

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Wed 1/21

11:22 am-7:30 am

1 stop13h 08m

Milan Malpensa

Wed 1/28

6:55 am-1:55 pm

1 stop14h 00m

$435

St. LouisMilan

STL - LIN

STLLIN

Lambert-St Louis

Wed 1/21

3:50 pm-10:05 am

1 stop11h 15m

Milan Linate

Wed 1/28

10:45 am-11:59 pm

2 stops20h 14m

$450

Kansas CityMilan

MCI - MXP

MCIMXP

Kansas City

Wed 2/11

6:30 pm-8:45 pm

2 stops19h 15m

Milan Malpensa

Wed 2/25

1:05 pm-9:59 pm

2 stops39h 54m

$469

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Wed 1/21

9:57 am-9:55 am

2 stops16h 58m

Milan Malpensa

Wed 1/28

1:05 pm-2:30 pm

2 stops32h 25m

$474

Kansas CityMilan

MCI - MXP

MCIMXP

Kansas City

Thu 3/5

6:00 am-9:55 am

2 stops20h 55m

Milan Malpensa

Thu 3/12

12:05 pm-9:59 pm

2 stops39h 54m

$474

Kansas CityMilan

MCI - MXP

MCIMXP

Kansas City

Thu 3/5

8:00 am-9:55 am

2 stops18h 55m

Milan Malpensa

Thu 3/12

12:05 pm-2:28 pm

2 stops32h 23m

$474

Kansas CityMilan

MCI - MXP

MCIMXP

Kansas City

Wed 1/21

8:00 am-9:55 am

2 stops18h 55m

Milan Malpensa

Wed 1/28

1:05 pm-10:32 am

2 stops28h 27m

$474

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Wed 1/21

11:22 am-7:55 am

1 stop13h 33m

Rome Fiumicino

Wed 1/28

7:05 am-1:55 pm

1 stop13h 50m

$474

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Mon 1/19

1:18 pm-9:45 am

1 stop13h 27m

Milan Malpensa

Mon 2/2

11:05 am-11:37 pm

1 stop19h 32m

$481

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/6

Showing 1-10 of 60 results

...

Best time to book a flight from Missouri to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Italy

What is the cheapest month to book a flight from Missouri to Italy?

Currently, January is the cheapest month in which you can book a flight from Missouri to Italy (average of $468). Flying from Missouri to Italy in July is currently the most expensive (average of $863). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to IT?

It’s typically best to fly out from Missouri to Italy in the evening. Doing so could potentially save you 19% on the flight price compared to flying in the morning, which is usually more expensive.

Related info for your journey

How long is the flight from Missouri to Italy?
For as low as $433, Lufthansa can have you in Italy from Missouri in 16h 20m. Airlines will cover a distance of 4752 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines to fly from Missouri to Italy one-way?
$265 is the cheapest one-way deal found within the past few days, from Lufthansa. You may also be able to find cheap deals on United Airlines and American Airlines, with prices starting from $322 and $418, respectively.
Can I find deals for flights from Missouri to Italy that include hotel bookings?
Yes. In addition to deals on Missouri to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Italy?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Italy.
Can I find deals for business class flights from Missouri to Italy?
Yes. Cheapflights offers flight deals from Missouri to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to Italy?
Currently, January is the cheapest month in which you can book a flight from Missouri to Italy (average of $468). Flying from Missouri to Italy in July is currently the most expensive (average of $863). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 9 airlines flying from Missouri to Italy

Airline	Cheapest	Average	Flexibility	On-time
British Airways	Cheapest$472	Average$1,011	FlexibilityNo cancel fee	On-time70%
United Airlines	Cheapest$485	Average$1,132	FlexibilityNo cancel fee	On-time69%
Lufthansa	Cheapest$492	Average$1,250	FlexibilityNo cancel fee	On-time76%
Iberia	Cheapest$536	Average$1,298	FlexibilityNo cancel fee	On-time77%
KLM	Cheapest$555	Average$937	FlexibilityNo cancel fee	On-time75%
Delta	Cheapest$587	Average$1,143	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$594	Average$1,168	FlexibilityNo cancel fee	On-time71%
Air France	Cheapest$655	Average$1,146	FlexibilityNo cancel fee	On-time77%
Air Canada	Cheapest$705	Average$1,202	FlexibilityNo cancel fee	On-time67%

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$258+ Cheap flights from Missouri to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Missouri to Italy

Cheapest flights from Missouri to ItalyExplore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Explore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Find flight deals from Missouri to Italy

Keep the following information in mind while searching for Missouri to Italy flight deals. Data was last updated December 8, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Italy that are best for you.

Best time to book a flight from Missouri to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Italy

What is the cheapest month to book a flight from Missouri to Italy?

What is the cheapest time of day to fly from MO to IT?

Find hourly flight availability from Missouri to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 8, 2025.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Missouri to Italy?

What are the cheapest airlines to fly from Missouri to Italy one-way?

Can I find deals for flights from Missouri to Italy that include hotel bookings?

How can I find direct flights from Missouri to Italy?

Can I find deals for business class flights from Missouri to Italy?

What is the cheapest month to book a flight from Missouri to Italy?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Italy

See prices for flight routes from nearby airports that may be better suited for you.

Top 9 airlines flying from Missouri to Italy

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Cheapest flights from Missouri to Italy
Explore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.