How long is the flight from Missouri to Italy?

For as low as $481, Air Canada can have you in Italy from Missouri in 12h 52m. Airlines will cover a distance of 4752 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines to fly from Missouri to Italy one-way?

$315 is the cheapest one-way deal found within the past few days, from Air Canada. You may also be able to find cheap deals on United Airlines and KLM, with prices starting from $315 and $315, respectively.

In terms of precipitation, rainfall in Italy ranges from 0.6 - 4.4 inches per month. November is typically the wettest month, when rainfall can reach 4.4 in. June is typically the driest time to visit Italy when rainfall is around 0.6 in.

If weather is an important factor for your trip to Italy, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 46.4 F).

How far in advance should I book a flight from Missouri to Italy?

Travelers have found it’s best to book a flight 38 days in advance to save up to 78% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 38 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from Missouri to Italy 1-2 weeks in advance for as low as $721, or $1,275 for flights within the next 24 hours.

What is the cheapest month to fly from Missouri to Italy?

November is one of the best times of the year to fly to Italy from Missouri. Prices for November average $1,100 per person but you can even find prices for as low as $594. The most expensive prices can be found in the month of June. Opting for a November flight can save you 43% on your journey compared to booking in June

Can I find deals for flights from Missouri to Italy that include hotel bookings?

Yes. In addition to deals on Missouri to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Italy?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Italy.

Can I find deals for business class flights from Missouri to Italy?

Yes. Cheapflights offers flight deals from Missouri to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$277+ Flights from Missouri to Italy

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Cheap flight deals from Missouri to Italy

Round-trip from	$472 (Mytrip)
One-way from	$277 (Kiwi.com)
Popular in	June
Cheapest in	November
Average price	$1,046

From Missouri to Italy

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One-way flight from Missouri to Italy

Search Deals

Highest demand for flights based on searches. 24% potential increase in price ($360 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($44 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Find flight deals from Missouri to Italy

Cheapest flights from Missouri to Italy
Explore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Tue 10/2810:00 amSTL - MXP

2 stops15h 30mAir Canada

Tue 11/43:05 pmMXP - STL

1 stop14h 40mAir Canada

Deal found 9/13

$471

Mon 10/209:15 amSTL - MXP

2 stops17h 45mMultiple Airlines

Wed 11/56:55 amMXP - STL

1 stop14h 00mMultiple Airlines

Deal found 9/15

$472

Tue 10/288:00 amSTL - MXP

1 stop23h 05mMultiple Airlines

Tue 11/49:45 amMXP - STL

1 stop13h 50mMultiple Airlines

Deal found 9/13

$473

Wed 10/294:50 pmSTL - MXP

1 stop12h 00mLufthansa

Wed 11/56:55 amMXP - STL

2 stops17h 44mLufthansa

Deal found 9/14

$477

Mon 10/205:28 pmSTL - MXP

1 stop12h 52mLufthansa

Wed 11/56:55 amMXP - STL

1 stop14h 00mLufthansa

Deal found 9/15

$481

Wed 10/2912:00 pmSTL - MXP

1 stop13h 30mUnited Airlines

Wed 11/53:05 pmMXP - STL

1 stop14h 40mUnited Airlines

Deal found 9/14

$498

Mon 10/209:20 amSTL - VCE

2 stops16h 45mUnited Airlines

Wed 11/511:05 amVCE - STL

1 stop19h 39mUnited Airlines

Deal found 9/14

$501

Mon 10/204:05 pmSTL - LIN

2 stops15h 45mMultiple Airlines

Wed 11/56:10 amLIN - STL

1 stop14h 45mMultiple Airlines

Deal found 9/15

$504

Wed 10/297:00 amSTL - MXP

2 stops19h 55mMultiple Airlines

Wed 11/56:55 amMXP - STL

2 stops17h 44mMultiple Airlines

Deal found 9/14

$505

Tue 10/2812:31 pmSTL - LIN

2 stops19h 44mMultiple Airlines

Tue 11/46:15 amLIN - STL

2 stops16h 32mMultiple Airlines

Deal found 9/13

$507

Wed 10/227:30 amMCI - NAP

2 stops19h 10mMultiple Airlines

Tue 11/42:35 pmNAP - MCI

2 stops38h 15mMultiple Airlines

Deal found 9/15

$524

Thu 10/3011:05 amSTL - MXP

1 stop20h 00mUnited Airlines

Thu 11/61:05 pmMXP - STL

2 stops33h 41mUnited Airlines

Deal found 9/14

$525

Best flights from Missouri to Italy
Discover carefully curated flight deals from Missouri to Italy that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2025.

Tue 10/2810:00 amSTL - MXP

2 stops15h 30mAir Canada

Tue 11/43:05 pmMXP - STL

1 stop14h 40mAir Canada

Deal found 9/13

$471

Mon 10/209:15 amSTL - MXP

2 stops17h 45mMultiple Airlines

Wed 11/56:55 amMXP - STL

1 stop14h 00mMultiple Airlines

Deal found 9/15

$472

Mon 10/205:28 pmSTL - MXP

1 stop12h 52mLufthansa

Wed 11/56:55 amMXP - STL

1 stop14h 00mLufthansa

Deal found 9/15

$481

Wed 10/2912:00 pmSTL - MXP

1 stop13h 30mUnited Airlines

Wed 11/53:05 pmMXP - STL

1 stop14h 40mUnited Airlines

Deal found 9/14

$498

Mon 11/312:36 pmMCI - MXP

1 stop13h 29mKLM

Wed 11/1212:00 pmMXP - MCI

1 stop35h 47mKLM

Deal found 9/14

$566

Wed 10/226:02 amMCI - NAP

1 stop20h 58mAmerican Airlines

Tue 11/46:15 amNAP - MCI

2 stops22h 08mAmerican Airlines

Deal found 9/15

$577

Wed 11/196:29 amMCI - NAP

2 stops21h 41mDelta

Thu 11/2711:50 amNAP - MCI

2 stops36h 38mDelta

Deal found 9/13

$596

Thu 12/119:31 amMCI - LIN

2 stops18h 24mIberia

Mon 1/128:25 pmLIN - MCI

2 stops29h 47mIberia

Deal found 9/14

$644

Wed 11/2611:32 amMCI - LIN

2 stops16h 58mBritish Airways

Sun 11/303:55 pmLIN - MCI

2 stops32h 51mBritish Airways

Deal found 9/13

$774

Tue 10/288:00 amSTL - MXP

1 stop23h 05mMultiple Airlines

Tue 11/49:45 amMXP - STL

1 stop13h 50mMultiple Airlines

Deal found 9/13

$473

Wed 10/294:50 pmSTL - MXP

1 stop12h 00mLufthansa

Wed 11/56:55 amMXP - STL

1 stop14h 00mLufthansa

Deal found 9/14

$488

Thu 10/3011:05 amSTL - MXP

1 stop20h 00mUnited Airlines

Thu 11/61:05 pmMXP - STL

2 stops33h 41mUnited Airlines

Deal found 9/14

$525

Last-minute flights from Missouri to Italy
Discover last-minute flight deals from Missouri to Italy. Data last updated September 15, 2025 and is based on user searches.

Mon 10/209:15 amSTL - MXP

2 stops17h 45mMultiple Airlines

Wed 11/56:55 amMXP - STL

1 stop14h 00mMultiple Airlines

Deal found 9/15

$472

Mon 10/205:28 pmSTL - MXP

1 stop12h 52mLufthansa

Wed 11/56:55 amMXP - STL

1 stop14h 00mLufthansa

Deal found 9/15

$481

Mon 10/209:20 amSTL - VCE

2 stops16h 45mUnited Airlines

Wed 11/511:05 amVCE - STL

1 stop19h 39mUnited Airlines

Deal found 9/14

$501

Mon 10/204:05 pmSTL - LIN

2 stops15h 45mMultiple Airlines

Wed 11/56:10 amLIN - STL

1 stop14h 45mMultiple Airlines

Deal found 9/15

$504

Mon 10/203:23 pmSTL - FCO

2 stops14h 42mUnited Airlines

Wed 11/57:05 amFCO - STL

1 stop13h 50mUnited Airlines

Deal found 9/15

$532

Tue 10/2810:00 amSTL - MXP

2 stops15h 30mAir Canada

Tue 11/43:05 pmMXP - STL

1 stop14h 40mAir Canada

Deal found 9/13

$471

Tue 10/288:00 amSTL - MXP

1 stop23h 05mMultiple Airlines

Tue 11/49:45 amMXP - STL

1 stop13h 50mMultiple Airlines

Deal found 9/13

$473

Tue 10/2812:31 pmSTL - LIN

2 stops19h 44mMultiple Airlines

Tue 11/46:15 amLIN - STL

2 stops16h 32mMultiple Airlines

Deal found 9/13

$507

Wed 10/294:50 pmSTL - MXP

1 stop12h 00mLufthansa

Wed 11/56:55 amMXP - STL

2 stops17h 44mLufthansa

Deal found 9/14

$477

Wed 10/2912:00 pmSTL - MXP

1 stop13h 30mUnited Airlines

Wed 11/53:05 pmMXP - STL

1 stop14h 40mUnited Airlines

Deal found 9/14

$498

Wed 10/297:00 amSTL - MXP

2 stops19h 55mMultiple Airlines

Wed 11/56:55 amMXP - STL

2 stops17h 44mMultiple Airlines

Deal found 9/14

$505

Thu 10/3011:05 amSTL - MXP

1 stop20h 00mUnited Airlines

Thu 11/61:05 pmMXP - STL

2 stops33h 41mUnited Airlines

Deal found 9/14

$525

One-way flights from Missouri to Italy
Search for one-way flight options from Missouri to Italy. Find affordable one-way fares based on user searches. Data last updated September 15, 2025.

Fri 10/1711:37 amMCI - FCO

3 stops46h 08mMultiple Airlines

Deal found 9/14

$277

Thu 10/910:57 amSTL - MXP

3 stops39h 58mMultiple Airlines

Deal found 9/15

$283

Mon 9/295:15 amMCI - FCO

3 stops35h 55mMultiple Airlines

Deal found 9/15

$284

Sun 11/167:02 pmSTL - FCO

2 stops36h 28mMultiple Airlines

Deal found 9/13

$291

Mon 10/2710:18 amSTL - MXP

3 stops42h 47mMultiple Airlines

Deal found 9/15

$301

Sun 10/125:15 amMCI - LIN

2 stops48h 15mMultiple Airlines

Deal found 9/12

$301

Sat 11/85:19 pmMCI - MXP

3 stops41h 26mMultiple Airlines

Deal found 9/14

$305

Sun 9/285:15 amMCI - FCO

2 stops36h 40mMultiple Airlines

Deal found 9/14

$308

Tue 10/2810:00 amSTL - MXP

2 stops15h 30mUnited Airlines

Deal found 9/15

$312

Mon 10/271:30 pmSTL - MXP

1 stop12h 35mKLM

Deal found 9/15

$315

Sat 11/85:19 pmMCI - LIN

3 stops45h 36mMultiple Airlines

Deal found 9/14

$318

Tue 10/288:40 pmSTL - MXP

3 stops43h 55mMultiple Airlines

Deal found 9/15

$320

Fly from

Fly to

Route

Depart

Return

Price

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Tue 10/28

10:00 am-7:30 am

2 stops15h 30m

Milan Malpensa

Tue 11/4

3:05 pm-10:45 pm

1 stop14h 40m

$471

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Mon 10/20

9:15 am-10:00 am

2 stops17h 45m

Milan Malpensa

Wed 11/5

6:55 am-1:55 pm

1 stop14h 00m

$472

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Tue 10/28

8:00 am-1:05 pm

1 stop23h 05m

Milan Malpensa

Tue 11/4

9:45 am-4:35 pm

1 stop13h 50m

$473

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Mon 10/20

5:28 pm-1:20 pm

1 stop12h 52m

Milan Malpensa

Wed 11/5

6:55 am-1:55 pm

1 stop14h 00m

$481

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Wed 10/29

4:50 pm-10:50 am

1 stop12h 00m

Milan Malpensa

Wed 11/5

6:55 am-1:55 pm

1 stop14h 00m

$488

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Wed 10/29

12:00 pm-7:30 am

1 stop13h 30m

Milan Malpensa

Wed 11/5

3:05 pm-10:45 pm

1 stop14h 40m

$498

St. LouisMilan

STL - LIN

STLLIN

Lambert-St Louis

Mon 10/20

4:05 pm-2:50 pm

2 stops15h 45m

Milan Linate

Wed 11/5

6:10 am-1:55 pm

1 stop14h 45m

$504

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Wed 10/29

7:00 am-8:55 am

2 stops19h 55m

Milan Malpensa

Wed 11/5

6:55 am-5:39 pm

2 stops17h 44m

$505

St. LouisMilan

STL - LIN

STLLIN

Lambert-St Louis

Tue 10/28

12:31 pm-2:15 pm

2 stops19h 44m

Milan Linate

Tue 11/4

6:15 am-3:47 pm

2 stops16h 32m

$507

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Thu 10/30

11:05 am-1:05 pm

1 stop20h 00m

Milan Malpensa

Thu 11/6

1:05 pm-3:46 pm

2 stops33h 41m

$525

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 60 results

...

Best time to book a flight from Missouri to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Italy

What is the cheapest month to book a flight from Missouri to Italy?

Currently, January is the cheapest month in which you can book a flight from Missouri to Italy (average of $703). Flying from Missouri to Italy in June is currently the most expensive (average of $1,202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to IT?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Italy as you normally would.

Related info for your journey

How long is the flight from Missouri to Italy?
For as low as $481, Air Canada can have you in Italy from Missouri in 12h 52m. Airlines will cover a distance of 4752 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines to fly from Missouri to Italy one-way?
$315 is the cheapest one-way deal found within the past few days, from Air Canada. You may also be able to find cheap deals on United Airlines and KLM, with prices starting from $315 and $315, respectively.
Can I find deals for flights from Missouri to Italy that include hotel bookings?
Yes. In addition to deals on Missouri to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Italy?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Italy.
Can I find deals for business class flights from Missouri to Italy?
Yes. Cheapflights offers flight deals from Missouri to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to Italy?
Currently, January is the cheapest month in which you can book a flight from Missouri to Italy (average of $703). Flying from Missouri to Italy in June is currently the most expensive (average of $1,202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 9 airlines flying from Missouri to Italy

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$485	Average$1,153	FlexibilityNo cancel fee	On-time69%
Iberia	Cheapest$536	Average$1,215	FlexibilityNo cancel fee	On-time77%
Delta	Cheapest$554	Average$1,080	FlexibilityNo cancel fee	On-timeN/A
British Airways	Cheapest$560	Average$1,165	FlexibilityNo cancel fee	On-time70%
KLM	Cheapest$573	Average$975	FlexibilityNo cancel fee	On-time75%
Lufthansa	Cheapest$639	Average$1,294	FlexibilityNo cancel fee	On-time76%
American Airlines	Cheapest$665	Average$1,188	FlexibilityNo cancel fee	On-time71%
Air Canada	Cheapest$705	Average$1,209	FlexibilityNo cancel fee	On-time67%
Air France	Cheapest$744	Average$1,295	FlexibilityNo cancel fee	On-time77%

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$277+ Cheap flights from Missouri to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/17. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Missouri to Italy

Keep the following information in mind while searching for Missouri to Italy flight deals. Data was last updated September 15, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Missouri to Italy

Cheapest flights from Missouri to ItalyExplore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Explore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Italy that are best for you.

Best time to book a flight from Missouri to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Italy

What is the cheapest month to book a flight from Missouri to Italy?

What is the cheapest time of day to fly from MO to IT?

Find hourly flight availability from Missouri to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Missouri to Italy?

What are the cheapest airlines to fly from Missouri to Italy one-way?

Can I find deals for flights from Missouri to Italy that include hotel bookings?

How can I find direct flights from Missouri to Italy?

Can I find deals for business class flights from Missouri to Italy?

What is the cheapest month to book a flight from Missouri to Italy?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Italy

See prices for flight routes from nearby airports that may be better suited for you.

Top 9 airlines flying from Missouri to Italy

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Cheapest flights from Missouri to Italy
Explore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.