How long is the flight from Missouri to Italy?

For as low as $513, United Airlines can have you in Italy from Missouri in 13h 41m. Airlines will cover a distance of 4752 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines to fly from Missouri to Italy one-way?

$360 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on United Airlines and American Airlines, with prices starting from $468 and $533, respectively.

In terms of precipitation, rainfall in Italy ranges from 0.6 - 4.4 inches per month. November is typically the wettest month, when rainfall can reach 4.4 in. June is typically the driest time to visit Italy when rainfall is around 0.6 in.

If weather is an important factor for your trip to Italy, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 46.4 F).

How far in advance should I book a flight from Missouri to Italy?

Travelers have found it’s best to book a flight 38 days in advance to save up to 78% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 38 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from Missouri to Italy 1-2 weeks in advance for as low as $950, or $1,275 for flights within the next 24 hours.

What is the cheapest month to fly from Missouri to Italy?

November is one of the best times of the year to fly to Italy from Missouri. Prices for November average $1,095 per person but you can even find prices for as low as $594. The most expensive prices can be found in the month of May. Opting for a November flight can save you 44% on your journey compared to booking in May

Can I find deals for flights from Missouri to Italy that include hotel bookings?

Yes. In addition to deals on Missouri to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Italy?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Italy.

Can I find deals for business class flights from Missouri to Italy?

Yes. Cheapflights offers flight deals from Missouri to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$268+ Flights from Missouri to Italy

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Cheap flight deals from Missouri to Italy

Round-trip from	$507 (United Airlines)
One-way from	$268 (Kiwi.com)
Popular in	May
Cheapest in	November
Average price	$1,107

From Missouri to Italy

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One-way flight from Missouri to Italy

Search Deals

Highest demand for flights based on searches. 19% potential increase in price ($271 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($45 potential savings vs. average RT price).

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Average for round-trip flights in August 2025

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Find flight deals from Missouri to Italy

Cheapest flights from Missouri to Italy
Explore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

Tue 12/211:50 amSTL - MXP

1 stop12h 40mUnited Airlines

Tue 12/161:05 pmMXP - STL

2 stops32h 20mUnited Airlines

Deal found 8/17

$507

Sun 11/304:05 pmSTL - MXP

2 stops34h 50mAir Canada

Sun 12/141:05 pmMXP - STL

2 stops32h 18mAir Canada

Deal found 8/17

$509

Mon 10/2710:00 amSTL - MXP

2 stops16h 55mUnited Airlines

Tue 11/41:05 pmMXP - STL

2 stops33h 44mUnited Airlines

Deal found 8/18

$513

Wed 12/34:05 pmSTL - MXP

2 stops34h 50mAir Canada

Tue 12/161:05 pmMXP - STL

3 stops30h 10mAir Canada

Deal found 8/17

$515

Sat 12/66:42 pmSTL - MXP

3 stops56h 13mAir Canada

Thu 12/181:05 pmMXP - STL

2 stops35h 49mAir Canada

Deal found 8/17

$518

Mon 10/276:30 amSTL - MXP

2 stops20h 25mAir Canada

Tue 11/41:05 pmMXP - STL

3 stops33h 44mAir Canada

Deal found 8/19

$519

Wed 10/2911:49 amSTL - MXP

2 stops39h 06mMultiple Airlines

Sun 11/96:55 amMXP - STL

1 stop14h 00mMultiple Airlines

Deal found 8/20

$527

Wed 12/34:05 pmSTL - MXP

2 stops34h 50mAir Canada

Sun 12/71:05 pmMXP - STL

2 stops33h 24mAir Canada

Deal found 8/18

$528

Wed 12/34:05 pmSTL - MXP

2 stops34h 50mMultiple Airlines

Sun 12/76:55 amMXP - STL

1 stop14h 00mMultiple Airlines

Deal found 8/17

$529

Thu 12/411:50 amSTL - MXP

1 stop12h 40mUnited Airlines

Mon 12/159:45 amMXP - STL

1 stop14h 44mUnited Airlines

Deal found 8/17

$530

Mon 12/16:30 amSTL - MXP

2 stops21h 20mUnited Airlines

Thu 12/181:05 pmMXP - STL

2 stops32h 21mUnited Airlines

Deal found 8/17

$533

Sun 11/305:24 pmSTL - MXP

1 stop12h 41mUnited Airlines

Wed 12/179:45 amMXP - STL

2 stops17h 03mUnited Airlines

Deal found 8/17

$534

Best flights from Missouri to Italy
Discover carefully curated flight deals from Missouri to Italy that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 20, 2025.

Mon 10/275:24 pmSTL - MXP

1 stop13h 41mUnited Airlines

Tue 11/41:05 pmMXP - STL

2 stops33h 44mUnited Airlines

Deal found 8/18

$513

Mon 10/2710:00 amSTL - MXP

2 stops16h 55mAir Canada

Tue 11/41:05 pmMXP - STL

2 stops33h 44mAir Canada

Deal found 8/19

$513

Wed 10/2911:49 amSTL - MXP

2 stops39h 06mMultiple Airlines

Sun 11/96:55 amMXP - STL

1 stop14h 00mMultiple Airlines

Deal found 8/20

$527

Mon 10/277:54 pmSTL - LIN

2 stops14h 26mBritish Airways

Tue 11/45:15 pmLIN - STL

2 stops32h 10mBritish Airways

Deal found 8/18

$567

Mon 10/2711:49 amSTL - VCE

1 stop15h 06mLufthansa

Fri 11/76:45 amVCE - STL

1 stop14h 10mLufthansa

Deal found 8/20

$600

Sat 11/151:45 pmMCI - NAP

2 stops41h 25mIberia

Sat 11/222:55 pmNAP - MCI

2 stops24h 51mIberia

Deal found 8/19

$618

Sat 11/159:45 amMCI - NAP

2 stops19h 00mAmerican Airlines

Sat 11/226:15 amNAP - MCI

2 stops22h 08mAmerican Airlines

Deal found 8/17

$652

Wed 9/2410:28 amMCI - NAP

1 stop13h 32mKLM

Tue 9/309:00 amNAP - MCI

1 stop19h 22mKLM

Deal found 8/19

$708

Wed 10/294:05 pmSTL - MXP

2 stops34h 50mAir Canada

Sun 11/91:05 pmMXP - STL

2 stops33h 41mAir Canada

Deal found 8/20

$527

Thu 11/611:05 amSTL - LIN

2 stops20h 10mUnited Airlines

Tue 11/186:15 amLIN - STL

2 stops40h 14mUnited Airlines

Deal found 8/18

$567

Mon 10/131:30 pmSTL - LIN

2 stops18h 20mMultiple Airlines

Wed 10/296:10 amLIN - STL

1 stop14h 45mMultiple Airlines

Deal found 8/18

$570

Tue 12/26:01 amMCI - FCO

1 stop19h 59mBritish Airways

Fri 12/121:00 pmFCO - MCI

1 stop16h 25mBritish Airways

Deal found 8/18

$600

Last-minute flights from Missouri to Italy
Discover last-minute flight deals from Missouri to Italy. Data last updated August 20, 2025 and is based on user searches.

Sun 9/79:15 amSTL - MXP

2 stops17h 45mAir Canada

Tue 9/2312:15 pmMXP - STL

1 stop14h 42mAir Canada

Deal found 8/18

$667

Sun 9/71:30 pmSTL - MXP

1 stop13h 30mMultiple Airlines

Tue 9/2312:15 pmMXP - STL

1 stop14h 42mMultiple Airlines

Deal found 8/18

$695

Thu 9/113:20 pmSTL - MXP

2 stops20h 25mUnited Airlines

Thu 9/1812:15 pmMXP - STL

2 stops34h 29mUnited Airlines

Deal found 8/18

$634

Thu 9/113:20 pmSTL - LIN

2 stops14h 00mMultiple Airlines

Thu 9/1812:45 pmLIN - STL

2 stops33h 33mMultiple Airlines

Deal found 8/18

$666

Tue 9/167:08 amSTL - MXP

2 stops19h 52mUnited Airlines

Tue 9/2312:15 pmMXP - STL

2 stops34h 29mUnited Airlines

Deal found 8/19

$567

Tue 9/166:35 amSTL - MXP

2 stops20h 25mAir Canada

Tue 9/2312:15 pmMXP - STL

1 stop14h 42mAir Canada

Deal found 8/19

$575

Tue 9/161:03 pmSTL - MXP

1 stop15h 17mIberia

Tue 9/231:20 pmMXP - STL

1 stop14h 46mIberia

Deal found 8/19

$590

Tue 9/167:04 pmSTL - LIN

2 stops16h 31mLufthansa

Tue 9/237:00 amLIN - STL

2 stops15h 44mLufthansa

Deal found 8/19

$628

Thu 9/184:05 pmSTL - MXP

2 stops14h 55mMultiple Airlines

Sun 9/287:00 amMXP - STL

2 stops23h 57mMultiple Airlines

Deal found 8/18

$711

Thu 9/251:30 pmSTL - MXP

1 stop13h 30mUnited Airlines

Sat 10/49:10 amMXP - STL

2 stops17h 32mUnited Airlines

Deal found 8/17

$674

Mon 9/295:15 amMCI - FCO

3 stops35h 55mMultiple Airlines

Wed 10/87:00 amFCO - MCI

2 stops23h 46mMultiple Airlines

Deal found 8/17

$655

Tue 9/305:15 amMCI - FCO

2 stops26h 15mMultiple Airlines

Wed 10/87:05 pmFCO - MCI

2 stops35h 41mMultiple Airlines

Deal found 8/18

$662

One-way flights from Missouri to Italy
Search for one-way flight options from Missouri to Italy. Find affordable one-way fares based on user searches. Data last updated August 20, 2025.

Sat 10/187:52 pmSTL - FCO

3 stops59h 38mMultiple Airlines

Deal found 8/17

$268

Sun 10/126:05 pmSTL - FCO

3 stops37h 25mMultiple Airlines

Deal found 8/17

$271

Mon 10/206:05 pmSTL - FCO

2 stops41h 00mMultiple Airlines

Deal found 8/17

$273

Thu 10/165:15 amMCI - FCO

2 stops50h 15mMultiple Airlines

Deal found 8/18

$276

Sat 10/117:00 pmSTL - FCO

3 stops41h 25mMultiple Airlines

Deal found 8/17

$283

Sun 9/214:00 pmSTL - FLR

3 stops48h 00mMultiple Airlines

Deal found 8/18

$283

Tue 10/147:52 pmSTL - FCO

3 stops46h 03mMultiple Airlines

Deal found 8/19

$284

Fri 10/1711:32 amSTL - MXP

3 stops41h 33mMultiple Airlines

Deal found 8/18

$285

Wed 11/1210:09 amMCI - FCO

2 stops45h 21mMultiple Airlines

Deal found 8/18

$286

Fri 10/1711:32 amSTL - FCO

2 stops43h 58mMultiple Airlines

Deal found 8/19

$288

Wed 10/87:00 amMCI - MXP

3 stops44h 00mMultiple Airlines

Deal found 8/19

$290

Mon 10/137:52 pmSTL - FCO

3 stops35h 38mMultiple Airlines

Deal found 8/19

$291

Fly from

Fly to

Route

Depart

Return

Price

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Mon 10/27

5:24 pm-1:05 pm

1 stop13h 41m

Milan Malpensa

Tue 11/4

1:05 pm-3:49 pm

2 stops33h 44m

$513

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Mon 10/27

10:00 am-8:55 am

2 stops16h 55m

Milan Malpensa

Tue 11/4

1:05 pm-3:49 pm

2 stops33h 44m

$513

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Wed 10/29

11:49 am-8:55 am

2 stops39h 06m

Milan Malpensa

Sun 11/9

6:55 am-1:55 pm

1 stop14h 00m

$527

St. LouisMilan

STL - MXP

STLMXP

Lambert-St Louis

Wed 10/29

4:05 pm-8:55 am

2 stops34h 50m

Milan Malpensa

Sun 11/9

1:05 pm-3:46 pm

2 stops33h 41m

$527

St. LouisMilan

STL - LIN

STLLIN

Lambert-St Louis

Mon 10/27

7:54 pm-4:20 pm

2 stops14h 26m

Milan Linate

Tue 11/4

5:15 pm-6:25 pm

2 stops32h 10m

$567

St. LouisMilan

STL - LIN

STLLIN

Lambert-St Louis

Thu 11/6

11:05 am-2:15 pm

2 stops20h 10m

Milan Linate

Tue 11/18

6:15 am-3:29 pm

2 stops40h 14m

$567

St. LouisMilan

STL - LIN

STLLIN

Lambert-St Louis

Mon 10/13

1:30 pm-2:50 pm

2 stops18h 20m

Milan Linate

Wed 10/29

6:10 am-2:55 pm

1 stop14h 45m

$570

St. LouisMilan

STL - LIN

STLLIN

Lambert-St Louis

Mon 10/27

4:05 pm-2:05 pm

2 stops16h 00m

Milan Linate

Tue 11/4

10:45 am-11:44 pm

2 stops19h 59m

$576

St. LouisVenice

STL - VCE

STLVCE

Lambert-St Louis

Mon 10/27

4:05 pm-6:25 pm

2 stops20h 20m

Venice Marco Polo

Fri 11/7

6:45 am-3:29 pm

2 stops39h 44m

$578

St. LouisRome

STL - FCO

STLFCO

Lambert-St Louis

Sun 11/30

6:30 am-7:45 am

1 stop18h 15m

Rome Fiumicino

Fri 12/12

12:50 pm-2:25 pm

2 stops32h 35m

$582

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Showing 1-10 of 60 results

...

Best time to book a flight from Missouri to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Italy

What is the cheapest month to book a flight from Missouri to Italy?

Currently, January is the cheapest month in which you can book a flight from Missouri to Italy (average of $703). Flying from Missouri to Italy in June is currently the most expensive (average of $1,205). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to IT?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Italy as you normally would.

Related info for your journey

How long is the flight from Missouri to Italy?
For as low as $513, United Airlines can have you in Italy from Missouri in 13h 41m. Airlines will cover a distance of 4752 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines to fly from Missouri to Italy one-way?
$360 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on United Airlines and American Airlines, with prices starting from $468 and $533, respectively.
Can I find deals for flights from Missouri to Italy that include hotel bookings?
Yes. In addition to deals on Missouri to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Italy?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Italy.
Can I find deals for business class flights from Missouri to Italy?
Yes. Cheapflights offers flight deals from Missouri to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to Italy?
Currently, January is the cheapest month in which you can book a flight from Missouri to Italy (average of $703). Flying from Missouri to Italy in June is currently the most expensive (average of $1,205). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 9 airlines flying from Missouri to Italy

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$485	Average$1,142	FlexibilityNo cancel fee	On-time69%
Iberia	Cheapest$536	Average$1,215	FlexibilityNo cancel fee	On-time77%
Delta	Cheapest$554	Average$1,060	FlexibilityNo cancel fee	On-timeN/A
KLM	Cheapest$573	Average$1,095	FlexibilityNo cancel fee	On-time75%
British Airways	Cheapest$654	Average$1,206	FlexibilityNo cancel fee	On-time70%
American Airlines	Cheapest$665	Average$1,187	FlexibilityNo cancel fee	On-time71%
Lufthansa	Cheapest$675	Average$1,347	FlexibilityNo cancel fee	On-time76%
Air Canada	Cheapest$705	Average$1,207	FlexibilityNo cancel fee	On-time67%
Air France	Cheapest$744	Average$1,108	FlexibilityNo cancel fee	On-time77%

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$268+ Cheap flights from Missouri to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Missouri to Italy

Keep the following information in mind while searching for Missouri to Italy flight deals. Data was last updated August 20, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Missouri to Italy

Cheapest flights from Missouri to ItalyExplore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

Explore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Italy that are best for you.

Best time to book a flight from Missouri to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Italy

What is the cheapest month to book a flight from Missouri to Italy?

What is the cheapest time of day to fly from MO to IT?

Find hourly flight availability from Missouri to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 20, 2025.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Missouri to Italy?

What are the cheapest airlines to fly from Missouri to Italy one-way?

Can I find deals for flights from Missouri to Italy that include hotel bookings?

How can I find direct flights from Missouri to Italy?

Can I find deals for business class flights from Missouri to Italy?

What is the cheapest month to book a flight from Missouri to Italy?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Italy

See prices for flight routes from nearby airports that may be better suited for you.

Top 9 airlines flying from Missouri to Italy

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Cheapest flights from Missouri to Italy
Explore the most affordable flight options available from Missouri to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.