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$234+ Cheap flights from Santa Fe (SAF) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/22. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — DSM
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Santa Fe to Iowa

Keep the following information in mind while searching for Santa Fe to Iowa flight deals. Data was last updated October 30, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$314
(United Airlines)

One-way from

$234
(American Airlines)
Provider with most accurate pricing for Santa Fe-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Santa Fe-Des Moines flights.
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From Santa Fe to Iowa
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One-way flight from Santa Fe to Iowa
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Find flight deals from Santa Fe to Iowa

Cheapest flights from Santa Fe to Iowa
Explore the most affordable flight options available from Santa Fe to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:00 pmSAF - DSM
1 stop4h 44mUnited Airlines
Sun 11/165:45 amDSM - SAF
1 stop4h 40mUnited Airlines
Deal found 10/28$254
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:16 pmSAF - DSM
1 stop4h 43mAmerican Airlines
Sun 11/95:26 pmDSM - SAF
1 stop5h 33mAmerican Airlines
Deal found 10/29$334
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/129:58 amSAF - DSM
1 stop7h 26mAmerican Airlines
Sun 11/165:00 amDSM - SAF
2 stops10h 52mAmerican Airlines
Deal found 10/28$370
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:00 pmSAF - DSM
1 stop4h 44mUnited Airlines
Sun 11/305:45 amDSM - SAF
1 stop4h 40mUnited Airlines
Deal found 10/28$476

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Santa Fe to Iowa that are best for you.

Fly from

Santa Fe

Fly to

Iowa

Route

Depart

Return

Price

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 11/12

6:00 pm-11:44 pm

1 stop4h 44m

Des Moines

Sun 11/16

5:45 am-9:25 am

1 stop4h 40m

$254

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 4/15

6:01 pm-11:39 pm

1 stop4h 38m

Des Moines

Sun 4/19

6:00 am-9:32 am

1 stop4h 32m

$314

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 11/12

9:58 am-6:24 pm

1 stop7h 26m

Des Moines

Sun 11/16

5:00 am-2:52 pm

2 stops10h 52m

$370

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 4/15

6:21 am-11:57 am

1 stop4h 36m

Des Moines

Sun 4/19

5:58 am-2:42 pm

2 stops9h 44m

$468

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 11/26

6:00 pm-11:44 pm

1 stop4h 44m

Des Moines

Sun 11/30

5:45 am-9:25 am

1 stop4h 40m

$476

Santa FeCedar Rapids

SAF - CID

SAFCID

Santa Fe

Sat 2/28

1:23 pm-8:36 pm

1 stop6h 13m

Cedar Rapids

Wed 3/4

4:40 pm-9:38 am

1 stop17h 58m

$528

Santa FeCedar Rapids

SAF - CID

SAFCID

Santa Fe

Sat 2/28

6:15 am-12:36 pm

1 stop5h 21m

Cedar Rapids

Wed 3/4

5:05 am-12:22 pm

1 stop8h 17m

$542

Santa FeCedar Rapids

SAF - CID

SAFCID

Santa Fe

Mon 12/22

3:27 pm-11:58 pm

1 stop7h 31m

$234

Santa FeCedar Rapids

SAF - CID

SAFCID

Santa Fe

Mon 12/22

6:02 pm-7:23 pm

2 stops24h 21m

$460

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Best time to book a flight from Santa Fe to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to Iowa

What is the cheapest month to book a flight from Santa Fe to Iowa?

Currently, May is the cheapest month in which you can book a flight from Santa Fe to Iowa (average of $211). Flying from Santa Fe to Iowa in February is currently the most expensive (average of $397). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Santa Fe to Iowa, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,034 reviews

Comfort

7.2

Entertainment

6.9

Crew

8.0

Overall

7.2

Boarding

7.5

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
11,034 reviews
American Airlines
7.2
Good
11,034 reviews

Comfort

7.2

Entertainment

6.9

Crew

8.0

Overall

7.2

Boarding

7.5

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santa Fe to Iowa?

    Santa Fe (SAF) is the airport you will fly out of if you book a flight from Santa Fe to Iowa. It is only a 9.8 mi journey to Santa Fe (SAF) from Santa Fe’s city center.

  • How long is the flight from Santa Fe to Iowa?

    Departing from Santa Fe to Iowa will take you 4h 44m. There are 785 mi between Santa Fe and Iowa. This flight may include one or multiple stops.

  • Can I find deals for flights from Santa Fe to Iowa that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Iowa.

  • Can I find deals for business class flights from Santa Fe to Iowa?

    Yes. Cheapflights offers flight deals from Santa Fe to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to Iowa?

    Currently, May is the cheapest month in which you can book a flight from Santa Fe to Iowa (average of $211). Flying from Santa Fe to Iowa in February is currently the most expensive (average of $397). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Santa Fe to Iowa

Discover the top airline that operate flights from Santa Fe to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$354Average$452FlexibilityNo cancel feeOn-time71%

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