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$118+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
jan. 11 — jan. 181
sø. 1/11
sø. 1/18
1 adult, Economy
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Cheap flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Desember 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 12/247:00 amTYS - OMA
1 stop7h 08mAmerican Airlines
on. 12/319:35 amOMA - TYS
1 stop7h 01mAmerican Airlines
Deal found 12/11$297
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 12/202:53 pmTYS - DSM
1 stop9h 39mAllegiant Air
ti. 12/237:30 amDSM - TYS
1 stop28h 32mAllegiant Air
Deal found 12/10$312
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 12/1810:03 pmTYS - DSM
1 stop21h 28mAllegiant Air
sø. 12/212:56 pmDSM - TYS
1 stop18h 35mAllegiant Air
Deal found 12/10$350
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 12/114:22 pmTYS - MLI
1 stop7h 21mAmerican Airlines
on. 12/176:00 amMLI - TYS
1 stop5h 44mAmerican Airlines
Deal found 12/10$354
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 12/267:00 amTYS - DSM
1 stop7h 21mAmerican Airlines
ti. 12/306:52 pmDSM - TYS
1 stop14h 58mAmerican Airlines
Deal found 12/11$393
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 12/156:18 pmTYS - MLI
1 stop5h 41mAmerican Airlines
fr. 1/25:43 pmMLI - TYS
1 stop5h 04mAmerican Airlines
Deal found 12/11$394
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 12/202:53 pmTYS - DSM
1 stop9h 39mMultiple Airlines
ti. 12/233:45 pmDSM - TYS
2 stops30h 06mMultiple Airlines
Deal found 12/10$395
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 12/258:30 amTYS - DSM
1 stop5h 51mAmerican Airlines
ma. 12/296:52 pmDSM - TYS
1 stop14h 58mAmerican Airlines
Deal found 12/9$408
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 12/185:00 amTYS - DSM
2 stops8h 26mAmerican Airlines
sø. 12/215:50 amDSM - TYS
1 stop4h 00mAmerican Airlines
Deal found 12/10$434
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 12/127:00 amTYS - DSM
1 stop4h 29mUnited Airlines
ma. 12/153:17 pmDSM - TYS
1 stop4h 47mUnited Airlines
Deal found 12/10$459
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 12/126:18 pmTYS - DSM
1 stop5h 41mAmerican Airlines
ma. 12/155:40 amDSM - TYS
2 stops7h 20mAmerican Airlines
Deal found 12/10$464
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 12/267:00 amTYS - DSM
1 stop7h 21mAmerican Airlines
sø. 12/286:52 pmDSM - TYS
1 stop14h 58mAmerican Airlines
Deal found 12/10$491

Find flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated Desember 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$289
(American Airlines)

One-way from

$120
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$407
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
Search Deals
From Knoxville McGhee Tyson to Iowa
Search Deals
One-way flight from Knoxville McGhee Tyson to Iowa
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($88 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($36 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Desember 12, 2025.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

on. 12/24

7:00 am-1:08 pm

1 stop7h 08m

Omaha Eppley Airfield

on. 12/31

9:35 am-5:36 pm

1 stop7h 01m

$297

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

lø. 1/31

11:07 am-3:09 pm

1 stop5h 02m

Moline Quad-City

on. 2/4

3:45 pm-8:52 pm

1 stop4h 07m

$319

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

lø. 2/21

1:55 pm-7:02 pm

1 stop6h 07m

Moline Quad-City

on. 2/25

8:15 am-1:20 pm

1 stop4h 05m

$321

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

lø. 1/17

1:59 pm-5:36 pm

1 stop4h 37m

Omaha Eppley Airfield

on. 1/21

3:00 pm-11:44 pm

1 stop7h 44m

$326

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

fr. 4/17

7:20 pm-11:55 pm

1 stop5h 35m

Omaha Eppley Airfield

sø. 4/19

6:30 pm-11:46 pm

1 stop4h 16m

$337

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

fr. 12/26

7:00 am-1:21 pm

1 stop7h 21m

Des Moines

ti. 12/30

6:52 pm-10:50 am

1 stop14h 58m

$393

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

to. 12/25

8:30 am-1:21 pm

1 stop5h 51m

Des Moines

ma. 12/29

6:52 pm-10:50 am

1 stop14h 58m

$408

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

fr. 12/26

7:00 am-1:21 pm

1 stop7h 21m

Des Moines

sø. 12/28

6:52 pm-10:50 am

1 stop14h 58m

$491

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

lø. 12/27

5:08 pm-8:15 am

1 stop16h 07m

Des Moines

ti. 12/30

6:52 pm-10:50 am

1 stop14h 58m

$505

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

fr. 1/16

7:20 pm-9:36 pm

2 stops27h 16m

Moline Quad-City

ma. 1/19

3:45 pm-2:49 pm

2 stops22h 04m

$538

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 24 results
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $127). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IA?

Find hourly flight availability from Knoxville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated Desember 12, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Iowa in the evening. If you’re flexible enough to do this you can expect to save up to 38% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated Desember 12, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like American Airlines and United Airlines fly from Knoxville to Iowa in about 5h 02m. The time it takes to get you to your destination can typically vary by up to 2h 06m. The distance between Knoxville and Iowa is about 524 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Moline Quad-City or Knoxville McGhee Tyson - Des Moines.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $127). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Iowa

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Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Desember 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$223Average$353FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$271FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$340FlexibilityNo cancel feeOn-time71%

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