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$169+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Mar 6 — Mar 131
Fri 3/6
Fri 3/13
1 adult, Economy
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Cheap flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.

This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:45 am
TYS
-
MLI
1 stop4h 26m
United Airlines
Sat 2/213:52 pm
MLI
-
TYS
1 stop3h 45m
United Airlines
Deal found 2/2$279
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1810:18 am
TYS
-
MLI
2 stops9h 14m
American Airlines
Sun 2/226:00 am
MLI
-
TYS
1 stop3h 45m
American Airlines
Deal found 2/3$284
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:13 am
TYS
-
DSM
1 stop5h 05m
Delta
Mon 4/274:23 pm
DSM
-
TYS
1 stop5h 36m
Delta
Deal found 2/1$293
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/174:29 pm
TYS
-
MLI
1 stop7h 59m
American Airlines
Sat 2/216:00 am
MLI
-
TYS
2 stops11h 13m
American Airlines
Deal found 2/2$310
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:00 am
TYS
-
DSM
1 stop7h 23m
United Airlines
Mon 3/303:21 pm
DSM
-
TYS
1 stop6h 08m
United Airlines
Deal found 2/1$329
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:45 am
TYS
-
OMA
1 stop4h 35m
United Airlines
Sat 2/283:22 pm
OMA
-
TYS
1 stop4h 15m
United Airlines
Deal found 1/31$332
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:00 pm
TYS
-
OMA
1 stop6h 50m
Southwest
Sat 9/267:05 am
OMA
-
TYS
1 stop3h 50m
Southwest
Deal found 2/3$337
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:55 pm
TYS
-
OMA
2 stops8h 50m
Southwest
Sun 9/276:15 am
OMA
-
TYS
1 stop6h 45m
Southwest
Deal found 2/2$342
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:24 pm
TYS
-
OMA
1 stop4h 32m
Delta
Sun 4/195:30 am
OMA
-
TYS
1 stop4h 47m
Delta
Deal found 2/2$347
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:54 pm
TYS
-
OMA
1 stop5h 38m
American Airlines
Sun 4/195:07 pm
OMA
-
TYS
1 stop5h 48m
American Airlines
Deal found 2/3$357
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/68:25 am
TYS
-
OMA
2 stops8h 45m
Southwest
Sun 8/96:15 am
OMA
-
TYS
1 stop6h 45m
Southwest
Deal found 2/3$362
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1311:45 am
TYS
-
OMA
1 stop5h 51m
American Airlines
Mon 3/163:00 pm
OMA
-
TYS
1 stop5h 54m
American Airlines
Deal found 2/1$367

Find flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated February 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(United Airlines)

One-way from

$169
(United Airlines)

Popular in

March

Cheapest in

September

Average price

$278
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
Search Deals
From Knoxville McGhee Tyson to Iowa
Search Deals
One-way flight from Knoxville McGhee Tyson to Iowa
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($87 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($40 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Tue 2/17

6:45 am-10:11 am

1 stop4h 26m

Moline Quad-City

Sat 2/21

3:52 pm-8:37 pm

1 stop3h 45m

$279

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Wed 2/18

4:29 pm-11:28 pm

1 stop7h 59m

Moline Quad-City

Sun 2/22

6:00 am-10:45 am

1 stop3h 45m

$279

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 4/23

6:13 am-10:18 am

1 stop5h 05m

Des Moines

Mon 4/27

4:23 pm-10:59 pm

1 stop5h 36m

$293

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Tue 2/17

4:29 pm-11:28 pm

1 stop7h 59m

Moline Quad-City

Sat 2/21

6:00 am-6:13 pm

2 stops11h 13m

$310

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Sun 2/22

6:45 am-10:20 am

1 stop4h 35m

Omaha Eppley Airfield

Sat 2/28

3:22 pm-8:37 pm

1 stop4h 15m

$332

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 3/27

7:00 am-1:23 pm

1 stop7h 23m

Des Moines

Mon 3/30

6:20 am-3:09 pm

2 stops7h 49m

$334

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Thu 7/16

7:30 am-1:24 pm

1 stop6h 54m

Omaha Eppley Airfield

Mon 7/20

6:30 pm-11:46 pm

1 stop4h 16m

$337

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 5/8

8:05 am-5:05 pm

2 stops10h 00m

Omaha Eppley Airfield

Sun 5/10

6:00 am-2:05 pm

1 stop7h 05m

$342

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 4/17

4:38 pm-8:29 pm

1 stop4h 51m

Omaha Eppley Airfield

Sun 4/19

5:30 am-11:17 am

1 stop4h 47m

$347

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 4/17

6:54 pm-11:32 pm

1 stop5h 38m

Omaha Eppley Airfield

Sun 4/19

5:07 pm-11:55 pm

1 stop5h 48m

$357

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/3

Showing 1-10 of 37 results
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $125). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated February 4, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,138 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,138 reviews
Delta
7.9
Good
8,138 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,236 reviews
Delta
7.9
Good
8,138 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,216 reviews
Delta
7.9
Good
8,138 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like United Airlines, American Airlines, and Delta fly from Knoxville to Iowa in about 4h 26m. The time it takes to get you to your destination can typically vary by up to 3h 33m. The distance between Knoxville and Iowa is about 524 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Des Moines. You may also consider Knoxville McGhee Tyson - Omaha Eppley Airfield or Knoxville McGhee Tyson - Moline Quad-City.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $125). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$223Average$369FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$298FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$366FlexibilityNo cancel feeOn-time71%

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