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$144+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Sep 3 — Sep 101
Thu 9/3
Thu 9/10
1 adult, Economy
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Cheap flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.

This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:50 pm
TYS
-
DSM
1 stop5h 35m
American Airlines
Tue 9/11:08 pm
DSM
-
TYS
1 stop6h 51m
American Airlines
Deal found 7/30$287
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:40 pm
TYS
-
OMA
1 stop7h 30m
United Airlines
Sat 8/226:02 am
OMA
-
TYS
1 stop6h 16m
United Airlines
Deal found 8/3$287
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:52 pm
TYS
-
OMA
1 stop6h 18m
American Airlines
Sat 8/2211:59 am
OMA
-
TYS
2 stops7h 59m
American Airlines
Deal found 8/3$292
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:40 am
TYS
-
OMA
1 stop5h 02m
Delta
Thu 9/36:15 pm
OMA
-
TYS
1 stop4h 37m
Delta
Deal found 7/30$301
This American Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:34 am
TYS
-
DSM
1 stop6h 51m
American Airlines
Sat 9/54:13 pm
DSM
-
TYS
1 stop6h 05m
American Airlines
Deal found 8/2$308
This American Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:53 pm
TYS
-
OMA
1 stop6h 14m
American Airlines
Mon 9/76:20 am
OMA
-
TYS
1 stop5h 36m
American Airlines
Deal found 8/2$308
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:15 am
TYS
-
DSM
1 stop7h 59m
United Airlines
Sat 9/53:20 pm
DSM
-
TYS
2 stops7h 39m
United Airlines
Deal found 8/2$313
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:25 pm
TYS
-
MLI
1 stop4h 05m
Delta
Mon 9/215:09 pm
MLI
-
TYS
1 stop5h 46m
Delta
Deal found 8/3$319
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:16 am
TYS
-
OMA
1 stop24h 56m
Allegiant Air
Mon 10/511:32 am
OMA
-
TYS
1 stop28h 42m
Allegiant Air
Deal found 8/3$324
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:50 pm
TYS
-
OMA
1 stop19h 15m
Allegiant Air
Mon 11/210:30 am
OMA
-
TYS
1 stop7h 54m
Allegiant Air
Deal found 7/31$325
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:35 pm
TYS
-
OMA
1 stop6h 30m
American Airlines
Sun 9/275:34 pm
OMA
-
TYS
1 stop5h 17m
American Airlines
Deal found 7/30$327
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:35 am
TYS
-
DSM
1 stop4h 43m
Delta
Tue 9/110:23 am
DSM
-
TYS
1 stop7h 08m
Delta
Deal found 8/3$329

Find flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated August 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$287
(American Airlines)

One-way from

$144
(Delta)

Popular in

March

Cheapest in

February

Average price

$338
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
Search Deals
From Knoxville McGhee Tyson to Iowa
Search Deals
One-way flight from Knoxville McGhee Tyson to Iowa
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($85 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 12% potential price decrease ($51 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 8/25

6:50 pm-11:25 pm

1 stop5h 35m

Des Moines

Tue 9/1

1:08 pm-8:59 pm

1 stop6h 51m

$287

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Tue 8/18

3:40 pm-10:10 pm

1 stop7h 30m

Omaha Eppley Airfield

Sat 8/22

6:02 am-1:18 pm

1 stop6h 16m

$287

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Sat 9/5

7:59 am-1:24 pm

1 stop6h 25m

Omaha Eppley Airfield

Mon 9/7

6:20 am-12:56 pm

1 stop5h 36m

$308

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 9/1

7:15 am-2:14 pm

1 stop7h 59m

Des Moines

Sat 9/5

3:20 pm-11:59 pm

2 stops7h 39m

$313

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Mon 11/23

7:21 pm-10:58 pm

1 stop4h 37m

Moline Quad-City

Sat 12/5

6:00 am-1:55 pm

1 stop6h 55m

$319

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 8/18

9:00 am-4:19 pm

1 stop8h 19m

Des Moines

Sat 9/12

8:00 am-1:18 pm

1 stop4h 18m

$329

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Tue 8/18

11:15 am-6:11 pm

2 stops7h 56m

Moline Quad-City

Wed 9/16

4:57 pm-10:42 pm

1 stop4h 45m

$339

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 8/18

1:55 pm-9:55 pm

2 stops9h 00m

Des Moines

Sat 9/12

5:30 am-7:25 pm

2 stops12h 55m

$345

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Thu 10/1

7:33 am-1:28 pm

1 stop6h 55m

Omaha Eppley Airfield

Sun 10/4

10:24 am-5:38 pm

1 stop6h 14m

$348

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Wed 9/23

8:55 am-12:39 pm

1 stop4h 44m

Omaha Eppley Airfield

Sun 9/27

5:25 am-12:06 pm

1 stop5h 41m

$348

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 40 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, February is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $226). Flying from Knoxville to Iowa in March is currently the most expensive (average of $666). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Iowa?

Airfare is typical for this route at the moment.
Knoxville to Iowa flights typically cost between $284 and $562 in August.
The cheapest round-trip price found within the last 5 days was $287 on American Airlines (Aug 25-Sep 1).

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated August 4, 2026.
Peruse reviews from past customers who have flown with United Airlines and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
10,059 reviews

Boarding

7.7

Entertainment

7.1

Crew

8.1

Food

6.6

Comfort

7.3

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Dawn,Aug 2026

ORD - DEN

I missed my connecting flight because our plane took off ten minutes late and then when we got to the airport another plane was in our shoot waiting to get fueled up and that took 30 minutes so I missed my connecting flight. I asked if I could get off and they assured me the plane would most likely wait for me since they know what time the planes get in because of an app. I was not happy. I had to wait till 7:25 to board the next flight and then that was delayed. Gates changed till 9:20. Terrible
United Airlines
7.4
Good
10,059 reviews
United Airlines
7.4
Good
10,059 reviews

Boarding

7.7

Entertainment

7.1

Crew

8.1

Food

6.6

Comfort

7.3

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Dawn,Aug 2026

ORD - DEN

I missed my connecting flight because our plane took off ten minutes late and then when we got to the airport another plane was in our shoot waiting to get fueled up and that took 30 minutes so I missed my connecting flight. I asked if I could get off and they assured me the plane would most likely wait for me since they know what time the planes get in because of an app. I was not happy. I had to wait till 7:25 to board the next flight and then that was delayed. Gates changed till 9:20. Terrible
American Airlines
7.1
Good
11,845 reviews
United Airlines
7.4
Good
10,059 reviews

Boarding

7.7

Entertainment

7.1

Crew

8.1

Food

6.6

Comfort

7.3

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Dawn,Aug 2026

ORD - DEN

I missed my connecting flight because our plane took off ten minutes late and then when we got to the airport another plane was in our shoot waiting to get fueled up and that took 30 minutes so I missed my connecting flight. I asked if I could get off and they assured me the plane would most likely wait for me since they know what time the planes get in because of an app. I was not happy. I had to wait till 7:25 to board the next flight and then that was delayed. Gates changed till 9:20. Terrible

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like American Airlines, United Airlines, and Delta fly from Knoxville to Iowa in about 4h 37m. The time it takes to get you to your destination can typically vary by up to 2h 53m. The distance between Knoxville and Iowa is about 524 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Des Moines or Knoxville McGhee Tyson - Moline Quad-City.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, February is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $226). Flying from Knoxville to Iowa in March is currently the most expensive (average of $666). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Knoxville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to Iowa

Discover the top 2 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$226Average$427FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$284Average$396FlexibilityNo cancel feeOn-time69%

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