Iowa

$119+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Jul 5 — Jul 121
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Cheap flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 5, 2026.

This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/163:38 pm
TYS
-
DSM
1 stop6h 49m
Allegiant Air
Mon 7/201:37 pm
DSM
-
TYS
1 stop8h 11m
Allegiant Air
Deal found 6/2$229
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/233:38 pm
TYS
-
DSM
1 stop6h 49m
Allegiant Air
Sun 7/2610:57 am
DSM
-
TYS
1 stop24h 06m
Allegiant Air
Deal found 6/1$237
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2312:00 pm
TYS
-
OMA
1 stop5h 30m
Delta
Sat 9/268:25 am
OMA
-
TYS
1 stop5h 25m
Delta
Deal found 5/31$242
This Booking.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:32 pm
TYS
-
OMA
1 stop23h 58m
Frontier
Tue 7/78:15 pm
OMA
-
TYS
1 stop22h 09m
Frontier
Deal found 6/2$270
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:19 pm
TYS
-
LSE
1 stop27h 17m
Allegiant Air
Sun 6/215:20 pm
LSE
-
TYS
1 stop26h 53m
Allegiant Air
Deal found 6/2$271
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/23:38 pm
TYS
-
DSM
1 stop6h 49m
Allegiant Air
Wed 7/810:59 am
DSM
-
TYS
2 stops52h 43m
Allegiant Air
Deal found 6/2$276
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:23 pm
TYS
-
DSM
1 stop19h 10m
Allegiant Air
Sat 7/114:59 pm
DSM
-
TYS
1 stop29h 04m
Allegiant Air
Deal found 6/3$279
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:30 am
TYS
-
OMA
1 stop14h 16m
Multiple Airlines
Mon 10/2610:30 am
OMA
-
TYS
1 stop29h 44m
Multiple Airlines
Deal found 6/4$287
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:15 am
TYS
-
DSM
2 stops16h 52m
Multiple Airlines
Sun 7/2610:57 am
DSM
-
TYS
1 stop24h 06m
Multiple Airlines
Deal found 6/1$296
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/184:05 pm
TYS
-
DSM
1 stop6h 42m
Allegiant Air
Sat 6/276:02 pm
DSM
-
TYS
1 stop27h 44m
Allegiant Air
Deal found 6/1$305
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/307:15 am
TYS
-
OMA
1 stop7h 10m
Delta
Tue 7/75:25 am
OMA
-
TYS
1 stop4h 45m
Delta
Deal found 6/2$307
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:45 am
TYS
-
MLI
1 stop5h 40m
Delta
Mon 9/75:09 pm
MLI
-
TYS
1 stop5h 43m
Delta
Deal found 6/1$309

Find flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated June 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$229
(Kiwi.com)

One-way from

$119
(Kiwi.com)

Popular in

March

Cheapest in

February

Average price

$456
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
From Knoxville McGhee Tyson to Iowa
One-way flight from Knoxville McGhee Tyson to Iowa
Highest demand for flights based on searches. 23% potential increase in price ($125 potential increase over avg. RT price).
Cheapest flight prices on average. 15% potential price decrease ($55 potential savings vs. average RT price).
Average for round-trip flights in June 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2026.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Tue 6/30

7:15 am-1:25 pm

1 stop7h 10m

Omaha Eppley Airfield

Tue 7/7

5:25 am-11:10 am

1 stop4h 45m

$307

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Fri 9/4

5:45 am-10:25 am

1 stop5h 40m

Moline Quad-City

Mon 9/7

5:09 pm-11:52 pm

1 stop5h 43m

$309

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Tue 6/30

5:40 pm-10:35 pm

1 stop5h 55m

Omaha Eppley Airfield

Tue 7/7

10:35 am-8:25 pm

2 stops8h 50m

$312

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 9/8

7:31 pm-11:44 pm

1 stop5h 13m

Des Moines

Mon 9/14

1:30 pm-9:06 pm

1 stop6h 36m

$326

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Thu 7/2

6:00 am-10:04 am

1 stop5h 04m

Moline Quad-City

Sun 7/5

2:31 pm-8:48 pm

1 stop5h 17m

$329

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Sat 8/29

5:45 am-2:04 pm

2 stops9h 19m

Omaha Eppley Airfield

Tue 9/1

7:25 am-6:17 pm

2 stops9h 52m

$332

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Sat 6/20

6:00 am-9:59 am

1 stop4h 59m

Moline Quad-City

Wed 6/24

1:15 pm-8:56 pm

1 stop6h 41m

$339

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Mon 6/15

6:08 pm-10:34 pm

1 stop5h 26m

Moline Quad-City

Sat 6/20

5:17 pm-12:02 am

1 stop5h 45m

$339

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Wed 7/15

12:45 pm-10:35 pm

2 stops10h 50m

Omaha Eppley Airfield

Mon 7/20

10:20 am-9:15 pm

2 stops9h 55m

$342

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Sat 6/20

4:43 pm-12:11 am

2 stops8h 28m

Moline Quad-City

Wed 6/24

6:52 pm-11:53 pm

1 stop4h 01m

$344

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/31

Showing 1-10 of 41 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $197). Flying from Knoxville to Iowa in March is currently the most expensive (average of $428). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Iowa?

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated June 5, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like Allegiant Air, Delta, and Southwest fly from Knoxville to Iowa in about 5h 55m. The time it takes to get you to your destination can typically vary by up to 1h 15m. The distance between Knoxville and Iowa is about 745 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Iowa?

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $197). Flying from Knoxville to Iowa in March is currently the most expensive (average of $428). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$226Average$380FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$338FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$341Average$404FlexibilityNo cancel feeOn-time69%

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