HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Iowa

$136+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Iowa with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/115:15 pm
TYS
-
DSM
1 stop4h 52m
American Airlines
Sun 2/152:14 pm
DSM
-
TYS
1 stop6h 24m
American Airlines
Deal found 1/19$311
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/275:40 am
TYS
-
OMA
1 stop5h 47m
Delta
Mon 3/306:09 pm
OMA
-
TYS
1 stop4h 48m
Delta
Deal found 1/21$318
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1410:55 am
TYS
-
MLI
1 stop6h 52m
United Airlines
Wed 2/188:15 am
MLI
-
TYS
1 stop4h 00m
United Airlines
Deal found 1/20$321
This Southwest deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:30 am
TYS
-
OMA
2 stops9h 50m
Southwest
Mon 3/306:40 am
OMA
-
TYS
1 stop11h 05m
Southwest
Deal found 1/21$329
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:33 pm
TYS
-
OMA
1 stop6h 24m
American Airlines
Mon 7/205:14 pm
OMA
-
TYS
1 stop5h 35m
American Airlines
Deal found 1/20$337
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:35 am
TYS
-
OMA
1 stop5h 29m
Delta
Sun 2/155:31 am
OMA
-
TYS
1 stop4h 37m
Delta
Deal found 1/21$338
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/16:45 am
TYS
-
DSM
1 stop5h 10m
United Airlines
Sat 2/283:24 pm
DSM
-
TYS
1 stop4h 13m
United Airlines
Deal found 1/19$350
This Southwest deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:35 am
TYS
-
OMA
2 stops10h 00m
Southwest
Sun 4/196:55 am
OMA
-
TYS
1 stop3h 45m
Southwest
Deal found 1/20$352
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:45 am
TYS
-
OMA
1 stop4h 44m
United Airlines
Wed 2/183:22 pm
OMA
-
TYS
1 stop4h 15m
United Airlines
Deal found 1/20$353
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/18:23 am
TYS
-
DSM
2 stops9h 01m
American Airlines
Sat 2/286:08 pm
DSM
-
TYS
1 stop5h 20m
American Airlines
Deal found 1/19$355
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/246:45 am
TYS
-
MLI
1 stop4h 27m
United Airlines
Mon 1/263:45 pm
MLI
-
TYS
1 stop4h 07m
United Airlines
Deal found 1/20$369
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/244:06 pm
TYS
-
MLI
1 stop6h 27m
American Airlines
Mon 1/2611:28 am
MLI
-
TYS
2 stops10h 26m
American Airlines
Deal found 1/20$374

Find flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated January 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$311
(American Airlines)

One-way from

$136
(Delta)

Popular in

March

Cheapest in

September

Average price

$348
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
Search Deals
From Knoxville McGhee Tyson to Iowa
Search Deals
One-way flight from Knoxville McGhee Tyson to Iowa
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($87 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($40 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 2/11

5:15 pm-9:07 pm

1 stop4h 52m

Des Moines

Sun 2/15

2:14 pm-9:38 pm

1 stop6h 24m

$311

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 3/27

5:40 am-10:27 am

1 stop5h 47m

Omaha Eppley Airfield

Mon 3/30

6:09 pm-11:57 pm

1 stop4h 48m

$318

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Sat 2/14

6:45 am-11:46 am

1 stop6h 01m

Moline Quad-City

Wed 2/18

3:52 pm-8:37 pm

1 stop3h 45m

$321

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 3/27

6:30 am-3:20 pm

2 stops9h 50m

Omaha Eppley Airfield

Mon 3/30

6:40 am-6:45 pm

1 stop11h 05m

$329

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 4/17

7:00 am-10:32 am

1 stop4h 32m

Omaha Eppley Airfield

Sun 4/19

3:22 pm-10:29 pm

1 stop6h 07m

$337

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Thu 7/16

6:33 pm-11:57 pm

1 stop6h 24m

Omaha Eppley Airfield

Mon 7/20

5:14 pm-11:49 pm

1 stop5h 35m

$337

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Thu 2/12

5:35 am-10:04 am

1 stop5h 29m

Omaha Eppley Airfield

Sun 2/15

5:31 am-11:08 am

1 stop4h 37m

$338

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 2/1

6:45 am-10:55 am

1 stop5h 10m

Des Moines

Sat 2/28

3:24 pm-8:37 pm

1 stop4h 13m

$350

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 4/17

6:35 am-3:35 pm

2 stops10h 00m

Omaha Eppley Airfield

Sun 4/19

6:55 am-11:40 am

1 stop3h 45m

$352

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Sat 2/14

6:45 am-10:29 am

1 stop4h 44m

Omaha Eppley Airfield

Wed 2/18

3:22 pm-8:37 pm

1 stop4h 15m

$353

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 42 results
1
2
3
...
5

Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $125). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated January 21, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,088 reviews
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,191 reviews
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,174 reviews
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Comfort

7.9

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like American Airlines, Delta, and United Airlines fly from Knoxville to Iowa in about 4h 52m. The time it takes to get you to your destination can typically vary by up to 1h 09m. The distance between Knoxville and Iowa is about 654 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Des Moines or Knoxville McGhee Tyson - Moline Quad-City.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $125). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Los Angeles flights
Nashville to Denver flights
Nashville to Fort Lauderdale flights
Nashville to Miami flights
Nashville to Seattle flights
Nashville to John F Kennedy Intl flights
Memphis to Las Vegas flights
Nashville to LaGuardia flights
Nashville to Orlando flights
Memphis to Hobby flights
Nashville to Newark flights
Nashville to Hobby flights
Nashville to Las Vegas flights
Nashville to Dallas/Fort Worth flights
Nashville to Sky Harbor Intl flights
Memphis to Orlando flights
Nashville to George Bush Intcntl flights
Memphis to LaGuardia flights
Nashville to O'Hare Intl flights
Memphis to Dallas/Fort Worth flights
Memphis to Miami flights
Knoxville to Denver flights
Memphis to Denver flights
Memphis to George Bush Intcntl flights
Nashville to Reagan-National flights
Nashville to Tampa flights
Memphis to Los Angeles flights
Nashville to Dulles Intl flights
Nashville to San Francisco flights
Nashville to Salt Lake City flights
Nashville to New Orleans flights
Memphis to John F Kennedy Intl flights
Nashville to Honolulu flights
Nashville to Boston flights
Memphis to Atlanta flights
Chattanooga to LaGuardia flights
Nashville to Baltimore flights
Nashville to Fort Myers flights
Knoxville to LaGuardia flights
Memphis to O'Hare Intl flights
Chattanooga to Orlando flights
Nashville to Minneapolis flights
Nashville to San Diego flights
Knoxville to Hobby flights
Nashville to Ontario flights
Memphis to Newark flights
Chattanooga to Las Vegas flights
Nashville to Austin flights
Chattanooga to Newark flights
Memphis to Seattle flights

Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$223Average$369FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$298FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$346FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.