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$88+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Apr 6 — Apr 131
Mon 4/6
Mon 4/13
1 adult, Economy
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Cheap flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 7, 2026.

This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:00 am
TYS
-
MLI
1 stop3h 58m
United Airlines
Sun 4/263:20 pm
MLI
-
TYS
1 stop6h 14m
United Airlines
Deal found 3/4$289
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:02 am
TYS
-
DSM
1 stop7h 05m
American Airlines
Sat 3/281:52 pm
DSM
-
TYS
1 stop7h 02m
American Airlines
Deal found 3/5$291
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/235:00 am
TYS
-
MLI
2 stops8h 21m
American Airlines
Sun 4/2612:51 pm
MLI
-
TYS
1 stop6h 27m
American Airlines
Deal found 3/4$294
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/97:00 am
TYS
-
DSM
1 stop6h 29m
United Airlines
Sat 4/116:20 am
DSM
-
TYS
2 stops7h 49m
United Airlines
Deal found 3/5$296
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:55 am
TYS
-
DSM
1 stop28h 11m
Allegiant Air
Fri 3/207:51 pm
DSM
-
TYS
1 stop26h 02m
Allegiant Air
Deal found 3/5$306
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:00 am
TYS
-
DSM
1 stop4h 30m
United Airlines
Tue 3/315:30 am
DSM
-
TYS
1 stop8h 36m
United Airlines
Deal found 3/5$310
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:00 am
TYS
-
OMA
1 stop4h 32m
United Airlines
Wed 4/1511:28 am
OMA
-
TYS
1 stop4h 33m
United Airlines
Deal found 3/6$317
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:00 am
TYS
-
OMA
1 stop4h 29m
United Airlines
Mon 5/411:31 am
OMA
-
TYS
1 stop4h 23m
United Airlines
Deal found 3/2$319
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:07 am
TYS
-
DSM
1 stop4h 11m
Delta
Wed 10/142:15 pm
DSM
-
TYS
1 stop6h 30m
Delta
Deal found 3/4$320
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:00 am
TYS
-
MLI
1 stop3h 58m
United Airlines
Tue 4/213:20 pm
MLI
-
TYS
1 stop6h 14m
United Airlines
Deal found 3/2$321
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:01 pm
TYS
-
OMA
1 stop6h 30m
United Airlines
Tue 5/126:00 am
OMA
-
TYS
2 stops7h 34m
United Airlines
Deal found 3/6$322
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:01 pm
TYS
-
OMA
1 stop6h 30m
United Airlines
Mon 5/256:25 pm
OMA
-
TYS
1 stop5h 05m
United Airlines
Deal found 3/2$328

Find flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated March 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$289
(United Airlines)

One-way from

$88
(Trip.com)

Popular in

October

Cheapest in

February

Average price

$318
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
Search Deals
From Knoxville McGhee Tyson to Iowa
Search Deals
One-way flight from Knoxville McGhee Tyson to Iowa
Search Deals
Highest demand for flights based on searches. 0% potential increase in price ($3 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 7, 2026.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Thu 4/23

7:00 am-9:58 am

1 stop3h 58m

Moline Quad-City

Sun 4/26

3:20 pm-10:34 pm

1 stop6h 14m

$289

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Wed 6/3

5:45 am-10:20 am

1 stop5h 35m

Moline Quad-City

Tue 6/9

5:00 pm-11:46 pm

1 stop5h 46m

$289

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 3/27

5:43 pm-9:40 pm

1 stop4h 57m

Des Moines

Tue 3/31

6:20 am-3:09 pm

2 stops7h 49m

$315
Quickest round-trip

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Sun 4/12

7:00 am-10:32 am

1 stop4h 32m

Omaha Eppley Airfield

Wed 4/15

11:28 am-5:01 pm

1 stop4h 33m

$317

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Sat 4/18

7:00 am-9:58 am

1 stop3h 58m

Moline Quad-City

Tue 4/21

3:20 pm-10:34 pm

1 stop6h 14m

$321

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 3/27

7:00 am-1:23 pm

1 stop7h 23m

Des Moines

Mon 3/30

3:04 pm-11:41 pm

1 stop7h 37m

$330

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 5/8

1:20 pm-6:30 pm

1 stop6h 10m

Omaha Eppley Airfield

Sun 5/10

5:07 pm-11:55 pm

1 stop5h 48m

$337

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 4/24

7:00 am-10:32 am

1 stop4h 32m

Omaha Eppley Airfield

Sun 4/26

3:22 pm-10:34 pm

1 stop6h 12m

$337

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 4/3

4:30 pm-11:42 pm

1 stop8h 12m

Des Moines

Fri 4/10

3:21 pm-10:34 pm

1 stop6h 13m

$343

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 4/24

6:35 am-12:55 pm

2 stops7h 20m

Omaha Eppley Airfield

Sun 4/26

7:10 am-3:15 pm

1 stop7h 05m

$352

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/2

Showing 1-10 of 35 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $125). Flying from Knoxville to Iowa in January is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated March 7, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,271 reviews

Food

7.2

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,271 reviews
Delta
7.9
Good
8,271 reviews

Food

7.2

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,404 reviews
Delta
7.9
Good
8,271 reviews

Food

7.2

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,398 reviews
Delta
7.9
Good
8,271 reviews

Food

7.2

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like United Airlines, Delta, and American Airlines fly from Knoxville to Iowa in about 3h 58m. The time it takes to get you to your destination can typically vary by up to 2h 12m. The distance between Knoxville and Iowa is about 524 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Des Moines or Knoxville McGhee Tyson - Moline Quad-City.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $125). Flying from Knoxville to Iowa in January is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$223Average$369FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$298FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$362FlexibilityNo cancel feeOn-time71%

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