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$127+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Feb 5 — Feb 121
Thu 2/5
Thu 2/12
1 adult, Economy
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Cheap flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated January 6, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$276
(American Airlines)

One-way from

$127
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$371
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
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From Knoxville McGhee Tyson to Iowa
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One-way flight from Knoxville McGhee Tyson to Iowa
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Highest demand for flights based on searches. 18% potential increase in price ($85 potential increase over avg. RT price).
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Cheapest flight prices on average. 11% potential price decrease ($39 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.

This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:51 amTYS - DSM
1 stop6h 14mAmerican Airlines
Tue 3/1010:04 amDSM - TYS
1 stop5h 27mAmerican Airlines
Deal found 1/5$276
This United Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/171:59 pmTYS - OMA
1 stop4h 37mUnited Airlines
Tue 1/203:21 pmOMA - TYS
1 stop4h 31mUnited Airlines
Deal found 1/5$305
This United Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/166:45 amTYS - MLI
1 stop4h 27mUnited Airlines
Tue 1/2010:47 amMLI - TYS
1 stop5h 06mUnited Airlines
Deal found 1/5$309
This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/164:00 pmTYS - MLI
1 stop6h 33mAmerican Airlines
Tue 1/2011:28 amMLI - TYS
2 stops8h 53mAmerican Airlines
Deal found 1/5$314
This Delta deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/206:30 amTYS - DSM
1 stop5h 21mDelta
Sat 1/246:24 amDSM - TYS
1 stop4h 49mDelta
Deal found 1/4$315
This United Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1410:55 amTYS - MLI
1 stop6h 52mUnited Airlines
Wed 2/188:15 amMLI - TYS
1 stop4h 00mUnited Airlines
Deal found 1/5$319
This United Airlines deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/202:25 pmTYS - DSM
2 stops8h 25mUnited Airlines
Sat 1/241:35 pmDSM - TYS
1 stop7h 56mUnited Airlines
Deal found 1/4$320
This Delta deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:30 amTYS - OMA
1 stop6h 54mDelta
Mon 7/206:30 pmOMA - TYS
1 stop4h 17mDelta
Deal found 1/6$337
This Southwest deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:40 pmTYS - OMA
1 stop7h 25mSouthwest
Wed 5/2710:25 amOMA - TYS
2 stops8h 15mSouthwest
Deal found 1/5$342
This Southwest deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:45 pmTYS - DSM
2 stops8h 30mSouthwest
Tue 3/105:30 amDSM - TYS
2 stops11h 10mSouthwest
Deal found 1/5$348
This United Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/218:45 amTYS - DSM
1 stop8h 43mUnited Airlines
Sun 1/258:10 amDSM - TYS
1 stop8h 55mUnited Airlines
Deal found 1/6$359
This Southwest deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:30 amTYS - OMA
2 stops8h 15mSouthwest
Sat 3/2112:55 pmOMA - TYS
1 stop7h 10mSouthwest
Deal found 1/5$368

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 6, 2026.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 3/5

7:51 am-1:05 pm

1 stop6h 14m

Des Moines

Tue 3/10

10:04 am-4:31 pm

1 stop5h 27m

$276

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Sat 1/17

11:07 am-5:36 pm

1 stop7h 29m

Omaha Eppley Airfield

Tue 1/20

3:21 pm-8:52 pm

1 stop4h 31m

$305

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Fri 1/16

6:45 am-10:12 am

1 stop4h 27m

Moline Quad-City

Tue 1/20

10:47 am-4:53 pm

1 stop5h 06m

$309

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Fri 1/16

4:00 pm-9:33 pm

1 stop6h 33m

Moline Quad-City

Tue 1/20

11:28 am-9:21 pm

2 stops8h 53m

$314

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 1/20

6:30 am-10:51 am

1 stop5h 21m

Des Moines

Sat 1/24

6:24 am-12:13 pm

1 stop4h 49m

$315

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Sat 2/14

10:55 am-4:47 pm

1 stop6h 52m

Moline Quad-City

Wed 2/18

8:15 am-1:15 pm

1 stop4h 00m

$319

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 1/20

2:25 pm-9:50 pm

2 stops8h 25m

Des Moines

Sat 1/24

1:35 pm-10:31 pm

1 stop7h 56m

$320

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Sun 5/24

4:40 pm-11:05 pm

1 stop7h 25m

Omaha Eppley Airfield

Wed 5/27

10:25 am-7:40 pm

2 stops8h 15m

$342

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 3/5

3:45 pm-11:15 pm

2 stops8h 30m

Des Moines

Tue 3/10

5:30 am-5:40 pm

2 stops11h 10m

$348

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 1/21

8:45 am-4:28 pm

1 stop8h 43m

Des Moines

Sun 1/25

8:10 am-6:05 pm

1 stop8h 55m

$359

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/6

Showing 1-10 of 27 results
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $125). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated January 6, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,018 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,018 reviews
Delta
7.9
Good
8,018 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,132 reviews
Delta
7.9
Good
8,018 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,083 reviews
Delta
7.9
Good
8,018 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like American Airlines, United Airlines, and Delta fly from Knoxville to Iowa in about 5h 21m. The time it takes to get you to your destination can typically vary by up to 2h 08m. The distance between Knoxville and Iowa is about 654 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Des Moines or Knoxville McGhee Tyson - Moline Quad-City.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $125). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$223Average$353FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$288FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$343FlexibilityNo cancel feeOn-time71%

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