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$169+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
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Find flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:23 amTYS - DSM
1 stop6h 24mAmerican Airlines
Wed 12/313:26 pmDSM - TYS
1 stop4h 55mAmerican Airlines
Deal found 11/24$271
This Kiwi.com deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:52 pmTYS - OMA
1 stop21h 39mMultiple Airlines
Sun 12/75:25 pmOMA - TYS
1 stop18h 26mMultiple Airlines
Deal found 11/26$276
This Kiwi.com deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:42 pmTYS - DSM
1 stop27h 45mMultiple Airlines
Tue 12/303:45 pmDSM - TYS
2 stops28h 22mMultiple Airlines
Deal found 11/25$305
This Delta deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/93:57 pmTYS - OMA
1 stop5h 53mDelta
Wed 12/107:00 amOMA - TYS
1 stop6h 52mDelta
Deal found 11/24$417
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/96:05 amTYS - OMA
2 stops9h 37mAmerican Airlines
Wed 12/105:00 amOMA - TYS
1 stop5h 35mAmerican Airlines
Deal found 11/24$422
This United Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/108:50 amTYS - DSM
1 stop8h 22mUnited Airlines
Sun 12/148:00 amDSM - TYS
1 stop4h 17mUnited Airlines
Deal found 11/25$429
This United Airlines deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1911:58 amTYS - OMA
1 stop8h 21mUnited Airlines
Mon 12/228:00 amOMA - TYS
2 stops10h 51mUnited Airlines
Deal found 11/26$440
This United Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/107:00 amTYS - MLI
1 stop4h 15mUnited Airlines
Sun 12/146:30 amMLI - TYS
1 stop5h 47mUnited Airlines
Deal found 11/25$458
This American Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:23 amTYS - DSM
1 stop6h 26mAmerican Airlines
Tue 12/301:34 pmDSM - TYS
1 stop6h 47mAmerican Airlines
Deal found 11/25$485
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/205:23 pmTYS - DSM
1 stop7h 09mAllegiant Air
Fri 12/268:00 amDSM - TYS
1 stop27h 27mAllegiant Air
Deal found 11/24$487
This Mytrip deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/219:56 pmTYS - OMA
1 stop11h 09mAllegiant Air
Sun 12/289:48 amOMA - TYS
1 stop6h 03mAllegiant Air
Deal found 11/26$487
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 amTYS - DSM
1 stop16h 13mAllegiant Air
Fri 12/268:00 amDSM - TYS
1 stop27h 27mAllegiant Air
Deal found 11/24$496

Cheap flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated November 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$271
(American Airlines)

One-way from

$169
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$343
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
Search Deals
From Knoxville McGhee Tyson to Iowa
Search Deals
One-way flight from Knoxville McGhee Tyson to Iowa
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($96 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($36 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 12/24

5:23 am-10:47 am

1 stop6h 24m

Des Moines

Wed 12/31

3:26 pm-9:21 pm

1 stop4h 55m

$271

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 12/23

5:42 pm-8:27 pm

1 stop27h 45m

Des Moines

Tue 12/30

3:45 pm-9:07 pm

2 stops28h 22m

$305

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 2/20

5:30 am-10:04 am

1 stop5h 34m

Omaha Eppley Airfield

Tue 2/24

7:06 am-3:15 pm

1 stop7h 09m

$307

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Sat 1/24

5:14 pm-9:33 pm

1 stop5h 19m

Moline Quad-City

Wed 1/28

3:58 pm-10:47 pm

1 stop5h 49m

$319

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 4/17

7:20 pm-11:55 pm

1 stop5h 35m

Omaha Eppley Airfield

Sun 4/19

6:30 pm-11:46 pm

1 stop4h 16m

$337

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Mon 1/5

6:09 pm-10:29 pm

1 stop5h 20m

Des Moines

Fri 1/9

7:34 am-4:19 pm

1 stop7h 45m

$377

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 2/20

11:42 am-6:58 pm

2 stops8h 16m

Omaha Eppley Airfield

Tue 2/24

7:01 am-3:27 pm

1 stop7h 26m

$382

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Mon 1/5

5:08 pm-11:30 pm

1 stop7h 22m

Des Moines

Fri 1/9

7:00 am-12:46 pm

1 stop4h 46m

$407

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Mon 1/5

5:35 pm-9:40 pm

1 stop5h 05m

Des Moines

Fri 1/9

8:00 am-7:50 pm

2 stops10h 50m

$412

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Wed 12/10

7:00 am-10:15 am

1 stop4h 15m

Moline Quad-City

Sun 12/14

6:30 am-1:17 pm

1 stop5h 47m

$458

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/24

Showing 1-10 of 19 results
1
2

Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $127). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IA?

Find hourly flight availability from Knoxville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 26, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Iowa in the evening. If you’re flexible enough to do this you can expect to save up to 38% on your trip compared to booking a flight in the morning.

How much does it cost to fly round-trip from Knoxville to Iowa?

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated November 26, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,046 reviews
Delta
7.9
Good
7,998 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,038 reviews
Delta
7.9
Good
7,998 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like American Airlines and Delta fly from Knoxville to Iowa in about 5h 34m. The time it takes to get you to your destination can typically vary by up to 50m. The distance between Knoxville and Iowa is about 745 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Des Moines or Knoxville McGhee Tyson - Moline Quad-City.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $127). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$223Average$353FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$271FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$341FlexibilityNo cancel feeOn-time71%

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