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$169+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheap flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated septiembre 11, 2025.

Round-trip from

$193
(American Airlines)

One-way from

$169
(United Airlines)

Popular in

March

Cheapest in

September

Average price

$248
From Knoxville McGhee Tyson to Iowa
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One-way flight from Knoxville McGhee Tyson to Iowa
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Highest demand for flights based on searches. 17% potential increase in price ($78 potential increase over avg. RT price).
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Cheapest flight prices on average. 9% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/85:00 amTYS - DSM
1 stop6h 45mAmerican Airlines
mié. 10/155:42 pmDSM - TYS
1 stop4h 25mAmerican Airlines
Deal found 9/10$193
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/151:13 pmTYS - OMA
1 stop5h 40mAmerican Airlines
lun. 11/243:38 pmOMA - TYS
1 stop7h 42mAmerican Airlines
Deal found 9/11$201
This Booking.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/238:17 pmTYS - OMA
1 stop24h 47mFrontier
dom. 10/268:59 pmOMA - TYS
1 stop21h 33mFrontier
Deal found 9/11$230
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/2311:00 amTYS - DSM
1 stop4h 33mUnited Airlines
sáb. 12/2711:35 amDSM - TYS
1 stop4h 25mUnited Airlines
Deal found 9/10$232
This Mytrip deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/99:50 pmTYS - DSM
1 stop11h 40mAllegiant Air
jue. 10/166:30 amDSM - TYS
1 stop9h 14mAllegiant Air
Deal found 9/11$237
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/306:22 pmTYS - MLI
1 stop6h 02mAmerican Airlines
sáb. 11/83:37 pmMLI - TYS
1 stop7h 31mAmerican Airlines
Deal found 9/11$249
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/267:00 amTYS - DSM
1 stop4h 32mUnited Airlines
mar. 9/302:58 pmDSM - TYS
1 stop7h 45mUnited Airlines
Deal found 9/11$266
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/252:07 pmTYS - OMA
1 stop5h 41mAmerican Airlines
lun. 9/297:08 amOMA - TYS
1 stop6h 35mAmerican Airlines
Deal found 9/10$279
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/147:43 pmTYS - DSM
1 stop4h 25mAmerican Airlines
dom. 10/195:00 amDSM - TYS
1 stop5h 44mAmerican Airlines
Deal found 9/11$289
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/1011:32 amTYS - OMA
1 stop9h 32mMultiple Airlines
dom. 10/128:59 pmOMA - TYS
2 stops22h 37mMultiple Airlines
Deal found 9/11$297
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/2511:00 amTYS - DSM
1 stop10h 40mAllegiant Air
lun. 9/298:00 amDSM - TYS
1 stop28h 29mAllegiant Air
Deal found 9/10$302
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/303:56 pmTYS - OMA
1 stop5h 17mAmerican Airlines
jue. 10/21:42 pmOMA - TYS
1 stop6h 32mAmerican Airlines
Deal found 9/10$305

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

mié. 10/8

5:00 am-10:45 am

1 stop6h 45m

Des Moines

mié. 10/15

5:42 pm-11:07 pm

1 stop4h 25m

$193

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

mié. 2/18

6:45 am-10:19 am

1 stop4h 34m

Omaha Eppley Airfield

sáb. 2/21

5:35 pm-11:00 pm

1 stop4h 25m

$217

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

jue. 10/23

8:17 pm-8:04 pm

1 stop24h 47m

Omaha Eppley Airfield

dom. 10/26

8:59 pm-7:32 pm

1 stop21h 33m

$230

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

mar. 12/23

11:00 am-2:33 pm

1 stop4h 33m

Des Moines

sáb. 12/27

11:35 am-5:00 pm

1 stop4h 25m

$232

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 10/9

9:50 pm-8:30 am

1 stop11h 40m

Des Moines

jue. 10/16

6:30 am-4:44 pm

1 stop9h 14m

$237

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

jue. 10/30

6:22 pm-11:24 pm

1 stop6h 02m

Moline Quad-City

sáb. 11/8

3:37 pm-12:08 am

1 stop7h 31m

$249

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

vie. 9/26

7:00 am-10:32 am

1 stop4h 32m

Des Moines

mar. 9/30

2:58 pm-11:43 pm

1 stop7h 45m

$266

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

mié. 2/18

5:50 am-12:03 pm

2 stops7h 13m

Omaha Eppley Airfield

sáb. 2/21

3:15 pm-10:58 pm

1 stop6h 43m

$268

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

jue. 9/25

2:07 pm-6:48 pm

1 stop5h 41m

Omaha Eppley Airfield

dom. 9/28

6:15 am-1:54 pm

1 stop6h 39m

$279

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

jue. 9/25

2:07 pm-6:48 pm

1 stop5h 41m

Omaha Eppley Airfield

lun. 9/29

7:08 am-2:43 pm

1 stop6h 35m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 33 results
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $336). Flying from Knoxville to Iowa in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IA?

Find hourly flight availability from Knoxville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 11, 2025.

When flying from Knoxville to Iowa, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated septiembre 11, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like American Airlines, Delta, and Frontier fly from Knoxville to Iowa in about 4h 34m. The time it takes to get you to your destination can typically vary by up to 20h 13m. The distance between Knoxville and Iowa is about 745 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Knoxville to Iowa one-way?

    $169 is the cheapest one-way deal found within the past few days, from United Airlines. You may also be able to find cheap deals on Frontier and Delta, with prices starting from $171 and $322, respectively.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Des Moines or Knoxville McGhee Tyson - La Crosse.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $336). Flying from Knoxville to Iowa in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$222Average$256FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$332FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$464FlexibilityNo cancel feeOn-time69%

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