$112+ Cheap flights from Knoxville (TYS) to Iowa
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Oct 30 — Nov 61
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Iowa with Cheapflights
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Cheapest flights from Knoxville to IowaExplore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 30, 2026.
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 30, 2026.
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:40 am -
1 stop6h 02m
Sat 10/3111:27 am -
1 stop5h 11m
Deal found 9/26![Delta logo]()
$303
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:35 pm -
2 stops8h 48m
Sat 10/319:36 am -
1 stop6h 23m
Deal found 9/26![United Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:05 pm -
1 stop5h 40m
Tue 10/204:12 pm -
1 stop6h 06m
Deal found 9/25![American Airlines logo]()
$335
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/304:11 pm -
1 stop6h 08m
Sun 11/15:05 pm -
1 stop4h 57m
Deal found 9/25![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:52 am -
1 stop6h 36m
Sun 11/1511:28 am -
1 stop5h 09m
Deal found 9/27![American Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/104:53 pm -
1 stop7h 59m
Wed 10/141:24 pm -
1 stop6h 25m
Deal found 9/25![United Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:58 pm -
1 stop6h 10m
Sat 10/176:13 pm -
1 stop4h 46m
Deal found 9/28![American Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:50 pm -
1 stop4h 29m
Sun 11/223:25 pm -
1 stop7h 07m
Deal found 9/29![American Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:58 pm -
1 stop5h 00m
Sun 10/185:07 am -
1 stop4h 58m
Deal found 9/29![American Airlines logo]()
$394
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:10 am -
2 stops13h 40m
Sat 10/315:20 am -
2 stops9h 10m
Deal found 9/26![Southwest logo]()
$401
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:40 pm -
1 stop5h 15m
Sun 11/226:05 am -
2 stops7h 43m
Deal found 9/29![United Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:56 am -
2 stops7h 11m
Sun 10/185:07 am -
1 stop4h 58m
Deal found 9/29![American Airlines logo]()
$431
Best flights from Knoxville to IowaDiscover carefully curated flight deals from Knoxville to Iowa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 30, 2026.
Discover carefully curated flight deals from Knoxville to Iowa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 30, 2026.
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/304:11 pm -
1 stop6h 08m
Sun 11/15:05 pm -
1 stop4h 57m
Deal found 9/26![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/104:53 pm -
1 stop7h 59m
Wed 10/141:24 pm -
1 stop6h 25m
Deal found 9/25![United Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:50 pm -
1 stop4h 29m
Sun 11/223:25 pm -
1 stop7h 07m
Deal found 9/29![American Airlines logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:15 am -
2 stops26h 19m
Sun 10/181:09 pm -
1 stop8h 52m
Deal found 9/29![Allegiant Air logo]()
$549
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:10 am -
2 stops13h 35m
Sat 10/245:50 am -
2 stops11h 05m
Deal found 9/26![Southwest logo]()
$560
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:16 pm -
1 stop4h 44m
Sun 10/185:30 am -
1 stop4h 19m
Deal found 9/29![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:58 pm -
1 stop5h 00m
Sun 10/185:07 am -
1 stop4h 58m
Deal found 9/29![American Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:40 pm -
1 stop5h 15m
Sun 11/226:05 am -
2 stops7h 43m
Deal found 9/29![United Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:56 am -
2 stops7h 11m
Sun 10/185:07 am -
1 stop4h 58m
Deal found 9/29![American Airlines logo]()
$431
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/139:45 am -
2 stops8h 43m
Sun 11/158:00 am -
1 stop4h 13m
Deal found 9/27![United Airlines logo]()
$433
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:45 am -
2 stops9h 30m
Tue 10/206:00 am -
2 stops7h 42m
Deal found 9/25![United Airlines logo]()
$445
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:22 pm -
1 stop4h 47m
Wed 11/116:15 am -
2 stops8h 00m
Deal found 9/27![Delta logo]()
$512
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:00 am -
2 stops8h 28m
Sun 11/15:00 am -
1 stop5h 04m
Deal found 9/29![American Airlines logo]()
$517
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:40 pm -
1 stop5h 15m
Fri 10/306:45 pm -
1 stop17h 28m
Deal found 9/28![United Airlines logo]()
$574
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:03 pm -
1 stop5h 44m
Fri 10/233:00 pm -
2 stops18h 37m
Deal found 9/28![United Airlines logo]()
$729
Last-minute flights from Knoxville to IowaDiscover last-minute flight deals from Knoxville to Iowa. Data last updated September 30, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Iowa. Data last updated September 30, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/39:36 pm -
1 stop24h 17m
Sat 10/249:00 am -
1 stop10h 50m
Deal found 9/26![Allegiant Air logo]()
$479
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:55 pm -
1 stop6h 25m
Fri 10/236:13 pm -
1 stop4h 46m
Deal found 9/28![American Airlines logo]()
$455
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/104:53 pm -
1 stop7h 59m
Wed 10/141:24 pm -
1 stop6h 25m
Deal found 9/25![United Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:05 pm -
1 stop5h 40m
Tue 10/204:12 pm -
1 stop6h 06m
Deal found 9/25![American Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:58 pm -
1 stop6h 10m
Sat 10/176:13 pm -
1 stop4h 46m
Deal found 9/28![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:45 am -
2 stops7h 56m
Tue 10/203:11 pm -
1 stop4h 38m
Deal found 9/25![United Airlines logo]()
$440
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:56 am -
2 stops7h 11m
Sun 10/185:07 am -
1 stop4h 58m
Deal found 9/29![American Airlines logo]()
$431
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:58 pm -
1 stop5h 00m
Sun 10/185:07 am -
1 stop4h 58m
Deal found 9/29![American Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:40 am -
1 stop6h 02m
Sat 10/3111:27 am -
1 stop5h 11m
Deal found 9/26![Delta logo]()
$303
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:35 pm -
2 stops8h 48m
Sat 10/319:36 am -
1 stop6h 23m
Deal found 9/26![United Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:10 am -
2 stops13h 40m
Sat 10/315:20 am -
2 stops9h 10m
Deal found 9/26![Southwest logo]()
$401
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/304:11 pm -
1 stop6h 08m
Sun 11/15:05 pm -
1 stop4h 57m
Deal found 9/25![Delta logo]()
$339
One-way flights from Knoxville to IowaSearch for one-way flight options from Knoxville to Iowa. Find affordable one-way fares based on user searches. Data last updated September 30, 2026.
Search for one-way flight options from Knoxville to Iowa. Find affordable one-way fares based on user searches. Data last updated September 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:36 pm -
1 stop13h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Allegiant Air logo]()
$112
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:45 am -
1 stop6h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Delta logo]()
$152
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:45 am -
2 stops10h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![United Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:02 pm -
1 stop25h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Allegiant Air logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:43 am -
1 stop8h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Allegiant Air logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:04 pm -
3 stops45h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Multiple Airlines logo]()
$214
This deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop5h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![United Airlines logo]()
$220
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:01 pm -
2 stops32h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Multiple Airlines logo]()
$223
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/228:04 pm -
1 stop4h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![American Airlines logo]()
$254
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:01 am -
2 stops7h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![American Airlines logo]()
$335
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:23 pm -
1 stop4h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Delta logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:29 pm -
1 stop16h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Allegiant Air logo]()
$460
Find flight deals from Knoxville to Iowa
Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated September 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $303 (Delta) |
One-way from | $112 (Kiwi.com) |
Popular in | March |
Cheapest in | February |
Average price | $517 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 30, 2026.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Thu 10/15
7:36 pm-8:35 am
1 stop13h 59m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$112
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Tue 10/27
11:45 am-4:55 pm
1 stop6h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$152
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Tue 10/27
9:45 am-7:16 pm
2 stops10h 31m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$157
KnoxvilleCedar Rapids
TYS Knoxville McGhee Tyson - CID Cedar Rapids
TYSCID
Knoxville McGhee Tyson
Wed 11/18
4:02 pm-5:00 pm
1 stop25h 58m
Cedar Rapids
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$180
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Fri 10/23
6:00 am-10:31 am
1 stop5h 31m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$220
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Thu 10/15
12:01 pm-7:30 pm
2 stops32h 29m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$223
KnoxvilleCedar Rapids
TYS Knoxville McGhee Tyson - CID Cedar Rapids
TYSCID
Knoxville McGhee Tyson
Sun 11/22
8:04 pm-11:58 pm
1 stop4h 54m
Cedar Rapids
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$254
KnoxvilleCedar Rapids
TYS Knoxville McGhee Tyson - CID Cedar Rapids
TYSCID
Knoxville McGhee Tyson
Wed 11/18
6:01 am-12:21 pm
2 stops7h 20m
Cedar Rapids
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$335
KnoxvilleCedar Rapids
TYS Knoxville McGhee Tyson - CID Cedar Rapids
TYSCID
Knoxville McGhee Tyson
Fri 10/30
4:11 pm-9:19 pm
1 stop6h 08m
Cedar Rapids
Sun 11/1
5:05 pm-11:02 pm
1 stop4h 57m
$339
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Sat 10/10
4:53 pm-11:52 pm
1 stop7h 59m
Des Moines
Wed 10/14
1:24 pm-8:49 pm
1 stop6h 25m
$367
Showing 1-10 of 25 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Iowa
Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
TYS-DSM
TYS-CID
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Iowa
TYS-USIA
TYS-DSM
TYS-CID
What is the cheapest month to book a flight from Knoxville to Iowa?
Currently, February is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $226). Flying from Knoxville to Iowa in March is currently the most expensive (average of $666). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Iowa
Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated September 30, 2026.
Peruse reviews from past customers who have flown with United Airlines and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.4
Comfort
7.3
Boarding
7.7
Crew
8.1
Food
6.7
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Overall
7.4
Comfort
7.3
Boarding
7.7
Crew
8.1
Food
6.7
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Overall
7.4
Comfort
7.3
Boarding
7.7
Crew
8.1
Food
6.7
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to Iowa
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Iowa by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Iowa by cabin class
Find flights from Knoxville to Iowa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Iowa flights
Browse other Knoxville and Iowa flight options. Last updated on September 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to Iowa flights
Consider these flights traveling from Knoxville to Iowa.
Top 2 airlines flying from Knoxville to Iowa
Discover the top 2 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$226 | Average$425 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$284 | Average$403 | FlexibilityNo cancel fee | On-time69% |