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$149+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:20 amTYS - MLI
1 stop10h 08mAllegiant Air
Sun 12/710:09 amMLI - TYS
1 stop10h 35mAllegiant Air
Deal found 11/4$241
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:39 pmTYS - MLI
1 stop5h 54mDelta
Sun 12/75:08 pmMLI - TYS
1 stop5h 20mDelta
Deal found 11/4$249
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:23 pmTYS - MLI
2 stops25h 05mAllegiant Air
Sun 12/710:09 amMLI - TYS
1 stop10h 35mAllegiant Air
Deal found 11/4$291
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:29 pmTYS - MLI
1 stop6h 18mAmerican Airlines
Sun 12/76:00 amMLI - TYS
2 stops7h 29mAmerican Airlines
Deal found 11/4$299
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/201:20 pmTYS - DSM
1 stop8h 54mAllegiant Air
Mon 11/246:31 pmDSM - TYS
1 stop27h 09mAllegiant Air
Deal found 11/5$307
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:59 pmTYS - OMA
1 stop5h 17mDelta
Wed 12/107:00 amOMA - TYS
1 stop6h 52mDelta
Deal found 11/6$307
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/201:20 pmTYS - DSM
1 stop8h 54mMultiple Airlines
Mon 11/246:40 amDSM - TYS
2 stops15h 12mMultiple Airlines
Deal found 11/5$311
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:18 pmTYS - OMA
1 stop6h 08mAmerican Airlines
Wed 12/106:00 amOMA - TYS
2 stops8h 14mAmerican Airlines
Deal found 11/6$312
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/257:00 amTYS - OMA
1 stop14h 01mMultiple Airlines
Fri 11/2811:26 amOMA - TYS
1 stop8h 57mMultiple Airlines
Deal found 11/5$319
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/268:04 pmTYS - DSM
1 stop5h 17mAmerican Airlines
Mon 12/15:26 pmDSM - TYS
1 stop5h 26mAmerican Airlines
Deal found 11/4$329
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1910:16 amTYS - OMA
1 stop4h 54mAmerican Airlines
Wed 12/179:23 amOMA - TYS
1 stop5h 09mAmerican Airlines
Deal found 11/6$347
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:00 amTYS - MLI
2 stops8h 11mAmerican Airlines
Sun 12/76:00 amMLI - TYS
2 stops7h 29mAmerican Airlines
Deal found 11/4$349

Cheap flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$277
(Delta)

One-way from

$149
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$452
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
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From Knoxville McGhee Tyson to Iowa
Search Deals
One-way flight from Knoxville McGhee Tyson to Iowa
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($75 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Fri 12/5

8:20 am-5:28 pm

1 stop10h 08m

Moline Quad-City

Sun 12/7

10:09 am-9:44 pm

1 stop10h 35m

$241

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Thu 12/4

5:39 pm-10:33 pm

1 stop5h 54m

Moline Quad-City

Sun 12/7

5:08 pm-11:28 pm

1 stop5h 20m

$249

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Thu 12/4

5:23 pm-5:28 pm

2 stops25h 05m

Moline Quad-City

Sun 12/7

10:09 am-9:44 pm

1 stop10h 35m

$291

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Fri 12/5

6:29 pm-11:47 pm

1 stop6h 18m

Moline Quad-City

Sun 12/7

6:00 am-2:29 pm

2 stops7h 29m

$299

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 2/20

9:13 am-1:16 pm

1 stop5h 03m

Des Moines

Mon 2/23

2:01 pm-10:00 pm

1 stop6h 59m

$300

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Thu 1/22

1:59 pm-5:36 pm

1 stop4h 37m

Omaha Eppley Airfield

Sat 1/24

8:00 am-1:24 pm

1 stop4h 24m

$307

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Mon 12/8

7:59 pm-12:16 am

1 stop5h 17m

Omaha Eppley Airfield

Wed 12/10

7:00 am-2:52 pm

1 stop6h 52m

$307

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 11/20

1:20 pm-9:14 pm

1 stop8h 54m

Des Moines

Mon 11/24

6:31 pm-10:40 pm

1 stop27h 09m

$307

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Mon 12/8

6:18 pm-11:26 pm

1 stop6h 08m

Omaha Eppley Airfield

Wed 12/10

6:00 am-3:14 pm

2 stops8h 14m

$312

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Tue 11/25

7:00 am-8:01 pm

1 stop14h 01m

Omaha Eppley Airfield

Fri 11/28

11:26 am-9:23 pm

1 stop8h 57m

$319

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/6

Showing 1-10 of 37 results
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $127). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IA?

Find hourly flight availability from Knoxville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Iowa in the evening. If you’re flexible enough to do this you can expect to save up to 38% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated November 6, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,001 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,001 reviews
Delta
7.9
Good
8,001 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,007 reviews
Delta
7.9
Good
8,001 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,040 reviews
Delta
7.9
Good
8,001 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like Allegiant Air, Delta, and American Airlines fly from Knoxville to Iowa in about 5h 54m. The time it takes to get you to your destination can typically vary by up to 4h 14m. The distance between Knoxville and Iowa is about 524 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Knoxville to Iowa one-way?

    $149 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $169 and $174, respectively.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Des Moines. You may also consider Knoxville McGhee Tyson - Omaha Eppley Airfield or Knoxville McGhee Tyson - Moline Quad-City.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $127). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$223Average$349FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$271FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$331FlexibilityNo cancel feeOn-time71%

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