HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Iowa

$100+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Aug 24 — Aug 311
Sun 8/24
Sun 8/31
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Iowa with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated August 19, 2025.

Round-trip from

$215
(Mytrip)

One-way from

$100
(United Airlines)

Popular in

March

Cheapest in

September

Average price

$348
From Knoxville McGhee Tyson to Iowa
Search Deals
One-way flight from Knoxville McGhee Tyson to Iowa
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($78 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2025.

This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/157:45 pmTYS - DSM
1 stop4h 21mAmerican Airlines
Mon 9/226:12 pmDSM - TYS
1 stop5h 09mAmerican Airlines
Deal found 8/18$249
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:40 amTYS - OMA
1 stop6h 54mDelta
Tue 10/1412:40 pmOMA - TYS
1 stop6h 56mDelta
Deal found 8/18$249
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/155:45 amTYS - DSM
2 stops9h 35mUnited Airlines
Mon 9/223:25 pmDSM - TYS
1 stop6h 20mUnited Airlines
Deal found 8/18$254
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2811:54 amTYS - DSM
1 stop6h 51mDelta
Sat 8/303:30 pmDSM - TYS
1 stop5h 57mDelta
Deal found 8/16$284
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/194:37 pmTYS - OMA
1 stop7h 45mAmerican Airlines
Sun 9/216:00 pmOMA - TYS
1 stop5h 07mAmerican Airlines
Deal found 8/18$284
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/282:16 pmTYS - DSM
1 stop5h 24mAmerican Airlines
Sat 8/306:00 amDSM - TYS
2 stops8h 35mAmerican Airlines
Deal found 8/16$289
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/97:00 amTYS - OMA
1 stop7h 00mAmerican Airlines
Mon 10/135:05 amOMA - TYS
1 stop7h 31mAmerican Airlines
Deal found 8/18$299
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/147:35 pmTYS - DSM
2 stops27h 54mAllegiant Air
Sun 9/216:30 amDSM - TYS
1 stop11h 15mAllegiant Air
Deal found 8/17$308
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/16:36 amTYS - DSM
1 stop4h 31mDelta
Fri 9/55:25 pmDSM - TYS
1 stop5h 30mDelta
Deal found 8/17$319
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/25:35 pmTYS - MLI
1 stop4h 37mUnited Airlines
Sat 9/610:45 amMLI - TYS
1 stop5h 15mUnited Airlines
Deal found 8/18$329
This Mytrip deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/147:00 amTYS - DSM
3 stops31h 32mMultiple Airlines
Sun 9/216:30 amDSM - TYS
1 stop11h 15mMultiple Airlines
Deal found 8/17$338
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/85:17 pmTYS - OMA
2 stops7h 42mAmerican Airlines
Mon 10/136:00 amOMA - TYS
1 stop5h 31mAmerican Airlines
Deal found 8/18$364

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 19, 2025.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Mon 9/15

7:45 pm-11:06 pm

1 stop4h 21m

Des Moines

Mon 9/22

6:12 pm-12:21 am

1 stop5h 09m

$249

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 10/10

8:10 pm-11:59 pm

1 stop4h 49m

Omaha Eppley Airfield

Tue 10/14

12:40 pm-8:36 pm

1 stop6h 56m

$249

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 10/10

8:10 pm-11:59 pm

1 stop4h 49m

Omaha Eppley Airfield

Mon 10/13

6:37 pm-11:46 pm

1 stop4h 09m

$249

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Thu 10/9

3:48 pm-9:01 pm

1 stop6h 13m

Omaha Eppley Airfield

Mon 10/13

6:37 pm-11:46 pm

1 stop4h 09m

$249

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Thu 10/9

6:40 am-10:14 am

1 stop4h 34m

Omaha Eppley Airfield

Tue 10/14

7:04 am-2:43 pm

1 stop6h 39m

$249

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Wed 10/8

5:16 pm-9:01 pm

1 stop4h 45m

Omaha Eppley Airfield

Mon 10/13

6:37 pm-11:46 pm

1 stop4h 09m

$249

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Wed 10/8

6:40 am-12:34 pm

1 stop6h 54m

Omaha Eppley Airfield

Tue 10/14

12:40 pm-8:36 pm

1 stop6h 56m

$249

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Mon 9/15

5:45 am-2:20 pm

2 stops9h 35m

Des Moines

Mon 9/22

3:25 pm-10:45 pm

1 stop6h 20m

$254

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 2/13

6:56 am-12:43 pm

1 stop6h 47m

Omaha Eppley Airfield

Sun 2/15

9:40 am-3:23 pm

1 stop4h 43m

$279

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 9/19

4:37 pm-11:22 pm

1 stop7h 45m

Omaha Eppley Airfield

Sun 9/21

6:00 pm-12:07 am

1 stop5h 07m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/18

Showing 1-10 of 27 results
1
2
3

Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $336). Flying from Knoxville to Iowa in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IA?

Find hourly flight availability from Knoxville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 19, 2025.

When flying from Knoxville to Iowa, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated August 19, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,922 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like American Airlines, Delta, and United Airlines fly from Knoxville to Iowa in about 4h 21m. The time it takes to get you to your destination can typically vary by up to 5h 14m. The distance between Knoxville and Iowa is about 654 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Des Moines or Knoxville McGhee Tyson - La Crosse.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $336). Flying from Knoxville to Iowa in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Seattle flights
Nashville to LaGuardia flights
Nashville to Las Vegas flights
Nashville to O'Hare Intl flights
Nashville to John F Kennedy Intl flights
Nashville to Newark flights
Nashville to Boston flights
Nashville to Denver flights
Memphis to LaGuardia flights
Memphis to Las Vegas flights
Nashville to Dallas/Fort Worth flights
Nashville to Hobby flights
Chattanooga to LaGuardia flights
Memphis to Newark flights
Nashville to Fort Lauderdale flights
Nashville to Orlando flights
Nashville to Miami flights
Memphis to Orlando flights
Nashville to San Francisco flights
Nashville to George Bush Intcntl flights
Nashville to Sky Harbor Intl flights
Memphis to Boston flights
Knoxville to Los Angeles flights
Memphis to Denver flights
Nashville to Salt Lake City flights
Chattanooga to John F Kennedy Intl flights
Memphis to Dallas/Fort Worth flights
Memphis to John F Kennedy Intl flights
Nashville to Los Angeles flights
Memphis to Augusta flights
Memphis to Atlanta flights
Knoxville to O'Hare Intl flights
Nashville to San Diego flights
Chattanooga to O'Hare Intl flights
Nashville to Reagan-National flights
Memphis to Hobby flights
Chattanooga to Las Vegas flights
Nashville to Tampa flights
Memphis to Miami flights
Nashville to Detroit flights
Knoxville to Denver flights
Nashville to Midway flights
Knoxville to LaGuardia flights
Nashville to Portland flights
Memphis to O'Hare Intl flights
Memphis to George Bush Intcntl flights
Memphis to Detroit flights
Chattanooga to San Diego flights
Nashville to Honolulu flights
Nashville to Minneapolis flights

Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$222Average$256FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$331FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$464FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.