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$138+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:24 pmTYS - DSM
1 stop5h 47mAmerican Airlines
Mon 12/294:16 pmDSM - TYS
1 stop4h 13mAmerican Airlines
Deal found 12/22$510
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:23 amTYS - DSM
1 stop6h 24mAmerican Airlines
Sat 12/276:30 amDSM - TYS
1 stop13h 51mAmerican Airlines
Deal found 12/21$512
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:58 amTYS - DSM
2 stops9h 32mUnited Airlines
Sat 12/273:00 pmDSM - TYS
1 stop7h 42mUnited Airlines
Deal found 12/21$534
This United Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:00 pmTYS - DSM
2 stops8h 40mUnited Airlines
Mon 12/296:46 pmDSM - TYS
2 stops19h 02mUnited Airlines
Deal found 12/22$599
This United Airlines deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/285:45 amTYS - DSM
2 stops9h 48mUnited Airlines
Wed 12/3111:35 amDSM - TYS
1 stop4h 25mUnited Airlines
Deal found 12/23$604
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:00 amTYS - OMA
1 stop7h 08mAmerican Airlines
Sun 12/283:44 pmOMA - TYS
1 stop7h 01mAmerican Airlines
Deal found 12/22$647
This Kiwi.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:21 pmTYS - OMA
1 stop17h 04mAllegiant Air
Sat 12/276:48 pmOMA - TYS
1 stop26h 51mAllegiant Air
Deal found 12/21$726
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amTYS - OMA
2 stops12h 36mAmerican Airlines
Sat 12/272:12 pmOMA - TYS
1 stop6h 09mAmerican Airlines
Deal found 12/21$814
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:05 amTYS - OMA
2 stops12h 14mUnited Airlines
Sat 12/276:10 amOMA - TYS
2 stops7h 38mUnited Airlines
Deal found 12/21$829

Find flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$286
(Delta)

One-way from

$138
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$407
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
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From Knoxville McGhee Tyson to Iowa
Search Deals
One-way flight from Knoxville McGhee Tyson to Iowa
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($87 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($35 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Sun 1/18

6:30 am-11:36 am

1 stop6h 06m

Omaha Eppley Airfield

Sun 1/25

6:05 am-12:13 pm

1 stop5h 08m

$286

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Sun 1/18

9:30 am-5:36 pm

2 stops9h 06m

Omaha Eppley Airfield

Sun 1/25

8:00 am-1:24 pm

1 stop4h 24m

$291

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 1/8

11:54 am-7:34 pm

1 stop8h 40m

Des Moines

Wed 1/14

7:34 am-4:19 pm

1 stop7h 45m

$293

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sat 2/14

6:45 am-10:53 am

1 stop5h 08m

Des Moines

Wed 2/18

3:24 pm-8:37 pm

1 stop4h 13m

$301

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Sat 2/14

6:45 am-10:29 am

1 stop4h 44m

Omaha Eppley Airfield

Wed 2/18

3:22 pm-8:37 pm

1 stop4h 15m

$305

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Wed 1/28

11:10 am-3:09 pm

1 stop4h 59m

Moline Quad-City

Sat 1/31

3:45 pm-8:52 pm

1 stop4h 07m

$321

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 4/3

6:21 pm-11:42 pm

1 stop6h 21m

Des Moines

Sun 4/5

1:40 pm-11:40 pm

2 stops9h 00m

$334

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 1/16

12:19 pm-4:50 pm

1 stop5h 31m

Omaha Eppley Airfield

Mon 1/19

1:42 pm-10:47 pm

1 stop8h 05m

$337

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 1/16

6:45 am-10:30 am

1 stop4h 45m

Omaha Eppley Airfield

Mon 1/19

3:00 pm-11:44 pm

1 stop7h 44m

$337

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 1/6

11:10 am-2:33 pm

1 stop4h 23m

Des Moines

Sat 1/10

7:50 am-1:24 pm

1 stop4h 34m

$359

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 34 results
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $127). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IA?

Find hourly flight availability from Knoxville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Iowa in the evening. If you’re flexible enough to do this you can expect to save up to 38% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated December 23, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,014 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,014 reviews
Delta
7.9
Good
8,014 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,105 reviews
Delta
7.9
Good
8,014 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,014 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like Delta and United Airlines fly from Knoxville to Iowa in about 6h 06m. The time it takes to get you to your destination can typically vary by up to 3h. The distance between Knoxville and Iowa is about 745 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Des Moines or Knoxville McGhee Tyson - Moline Quad-City.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $127). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$223Average$353FlexibilityNo cancel feeOn-time69%
DeltaCheapest$232Average$271FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$341FlexibilityNo cancel feeOn-time71%

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