HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Iowa

$199+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Nov 13 — Nov 201
Thu 11/13
Thu 11/20
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Iowa with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/99:00 amTYS - DSM
1 stop6h 01mAllegiant Air
Sun 11/162:51 pmDSM - TYS
1 stop17h 34mAllegiant Air
Deal found 10/12$232
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:43 pmTYS - DSM
1 stop10h 38mAllegiant Air
Sun 12/74:21 pmDSM - TYS
1 stop25h 53mAllegiant Air
Deal found 10/13$254
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/99:00 amTYS - DSM
1 stop6h 01mMultiple Airlines
Sun 11/169:03 pmDSM - TYS
2 stops25h 11mMultiple Airlines
Deal found 10/12$260
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/74:27 pmTYS - OMA
1 stop8h 03mAmerican Airlines
Sun 11/96:11 amOMA - TYS
1 stop5h 48mAmerican Airlines
Deal found 10/12$269
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/247:44 pmTYS - DSM
1 stop23h 16mAllegiant Air
Sun 11/162:51 pmDSM - TYS
1 stop17h 34mAllegiant Air
Deal found 10/11$274
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:14 pmTYS - OMA
2 stops9h 44mAmerican Airlines
Fri 12/126:00 amOMA - TYS
1 stop7h 27mAmerican Airlines
Deal found 10/12$274
This Mytrip deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:43 pmTYS - DSM
2 stops20h 58mMultiple Airlines
Sun 12/72:56 pmDSM - TYS
1 stop16h 37mMultiple Airlines
Deal found 10/13$275
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/252:20 pmTYS - DSM
1 stop18h 42mAllegiant Air
Wed 10/2911:19 amDSM - TYS
1 stop9h 37mAllegiant Air
Deal found 10/12$295
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/247:44 pmTYS - DSM
1 stop23h 16mMultiple Airlines
Sun 11/169:03 pmDSM - TYS
2 stops25h 11mMultiple Airlines
Deal found 10/11$299
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:00 amTYS - OMA
1 stop5h 39mAmerican Airlines
Fri 11/76:12 pmOMA - TYS
1 stop4h 56mAmerican Airlines
Deal found 10/12$299
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1412:49 pmTYS - DSM
1 stop4h 30mDelta
Tue 11/184:59 pmDSM - TYS
1 stop5h 10mDelta
Deal found 10/13$300
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/182:35 pmTYS - OMA
1 stop19h 47mMultiple Airlines
Sat 10/258:59 pmOMA - TYS
1 stop15h 34mMultiple Airlines
Deal found 10/13$304

Cheap flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated October 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$251
(Delta)

One-way from

$199
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$436
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
Search Deals
From Knoxville McGhee Tyson to Iowa
Search Deals
One-way flight from Knoxville McGhee Tyson to Iowa
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($73 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 11/9

9:00 am-2:01 pm

1 stop6h 01m

Des Moines

Sun 11/16

2:51 pm-9:25 am

1 stop17h 34m

$232

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Wed 2/18

6:45 am-12:26 pm

1 stop6h 41m

Omaha Eppley Airfield

Sat 2/21

4:00 pm-11:44 pm

1 stop6h 44m

$251

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 12/5

4:38 pm-10:33 pm

1 stop6h 55m

Omaha Eppley Airfield

Fri 12/12

6:00 am-2:27 pm

1 stop7h 27m

$269

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 11/14

5:34 pm-9:08 pm

1 stop4h 34m

Omaha Eppley Airfield

Sun 11/16

6:19 am-11:45 am

1 stop4h 26m

$269

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 10/24

7:44 pm-6:00 pm

1 stop23h 16m

Des Moines

Sun 11/16

2:51 pm-9:25 am

1 stop17h 34m

$274

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 12/4

12:43 pm-8:41 am

2 stops20h 58m

Des Moines

Sun 12/7

2:56 pm-8:33 am

1 stop16h 37m

$275

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sat 10/25

2:20 pm-8:02 am

1 stop18h 42m

Des Moines

Wed 10/29

11:19 am-9:56 pm

1 stop9h 37m

$295

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Sat 11/1

6:00 am-10:39 am

1 stop5h 39m

Omaha Eppley Airfield

Fri 11/7

6:12 pm-12:08 am

1 stop4h 56m

$299

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 11/14

12:49 pm-4:19 pm

1 stop4h 30m

Des Moines

Tue 11/18

7:46 am-4:46 pm

1 stop8h 00m

$300

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 10/24

8:10 pm-11:59 pm

1 stop4h 49m

Omaha Eppley Airfield

Mon 10/27

6:00 am-3:41 pm

1 stop8h 41m

$304

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/11

Showing 1-10 of 29 results
1
2
3

Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $127). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IA?

Find hourly flight availability from Knoxville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 14, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Iowa in the evening. If you’re flexible enough to do this you can expect to save up to 38% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated October 14, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,975 reviews

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,975 reviews
Delta
8.0
Very good
7,975 reviews

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,976 reviews
Delta
8.0
Very good
7,975 reviews

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,042 reviews
Delta
8.0
Very good
7,975 reviews

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to Iowa?

    Airlines like Allegiant Air, Delta, and American Airlines fly from Knoxville to Iowa in about 6h 01m. The time it takes to get you to your destination can typically vary by up to 54m. The distance between Knoxville and Iowa is about 654 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Knoxville to Iowa one-way?

    $199 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and Allegiant Air, with prices starting from $204 and $257, respectively.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Des Moines. You may also consider Knoxville McGhee Tyson - Omaha Eppley Airfield or Knoxville McGhee Tyson - Moline Quad-City.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $127). Flying from Knoxville to Iowa in March is currently the most expensive (average of $265). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to John F Kennedy Intl flights
Nashville to Los Angeles flights
Nashville to LaGuardia flights
Nashville to Las Vegas flights
Nashville to Newark flights
Memphis to Las Vegas flights
Nashville to Orlando flights
Nashville to Dallas/Fort Worth flights
Nashville to Fort Lauderdale flights
Nashville to Hobby flights
Nashville to O'Hare Intl flights
Memphis to Dallas/Fort Worth flights
Memphis to LaGuardia flights
Nashville to Denver flights
Chattanooga to LaGuardia flights
Nashville to Sky Harbor Intl flights
Memphis to Newark flights
Nashville to Seattle flights
Memphis to Denver flights
Nashville to Miami flights
Nashville to George Bush Intcntl flights
Chattanooga to Las Vegas flights
Knoxville to LaGuardia flights
Nashville to Boston flights
Memphis to Hobby flights
Memphis to Los Angeles flights
Memphis to Orlando flights
Memphis to O'Hare Intl flights
Nashville to Baltimore flights
Chattanooga to John F Kennedy Intl flights
Memphis to John F Kennedy Intl flights
Nashville to Raleigh flights
Nashville to Philadelphia flights
Nashville to Reagan-National flights
Nashville to Ontario flights
Nashville to Dulles Intl flights
Memphis to George Bush Intcntl flights
Knoxville to Orlando Sanford Intl flights
Nashville to Salt Lake City flights
Knoxville to O'Hare Intl flights
Knoxville to John F Kennedy Intl flights
Nashville to Santa Ana flights
Memphis to Miami flights
Chattanooga to Orlando flights
Memphis to Reagan-National flights
Chattanooga to Newark flights
Knoxville to Denver flights
Nashville to Austin flights
Memphis to Sky Harbor Intl flights
Knoxville to Dallas/Fort Worth flights

Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$232Average$271FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$362FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$342FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.