
Keep the following information in mind while searching for Knoxville to Illinois flight deals. Data was last updated November 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $246 (Kiwi.com) |
One-way from | $54 (Super.com) |
Popular in | September |
Cheapest in | January |
Average price | $359 |
Good round-trip deal | $85 or less |
Good one-way deal | $70 or less |
Fly from
Fly to
Route
Depart
Return
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Fri 11/20
1:01 pm-1:40 pm
Nonstop1h 39m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Sat 12/12
2:50 pm-7:35 pm
1 stop5h 45m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Mon 12/7
5:15 pm-10:45 pm
1 stop6h 30m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Fri 12/4
2:40 pm-10:45 pm
2 stops9h 05m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - MDW Chicago Midway
TYSMDW
Knoxville McGhee Tyson
Fri 11/20
7:25 pm-12:10 am
1 stop5h 45m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Sat 12/12
6:00 am-7:06 am
Nonstop2h 06m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Mon 12/7
7:44 am-9:10 am
Nonstop2h 26m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Sat 3/13
5:45 pm-6:46 pm
Nonstop2h 01m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Mon 12/14
7:44 am-9:10 am
Nonstop2h 26m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
KnoxvilleChicago
TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl
TYSORD
Knoxville McGhee Tyson
Mon 12/7
5:35 pm-6:36 pm
Nonstop2h 01m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
Everything you need to know about your flight from Knoxville to Illinois
Entertainment
Boarding
Overall
Food
Crew
Comfort
Reviews
Reza,Jun 2026
TPA - MDW
Entertainment
Boarding
Overall
Food
Crew
Comfort
Reviews
Reza,Jun 2026
TPA - MDW
Entertainment
Boarding
Overall
Food
Crew
Comfort
Reviews
Reza,Jun 2026
TPA - MDW
Entertainment
Boarding
Overall
Food
Crew
Comfort
Reviews
Reza,Jun 2026
TPA - MDW
Entertainment
Boarding
Overall
Food
Crew
Comfort
Reviews
Reza,Jun 2026
TPA - MDW
Find useful and relevant information for your journey from Knoxville to Illinois. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$78 | Average$141 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$189 | Average$335 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$207 | Average$360 | FlexibilityNo cancel fee | On-time71% |