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Guayaquil

$200+ Cheap flights from South Carolina to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GYE
Dec 16 — Dec 231
Tue 12/16
Tue 12/23
1 adult, Economy
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Find flight deals from South Carolina to Guayaquil

Cheapest flights from South Carolina to Guayaquil
Explore the most affordable flight options available from South Carolina to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 16, 2025.

This KAYAK deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:00 amCLT - GYE
1 stop16h 43mSpirit Airlines
Mon 12/812:49 amGYE - CLT
1 stop13h 14mSpirit Airlines
Deal found 11/15$380
This KAYAK deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:55 amCLT - GYE
1 stop14h 48mSpirit Airlines
Sat 12/1312:49 amGYE - CLT
1 stop8h 50mSpirit Airlines
Deal found 11/15$426
This Kiwi.com deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:55 amCLT - GYE
1 stop14h 48mMultiple Airlines
Fri 1/96:50 pmGYE - CLT
1 stop17h 32mMultiple Airlines
Deal found 11/14$447
This Kiwi.com deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/158:54 amCLT - GYE
1 stop14h 49mMultiple Airlines
Mon 1/126:50 pmGYE - CLT
2 stops24h 59mMultiple Airlines
Deal found 11/15$457
This KAYAK deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/142:58 pmCLT - GYE
1 stop8h 45mSpirit Airlines
Sat 12/2012:49 amGYE - CLT
1 stop8h 50mSpirit Airlines
Deal found 11/14$467
This KAYAK deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amCLT - GYE
1 stop16h 53mSpirit Airlines
Thu 2/51:26 amGYE - CLT
1 stop16h 35mSpirit Airlines
Deal found 11/15$471
This Kiwi.com deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/52:58 pmCLT - GYE
1 stop8h 45mMultiple Airlines
Sun 12/146:50 pmGYE - CLT
1 stop24h 20mMultiple Airlines
Deal found 11/15$492
This Kiwi.com deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:38 pmCLT - GYE
2 stops25h 57mMultiple Airlines
Thu 1/151:26 amGYE - CLT
1 stop16h 47mMultiple Airlines
Deal found 11/14$494
This American Airlines deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:00 amCHS - GYE
1 stop17h 06mAmerican Airlines
Sun 11/306:00 amGYE - CHS
1 stop26h 43mAmerican Airlines
Deal found 11/15$635
This KAYAK deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2610:18 pmCHS - GYE
1 stop25h 35mSpirit Airlines
Thu 1/112:49 amGYE - CHS
1 stop20h 34mSpirit Airlines
Deal found 11/16$725
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:06 pmCHS - GYE
1 stop27h 44mAmerican Airlines
Fri 1/26:08 amGYE - CHS
1 stop26h 39mAmerican Airlines
Deal found 11/16$1,003
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/268:07 pmCHS - GYE
1 stop27h 43mAmerican Airlines
Fri 1/26:08 amGYE - CHS
1 stop26h 39mAmerican Airlines
Deal found 11/16$1,004

Cheap flight deals from South Carolina to Guayaquil

Keep the following information in mind while searching for South Carolina to Guayaquil flight deals. Data was last updated November 16, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$276
(Priceline)

One-way from

$200
(Kiwi.com)
Provider with most accurate pricing for Myrtle Beach Intl-Guayaquil Jose Joaquin de Olmedo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Guayaquil Jose Joaquin de Olmedo flights.
Search Deals
From South Carolina to Guayaquil Jose Joaquin de Olmedo
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One-way flight from South Carolina to Guayaquil Jose Joaquin de Olmedo
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Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 16, 2025.
Use the filters below to find and compare flights from South Carolina to Guayaquil that are best for you.

Fly from

South Carolina

Fly to

Guayaquil

Route

Depart

Return

Price

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Wed 2/4

7:00 am-12:21 am

1 stop17h 21m

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

12:59 am-6:02 pm

1 stop17h 03m

$289

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 2/5

1:24 pm-12:21 am

1 stop10h 57m

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

12:59 am-6:02 pm

1 stop17h 03m

$291

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Sun 1/25

7:00 am-12:21 am

1 stop17h 21m

Guayaquil Jose Joaquin de Olmedo

Wed 1/28

1:26 am-6:01 pm

1 stop16h 35m

$299

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Sat 1/10

7:00 am-12:21 am

1 stop17h 21m

Guayaquil Jose Joaquin de Olmedo

Tue 1/13

1:26 am-10:58 am

1 stop9h 32m

$316

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Sat 1/10

7:00 am-5:20 am

1 stop22h 20m

Guayaquil Jose Joaquin de Olmedo

Wed 1/14

6:50 pm-12:22 pm

1 stop17h 32m

$322

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Wed 2/4

7:00 am-12:21 am

1 stop17h 21m

Guayaquil Jose Joaquin de Olmedo

Sat 2/7

1:26 am-8:26 am

1 stop31h 00m

$322

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Wed 2/4

9:55 pm-12:21 am

2 stops26h 26m

Guayaquil Jose Joaquin de Olmedo

Tue 2/17

12:59 am-11:29 am

3 stops34h 30m

$437

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Wed 1/28

9:55 pm-12:21 am

2 stops26h 26m

Guayaquil Jose Joaquin de Olmedo

Tue 2/10

1:26 am-2:34 pm

2 stops13h 08m

$516

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Wed 2/4

10:18 am-11:22 pm

2 stops13h 04m

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

3:31 pm-11:44 am

2 stops20h 13m

$539

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Wed 1/28

6:23 am-11:22 pm

2 stops16h 59m

Guayaquil Jose Joaquin de Olmedo

Wed 2/11

7:15 am-11:57 pm

2 stops16h 42m

$539

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/14

Showing 1-10 of 20 results
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Best time to book a flight from South Carolina to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Guayaquil

What is the cheapest time of day to fly from SC to GYE?

Find hourly flight availability from South Carolina to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 16, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 38% on flights from South Carolina to Guayaquil by exploring options for tickets at noon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Guayaquil from South Carolina?

    Guayaquil Jose Joaquin de Olmedo (GYE), located 2.5 mi from the city center, is the airport you fly into when you book flights from South Carolina to Guayaquil.

  • How long is the flight from South Carolina to Guayaquil?

    There are many flights that can get you from South Carolina to Guayaquil in 13h 04m. Fly via Spirit Airlines or American Airlines to get the fastest option. The distance from South Carolina to Guayaquil is about 2475 mi. This flight may include one or multiple stops.

  • What are the most popular routes from South Carolina to Guayaquil?

    The most popular route from South Carolina to Guayaquil is Charlotte Douglas - Guayaquil Jose Joaquin de Olmedo. You may also consider Charleston - Guayaquil Jose Joaquin de Olmedo or Myrtle Beach Intl - Guayaquil Jose Joaquin de Olmedo.

  • Can I find deals for flights from South Carolina to Guayaquil that include hotel bookings?

    Yes. In addition to deals on South Carolina to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Guayaquil.

  • Can I find deals for business class flights from South Carolina to Guayaquil?

    Yes. Cheapflights offers flight deals from South Carolina to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from South Carolina to Guayaquil

Discover the top airline that operate flights from South Carolina to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$519Average$979FlexibilityNo cancel feeOn-time71%

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