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Guayaquil

$97+ Cheap flights from South Carolina to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/29. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GYE
Jan 25 — Feb 11
Sun 1/25
Sun 2/1
1 adult, Economy
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Cheap flight deals from South Carolina to Guayaquil

Cheapest flights from South Carolina to Guayaquil
Explore the most affordable flight options available from South Carolina to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 26, 2025.

This eDestinos deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:34 pmCLT - GYE
2 stops26h 19mSpirit Airlines
Thu 2/51:26 amGYE - CLT
2 stops15h 28mSpirit Airlines
Deal found 12/24$557
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:07 pmCHS - GYE
1 stop27h 43mAmerican Airlines
Fri 1/26:08 amGYE - CHS
1 stop26h 39mAmerican Airlines
Deal found 12/26$715
This KAYAK deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:38 pmCLT - GYE
1 stop26h 15mSpirit Airlines
Sat 1/312:49 amGYE - CLT
1 stop8h 50mSpirit Airlines
Deal found 12/24$785
This FlightHub deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:00 amCLT - GYE
1 stop16h 53mSpirit Airlines
Wed 1/71:26 amGYE - CLT
2 stops15h 28mSpirit Airlines
Deal found 12/25$812
This American Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/268:07 pmCHS - GYE
1 stop27h 43mAmerican Airlines
Fri 1/26:08 amGYE - CHS
1 stop26h 39mAmerican Airlines
Deal found 12/25$946
This Ovago deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:03 pmCHS - GYE
1 stop20h 07mJetBlue
Fri 1/27:30 amGYE - CHS
1 stop11h 53mJetBlue
Deal found 12/24$964
This KAYAK deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/269:34 pmCLT - GYE
2 stops50h 19mSpirit Airlines
Sat 1/312:49 amGYE - CLT
1 stop8h 50mSpirit Airlines
Deal found 12/24$1,104
This Ovago deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2711:16 amCHS - GYE
1 stop18h 13mJetBlue
Fri 1/27:30 amGYE - CHS
1 stop11h 53mJetBlue
Deal found 12/24$1,139
This United Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:30 amCHS - GYE
2 stops14h 13mUnited Airlines
Fri 1/28:34 amGYE - CHS
2 stops26h 01mUnited Airlines
Deal found 12/24$1,153
This United Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/275:00 pmCHS - GYE
2 stops27h 43mUnited Airlines
Fri 1/28:34 amGYE - CHS
2 stops26h 01mUnited Airlines
Deal found 12/25$1,160
This KAYAK deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2610:18 pmCHS - GYE
1 stop25h 35mSpirit Airlines
Thu 1/112:49 amGYE - CHS
2 stops12h 21mSpirit Airlines
Deal found 12/24$1,265

Find flight deals from South Carolina to Guayaquil

Keep the following information in mind while searching for South Carolina to Guayaquil flight deals. Data was last updated December 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$261
(KAYAK)

One-way from

$97
(Priceline)
Provider with most accurate pricing for Myrtle Beach Intl-Guayaquil Jose Joaquin de Olmedo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Guayaquil Jose Joaquin de Olmedo flights.
Search Deals
From South Carolina to Guayaquil Jose Joaquin de Olmedo
Search Deals
One-way flight from South Carolina to Guayaquil Jose Joaquin de Olmedo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from South Carolina to Guayaquil that are best for you.

Fly from

South Carolina

Fly to

Guayaquil

Route

Depart

Return

Price

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Wed 1/21

6:00 am-12:21 am

1 stop18h 21m

Guayaquil Jose Joaquin de Olmedo

Tue 1/27

1:26 am-10:55 am

1 stop9h 29m

$261

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 2/19

1:24 pm-12:04 am

1 stop10h 40m

Guayaquil Jose Joaquin de Olmedo

Mon 3/2

12:59 am-4:54 pm

2 stops15h 55m

$282

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 2/5

11:12 am-12:21 am

2 stops13h 09m

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

12:59 am-4:54 pm

2 stops15h 55m

$286

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Wed 2/18

7:05 pm-12:04 am

1 stop28h 59m

Guayaquil Jose Joaquin de Olmedo

Sun 3/1

12:59 am-8:26 am

1 stop31h 27m

$295

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 2/19

11:00 am-12:04 am

1 stop13h 04m

Guayaquil Jose Joaquin de Olmedo

Mon 3/2

12:59 am-11:56 pm

1 stop22h 57m

$296

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Fri 2/20

6:37 pm-12:04 am

1 stop29h 27m

Guayaquil Jose Joaquin de Olmedo

Mon 3/2

12:59 am-11:56 pm

1 stop22h 57m

$296

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 2/19

11:00 am-12:04 am

1 stop13h 04m

Guayaquil Jose Joaquin de Olmedo

Sun 3/1

12:59 am-8:26 am

1 stop31h 27m

$296

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sat 1/24

12:09 pm-5:16 am

2 stops17h 07m

Guayaquil Jose Joaquin de Olmedo

Fri 1/30

1:26 am-5:36 pm

1 stop16h 10m

$303

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sat 1/24

6:35 pm-12:21 am

1 stop29h 46m

Guayaquil Jose Joaquin de Olmedo

Fri 1/30

1:26 am-5:36 pm

1 stop16h 10m

$311

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Sun 2/8

6:00 am-12:21 am

1 stop18h 21m

Guayaquil Jose Joaquin de Olmedo

Sat 2/21

12:59 am-6:02 pm

1 stop17h 03m

$311

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/23

Showing 1-10 of 26 results
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Best time to book a flight from South Carolina to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Guayaquil

What is the cheapest time of day to fly from SC to GYE?

Find hourly flight availability from South Carolina to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 26, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 38% on flights from South Carolina to Guayaquil by exploring options for tickets at noon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Guayaquil from South Carolina?

    Guayaquil Jose Joaquin de Olmedo (GYE), located 2.5 mi from the city center, is the airport you fly into when you book flights from South Carolina to Guayaquil.

  • How long is the flight from South Carolina to Guayaquil?

    There are many flights that can get you from South Carolina to Guayaquil in 17h 07m. Fly via Spirit Airlines or JetBlue to get the fastest option. The distance from South Carolina to Guayaquil is about 2420 mi. This flight may include one or multiple stops.

  • What are the most popular routes from South Carolina to Guayaquil?

    The most popular route from South Carolina to Guayaquil is Charlotte Douglas - Guayaquil Jose Joaquin de Olmedo. You may also consider Charleston - Guayaquil Jose Joaquin de Olmedo or Myrtle Beach Intl - Guayaquil Jose Joaquin de Olmedo.

  • Can I find deals for flights from South Carolina to Guayaquil that include hotel bookings?

    Yes. In addition to deals on South Carolina to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Guayaquil.

  • Can I find deals for business class flights from South Carolina to Guayaquil?

    Yes. Cheapflights offers flight deals from South Carolina to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from South Carolina to Guayaquil

Discover the top airline that operate flights from South Carolina to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$863Average$979FlexibilityNo cancel feeOn-time71%

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