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Guayaquil

$118+ Cheap flights from South Carolina to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GYE
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
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Find flight deals from South Carolina to Guayaquil

Cheapest flights from South Carolina to Guayaquil
Explore the most affordable flight options available from South Carolina to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

This Orbitz deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/98:55 amCLT - GYE
1 stop14h 48mSpirit Airlines
Wed 12/1712:49 amGYE - CLT
2 stops19h 50mSpirit Airlines
Deal found 11/25$353
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/102:58 pmCLT - GYE
2 stops46h 36mMultiple Airlines
Wed 12/1712:49 amGYE - CLT
1 stop8h 50mMultiple Airlines
Deal found 11/24$365
This Kiwi.com deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:38 pmCLT - GYE
2 stops37h 40mMultiple Airlines
Mon 12/2912:49 amGYE - CLT
1 stop8h 50mMultiple Airlines
Deal found 11/26$375
This Mytrip deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/81:57 pmCLT - GYE
1 stop15h 23mMultiple Airlines
Wed 12/1712:49 amGYE - CLT
1 stop8h 50mMultiple Airlines
Deal found 11/24$380
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/118:55 amCLT - GYE
2 stops28h 39mMultiple Airlines
Wed 12/1712:49 amGYE - CLT
1 stop8h 50mMultiple Airlines
Deal found 11/24$381
This Kiwi.com deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:00 amCLT - GYE
2 stops28h 18mMultiple Airlines
Wed 12/316:50 pmGYE - CLT
1 stop21h 06mMultiple Airlines
Deal found 11/26$384
This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:38 pmCLT - GYE
2 stops37h 40mMultiple Airlines
Mon 12/2912:49 amGYE - CLT
1 stop8h 50mMultiple Airlines
Deal found 11/23$387
This KAYAK deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/78:55 amCLT - GYE
1 stop14h 48mSpirit Airlines
Wed 12/1712:49 amGYE - CLT
1 stop8h 50mSpirit Airlines
Deal found 11/25$391
This Spirit Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/89:54 amMYR - GYE
1 stop13h 49mSpirit Airlines
Wed 12/1012:49 amGYE - MYR
1 stop16h 59mSpirit Airlines
Deal found 11/25$483
This Priceline deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:54 amMYR - GYE
1 stop13h 59mSpirit Airlines
Thu 1/112:49 amGYE - MYR
1 stop17h 19mSpirit Airlines
Deal found 11/25$652
This Kiwi.com deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:54 amMYR - GYE
1 stop13h 59mMultiple Airlines
Thu 1/112:49 amGYE - MYR
2 stops17h 22mMultiple Airlines
Deal found 11/25$744
This KAYAK deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2610:18 pmCHS - GYE
1 stop25h 35mSpirit Airlines
Thu 1/112:49 amGYE - CHS
1 stop20h 34mSpirit Airlines
Deal found 11/25$816

Cheap flight deals from South Carolina to Guayaquil

Keep the following information in mind while searching for South Carolina to Guayaquil flight deals. Data was last updated November 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$284
(Spirit Airlines)

One-way from

$118
(KAYAK)
Provider with most accurate pricing for Myrtle Beach Intl-Guayaquil Jose Joaquin de Olmedo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Guayaquil Jose Joaquin de Olmedo flights.
Search Deals
From South Carolina to Guayaquil Jose Joaquin de Olmedo
Search Deals
One-way flight from South Carolina to Guayaquil Jose Joaquin de Olmedo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from South Carolina to Guayaquil that are best for you.

Fly from

South Carolina

Fly to

Guayaquil

Route

Depart

Return

Price

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Sun 1/25

7:00 am-12:21 am

1 stop17h 21m

Guayaquil Jose Joaquin de Olmedo

Tue 1/27

1:26 am-10:58 am

1 stop9h 32m

$286

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Wed 2/4

7:00 am-12:21 am

1 stop17h 21m

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

12:59 am-6:02 pm

1 stop17h 03m

$291

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Fri 1/16

7:00 am-5:20 am

1 stop22h 20m

Guayaquil Jose Joaquin de Olmedo

Fri 2/6

6:50 pm-12:22 pm

1 stop17h 32m

$313

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Sun 1/25

1:24 pm-12:21 am

1 stop10h 57m

Guayaquil Jose Joaquin de Olmedo

Mon 1/26

1:26 am-4:54 pm

2 stops15h 28m

$317

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 1/8

6:56 pm-12:21 am

1 stop29h 25m

Guayaquil Jose Joaquin de Olmedo

Fri 1/16

1:26 am-4:54 pm

2 stops15h 28m

$333

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Sun 2/8

1:24 pm-12:21 am

1 stop10h 57m

Guayaquil Jose Joaquin de Olmedo

Sat 2/21

12:59 am-6:02 pm

1 stop17h 03m

$342

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Mon 1/26

6:10 am-11:22 pm

2 stops17h 12m

Guayaquil Jose Joaquin de Olmedo

Wed 1/28

7:15 am-3:27 pm

2 stops32h 12m

$420

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Mon 12/8

9:54 am-11:43 pm

1 stop13h 49m

Guayaquil Jose Joaquin de Olmedo

Wed 12/10

12:49 am-5:48 pm

1 stop16h 59m

$483

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Mon 1/26

5:53 pm-7:20 am

1 stop13h 27m

Guayaquil Jose Joaquin de Olmedo

Wed 1/28

4:30 pm-11:20 am

1 stop18h 50m

$528

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Tue 12/30

9:54 am-11:53 pm

1 stop13h 59m

Guayaquil Jose Joaquin de Olmedo

Thu 1/1

12:49 am-6:08 pm

1 stop17h 19m

$652

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/24

Showing 1-10 of 19 results
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Best time to book a flight from South Carolina to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Guayaquil

What is the cheapest time of day to fly from SC to GYE?

Find hourly flight availability from South Carolina to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 26, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 38% on flights from South Carolina to Guayaquil by exploring options for tickets at noon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Guayaquil from South Carolina?

    Guayaquil Jose Joaquin de Olmedo (GYE), located 2.5 mi from the city center, is the airport you fly into when you book flights from South Carolina to Guayaquil.

  • How long is the flight from South Carolina to Guayaquil?

    There are many flights that can get you from South Carolina to Guayaquil in 13h 27m. Fly via Spirit Airlines, American Airlines, or Delta to get the fastest option. The distance from South Carolina to Guayaquil is about 2420 mi. This flight may include one or multiple stops.

  • What are the most popular routes from South Carolina to Guayaquil?

    The most popular route from South Carolina to Guayaquil is Charlotte Douglas - Guayaquil Jose Joaquin de Olmedo. You may also consider Charleston - Guayaquil Jose Joaquin de Olmedo or Myrtle Beach Intl - Guayaquil Jose Joaquin de Olmedo.

  • Can I find deals for flights from South Carolina to Guayaquil that include hotel bookings?

    Yes. In addition to deals on South Carolina to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Guayaquil.

  • Can I find deals for business class flights from South Carolina to Guayaquil?

    Yes. Cheapflights offers flight deals from South Carolina to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from South Carolina to Guayaquil

Discover the top airline that operate flights from South Carolina to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$543Average$979FlexibilityNo cancel feeOn-time71%

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