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Guayaquil

$132+ Cheap flights from South Carolina to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GYE
бер. 17 — бер. 241
вт 3/17
вт 3/24
1 adult, Economy
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Cheap flight deals from South Carolina to Guayaquil

Cheapest flights from South Carolina to Guayaquil
Explore the most affordable flight options available from South Carolina to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on лютий 15, 2026.

This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ср 4/296:00 am
CHS
-
GYE
1 stop16h 12m
American Airlines
нд 5/32:31 pm
GYE
-
CHS
1 stop19h 03m
American Airlines
Deal found 2/15$294
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
пн 9/148:43 pm
CHS
-
GYE
2 stops17h 50m
American Airlines
пн 9/212:33 pm
GYE
-
CHS
2 stops20h 38m
American Airlines
Deal found 2/12$295
This Cheapflightsfares deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
вт 6/28:55 am
CLT
-
GYE
1 stop15h 09m
Spirit Airlines
ср 8/2611:59 pm
GYE
-
CLT
1 stop13h 03m
Spirit Airlines
Deal found 2/12$311
This CheapOair deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
вт 4/286:00 am
CLT
-
GYE
1 stop18h 04m
Spirit Airlines
вт 5/511:59 pm
GYE
-
CLT
1 stop9h 18m
Spirit Airlines
Deal found 2/15$332
This Cheapflightsfares deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ср 3/186:00 am
CLT
-
GYE
1 stop18h 04m
Spirit Airlines
вт 3/2411:59 pm
GYE
-
CLT
1 stop19h 18m
Spirit Airlines
Deal found 2/12$338
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
вт 3/171:20 pm
CLT
-
GYE
1 stop10h 44m
Spirit Airlines
пт 3/2011:59 pm
GYE
-
CLT
1 stop23h 39m
Spirit Airlines
Deal found 2/11$339
This CheapOair deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
вт 4/288:55 am
CLT
-
GYE
1 stop15h 09m
Spirit Airlines
ср 5/611:59 pm
GYE
-
CLT
1 stop9h 18m
Spirit Airlines
Deal found 2/15$346
This KAYAK deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
пн 3/91:24 pm
CLT
-
GYE
1 stop10h 40m
Spirit Airlines
вт 3/2411:59 pm
GYE
-
CLT
1 stop19h 18m
Spirit Airlines
Deal found 2/14$348
This Avianca Connect deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
чт 5/143:08 pm
CLT
-
GYE
1 stop15h 27m
Multiple Airlines
нд 5/176:45 pm
GYE
-
CLT
1 stop24h 44m
Multiple Airlines
Deal found 2/11$351
This Avianca deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
пн 9/146:40 pm
CHS
-
GYE
1 stop17h 00m
Multiple Airlines
пн 9/218:00 pm
GYE
-
CHS
1 stop13h 25m
Multiple Airlines
Deal found 2/12$352
This CheapOair deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
чт 3/121:20 pm
CLT
-
GYE
1 stop10h 44m
Spirit Airlines
пт 3/2011:59 pm
GYE
-
CLT
1 stop23h 39m
Spirit Airlines
Deal found 2/14$354
This Avianca deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
сб 3/218:59 pm
CHS
-
GYE
2 stops13h 16m
Multiple Airlines
сб 3/284:05 pm
GYE
-
CHS
1 stop15h 41m
Multiple Airlines
Deal found 2/15$361

Find flight deals from South Carolina to Guayaquil

Keep the following information in mind while searching for South Carolina to Guayaquil flight deals. Data was last updated лютий 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$294
(American Airlines)

One-way from

$132
(Kiwi.com)
Provider with most accurate pricing for Myrtle Beach Intl-Guayaquil Jose Joaquin de Olmedo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Guayaquil Jose Joaquin de Olmedo flights.
Search Deals
From South Carolina to Guayaquil Jose Joaquin de Olmedo
Search Deals
One-way flight from South Carolina to Guayaquil Jose Joaquin de Olmedo
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated лютий 15, 2026.
Use the filters below to find and compare flights from South Carolina to Guayaquil that are best for you.

Fly from

South Carolina

Fly to

Guayaquil

Route

Depart

Return

Price

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

ср 4/29

6:00 am-9:12 pm

1 stop16h 12m

Guayaquil Jose Joaquin de Olmedo

нд 5/3

2:31 pm-10:34 am

1 stop19h 03m

$294

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

вт 4/28

6:00 am-11:01 pm

1 stop18h 01m

Guayaquil Jose Joaquin de Olmedo

вт 5/5

11:59 pm-2:13 pm

1 stop13h 14m

$332

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

ср 3/18

6:00 am-11:04 pm

1 stop18h 04m

Guayaquil Jose Joaquin de Olmedo

вт 3/24

11:59 pm-8:17 pm

1 stop19h 18m

$338

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

вт 3/17

1:20 pm-11:04 pm

1 stop10h 44m

Guayaquil Jose Joaquin de Olmedo

пт 3/20

11:59 pm-12:38 am

1 stop23h 39m

$339

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

вт 4/28

6:00 am-11:04 pm

1 stop18h 04m

Guayaquil Jose Joaquin de Olmedo

ср 5/6

11:59 pm-10:17 am

1 stop9h 18m

$346

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

чт 5/14

3:08 pm-5:35 am

1 stop15h 27m

Guayaquil Jose Joaquin de Olmedo

нд 5/17

6:45 pm-8:29 pm

1 stop24h 44m

$351

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

сб 3/21

8:59 pm-9:15 am

2 stops13h 16m

Guayaquil Jose Joaquin de Olmedo

сб 3/28

4:05 pm-8:46 am

1 stop15h 41m

$361

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

пн 4/6

7:00 am-5:20 am

1 stop23h 20m

Guayaquil Jose Joaquin de Olmedo

пн 4/13

6:45 pm-12:07 pm

1 stop16h 22m

$370

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

пн 3/16

6:28 pm-9:15 am

2 stops39h 47m

Guayaquil Jose Joaquin de Olmedo

пн 3/23

11:59 pm-5:33 pm

1 stop16h 34m

$376

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

пн 3/16

6:28 pm-11:04 pm

1 stop29h 36m

Guayaquil Jose Joaquin de Olmedo

пн 3/23

11:59 pm-5:33 pm

1 stop16h 34m

$380

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/14

Showing 1-10 of 30 results
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Best time to book a flight from South Carolina to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Guayaquil
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Guayaquil from South Carolina?

    Guayaquil Jose Joaquin de Olmedo (GYE), located 2.5 mi from the city center, is the airport you fly into when you book flights from South Carolina to Guayaquil.

  • How long is the flight from South Carolina to Guayaquil?

    There are many flights that can get you from South Carolina to Guayaquil in 16h 12m. Fly via American Airlines or Spirit Airlines to get the fastest option. The distance from South Carolina to Guayaquil is about 2420 mi. This flight may include one or multiple stops.

  • What are the most popular routes from South Carolina to Guayaquil?

    The most popular route from South Carolina to Guayaquil is Charlotte Douglas - Guayaquil Jose Joaquin de Olmedo. You may also consider Charleston - Guayaquil Jose Joaquin de Olmedo or Myrtle Beach Intl - Guayaquil Jose Joaquin de Olmedo.

  • Can I find deals for flights from South Carolina to Guayaquil that include hotel bookings?

    Yes. In addition to deals on South Carolina to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Guayaquil.

  • Can I find deals for business class flights from South Carolina to Guayaquil?

    Yes. Cheapflights offers flight deals from South Carolina to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from South Carolina to Guayaquil

Discover the top airline that operate flights from South Carolina to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated лютий 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$813Average$1,071FlexibilityNo cancel feeOn-time71%

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