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Guayaquil

$164+ Cheap flights from South Carolina to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GYE
Nov 16 — Nov 231
Sun 11/16
Sun 11/23
1 adult, Economy
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Find flight deals from South Carolina to Guayaquil

Cheapest flights from South Carolina to Guayaquil
Explore the most affordable flight options available from South Carolina to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 17, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/710:40 amCHS - GYE
1 stop13h 03mSpirit Airlines
Sat 12/1312:59 amGYE - CHS
1 stop8h 46mSpirit Airlines
Deal found 10/16$328
This Avianca Connect deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/69:38 pmCLT - GYE
2 stops20h 52mMultiple Airlines
Mon 11/106:55 pmGYE - CLT
2 stops18h 05mMultiple Airlines
Deal found 10/15$344
This Avianca Connect deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/311:49 pmCLT - GYE
1 stop16h 31mMultiple Airlines
Tue 11/47:05 pmGYE - CLT
1 stop17h 55mMultiple Airlines
Deal found 10/15$363
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1010:42 pmCLT - GYE
2 stops21h 38mMultiple Airlines
Mon 11/176:50 pmGYE - CLT
1 stop18h 10mMultiple Airlines
Deal found 10/14$375
This Mytrip deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:00 amCLT - GYE
1 stop16h 43mSpirit Airlines
Tue 12/1612:59 amGYE - CLT
1 stop13h 21mSpirit Airlines
Deal found 10/15$378
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/710:40 amCHS - GYE
1 stop13h 03mMultiple Airlines
Sun 12/147:40 pmGYE - CHS
1 stop15h 20mMultiple Airlines
Deal found 10/16$448
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/76:31 pmCHS - GYE
2 stops31h 09mDelta
Sun 12/144:30 pmGYE - CHS
1 stop18h 06mDelta
Deal found 10/16$452
This Avianca Connect deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/79:38 pmCLT - GYE
2 stops11h 37mMultiple Airlines
Sat 11/83:30 amGYE - CLT
2 stops17h 03mMultiple Airlines
Deal found 10/15$498
This United deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/183:53 pmMYR - GYE
2 stops41h 22mMultiple Airlines
Mon 12/112:20 pmGYE - MYR
2 stops48h 15mMultiple Airlines
Deal found 10/15$607
This KAYAK deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:59 pmMYR - GYE
2 stops28h 44mSpirit Airlines
Mon 12/2212:59 amGYE - MYR
1 stop17h 09mSpirit Airlines
Deal found 10/15$746
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/217:00 amCHS - GYE
2 stops13h 10mAmerican Airlines
Fri 10/318:15 amGYE - CHS
2 stops25h 30mAmerican Airlines
Deal found 10/15$768
This SmartFares deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:02 pmCHS - GYE
1 stop20h 08mJetBlue
Thu 1/84:45 pmGYE - CHS
1 stop18h 00mJetBlue
Deal found 10/15$806

Cheap flight deals from South Carolina to Guayaquil

Keep the following information in mind while searching for South Carolina to Guayaquil flight deals. Data was last updated October 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$328
(Cheapflightsfares)

One-way from

$164
(American Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Guayaquil Jose Joaquin de Olmedo flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Guayaquil Jose Joaquin de Olmedo flights.
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From South Carolina to Guayaquil Jose Joaquin de Olmedo
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One-way flight from South Carolina to Guayaquil Jose Joaquin de Olmedo
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Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 17, 2025.
Use the filters below to find and compare flights from South Carolina to Guayaquil that are best for you.

Fly from

South Carolina

Fly to

Guayaquil

Route

Depart

Return

Price

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sun 12/7

10:40 am-11:43 pm

1 stop13h 03m

Guayaquil Jose Joaquin de Olmedo

Sat 12/13

12:59 am-9:45 am

1 stop8h 46m

$328

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Fri 11/7

9:38 pm-2:30 pm

2 stops16h 52m

Guayaquil Jose Joaquin de Olmedo

Sun 11/9

6:55 pm-7:47 am

2 stops12h 52m

$344

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Fri 10/31

1:49 pm-5:20 am

1 stop16h 31m

Guayaquil Jose Joaquin de Olmedo

Tue 11/4

7:05 pm-1:00 pm

1 stop17h 55m

$363

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Mon 12/8

7:00 am-11:43 pm

1 stop16h 43m

Guayaquil Jose Joaquin de Olmedo

Tue 12/16

12:59 am-2:20 pm

1 stop13h 21m

$378

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Mon 11/10

9:38 pm-9:15 am

2 stops11h 37m

Guayaquil Jose Joaquin de Olmedo

Sun 11/16

3:30 am-5:25 pm

2 stops13h 55m

$391

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Tue 3/3

4:43 pm-2:30 pm

1 stop21h 47m

Guayaquil Jose Joaquin de Olmedo

Sun 3/8

2:40 pm-3:48 pm

1 stop24h 08m

$441

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sun 12/7

10:40 am-11:43 pm

1 stop13h 03m

Guayaquil Jose Joaquin de Olmedo

Sun 12/14

7:40 pm-11:00 am

1 stop15h 20m

$448

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sun 12/7

6:31 pm-1:40 am

2 stops31h 09m

Guayaquil Jose Joaquin de Olmedo

Sun 12/14

4:30 pm-10:36 am

1 stop18h 06m

$452

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Tue 3/3

8:37 pm-1:33 pm

2 stops16h 56m

Guayaquil Jose Joaquin de Olmedo

Sun 3/8

2:33 pm-12:09 pm

2 stops20h 36m

$467

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 11/6

9:38 pm-6:30 pm

2 stops20h 52m

Guayaquil Jose Joaquin de Olmedo

Sun 11/9

3:30 am-8:33 pm

2 stops17h 03m

$486

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 31 results
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Best time to book a flight from South Carolina to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Guayaquil

What is the cheapest time of day to fly from SC to GYE?

Find hourly flight availability from South Carolina to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 17, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 38% on flights from South Carolina to Guayaquil by exploring options for tickets at noon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Guayaquil from South Carolina?

    Guayaquil Jose Joaquin de Olmedo (GYE), located 2.5 mi from the city center, is the airport you fly into when you book flights from South Carolina to Guayaquil.

  • How long is the flight from South Carolina to Guayaquil?

    There are many flights that can get you from South Carolina to Guayaquil in 13h 03m. Fly via Spirit Airlines, JetBlue, or Delta to get the fastest option. The distance from South Carolina to Guayaquil is about 2420 mi. This flight may include one or multiple stops.

  • What are the most popular routes from South Carolina to Guayaquil?

    The most popular route from South Carolina to Guayaquil is Charlotte Douglas - Guayaquil Jose Joaquin de Olmedo. You may also consider Myrtle Beach Intl - Guayaquil Jose Joaquin de Olmedo or Charleston - Guayaquil Jose Joaquin de Olmedo.

  • Can I find deals for flights from South Carolina to Guayaquil that include hotel bookings?

    Yes. In addition to deals on South Carolina to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Guayaquil.

  • Can I find deals for business class flights from South Carolina to Guayaquil?

    Yes. Cheapflights offers flight deals from South Carolina to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for South Carolina to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from South Carolina to Guayaquil

Discover the top airline that operate flights from South Carolina to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$519Average$979FlexibilityNo cancel feeOn-time71%

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