How popular is this Panama City to Guayaquil flight route?

The Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

What are the cheapest airlines flying from Panama City to Guayaquil round-trip?

Flying on Copa Airlines is currently your cheapest option to Guayaquil, with prices starting at $330. Additional round-trip tickets that might be worth considering are offered by Avianca and United Airlines, with the lowest prices starting at $338 and $1,373, respectively.

What are the cheapest airlines to fly from Panama City to Guayaquil one-way?

One-way options have recently been found by users for as low as $168 on Avianca. Other airlines that offer cheap prices include Copa Airlines from $180 and United Airlines from $1,109 one-way.

What is the cheapest day to fly from Panama City to Guayaquil?

Travelers seeking maximum savings on their Panama City to Guayaquil flight should consider departing on Wednesday mornings when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Guayaquil ranges from 0.0 - 11.0 inches per month. March is typically the wettest month, when rainfall can reach 11.0 in. July is typically the driest time to visit Guayaquil when rainfall is around 0.0 in.

If weather is an important factor for your trip to Guayaquil, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 77.0 F).

What are the most reliable airlines from Panama City to Guayaquil?

Consider United Airlines (88%), Copa Airlines (85%) or KLM (84%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Guayaquil.

What is the cheapest day to fly round-trip from Panama City to Guayaquil?

Travelers have found that booking a Monday departure is the best way to save up to 33% on the cost of booking your flights compared to booking on days of the week where this route is of high demand.

How far in advance should I book a flight from Panama City to Guayaquil?

When searching for a good deal, it’s best to be prepared for potential fluctuations in price. We recommend booking at least 11 days in advance, which can save you up to 50% on flights from Panama City to Guayaquil compared to booking the week you need them. Waiting 11 days out may not be for everyone, so we have options available for flights within the next two weeks, with the lowest price starting at $154. For sooner than that we have options available in the next 3 days from $232.

What is the cheapest month to fly from Panama City to Guayaquil?

Flights from Panama City to Guayaquil lean towards being more expensive in March. Prices are generally better when you fly from Panama City to Guayaquil in February, with the cheapest ticket starting at $166.

What airports do I use to fly from Panama City to Guayaquil?

You will need to book a flight from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo if you want to fly from Panama City to Guayaquil. At least 2 different airlines have flights from Tocumen Intl (PTY) to Jose Joaquin de Olmedo (GYE) on a regular basis. There are 6 flights to Guayaquil from the Panama City airport per day. If you manage to book one that is nonstop, then you can expect the flight time from PTY to GYE to be around 2h 14m.

Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?

Yes. In addition to deals on Panama City to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Guayaquil?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Guayaquil.

Can I find deals for business class flights from Panama City to Guayaquil?

Yes. Cheapflights offers flight deals from Panama City to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$168+ Flights from Panama City to Guayaquil

Q: How much does it cost to fly round-trip from Panama City to Guayaquil?

Airfare is above average for this route at the moment. Panama City to Guayaquil flights typically cost between $280 and $317 in September. The cheapest round-trip price found within the last 3 days was $330 on Copa Airlines (Sep 10-Oct 1).

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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo are usually found in February or September, booked 10 days in advance, depart on a Tuesday or Monday and return on a Thursday

Cheap flight deals from Panama City to Guayaquil

Round-trip from	$330 (Copa Airlines)
One-way from	$168 (FlightHub)
Popular in	March
Cheapest in	February
Average price	$307

From Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo

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One-way flight from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo

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Highest demand for flights based on searches. 4% potential increase in price ($13 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Panama City to Guayaquil

Cheapest flights from Panama City to Guayaquil
Explore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

Wed 9/1011:31 amPTY - GYE

Nonstop2h 15mCopa Airlines

Wed 10/12:44 pmGYE - PTY

Nonstop2h 11mCopa Airlines

Deal found 7/29

$330

Tue 9/93:20 amPTY - GYE

1 stop6h 35mAvianca

Tue 9/303:35 amGYE - PTY

1 stop12h 55mAvianca

Deal found 7/29

$338

Sat 9/139:01 amPTY - GYE

Nonstop2h 14mMultiple Airlines

Sat 9/206:25 pmGYE - PTY

1 stop5h 45mMultiple Airlines

Deal found 7/30

$378

Wed 9/1010:00 amPTY - GYE

2 stops16h 05mUnited Airlines

Tue 9/303:15 amGYE - PTY

2 stops39h 22mUnited Airlines

Deal found 7/29

$1,373

Best flights from Panama City to Guayaquil
Discover carefully curated flight deals from Panama City to Guayaquil that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2025.

Wed 9/1011:31 amPTY - GYE

Nonstop2h 15mCopa Airlines

Wed 10/12:44 pmGYE - PTY

Nonstop2h 11mCopa Airlines

Deal found 7/29

$330

Tue 9/93:20 amPTY - GYE

1 stop6h 35mAvianca

Tue 9/303:35 amGYE - PTY

1 stop12h 55mAvianca

Deal found 7/29

$338

Sat 9/139:01 amPTY - GYE

Nonstop2h 14mMultiple Airlines

Sat 9/206:25 pmGYE - PTY

1 stop5h 45mMultiple Airlines

Deal found 7/30

$378

Wed 9/1010:00 amPTY - GYE

2 stops16h 05mUnited Airlines

Tue 9/303:15 amGYE - PTY

2 stops39h 22mUnited Airlines

Deal found 7/29

$1,373

Last-minute flights from Panama City to Guayaquil
Discover last-minute flight deals from Panama City to Guayaquil. Data last updated July 30, 2025 and is based on user searches.

Wed 7/303:20 amPTY - GYE

1 stop5h 15mAvianca

Wed 8/1311:05 amGYE - PTY

1 stop5h 25mAvianca

Deal found 7/29

$330

Tue 8/53:20 amPTY - GYE

1 stop6h 35mAvianca

Sun 8/108:50 amGYE - PTY

1 stop7h 40mAvianca

Deal found 7/30

$424

Tue 8/53:20 amPTY - GYE

1 stop5h 15mMultiple Airlines

Sun 8/106:32 pmGYE - PTY

Nonstop2h 09mMultiple Airlines

Deal found 7/30

$457

Wed 8/69:01 amPTY - GYE

Nonstop2h 14mCopa Airlines

Sun 8/106:32 pmGYE - PTY

Nonstop2h 09mCopa Airlines

Deal found 7/30

$398

Wed 8/63:30 pmPTY - GYE

2 stops34h 35mUnited Airlines

Sat 8/93:15 amGYE - PTY

2 stops34h 35mUnited Airlines

Deal found 7/30

$3,197

Wed 8/203:30 pmPTY - GYE

2 stops34h 35mUnited Airlines

Fri 8/293:15 amGYE - PTY

2 stops34h 35mUnited Airlines

Deal found 7/29

$1,639

Thu 8/289:01 amPTY - GYE

Nonstop2h 14mCopa Airlines

Sat 8/302:47 pmGYE - PTY

Nonstop2h 08mCopa Airlines

Deal found 7/29

$339

One-way flights from Panama City to Guayaquil
Search for one-way flight options from Panama City to Guayaquil. Find affordable one-way fares based on user searches. Data last updated July 30, 2025.

Sat 8/303:20 amPTY - GYE

1 stop5h 15mAvianca

Deal found 7/29

$168

Tue 11/259:40 pmPTY - GYE

Nonstop2h 15mCopa Airlines

Deal found 7/29

$180

Fri 8/153:30 pmPTY - GYE

2 stops34h 35mUnited Airlines

Deal found 7/29

$1,109

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 9/10

11:31 am-1:46 pm

Nonstop2h 15m

Guayaquil Jose Joaquin de Olmedo

Wed 10/1

2:44 pm-4:55 pm

Nonstop2h 11m

$330

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Tue 9/9

3:20 am-9:55 am

1 stop6h 35m

Guayaquil Jose Joaquin de Olmedo

Tue 9/30

3:35 am-4:30 pm

1 stop12h 55m

$338

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Sat 9/13

9:01 am-11:15 am

Nonstop2h 14m

Guayaquil Jose Joaquin de Olmedo

Sat 9/20

6:25 pm-12:10 am

1 stop5h 45m

$378

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 9/10

10:00 am-2:05 am

2 stops16h 05m

Guayaquil Jose Joaquin de Olmedo

Tue 9/30

3:15 am-6:37 pm

2 stops39h 22m

$1,373

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Sat 8/30

3:20 am-8:35 am

1 stop5h 15m

$168

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Tue 11/25

9:40 pm-11:55 pm

Nonstop2h 15m

$180

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Fri 8/15

3:30 pm-2:05 am

2 stops34h 35m

$1,109

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Panama City to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Guayaquil

How far ahead should I book a flight from Panama City to Guayaquil?

Booking 10 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Guayaquil. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Guayaquil?

Currently, April is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of $440). Flying from Panama City to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to GYE?

A simple way to save on the total cost of your ticket is to fly from Panama City to Guayaquil in the morning. If you’re flexible enough to do this you can expect to save up to 16% on your trip compared to booking a flight at noon.

How much does it cost to fly round-trip from Panama City to Guayaquil?

Reviews of airlines servicing Guayaquil

See what other customers who have flown with Copa Airlines, United Airlines, and Avianca from Panama City to Guayaquil have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Copa Airlines

7.5

Good

1,493 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Copa Airlines

7.5

Good

1,493 reviews

Copa Airlines

7.5

Good

1,493 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

United Airlines

7.4

Good

8,896 reviews

Copa Airlines

7.5

Good

1,493 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Avianca

6.7

Okay

2,387 reviews

Copa Airlines

7.5

Good

1,493 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Related info for your journey

What airports do I use to fly from Panama City to Guayaquil?
You will need to book a flight from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo if you want to fly from Panama City to Guayaquil. At least 2 different airlines have flights from Tocumen Intl (PTY) to Jose Joaquin de Olmedo (GYE) on a regular basis. There are 6 flights to Guayaquil from the Panama City airport per day. If you manage to book one that is nonstop, then you can expect the flight time from PTY to GYE to be around 2h 14m.
How popular is this Panama City to Guayaquil flight route?
The Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
What are the cheapest airlines flying from Panama City to Guayaquil round-trip?
Flying on Copa Airlines is currently your cheapest option to Guayaquil, with prices starting at $330. Additional round-trip tickets that might be worth considering are offered by Avianca and United Airlines, with the lowest prices starting at $338 and $1,373, respectively.
What are the cheapest airlines to fly from Panama City to Guayaquil one-way?
One-way options have recently been found by users for as low as $168 on Avianca. Other airlines that offer cheap prices include Copa Airlines from $180 and United Airlines from $1,109 one-way.
What are the most reliable airlines from Panama City to Guayaquil?
Consider United Airlines (88%), Copa Airlines (85%) or KLM (84%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Guayaquil.
Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?
Yes. In addition to deals on Panama City to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Guayaquil?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Guayaquil.
Can I find deals for business class flights from Panama City to Guayaquil?
Yes. Cheapflights offers flight deals from Panama City to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Guayaquil?
Currently, April is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of $440). Flying from Panama City to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Panama City to Guayaquil

Panama City to Quito flights

Other flights to Guayaquil

Top 2 airlines flying from Panama City to Guayaquil

Airline	Cheapest	Average	Flexibility	On-time
Copa Airlines	Cheapest$232	Average$307	FlexibilityNo cancel fee	On-time70%
Avianca	Cheapest$232	Average$316	FlexibilityNo cancel fee	On-time71%

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$168+ Cheap flights from Panama City (PTY) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Guayaquil with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo are usually found in February or September, booked 10 days in advance, depart on a Tuesday or Monday and return on a Thursday

Cheap flight deals from Panama City to Guayaquil

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Panama City to Guayaquil

Cheapest flights from Panama City to GuayaquilExplore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

Explore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.

Best time to book a flight from Panama City to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Guayaquil

How far ahead should I book a flight from Panama City to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Guayaquil. Price data was last updated on July 25, 2025.

What is the cheapest month to book a flight from Panama City to Guayaquil?

What is the cheapest time of day to fly from PTY to GYE?

Find hourly flight availability from Panama City to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

How much does it cost to fly round-trip from Panama City to Guayaquil?

Reviews of airlines servicing Guayaquil

See what other customers who have flown with Copa Airlines, United Airlines, and Avianca from Panama City to Guayaquil have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Panama City to Guayaquil?

How popular is this Panama City to Guayaquil flight route?

What are the cheapest airlines flying from Panama City to Guayaquil round-trip?

What are the cheapest airlines to fly from Panama City to Guayaquil one-way?

What are the most reliable airlines from Panama City to Guayaquil?

Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?

How can I find direct flights from Panama City to Guayaquil?

Can I find deals for business class flights from Panama City to Guayaquil?

What is the cheapest month to book a flight from Panama City to Guayaquil?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Panama City to Guayaquil

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Cheapest flights from Panama City to Guayaquil
Explore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.