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Guayaquil

$194+ Cheap flights from Panama City (PTY) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GYE
Apr 13 — Apr 201
Mon 4/13
Mon 4/20
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo are usually found in May or June, booked 79 days in advance, depart on a Wednesday or Monday and return on a Friday

Cheap flight deals from Panama City to Guayaquil

Cheapest flights from Panama City to Guayaquil
Explore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 14, 2026.

This FlightHub deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:50 pm
PTY
-
GYE
1 stop5h 45m
Avianca
Sat 3/2110:25 am
GYE
-
PTY
1 stop6h 30m
Avianca
Deal found 3/9$372
This Copa Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/109:02 am
PTY
-
GYE
Nonstop2h 16m
Copa Airlines
Sat 3/212:35 pm
GYE
-
PTY
Nonstop2h 09m
Copa Airlines
Deal found 3/9$375
This FlightHub deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/132:55 pm
PTY
-
GYE
1 stop8h 40m
Avianca
Sun 3/156:55 pm
GYE
-
PTY
1 stop6h 05m
Avianca
Deal found 3/10$382
This Trip.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:10 am
PTY
-
GYE
1 stop7h 25m
Avianca
Sun 5/319:05 am
GYE
-
PTY
1 stop7h 55m
Avianca
Deal found 3/14$386
This Copa Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:48 pm
PTY
-
GYE
Nonstop2h 14m
Copa Airlines
Sun 4/56:33 pm
GYE
-
PTY
Nonstop2h 07m
Copa Airlines
Deal found 3/10$391
This Trip.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1510:10 am
PTY
-
GYE
1 stop4h 25m
Avianca
Fri 7/316:50 pm
GYE
-
PTY
1 stop5h 45m
Avianca
Deal found 3/12$398
This Copa Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:21 am
PTY
-
GYE
Nonstop2h 14m
Copa Airlines
Sat 4/254:29 am
GYE
-
PTY
Nonstop2h 12m
Copa Airlines
Deal found 3/10$408
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/109:02 am
PTY
-
GYE
Nonstop2h 16m
Multiple Airlines
Sat 3/214:40 am
GYE
-
PTY
1 stop9h 20m
Multiple Airlines
Deal found 3/9$414
This Copa Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:39 pm
PTY
-
GYE
Nonstop2h 14m
Copa Airlines
Fri 7/318:27 am
GYE
-
PTY
Nonstop2h 13m
Copa Airlines
Deal found 3/13$418
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:48 pm
PTY
-
GYE
Nonstop2h 14m
Multiple Airlines
Sun 4/510:05 am
GYE
-
PTY
1 stop6h 55m
Multiple Airlines
Deal found 3/9$420
This Avianca deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/710:10 am
PTY
-
GYE
1 stop4h 25m
Avianca
Fri 5/154:40 pm
GYE
-
PTY
2 stops7h 55m
Avianca
Deal found 3/9$425
This Trip.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:55 pm
PTY
-
GYE
1 stop18h 20m
Avianca
Fri 3/2710:25 am
GYE
-
PTY
1 stop6h 30m
Avianca
Deal found 3/10$426

Find flight deals from Panama City to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$375
(Copa Airlines)

One-way from

$194
(Copa Airlines)

Popular in

January

Cheapest in

May

Average price

$339

Good one-way deal

$188 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Guayaquil Jose Joaquin de Olmedo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Guayaquil Jose Joaquin de Olmedo flights.
Search Deals
From Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo
Search Deals
One-way flight from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($15 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($3 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2026.
Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Thu 5/7

11:21 am-1:33 pm

Nonstop2h 12m

Guayaquil Jose Joaquin de Olmedo

Fri 5/15

4:29 am-6:41 am

Nonstop2h 12m

$375

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Thu 4/2

10:10 am-2:35 pm

1 stop4h 25m

Guayaquil Jose Joaquin de Olmedo

Sun 4/5

10:05 am-5:00 pm

1 stop6h 55m

$375

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 4/22

9:48 pm-12:02 am

Nonstop2h 14m

Guayaquil Jose Joaquin de Olmedo

Tue 4/28

2:43 pm-4:55 pm

Nonstop2h 12m

$375

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Thu 5/7

5:55 pm-11:30 pm

1 stop5h 35m

Guayaquil Jose Joaquin de Olmedo

Thu 5/14

3:30 am-9:15 am

1 stop5h 45m

$375

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 4/1

11:21 am-1:35 pm

Nonstop2h 14m

Guayaquil Jose Joaquin de Olmedo

Fri 5/1

4:29 am-6:41 am

Nonstop2h 12m

$375

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Thu 4/16

11:21 am-1:35 pm

Nonstop2h 14m

Guayaquil Jose Joaquin de Olmedo

Thu 4/30

12:22 pm-2:34 pm

Nonstop2h 12m

$375
Quickest round-trip

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Mon 4/13

9:48 pm-12:02 am

Nonstop2h 14m

Guayaquil Jose Joaquin de Olmedo

Sun 4/19

6:33 pm-8:40 pm

Nonstop2h 07m

$375

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Thu 4/2

11:21 am-1:35 pm

Nonstop2h 14m

Guayaquil Jose Joaquin de Olmedo

Sun 4/5

12:22 pm-2:34 pm

Nonstop2h 12m

$375

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 7/15

10:10 am-2:35 pm

1 stop4h 25m

Guayaquil Jose Joaquin de Olmedo

Fri 7/31

6:50 pm-12:35 am

1 stop5h 45m

$398

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 4/22

9:48 pm-12:02 am

Nonstop2h 14m

Guayaquil Jose Joaquin de Olmedo

Sat 4/25

4:29 am-6:41 am

Nonstop2h 12m

$408

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/10

Showing 1-10 of 19 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Panama City-Guayaquil flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Guayaquil flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Guayaquil flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Guayaquil flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Guayaquil

How far ahead should I book a flight from Panama City to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Guayaquil. Price data was last updated on March 6, 2026.

Booking 79 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Guayaquil. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Guayaquil?

Currently, May is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of $122). Flying from Panama City to Guayaquil in November is currently the most expensive (average of $312). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to GYE?

Find hourly flight availability from Panama City to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 14, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Guayaquil as you normally would.

How much does it cost to fly round-trip from Panama City to Guayaquil?

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated March 14, 2026.
See what other customers who have flown with Copa Airlines and Avianca from Panama City to Guayaquil have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,570 reviews

Entertainment

6.8

Boarding

7.8

Crew

8.1

Overall

7.5

Comfort

7.4

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Copa Airlines
7.5
Good
1,570 reviews
Copa Airlines
7.5
Good
1,570 reviews

Entertainment

6.8

Boarding

7.8

Crew

8.1

Overall

7.5

Comfort

7.4

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Avianca
6.5
Okay
2,499 reviews
Copa Airlines
7.5
Good
1,570 reviews

Entertainment

6.8

Boarding

7.8

Crew

8.1

Overall

7.5

Comfort

7.4

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Guayaquil?

    You will need to book a flight from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo if you want to fly from Panama City to Guayaquil. At least 2 different airlines have flights from Tocumen Intl (PTY) to Jose Joaquin de Olmedo (GYE) on a regular basis. There are 14 flights to Guayaquil from the Panama City airport per day. If you manage to book one that is nonstop, then you can expect the flight time from PTY to GYE to be around 2h 14m.

  • How popular is this Panama City to Guayaquil flight route?

    The Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Guayaquil?

    For as low as $375, Copa Airlines can have you in Guayaquil from Panama City in 2h 12m. Panama City and Guayaquil are separated by a distance of 776 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City to Guayaquil round-trip?

    Flying on Copa Airlines is currently your cheapest option to Guayaquil, with prices starting at $125. Another option worth looking into is Avianca, starting at $177 round trip. Users have found that Copa Airlines is 61% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Panama City to Guayaquil?

    Consider United Airlines (91%), KLM (91%) or Air France (90%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Guayaquil.

  • What are the cheapest flights from Panama City to Guayaquil?

    Looking for the cheapest flight from Panama City to Guayaquil? While on average our users pay $188, our data indicates the cheapest price to be $145. The most popular route (Panama City Tocumen Intl - Guayaquil Jose Joaquin de Olmedo), is priced around $418.

  • Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Panama City to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Guayaquil.

  • Can I find deals for business class flights from Panama City to Guayaquil?

    Yes. Cheapflights offers flight deals from Panama City to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Guayaquil?

    Currently, May is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of $122). Flying from Panama City to Guayaquil in November is currently the most expensive (average of $312). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Guayaquil

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Top 2 airlines flying from Panama City to Guayaquil

Discover the top 2 airlines that operate flights from Panama City to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$125Average$347FlexibilityNo cancel feeOn-time70%
AviancaCheapest$177Average$339FlexibilityNo cancel feeOn-time71%

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