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Guayaquil

$164+ Cheap flights from Panama City (PTY) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GYE
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo are usually found in February or May, booked 10 days in advance, depart on a Saturday or Monday and return on a Friday

Cheap flight deals from Panama City to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$330
(Avianca)

One-way from

$164
(Mytrip)

Popular in

March

Cheapest in

February

Average price

$330

Good round-trip deal

$347 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Guayaquil Jose Joaquin de Olmedo flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Guayaquil Jose Joaquin de Olmedo flights.
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From Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo
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One-way flight from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo
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Highest demand for flights based on searches. 2% potential increase in price ($7 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo.
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Find flight deals from Panama City to Guayaquil

Cheapest flights from Panama City to Guayaquil
Explore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This Avianca deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/192:55 amPTY - GYE
1 stop6h 20mAvianca
Mon 12/13:30 amGYE - PTY
1 stop5h 20mAvianca
Deal found 10/27$330
This Avianca deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/92:55 amPTY - GYE
1 stop6h 20mAvianca
Tue 1/66:55 pmGYE - PTY
1 stop6h 05mAvianca
Deal found 10/28$341
This Copa Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/219:02 amPTY - GYE
Nonstop2h 16mCopa Airlines
Thu 1/86:33 pmGYE - PTY
Nonstop2h 08mCopa Airlines
Deal found 10/28$348
This Avianca deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/132:55 amPTY - GYE
2 stops9h 35mAvianca
Wed 1/73:35 pmGYE - PTY
1 stop9h 05mAvianca
Deal found 10/28$351
This Copa Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2411:19 amPTY - GYE
Nonstop2h 17mCopa Airlines
Wed 12/312:20 pmGYE - PTY
Nonstop2h 12mCopa Airlines
Deal found 10/28$355
This Avianca deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/292:55 amPTY - GYE
2 stops8h 30mAvianca
Sat 11/83:30 amGYE - PTY
1 stop5h 20mAvianca
Deal found 10/28$362
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:50 pmPTY - GYE
1 stop15h 25mAvianca
Thu 11/66:55 pmGYE - PTY
1 stop6h 05mAvianca
Deal found 10/28$370

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.

Fly from

Panama City

Fly to

Guayaquil

Route

Depart

Return

Price

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 11/19

2:55 am-9:15 am

1 stop6h 20m

Guayaquil Jose Joaquin de Olmedo

Tue 12/2

6:55 pm-1:00 am

1 stop6h 05m

$330

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Mon 11/24

9:45 am-5:45 pm

1 stop8h 00m

Guayaquil Jose Joaquin de Olmedo

Wed 12/3

3:35 pm-12:40 am

1 stop9h 05m

$330

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Thu 11/20

9:02 am-11:18 am

Nonstop2h 16m

Guayaquil Jose Joaquin de Olmedo

Tue 12/2

12:20 pm-2:32 pm

Nonstop2h 12m

$348

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Mon 12/22

6:27 pm-8:43 pm

Nonstop2h 16m

Guayaquil Jose Joaquin de Olmedo

Mon 12/29

6:34 pm-8:41 pm

Nonstop2h 07m

$348

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Thu 4/9

6:27 pm-8:46 pm

Nonstop2h 19m

Guayaquil Jose Joaquin de Olmedo

Thu 4/16

6:33 pm-8:41 pm

Nonstop2h 08m

$348

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Tue 12/23

6:27 pm-8:43 pm

Nonstop2h 16m

Guayaquil Jose Joaquin de Olmedo

Sun 1/4

12:20 pm-2:28 pm

Nonstop2h 08m

$348

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 12/17

11:17 am-1:34 pm

Nonstop2h 17m

Guayaquil Jose Joaquin de Olmedo

Mon 1/12

4:33 am-6:41 am

Nonstop2h 08m

$348

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Sat 11/15

9:45 am-2:30 pm

1 stop4h 45m

$164

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 11/5

2:55 am-9:15 am

1 stop6h 20m

$171

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Fri 12/5

5:50 pm-1:05 am

1 stop7h 15m

$171

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 16 results
1
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Compare providers for flights from Panama City to Guayaquil

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Guayaquil in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Guayaquil flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Guayaquil flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Guayaquil flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Guayaquil flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Guayaquil

How far ahead should I book a flight from Panama City to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Guayaquil. Price data was last updated on October 24, 2025.

Booking 10 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Guayaquil. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Guayaquil?

Currently, May is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of $122). Flying from Panama City to Guayaquil in March is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to GYE?

Find hourly flight availability from Panama City to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 29, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Guayaquil as you normally would.

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated October 29, 2025.
See what other customers who have flown with Copa Airlines and Avianca from Panama City to Guayaquil have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,563 reviews

Boarding

7.8

Crew

8.1

Overall

7.6

Food

6.8

Entertainment

6.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,563 reviews
Copa Airlines
7.6
Good
1,563 reviews

Boarding

7.8

Crew

8.1

Overall

7.6

Food

6.8

Entertainment

6.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,467 reviews
Copa Airlines
7.6
Good
1,563 reviews

Boarding

7.8

Crew

8.1

Overall

7.6

Food

6.8

Entertainment

6.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Guayaquil?

    You will need to book a flight from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo if you want to fly from Panama City to Guayaquil. At least 2 different airlines have flights from Tocumen Intl (PTY) to Jose Joaquin de Olmedo (GYE) on a regular basis. There are 9 flights to Guayaquil from the Panama City airport per day. If you manage to book one that is nonstop, then you can expect the flight time from PTY to GYE to be around 2h 15m.

  • How popular is this Panama City to Guayaquil flight route?

    The Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Guayaquil?

    For as low as $348, Avianca can have you in Guayaquil from Panama City in 2h 16m. Panama City and Guayaquil are separated by a distance of 776 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City to Guayaquil round-trip?

    Flying on Copa Airlines is currently your cheapest option to Guayaquil, with prices starting at $232. Another option worth looking into is Avianca, starting at $232 round trip. Users have found that Copa Airlines is 27% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Panama City to Guayaquil?

    Consider KLM (95%), United Airlines (94%) or Air France (93%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Guayaquil.

  • What are the cheapest flights from Panama City to Guayaquil?

    Looking for the cheapest flight from Panama City to Guayaquil? While on average our users pay $347, our data indicates the cheapest price to be $347. The most popular route (Panama City Tocumen Intl - Guayaquil Jose Joaquin de Olmedo), is priced around $348.

  • Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Panama City to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Guayaquil.

  • Can I find deals for business class flights from Panama City to Guayaquil?

    Yes. Cheapflights offers flight deals from Panama City to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Guayaquil?

    Currently, May is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of $122). Flying from Panama City to Guayaquil in March is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Panama City to Guayaquil

Discover the top 2 airlines that operate flights from Panama City to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$232Average$321FlexibilityNo cancel feeOn-time70%
AviancaCheapest$232Average$330FlexibilityNo cancel feeOn-time71%

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