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Guayaquil

$171+ Cheap flights from Panama City (PTY) to Guayaquil (GYE)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GYE
Oct 13 — Oct 201
Mon 10/13
Mon 10/20
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo are usually found in February or May, booked 10 days in advance, depart on a Friday or Monday and return on a Friday

Cheap flight deals from Panama City to Guayaquil

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 13, 2025.

Round-trip from

$329
(Avianca)

One-way from

$171
(Priceline)

Popular in

March

Cheapest in

February

Average price

$317
From Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo
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One-way flight from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo
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Highest demand for flights based on searches. 3% potential increase in price ($10 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Panama City to Guayaquil

Cheapest flights from Panama City to Guayaquil
Explore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2025.

This Avianca deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/303:20 amPTY - GYE
1 stop5h 15mAvianca
Thu 10/24:15 amGYE - PTY
1 stop4h 40mAvianca
Deal found 9/11$329
This Priceline deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/93:20 amPTY - GYE
1 stop5h 15mAvianca
Wed 10/154:15 amGYE - PTY
1 stop5h 55mAvianca
Deal found 9/12$330
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3011:17 amPTY - GYE
Nonstop2h 15mCopa Airlines
Sat 11/84:31 amGYE - PTY
Nonstop2h 08mCopa Airlines
Deal found 9/11$339
This Priceline deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1210:05 pmPTY - GYE
1 stop10h 30mAvianca
Sun 9/148:50 amGYE - PTY
1 stop12h 20mAvianca
Deal found 9/10$341
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:40 pmPTY - GYE
Nonstop2h 13mCopa Airlines
Sat 11/84:31 amGYE - PTY
Nonstop2h 08mCopa Airlines
Deal found 9/11$348
This Avianca deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/252:55 amPTY - GYE
2 stops9h 15mAvianca
Mon 12/16:55 pmGYE - PTY
1 stop5h 45mAvianca
Deal found 9/12$350
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/19:02 amPTY - GYE
Nonstop2h 16mCopa Airlines
Sat 11/154:31 amGYE - PTY
Nonstop2h 08mCopa Airlines
Deal found 9/11$355
This Avianca deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:55 amPTY - GYE
1 stop6h 20mAvianca
Sun 11/93:30 amGYE - PTY
1 stop5h 20mAvianca
Deal found 9/12$357
This Copa Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/109:01 amPTY - GYE
Nonstop2h 14mCopa Airlines
Wed 10/156:33 pmGYE - PTY
Nonstop2h 08mCopa Airlines
Deal found 9/12$358
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3011:17 amPTY - GYE
Nonstop2h 15mCopa Airlines
Sun 11/94:31 amGYE - PTY
Nonstop2h 08mCopa Airlines
Deal found 9/11$364

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 13, 2025.
Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.

Fly from

Panama City

Fly to

Guayaquil

Route

Depart

Return

Price

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 10/1

11:00 am-5:20 pm

1 stop6h 20m

Guayaquil Jose Joaquin de Olmedo

Wed 10/1

3:35 am-8:55 am

1 stop5h 20m

$329

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Tue 9/30

3:20 am-8:35 am

1 stop5h 15m

Guayaquil Jose Joaquin de Olmedo

Thu 10/9

9:45 am-4:30 pm

1 stop6h 45m

$330

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Fri 10/10

11:00 am-5:20 pm

1 stop6h 20m

Guayaquil Jose Joaquin de Olmedo

Wed 10/15

11:05 am-4:30 pm

1 stop5h 25m

$330

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Tue 11/25

2:55 am-9:15 am

1 stop6h 20m

Guayaquil Jose Joaquin de Olmedo

Mon 12/1

6:55 pm-12:40 am

1 stop5h 45m

$330

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Mon 12/22

9:40 pm-11:57 pm

Nonstop2h 17m

Guayaquil Jose Joaquin de Olmedo

Mon 12/29

6:34 pm-8:41 pm

Nonstop2h 07m

$339

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Fri 10/24

9:01 am-11:15 am

Nonstop2h 14m

Guayaquil Jose Joaquin de Olmedo

Sun 10/26

2:54 pm-5:05 pm

Nonstop2h 11m

$339

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Thu 10/16

9:01 am-11:15 am

Nonstop2h 14m

Guayaquil Jose Joaquin de Olmedo

Wed 10/29

2:54 pm-5:05 pm

Nonstop2h 11m

$339

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 10/29

9:40 pm-11:53 pm

Nonstop2h 13m

Guayaquil Jose Joaquin de Olmedo

Sat 11/8

4:31 am-6:39 am

Nonstop2h 08m

$339

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Wed 10/1

11:00 am-11:20 pm

1 stop12h 20m

$171

Panama CityGuayaquil

PTY - GYE

PTYGYE

Panama City Tocumen Intl

Thu 10/16

11:31 am-1:46 pm

Nonstop2h 15m

$180

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 17 results
1
2

Best time to book a flight from Panama City to Guayaquil

Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Guayaquil

How far ahead should I book a flight from Panama City to Guayaquil?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Guayaquil. Price data was last updated on September 12, 2025.

Booking 10 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Guayaquil. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Guayaquil?

Currently, April is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of $440). Flying from Panama City to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to GYE?

Find hourly flight availability from Panama City to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 13, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City to Guayaquil in the afternoon. If you’re flexible enough to do this you can expect to save up to 18% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Guayaquil

Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated September 13, 2025.
See what other customers who have flown with Copa Airlines and Avianca from Panama City to Guayaquil have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Crew

8.1

Overall

7.6

Entertainment

6.8

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Crew

8.1

Overall

7.6

Entertainment

6.8

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,435 reviews
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Crew

8.1

Overall

7.6

Entertainment

6.8

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Guayaquil?

    You will need to book a flight from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo if you want to fly from Panama City to Guayaquil. At least 2 different airlines have flights from Tocumen Intl (PTY) to Jose Joaquin de Olmedo (GYE) on a regular basis. There are 8 flights to Guayaquil from the Panama City airport per day. If you manage to book one that is nonstop, then you can expect the flight time from PTY to GYE to be around 2h 14m.

  • How popular is this Panama City to Guayaquil flight route?

    The Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Guayaquil?

    For as low as $329, Avianca can have you in Guayaquil from Panama City in 6h 20m. Panama City and Guayaquil are separated by a distance of 776 mi.

  • What are the cheapest airlines flying from Panama City to Guayaquil round-trip?

    Flying on Copa Airlines is currently your cheapest option to Guayaquil, with prices starting at $232. Another option worth looking into is Avianca, starting at $232 round trip. Users have found that Copa Airlines is 26% cheaper than the other options available to this destination.

  • What are the most reliable airlines from Panama City to Guayaquil?

    Consider United Airlines (91%), Copa Airlines (89%) or KLM (87%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Guayaquil.

  • Can I find deals for flights from Panama City to Guayaquil that include hotel bookings?

    Yes. In addition to deals on Panama City to Guayaquil flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Guayaquil?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Guayaquil.

  • Can I find deals for business class flights from Panama City to Guayaquil?

    Yes. Cheapflights offers flight deals from Panama City to Guayaquil by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Guayaquil?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of $440). Flying from Panama City to Guayaquil in December is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to Guayaquil

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Quito flights

Top 2 airlines flying from Panama City to Guayaquil

Discover the top 2 airlines that operate flights from Panama City to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$232Average$307FlexibilityNo cancel feeOn-time70%
AviancaCheapest$232Average$330FlexibilityNo cancel feeOn-time71%

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