$389+ Cheap flights from Greenville (GSP) to Guayaquil (GYE)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/1. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — GYE
Oct 24 — Oct 311
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Greenville to Guayaquil with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to Guayaquil
Cheapest
Best
Last-minute
One-way
Cheapest flights from Greenville to GuayaquilExplore the most affordable flight options available from Greenville to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
Explore the most affordable flight options available from Greenville to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:41 pm -
2 stops18h 53m
Wed 11/116:00 am -
2 stops16h 59m
Deal found 9/20![American Airlines logo]()
$671
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:12 pm -
1 stop18h 22m
Tue 11/246:00 am -
1 stop13h 46m
Deal found 9/23![American Airlines logo]()
$686
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:08 pm -
1 stop18h 21m
Mon 11/96:00 am -
1 stop17h 24m
Deal found 9/23![American Airlines logo]()
$711
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:12 pm -
1 stop27h 04m
Sat 11/146:00 am -
1 stop13h 42m
Deal found 9/23![American Airlines logo]()
$722
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:58 pm -
2 stops20h 33m
Mon 12/146:00 am -
2 stops14h 53m
Deal found 9/20![American Airlines logo]()
$854
This KAYAK deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:58 pm -
2 stops20h 33m
Mon 12/146:00 am -
1 stop17h 52m
Deal found 9/20![GOL logo]()
$1,191
This Ovago deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:02 pm -
2 stops20h 28m
Sat 1/23:30 pm -
2 stops20h 24m
Deal found 9/21![GOL logo]()
$1,544
Best flights from Greenville to GuayaquilDiscover carefully curated flight deals from Greenville to Guayaquil that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
Discover carefully curated flight deals from Greenville to Guayaquil that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:52 pm -
2 stops18h 42m
Sat 11/146:00 am -
1 stop17h 52m
Deal found 9/23![American Airlines logo]()
$716
This KAYAK deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:58 pm -
2 stops20h 33m
Mon 12/146:00 am -
1 stop17h 52m
Deal found 9/20![GOL logo]()
$1,191
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/167:14 am -
1 stop15h 28m
Sat 2/277:11 am -
1 stop16h 47m
Deal found 9/23![American Airlines logo]()
$738
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:58 pm -
2 stops20h 33m
Mon 12/146:00 am -
2 stops14h 53m
Deal found 9/20![American Airlines logo]()
$854
This Ovago deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:02 pm -
2 stops20h 28m
Sat 1/23:30 pm -
2 stops20h 24m
Deal found 9/21![GOL logo]()
$1,544
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:02 pm -
2 stops20h 28m
Sat 1/26:00 am -
1 stop18h 55m
Deal found 9/21![American Airlines logo]()
$1,568
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:26 am -
3 stops13h 14m
Sat 11/142:47 pm -
2 stops19h 15m
Deal found 9/23![United Airlines logo]()
$7,941
Last-minute flights from Greenville to GuayaquilDiscover last-minute flight deals from Greenville to Guayaquil. Data last updated September 24, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to Guayaquil. Data last updated September 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:08 pm -
1 stop18h 21m
Mon 11/96:00 am -
1 stop17h 24m
Deal found 9/23![American Airlines logo]()
$711
One-way flights from Greenville to GuayaquilSearch for one-way flight options from Greenville to Guayaquil. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
Search for one-way flight options from Greenville to Guayaquil. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/18:57 pm -
3 stops26h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/72:58 pm -
3 stops44h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:12 pm -
1 stop18h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![American Airlines logo]()
$462
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/77:41 pm -
2 stops18h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![American Airlines logo]()
$468
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/17:14 am -
1 stop15h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$480
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:26 am -
3 stops13h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![United Airlines logo]()
$3,955
Find flight deals from Greenville to Guayaquil
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 24, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $671 (American Airlines) |
One-way from | $389 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
Use the filters below to find and compare flights from Greenville to Guayaquil that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleGuayaquil
GSP Greenville - GYE Guayaquil Jose Joaquin de Olmedo
GSPGYE
Greenville
Mon 3/1
8:57 pm-11:41 pm
3 stops26h 44m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$389
GreenvilleGuayaquil
GSP Greenville - GYE Guayaquil Jose Joaquin de Olmedo
GSPGYE
Greenville
Mon 12/7
2:58 pm-11:22 am
3 stops44h 24m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$423
GreenvilleGuayaquil
GSP Greenville - GYE Guayaquil Jose Joaquin de Olmedo
GSPGYE
Greenville
Sun 11/1
8:12 pm-2:34 pm
1 stop18h 22m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$462
GreenvilleGuayaquil
GSP Greenville - GYE Guayaquil Jose Joaquin de Olmedo
GSPGYE
Greenville
Mon 12/7
7:41 pm-2:31 pm
2 stops18h 50m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$468
GreenvilleGuayaquil
GSP Greenville - GYE Guayaquil Jose Joaquin de Olmedo
GSPGYE
Greenville
Mon 3/1
7:14 am-10:42 pm
1 stop15h 28m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$480
GreenvilleGuayaquil
GSP Greenville - GYE Guayaquil Jose Joaquin de Olmedo
GSPGYE
Greenville
Sat 11/7
7:52 pm-2:34 pm
2 stops18h 42m
Guayaquil Jose Joaquin de Olmedo
Sat 11/14
6:00 am-11:52 pm
1 stop17h 52m
$716
GreenvilleGuayaquil
GSP Greenville - GYE Guayaquil Jose Joaquin de Olmedo
GSPGYE
Greenville
Tue 2/16
7:14 am-10:42 pm
1 stop15h 28m
Guayaquil Jose Joaquin de Olmedo
Sat 2/27
7:11 am-11:58 pm
1 stop16h 47m
$738
GreenvilleGuayaquil
GSP Greenville - GYE Guayaquil Jose Joaquin de Olmedo
GSPGYE
Greenville
Fri 12/11
5:58 pm-2:31 pm
2 stops20h 33m
Guayaquil Jose Joaquin de Olmedo
Mon 12/14
6:00 am-8:53 pm
2 stops14h 53m
$854
GreenvilleGuayaquil
GSP Greenville - GYE Guayaquil Jose Joaquin de Olmedo
GSPGYE
Greenville
Fri 12/11
5:58 pm-2:31 pm
2 stops20h 33m
Guayaquil Jose Joaquin de Olmedo
Mon 12/14
6:00 am-11:52 pm
1 stop17h 52m
$1,191
GreenvilleGuayaquil
GSP Greenville - GYE Guayaquil Jose Joaquin de Olmedo
GSPGYE
Greenville
Tue 12/22
6:02 pm-2:30 pm
2 stops20h 28m
Guayaquil Jose Joaquin de Olmedo
Sat 1/2
3:30 pm-11:54 am
2 stops20h 24m
$1,544
Showing 1-10 of 13 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Greenville-Guayaquil flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Greenville-Guayaquil flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Greenville-Guayaquil flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-Guayaquil flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to Guayaquil
Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Greenville with our price prediction graph.
GSP-GYE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Guayaquil
Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated September 24, 2026.
See what other customers who have flown with American Airlines from Greenville to Guayaquil have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.4
Comfort
7.2
Crew
7.9
Overall
7.0
Entertainment
6.8
Food
6.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Boarding
7.4
Comfort
7.2
Crew
7.9
Overall
7.0
Entertainment
6.8
Food
6.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Greenville to Guayaquil. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Guayaquil flight routes
Other flight options
Other flights from Greenville
Popular flights
Alternative routes for Greenville to Guayaquil
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Guayaquil by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Greenville to Guayaquil by cabin class
Find flights from Greenville to Guayaquil, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Guayaquil
Explore flights to Guayaquil departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 24, 2026.
Greenville and Guayaquil flights
Browse other Greenville and Guayaquil flight options. Last updated on September 24, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on September 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Greenville to Guayaquil
Discover the top airline that operate flights from Greenville to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$664 | Average$938 | FlexibilityNo cancel fee | On-time71% |