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$220+ Cheap flights from Panama City, FL to Greenville (ECP - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/4. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — GSP
Jan 21 — Jan 281
Wed 1/21
Wed 1/28
1 adult, Economy
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Cheap flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 22, 2025.

This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:09 pmECP - GSP
1 stop4h 34mAmerican Airlines
Wed 1/218:09 amGSP - ECP
1 stop4h 24mAmerican Airlines
Deal found 12/21$340
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:09 pmECP - GSP
1 stop4h 34mAmerican Airlines
Thu 1/2212:09 pmGSP - ECP
1 stop6h 24mAmerican Airlines
Deal found 12/21$349
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:09 pmECP - GSP
1 stop4h 34mAmerican Airlines
Mon 1/198:09 amGSP - ECP
1 stop4h 24mAmerican Airlines
Deal found 12/21$379
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/297:02 pmECP - GSP
1 stop3h 30mDelta
Sun 1/185:40 amGSP - ECP
1 stop4h 24mDelta
Deal found 12/21$393
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/292:04 pmECP - GSP
1 stop4h 09mDelta
Wed 1/215:40 amGSP - ECP
1 stop3h 59mDelta
Deal found 12/21$414
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/297:02 pmECP - GSP
1 stop3h 30mDelta
Thu 1/223:05 pmGSP - ECP
1 stop5h 45mDelta
Deal found 12/21$423
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:09 pmECP - GSP
1 stop4h 34mAmerican Airlines
Fri 1/236:00 amGSP - ECP
1 stop6h 33mAmerican Airlines
Deal found 12/21$434
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:02 amECP - GSP
1 stop2h 56mDelta
Fri 1/237:46 pmGSP - ECP
1 stop3h 52mDelta
Deal found 12/21$442
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2911:11 amECP - GSP
1 stop5h 42mAmerican Airlines
Wed 1/217:00 amGSP - ECP
2 stops11h 33mAmerican Airlines
Deal found 12/21$449
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2911:11 amECP - GSP
1 stop3h 24mAmerican Airlines
Thu 1/227:00 amGSP - ECP
2 stops11h 33mAmerican Airlines
Deal found 12/21$458

Find flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 22, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$333
(United Airlines)

One-way from

$220
(Delta)

Popular in

April

Cheapest in

September

Average price

$538
Provider with most accurate pricing for Panama City NW Florida Beaches-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Greenville flights.
Search Deals
From Panama City NW Florida Beaches to Greenville
Search Deals
One-way flight from Panama City NW Florida Beaches to Greenville
Search Deals
Highest demand for flights based on searches. 26% potential increase in price ($149 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($38 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 22, 2025.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Panama City

Fly to

Greenville

Route

Depart

Return

Price

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sat 1/17

6:30 am-3:35 pm

1 stop8h 05m

Greenville

Tue 1/20

6:49 am-12:02 pm

1 stop6h 13m

$333

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sun 1/4

7:02 pm-11:30 pm

1 stop3h 28m

Greenville

Sun 1/18

6:50 am-9:04 am

1 stop3h 14m

$383

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sun 1/4

7:02 pm-11:30 pm

1 stop3h 28m

Greenville

Wed 1/21

3:05 pm-6:14 pm

1 stop4h 09m

$404

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sun 1/4

7:02 pm-11:30 pm

1 stop3h 28m

Greenville

Sat 1/24

10:37 am-12:24 pm

1 stop2h 47m

$413

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sun 1/4

7:02 pm-11:30 pm

1 stop3h 28m

Greenville

Mon 1/19

3:05 pm-7:50 pm

1 stop5h 45m

$413

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sun 1/4

7:02 pm-11:30 pm

1 stop3h 28m

Greenville

Thu 1/22

3:05 pm-7:50 pm

1 stop5h 45m

$413

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 1/1

7:15 am-2:03 pm

1 stop5h 48m

Greenville

Wed 1/21

8:09 am-11:33 am

1 stop4h 24m

$432

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 1/1

7:15 am-2:03 pm

1 stop5h 48m

Greenville

Tue 1/20

6:00 am-11:33 am

1 stop6h 33m

$432

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sun 1/4

7:02 pm-11:30 pm

1 stop3h 28m

Greenville

Fri 1/23

3:05 pm-7:50 pm

1 stop5h 45m

$432

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sun 1/4

7:02 pm-11:30 pm

1 stop3h 28m

$220

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/20

Showing 1-10 of 11 results
1
2

Compare providers for flights from Panama City to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Greenville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Greenville

What is the cheapest month to book a flight from Panama City, Florida to Greenville?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $76). Flying from Panama City, Florida to Greenville in February is currently the most expensive (average of $246). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to GSP?

Find hourly flight availability from Panama City to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 22, 2025.

When flying from Panama City, Florida to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 86% versus a flight in the evening.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated December 22, 2025.
Peruse reviews from past customers who have flown with Delta from Panama City to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,014 reviews

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,014 reviews
Delta
7.9
Good
8,014 reviews

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.1

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Greenville?

    United Airlines and Delta can get you from Panama City, Florida to Greenville in just under 3h 28m. Your travel time can differ by up to 4h 37m. There are 376 mi between Panama City, Florida and Greenville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Panama City, Florida to Greenville round-trip?

    Currently priced at $202, Delta will fly you from Panama City, Florida to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. You may be able to fly from Panama City, Florida to Greenville for 51% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Greenville?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $76). Flying from Panama City, Florida to Greenville in February is currently the most expensive (average of $246). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top airline flying from Panama City to Greenville

Discover the top airline that operate flights from Panama City to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$202Average$382FlexibilityNo cancel feeOn-timeN/A

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