HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Greenville

$119+ Cheap flights from Panama City, FL to Greenville (ECP - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — GSP
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$373
(American Airlines)

One-way from

$119
(Delta)

Popular in

April

Cheapest in

September

Average price

$202
From Panama City NW Florida Beaches to Greenville
Search Deals
One-way flight from Panama City NW Florida Beaches to Greenville
Search Deals
Highest demand for flights based on searches. 25% potential increase in price ($144 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($33 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:41 pmECP - GSP
1 stop3h 43mAmerican Airlines
Sun 11/27:45 amGSP - ECP
1 stop3h 48mAmerican Airlines
Deal found 9/14$373
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/296:54 pmECP - GSP
1 stop3h 58mDelta
Fri 10/35:30 amGSP - ECP
1 stop3h 38mDelta
Deal found 9/14$411
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/154:46 pmECP - GSP
1 stop4h 41mDelta
Mon 9/225:30 amGSP - ECP
1 stop3h 38mDelta
Deal found 9/14$529
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1510:40 amECP - GSP
2 stops9h 20mSouthwest
Mon 9/2210:45 amGSP - ECP
2 stops7h 10mSouthwest
Deal found 9/14$585
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3110:04 amECP - GSP
2 stops27h 55mUnited Airlines
Sun 11/24:17 pmGSP - ECP
2 stops22h 40mUnited Airlines
Deal found 9/14$658
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/293:03 pmECP - GSP
2 stops22h 08mUnited Airlines
Fri 10/34:29 pmGSP - ECP
2 stops22h 22mUnited Airlines
Deal found 9/14$768

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Panama City

Fly to

Greenville

Route

Depart

Return

Price

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 9/29

6:54 pm-11:52 pm

1 stop3h 58m

Greenville

Fri 10/3

5:30 am-8:08 am

1 stop3h 38m

$411

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 10/31

6:44 am-10:37 pm

2 stops14h 53m

Greenville

Sun 11/2

7:45 am-10:33 am

1 stop3h 48m

$516

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 9/29

3:03 pm-2:11 pm

2 stops22h 08m

Greenville

Fri 10/3

4:29 pm-1:51 pm

2 stops22h 22m

$768

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 10/15

5:32 pm-10:18 pm

1 stop3h 46m

$119

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 10/15

9:50 am-6:30 pm

2 stops7h 40m

$269

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sun 9/21

6:59 pm-11:52 pm

1 stop3h 53m

$324

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sun 9/21

6:54 pm-11:52 pm

1 stop3h 58m

$379

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sun 9/21

5:06 pm-9:49 am

2 stops15h 43m

$851

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Greenville

What is the cheapest month to book a flight from Panama City, Florida to Greenville?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $321). Flying from Panama City, Florida to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to GSP?

Find hourly flight availability from Panama City to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Panama City, Florida to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 39% versus a flight in the morning.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated September 15, 2025.
Peruse reviews from past customers who have flown with Delta from Panama City to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Greenville?

    Delta, American Airlines, and United Airlines can get you from Panama City, Florida to Greenville in just under 3h 58m. Your travel time can differ by up to 18h 10m. There are 376 mi between Panama City, Florida and Greenville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Panama City, Florida to Greenville round-trip?

    Currently priced at $202, Delta will fly you from Panama City, Florida to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. You may be able to fly from Panama City, Florida to Greenville for 52% less than the average price by searching for this airline.

  • What are the cheapest airlines to fly from Panama City, Florida to Greenville one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $119. Users have also found prices from $269 and $324 on Southwest and American Airlines, respectively.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Greenville?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $321). Flying from Panama City, Florida to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Greenville

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to Charlotte flights
Miami to Charlotte flights
Tampa to Charlotte flights
Orlando to Charlotte flights
West Palm Beach to Charlotte flights
Fort Lauderdale to Charleston flights
Jacksonville to Charlotte flights
Tampa to Charleston flights
Fort Myers to Charlotte flights
Tampa to Savannah flights
Fort Lauderdale to Myrtle Beach flights
Tampa to Greenville flights
Miami to Charleston flights
Tallahassee to Charlotte flights
Fort Myers to Charleston flights
Orlando to Charleston flights
Orlando to Myrtle Beach flights
Pensacola to Charlotte flights
Miami to Greenville flights
Miami to Savannah flights
Orlando to Greenville flights
Sarasota to Charlotte flights
Jacksonville to Greenville flights
Melbourne to Charlotte flights
Panama City to Charleston flights
Fort Lauderdale to Greenville flights
West Palm Beach to Charleston flights
Orlando to Savannah flights
Tampa to Columbia flights
Miami to Columbia flights
West Palm Beach to Savannah flights
West Palm Beach to Greenville flights
Orlando to Columbia flights
Fort Lauderdale to Savannah flights
Fort Myers to Savannah flights
West Palm Beach to Myrtle Beach flights
West Palm Beach to Columbia flights
Gainesville to Charlotte flights
Fort Myers to Greenville flights
Sarasota to Charleston flights
Sarasota to Savannah flights
Sarasota to Greenville flights
Tampa to Myrtle Beach flights
Pensacola to Savannah flights
Fort Lauderdale to Columbia flights
West Palm Beach to Augusta flights
Pensacola to Charleston flights
Fort Myers to Myrtle Beach flights
Miami to Myrtle Beach flights
Tampa to Hilton Head Island flights

Top airline flying from Panama City to Greenville

Discover the top airline that operate flights from Panama City to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$202Average$386FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.