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$308+ Cheap flights from Panama City, FL to Greenville (ECP - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — GSP
Feb 19 — Feb 261
Thu 2/19
Thu 2/26
1 adult, Economy
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Find cheap flights from Panama City to Greenville with Cheapflights

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Cheap flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/148:15 am
ECP
-
GSP
1 stop3h 05m
Delta
Thu 4/237:59 pm
GSP
-
ECP
1 stop4h 06m
Delta
Deal found 1/20$308
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/204:04 pm
ECP
-
GSP
1 stop4h 34m
Delta
Sun 2/226:49 am
GSP
-
ECP
1 stop2h 52m
Delta
Deal found 1/19$327
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/144:40 pm
ECP
-
GSP
1 stop5h 22m
American Airlines
Wed 4/225:20 am
GSP
-
ECP
1 stop5h 43m
American Airlines
Deal found 1/20$349
This Southwest deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2012:35 pm
ECP
-
GSP
1 stop5h 30m
Southwest
Sun 2/228:30 am
GSP
-
ECP
2 stops15h 00m
Southwest
Deal found 1/19$368
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/141:01 pm
ECP
-
GSP
1 stop7h 58m
United Airlines
Wed 2/186:50 am
GSP
-
ECP
1 stop6h 14m
United Airlines
Deal found 1/19$388
This Southwest deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:15 am
ECP
-
GSP
1 stop3h 55m
Southwest
Thu 4/2312:35 pm
GSP
-
ECP
2 stops10h 05m
Southwest
Deal found 1/20$391
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/51:30 pm
ECP
-
GSP
1 stop6h 03m
Delta
Fri 4/107:59 pm
GSP
-
ECP
1 stop4h 05m
Delta
Deal found 1/20$402
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/44:45 pm
ECP
-
GSP
1 stop4h 07m
Delta
Sun 2/85:40 am
GSP
-
ECP
1 stop3h 59m
Delta
Deal found 1/20$439
This Southwest deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:15 am
ECP
-
GSP
1 stop3h 55m
Southwest
Wed 4/228:20 am
GSP
-
ECP
2 stops13h 05m
Southwest
Deal found 1/20$480

Find flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$308
(Delta)

Popular in

April

Cheapest in

September

Average price

$547
Provider with most accurate pricing for Panama City NW Florida Beaches-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Greenville flights.
Search Deals
From Panama City NW Florida Beaches to Greenville
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($96 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($38 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Panama City

Fly to

Greenville

Route

Depart

Return

Price

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 4/14

8:15 am-12:20 pm

1 stop3h 05m

Greenville

Thu 4/23

7:59 pm-11:05 pm

1 stop4h 06m

$308

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 4/6

6:43 pm-11:54 pm

1 stop4h 11m

Greenville

Fri 4/10

7:59 pm-11:04 pm

1 stop4h 05m

$327

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 2/20

4:04 pm-9:38 pm

1 stop4h 34m

Greenville

Sun 2/22

6:49 am-8:41 am

1 stop2h 52m

$327

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 4/14

4:40 pm-11:02 pm

1 stop5h 22m

Greenville

Wed 4/22

5:20 am-10:03 am

1 stop5h 43m

$349

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sat 2/14

1:01 pm-9:59 pm

1 stop7h 58m

Greenville

Wed 2/18

6:50 am-12:04 pm

1 stop6h 14m

$388

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 4/14

7:55 am-8:00 pm

2 stops11h 05m

Greenville

Thu 4/23

12:35 pm-9:40 pm

2 stops10h 05m

$397

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 2/4

4:45 pm-9:52 pm

1 stop4h 07m

Greenville

Sun 2/8

5:40 am-8:39 am

1 stop3h 59m

$439

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 4/14

7:15 am-12:10 pm

1 stop3h 55m

Greenville

Wed 4/22

8:20 am-8:25 pm

2 stops13h 05m

$480

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 1/30

6:00 am-11:03 am

1 stop4h 03m

Greenville

Mon 2/2

5:40 am-8:39 am

1 stop3h 59m

$498

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Compare providers for flights from Panama City to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Greenville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Greenville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Greenville

What is the cheapest month to book a flight from Panama City, Florida to Greenville?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $76). Flying from Panama City, Florida to Greenville in February is currently the most expensive (average of $246). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated January 20, 2026.
Peruse reviews from past customers who have flown with Delta from Panama City to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,077 reviews

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,077 reviews
Delta
7.9
Good
8,077 reviews

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Greenville?

    Delta, American Airlines, and United Airlines can get you from Panama City, Florida to Greenville in just under 3h 05m. Your travel time can differ by up to 4h 53m. There are 376 mi between Panama City, Florida and Greenville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Panama City, Florida to Greenville round-trip?

    Currently priced at $202, Delta will fly you from Panama City, Florida to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. You may be able to fly from Panama City, Florida to Greenville for 50% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Greenville?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $76). Flying from Panama City, Florida to Greenville in February is currently the most expensive (average of $246). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top airline flying from Panama City to Greenville

Discover the top airline that operate flights from Panama City to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$202Average$271FlexibilityNo cancel feeOn-timeN/A

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