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$125+ Cheap flights from Panama City, FL to Greenville (ECP - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/9. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — GSP
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$278
(Delta)

One-way from

$125
(American Airlines)

Popular in

April

Cheapest in

June

Average price

$242
From Panama City NW Florida Beaches to Greenville
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One-way flight from Panama City NW Florida Beaches to Greenville
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Highest demand for flights based on searches. 20% potential increase in price ($114 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($34 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/239:18 amECP - GSP
1 stop3h 57mDelta
Mon 7/285:30 amGSP - ECP
1 stop4h 03mDelta
Deal found 6/10$278
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/56:06 pmECP - GSP
1 stop3h 52mAmerican Airlines
Sun 9/76:00 amGSP - ECP
1 stop4h 42mAmerican Airlines
Deal found 6/11$299
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/510:40 amECP - GSP
1 stop6h 25mSouthwest
Sun 9/77:15 amGSP - ECP
2 stops11h 25mSouthwest
Deal found 6/11$330
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/232:05 pmECP - GSP
2 stops23h 12mUnited Airlines
Mon 7/285:34 pmGSP - ECP
1 stop21h 43mUnited Airlines
Deal found 6/10$647

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Panama City

Fly to

Greenville

Route

Depart

Return

Price

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 7/23

9:18 am-2:15 pm

1 stop3h 57m

Greenville

Mon 7/28

5:30 am-8:33 am

1 stop4h 03m

$278

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 9/5

6:06 pm-10:58 pm

1 stop3h 52m

Greenville

Sun 9/7

6:00 am-9:42 am

1 stop4h 42m

$299

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 9/5

10:40 am-6:05 pm

1 stop6h 25m

Greenville

Sun 9/7

7:15 am-5:40 pm

2 stops11h 25m

$330

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 7/23

2:05 pm-2:17 pm

2 stops23h 12m

Greenville

Mon 7/28

5:34 pm-2:17 pm

1 stop21h 43m

$647

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 7/9

5:30 am-10:43 am

1 stop4h 13m

$125

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 6/30

7:25 am-2:14 pm

1 stop5h 49m

$170

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 7/9

7:15 am-8:30 pm

2 stops12h 15m

$179

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 6/25

3:20 pm-12:04 pm

3 stops19h 44m

$533

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Greenville

What is the cheapest month to book a flight from Panama City, Florida to Greenville?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $329). Flying from Panama City, Florida to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to GSP?

Find hourly flight availability from Panama City to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from Panama City, Florida to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 39% versus a flight in the morning.

Rainfall in Greenville by month

Plan your trip to Greenville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Greenville ranges from 3.6 - 5.1 inches per month. March is typically the wettest month, when rainfall can reach 5.1 in. November is typically the driest time to visit Greenville when rainfall is around 3.6 in.

Temperature in Greenville by month

Plan your trip to Greenville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Greenville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated June 12, 2025.
Southwest
8.0
Very good
4,287 reviews

Entertainment

7.6

Overall

8.0

Boarding

8.2

Food

7.1

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,287 reviews
Southwest
8.0
Very good
4,287 reviews

Entertainment

7.6

Overall

8.0

Boarding

8.2

Food

7.1

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,946 reviews
Southwest
8.0
Very good
4,287 reviews

Entertainment

7.6

Overall

8.0

Boarding

8.2

Food

7.1

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,790 reviews
Southwest
8.0
Very good
4,287 reviews

Entertainment

7.6

Overall

8.0

Boarding

8.2

Food

7.1

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,287 reviews

Entertainment

7.6

Overall

8.0

Boarding

8.2

Food

7.1

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City, Florida to Greenville round-trip?

    Currently priced at $278, Delta will fly you from Panama City, Florida to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Southwest - these airlines can fly you to your destination from $299 and $330, respectively. You may be able to fly from Panama City, Florida to Greenville for 38% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Panama City, Florida to Greenville one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $125. Users have also found prices from $170 and $179 on Delta and Southwest, respectively.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $329). Flying from Panama City, Florida to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 2 airlines flying from Panama City to Greenville

Discover the top 2 airlines that operate flights from Panama City to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$242Average$486FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$256Average$476FlexibilityNo cancel feeOn-time71%

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