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Greenville

$308+ Cheap flights from Panama City, FL to Greenville (ECP - GSP)

ECP — GSP
Nov 23 — Nov 301
Mon 11/23
Mon 11/30
1 adult, Economy
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Find cheap flights from Panama City to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville

Thu 11/127:10 am -
1 stop4h 02m
Sun 11/158:35 pm -
1 stop4h 13m
Deal found 10/20$308
Tue 12/159:05 am -
1 stop5h 12m
Wed 12/166:30 am -
1 stop7h 47m
Deal found 10/20$337
Thu 11/1211:25 am -
2 stops9h 20m
Sun 11/156:40 am -
1 stop3h 55m
Deal found 10/20$452
Thu 12/244:10 pm -
1 stop3h 40m
Sat 12/264:55 pm -
1 stop5h 40m
Deal found 10/21$528
Sun 11/15:55 pm -
1 stop4h 00m
Sun 11/86:40 am -
1 stop3h 55m
Deal found 10/19$609
Thu 12/248:06 am -
1 stop4h 49m
Sat 12/264:07 pm -
1 stop4h 29m
Deal found 10/21$659

Find flight deals from Panama City to Greenville

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$308
(American Airlines)

Popular in

September

Cheapest in

August

Average price

$378
Provider with most accurate pricing for Panama City NW Florida Beaches-Greenville flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Greenville flights.
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From Panama City NW Florida Beaches to Greenville
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($53 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 12% potential price decrease ($61 potential savings vs. average RT price).
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Average for round-trip flights in October 2026
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Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityGreenville

ECP Panama City NW Florida Beaches - GSP Greenville

ECPGSP

Panama City NW Florida Beaches

Tue 12/15

9:05 am-3:17 pm

1 stop5h 12m

Greenville

Wed 12/16

6:30 am-1:17 pm

1 stop7h 47m

$337

Panama CityGreenville

ECP Panama City NW Florida Beaches - GSP Greenville

ECPGSP

Panama City NW Florida Beaches

Thu 12/24

10:05 am-8:50 pm

2 stops9h 45m

Greenville

Sat 12/26

4:55 pm-9:35 pm

1 stop5h 40m

$533
Quickest round-trip

Panama CityGreenville

ECP Panama City NW Florida Beaches - GSP Greenville

ECPGSP

Panama City NW Florida Beaches

Thu 12/24

8:06 am-1:55 pm

1 stop4h 49m

Greenville

Sat 12/26

4:07 pm-7:36 pm

1 stop4h 29m

$659

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/19

Sorted by cheapest first

Compare providers for flights from Panama City to Greenville

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Greenville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price

Reviews of airlines servicing Greenville

Peruse reviews from past customers who have flown with Delta from Panama City to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,678 reviews

Entertainment

7.8

Food

7.2

Overall

7.8

Crew

8.5

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Jorge,Aug 2026

TPA - ATL

Although I still enjoy flying Delta, the overall flying experience feels cheapened. But I guess that is true of most, if not all american carriers.
Delta
7.8
Good
8,678 reviews
Delta
7.8
Good
8,678 reviews

Entertainment

7.8

Food

7.2

Overall

7.8

Crew

8.5

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Jorge,Aug 2026

TPA - ATL

Although I still enjoy flying Delta, the overall flying experience feels cheapened. But I guess that is true of most, if not all american carriers.

Related info for your journey

  • How long is the flight from Panama City, Florida to Greenville?

    United Airlines and Southwest can get you from Panama City, Florida to Greenville in just under 5h 12m. Your travel time can differ by up to 4h 33m. There are 376 mi between Panama City, Florida and Greenville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Panama City, Florida to Greenville round-trip?

    Currently priced at $261, Delta will fly you from Panama City, Florida to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. You may be able to fly from Panama City, Florida to Greenville for 52% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Greer
Simpsonville
Greenwood
Duncan
Anderson
Seneca

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Panama City to Greenville

AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$261Average$347FlexibilityNo cancel feeOn-timeN/A

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