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$162+ Cheap flights from Panama City, FL to Greenville (ECP - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — GSP
Jun 19 — Jun 261
Fri 6/19
Fri 6/26
1 adult, Economy
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Cheap flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 20, 2026.

This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/64:10 pm
ECP
-
GSP
1 stop4h 25m
Southwest
Tue 8/117:00 am
GSP
-
ECP
1 stop3h 40m
Southwest
Deal found 5/19$313
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:41 am
ECP
-
GSP
1 stop5h 32m
Delta
Wed 6/248:52 am
GSP
-
ECP
1 stop4h 34m
Delta
Deal found 5/19$325
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:05 pm
ECP
-
GSP
1 stop3h 32m
Delta
Thu 11/55:40 am
GSP
-
ECP
1 stop3h 37m
Delta
Deal found 5/18$335
This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:50 am
ECP
-
GSP
1 stop3h 25m
Southwest
Wed 6/247:00 am
GSP
-
ECP
2 stops10h 45m
Southwest
Deal found 5/19$336
This Southwest deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:55 am
ECP
-
GSP
1 stop3h 30m
Southwest
Thu 11/510:45 am
GSP
-
ECP
2 stops12h 00m
Southwest
Deal found 5/18$340
This Southwest deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:50 am
ECP
-
GSP
1 stop3h 25m
Southwest
Tue 6/167:00 am
GSP
-
ECP
1 stop3h 30m
Southwest
Deal found 5/18$345

Find flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$313
(Southwest)

One-way from

$162
(Southwest)

Popular in

July

Cheapest in

September

Average price

$491
Provider with most accurate pricing for Panama City NW Florida Beaches-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Greenville flights.
Search Deals
From Panama City NW Florida Beaches to Greenville
Search Deals
One-way flight from Panama City NW Florida Beaches to Greenville
Search Deals
High demand for flights, 2% potential price rise
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 20, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 8/6

4:10 pm-9:35 pm

1 stop4h 25m

Greenville

Tue 8/11

8:10 am-6:10 pm

2 stops11h 00m

$318

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 6/18

7:50 am-12:15 pm

1 stop3h 25m

Greenville

Wed 6/24

7:00 am-4:45 pm

2 stops10h 45m

$336

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sun 11/1

7:55 am-12:25 pm

1 stop3h 30m

Greenville

Thu 11/5

10:45 am-9:45 pm

2 stops12h 00m

$340
Quickest round-trip

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 6/15

7:50 am-12:15 pm

1 stop3h 25m

Greenville

Tue 6/16

7:00 am-9:30 am

1 stop3h 30m

$345

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sat 5/30

6:00 am-10:39 am

1 stop3h 39m

Greenville

Wed 6/3

5:40 am-8:30 am

1 stop3h 50m

$459

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sat 5/30

7:55 am-4:35 pm

2 stops7h 40m

Greenville

Wed 6/3

8:20 am-6:55 pm

2 stops11h 35m

$469

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 9/22

1:54 pm-10:53 pm

1 stop7h 59m

Greenville

Wed 9/23

5:50 am-1:13 pm

1 stop8h 23m

$474
Cheapest one-way

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 8/20

10:00 am-8:15 pm

2 stops9h 15m

$167
Quickest one-way

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 6/2

7:41 am-2:15 pm

1 stop5h 34m

$230

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 6/1

12:20 pm-10:35 pm

2 stops9h 15m

$235

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/20

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

Compare providers for flights from Panama City to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Greenville in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Greenville

How much does it cost to fly round-trip from Panama City, Florida to Greenville?

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated May 20, 2026.
Peruse reviews from past customers who have flown with Delta from Panama City to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,454 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Comfort

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,454 reviews
Delta
7.9
Good
8,454 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Comfort

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Greenville?

    Southwest can get you from Panama City, Florida to Greenville in just under 4h 25m. Your travel time can differ by up to . There are 376 mi between Panama City, Florida and Greenville.

  • What is the cheapest airline to fly from Panama City, Florida to Greenville round-trip?

    Currently priced at $202, Delta will fly you from Panama City, Florida to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. You may be able to fly from Panama City, Florida to Greenville for 51% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Greer
Simpsonville
Greenwood
Duncan
Seneca

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Top airline flying from Panama City to Greenville

Discover the top airline that operate flights from Panama City to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$202Average$271FlexibilityNo cancel feeOn-timeN/A

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