$176+ Cheap flights from Panama City, FL to Greenville (ECP - GSP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — GSP
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Greenville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Greenville
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Best
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One-way
Cheapest flights from Panama City to GreenvilleExplore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 pm -
1 stop3h 50m
Mon 11/26:40 am -
1 stop3h 55m
Deal found 9/17![Southwest logo]()
$303
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/151:58 pm -
1 stop6h 01m
Wed 12/166:30 am -
1 stop7h 47m
Deal found 9/15![United Airlines logo]()
$315
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:59 pm -
1 stop3h 48m
Sun 12/67:25 pm -
1 stop4h 52m
Deal found 9/16![Delta logo]()
$328
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:55 am -
1 stop5h 15m
Sun 12/66:40 am -
2 stops11h 40m
Deal found 9/16![Southwest logo]()
$333
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:34 pm -
1 stop4h 17m
Sat 10/105:40 am -
1 stop3h 34m
Deal found 9/17![Delta logo]()
$385
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:45 am -
1 stop3h 40m
Sun 10/46:15 am -
1 stop4h 00m
Deal found 9/15![Southwest logo]()
$465
Best flights from Panama City to GreenvilleDiscover carefully curated flight deals from Panama City to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from Panama City to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 pm -
1 stop3h 50m
Mon 11/26:40 am -
1 stop3h 55m
Deal found 9/17![Southwest logo]()
$303
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/151:58 pm -
1 stop6h 01m
Wed 12/166:30 am -
1 stop7h 47m
Deal found 9/16![United Airlines logo]()
$315
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:59 pm -
1 stop3h 48m
Sun 12/67:25 pm -
1 stop4h 52m
Deal found 9/16![Delta logo]()
$328
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:55 am -
1 stop5h 15m
Sun 12/610:45 am -
1 stop4h 40m
Deal found 9/16![Southwest logo]()
$328
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:34 pm -
1 stop4h 17m
Sat 10/105:40 am -
1 stop3h 34m
Deal found 9/17![Delta logo]()
$385
Last-minute flights from Panama City to GreenvilleDiscover last-minute flight deals from Panama City to Greenville. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Greenville. Data last updated September 18, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:45 am -
1 stop3h 40m
Sun 10/46:15 am -
1 stop4h 00m
Deal found 9/15![Southwest logo]()
$465
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/32:10 pm -
1 stop4h 20m
Thu 10/86:25 am -
2 stops12h 00m
Deal found 9/14![Southwest logo]()
$476
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:32 pm -
1 stop4h 27m
Thu 10/88:33 pm -
1 stop4h 20m
Deal found 9/14![American Airlines logo]()
$484
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:34 pm -
1 stop4h 17m
Sat 10/105:40 am -
1 stop3h 34m
Deal found 9/17![Delta logo]()
$385
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:10 pm -
1 stop3h 55m
Sat 10/1011:20 am -
2 stops9h 35m
Deal found 9/17![Southwest logo]()
$492
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 pm -
1 stop3h 50m
Mon 11/26:40 am -
1 stop3h 55m
Deal found 9/17![Southwest logo]()
$303
One-way flights from Panama City to GreenvilleSearch for one-way flight options from Panama City to Greenville. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from Panama City to Greenville. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:20 pm -
1 stop3h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Delta logo]()
$176
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:40 am -
1 stop3h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Southwest logo]()
$190
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:10 pm -
2 stops6h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$224
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:35 am -
1 stop4h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Delta logo]()
$245
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/269:23 am -
1 stop4h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Delta logo]()
$334
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:15 am -
2 stops10h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$339
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:25 am -
2 stops11h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$425
Find flight deals from Panama City to Greenville
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $303 (Southwest) |
One-way from | $176 (Delta) |
Popular in | April |
Cheapest in | October |
Average price | $528 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityGreenville
ECP Panama City NW Florida Beaches - GSP Greenville
ECPGSP
Panama City NW Florida Beaches
Fri 10/16
6:20 pm-10:51 pm
1 stop3h 31m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$176
Quickest round-trip
Panama CityGreenville
ECP Panama City NW Florida Beaches - GSP Greenville
ECPGSP
Panama City NW Florida Beaches
Sat 10/3
7:40 am-12:10 pm
1 stop3h 30m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$190
Panama CityGreenville
ECP Panama City NW Florida Beaches - GSP Greenville
ECPGSP
Panama City NW Florida Beaches
Fri 10/16
3:10 pm-10:50 pm
2 stops6h 40m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$224
Panama CityGreenville
ECP Panama City NW Florida Beaches - GSP Greenville
ECPGSP
Panama City NW Florida Beaches
Sun 10/4
7:35 am-12:50 pm
1 stop4h 15m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$245
Panama CityGreenville
ECP Panama City NW Florida Beaches - GSP Greenville
ECPGSP
Panama City NW Florida Beaches
Fri 10/30
6:00 pm-10:50 pm
1 stop3h 50m
Greenville
Mon 11/2
6:40 am-9:35 am
1 stop3h 55m
$303
Panama CityGreenville
ECP Panama City NW Florida Beaches - GSP Greenville
ECPGSP
Panama City NW Florida Beaches
Tue 12/15
1:58 pm-8:59 pm
1 stop6h 01m
Greenville
Wed 12/16
6:30 am-1:17 pm
1 stop7h 47m
$315
Panama CityGreenville
ECP Panama City NW Florida Beaches - GSP Greenville
ECPGSP
Panama City NW Florida Beaches
Thu 12/3
6:59 pm-11:47 pm
1 stop3h 48m
Greenville
Sun 12/6
7:25 pm-11:17 pm
1 stop4h 52m
$328
Panama CityGreenville
ECP Panama City NW Florida Beaches - GSP Greenville
ECPGSP
Panama City NW Florida Beaches
Thu 12/3
7:55 am-2:10 pm
1 stop5h 15m
Greenville
Sun 12/6
10:45 am-2:25 pm
1 stop4h 40m
$328
Panama CityGreenville
ECP Panama City NW Florida Beaches - GSP Greenville
ECPGSP
Panama City NW Florida Beaches
Sat 9/26
9:23 am-2:55 pm
1 stop4h 32m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$334
Panama CityGreenville
ECP Panama City NW Florida Beaches - GSP Greenville
ECPGSP
Panama City NW Florida Beaches
Sat 9/26
7:15 am-7:00 pm
2 stops10h 45m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$339
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Panama City to Greenville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Greenville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Greenville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Greenville
Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
ECP-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Greenville
Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated September 18, 2026.
Peruse reviews from past customers who have flown with Delta from Panama City to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Greenville?
Book flights to Greenville if you plan to visit one of these locationsGreer
Simpsonville
Greenwood
Duncan
Anderson
Seneca
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Other flights to Greenville
Explore flights to Greenville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
Panama City and Greenville flights
Browse other Panama City and Greenville flight options. Last updated on September 18, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama City to Greenville
Discover the top airline that operate flights from Panama City to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$261 | Average$347 | FlexibilityNo cancel fee | On-timeN/A |