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Greenville

$194+ Cheap flights from Panama City, FL to Greenville (ECP - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/2. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — GSP
sep. 2 — sep. 91
mar. 9/2
mar. 9/9
1 adult, Economy
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Cheap flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 28, 2025.

Round-trip from

$217
(Delta)

One-way from

$194
(Southwest)

Popular in

April

Cheapest in

September

Average price

$476
From Panama City NW Florida Beaches to Greenville
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One-way flight from Panama City NW Florida Beaches to Greenville
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Highest demand for flights based on searches. 24% potential increase in price ($139 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($33 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 28, 2025.

This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/247:00 amECP - GSP
1 stop5h 28mDelta
mié. 10/15:30 amGSP - ECP
1 stop5h 25mDelta
Deal found 8/28$217
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/207:00 amECP - GSP
1 stop3h 24mDelta
mié. 9/245:30 amGSP - ECP
1 stop3h 38mDelta
Deal found 8/27$223
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/179:13 amECP - GSP
1 stop3h 15mDelta
mié. 9/245:30 amGSP - ECP
1 stop3h 38mDelta
Deal found 8/27$227
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/207:00 amECP - GSP
1 stop5h 09mDelta
lun. 9/225:30 amGSP - ECP
1 stop3h 38mDelta
Deal found 8/27$229
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/177:00 amECP - GSP
1 stop3h 24mDelta
lun. 9/225:30 amGSP - ECP
1 stop3h 38mDelta
Deal found 8/27$233
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/172:05 pmECP - GSP
1 stop4h 17mDelta
vie. 9/196:13 pmGSP - ECP
1 stop5h 50mDelta
Deal found 8/27$252
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/244:46 pmECP - GSP
1 stop5h 48mDelta
vie. 10/36:13 pmGSP - ECP
1 stop5h 50mDelta
Deal found 8/28$277
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/187:00 amECP - GSP
1 stop5h 28mDelta
mar. 9/235:30 amGSP - ECP
1 stop3h 38mDelta
Deal found 8/27$278
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/187:00 amECP - GSP
1 stop5h 28mDelta
sáb. 9/205:30 amGSP - ECP
1 stop3h 38mDelta
Deal found 8/27$284
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/177:00 amECP - GSP
1 stop5h 28mDelta
jue. 9/187:45 pmGSP - ECP
1 stop4h 18mDelta
Deal found 8/27$288
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/1711:00 amECP - GSP
1 stop3h 22mDelta
dom. 9/215:30 amGSP - ECP
1 stop3h 38mDelta
Deal found 8/27$292
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/187:00 amECP - GSP
1 stop5h 28mDelta
vie. 9/194:35 pmGSP - ECP
1 stop3h 55mDelta
Deal found 8/27$303

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 28, 2025.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Panama City

Fly to

Greenville

Route

Depart

Return

Price

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

mié. 9/24

7:00 am-1:28 pm

1 stop5h 28m

Greenville

mié. 10/1

5:30 am-9:55 am

1 stop5h 25m

$217

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

mié. 9/24

2:05 pm-9:07 pm

1 stop6h 02m

Greenville

mar. 9/30

6:35 am-9:55 am

1 stop4h 20m

$217

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

sáb. 11/8

6:00 am-10:09 am

1 stop3h 09m

Greenville

mar. 11/11

5:35 am-8:35 am

1 stop4h 00m

$223

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

mié. 9/24

7:00 am-1:28 pm

1 stop5h 28m

Greenville

jue. 10/2

5:30 am-8:08 am

1 stop3h 38m

$223

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

mié. 9/24

2:05 pm-7:22 pm

1 stop4h 17m

Greenville

lun. 9/29

7:35 am-9:55 am

1 stop3h 20m

$223

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

sáb. 11/8

5:00 pm-11:54 pm

1 stop5h 54m

Greenville

mié. 11/12

10:08 am-12:47 pm

1 stop3h 39m

$223

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

lun. 9/22

6:54 pm-11:52 pm

1 stop3h 58m

Greenville

mié. 9/24

5:30 am-8:08 am

1 stop3h 38m

$223

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

sáb. 9/20

6:00 am-11:24 am

1 stop4h 24m

Greenville

mar. 9/23

6:35 am-9:55 am

1 stop4h 20m

$223

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

sáb. 9/20

7:00 am-11:24 am

1 stop3h 24m

Greenville

mié. 9/24

5:30 am-8:08 am

1 stop3h 38m

$223

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

lun. 9/22

6:54 pm-11:52 pm

1 stop3h 58m

Greenville

mar. 9/23

5:30 am-9:55 am

1 stop5h 25m

$223

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/28

Showing 1-10 of 15 results
1
2

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Greenville

What is the cheapest month to book a flight from Panama City, Florida to Greenville?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $329). Flying from Panama City, Florida to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to GSP?

Find hourly flight availability from Panama City to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 28, 2025.

When flying from Panama City, Florida to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 39% versus a flight in the morning.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated agosto 28, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Panama City to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,977 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Greenville?

    Delta can get you from Panama City, Florida to Greenville in just under 5h 28m. Your travel time can differ by up to . There are 376 mi between Panama City, Florida and Greenville.

  • What are the cheapest airlines flying from Panama City, Florida to Greenville round-trip?

    Currently priced at $202, Delta will fly you from Panama City, Florida to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $256. You may be able to fly from Panama City, Florida to Greenville for 52% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Panama City, Florida to Greenville one-way?

    For one-way options, check prices for Southwest. According to our data, you can fly for as low as $194. Users have also found prices from $300 and $444 on Delta and United Airlines, respectively.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $329). Flying from Panama City, Florida to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 2 airlines flying from Panama City to Greenville

Discover the top 2 airlines that operate flights from Panama City to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$202Average$415FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$256Average$589FlexibilityNo cancel feeOn-time71%

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