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$169+ Cheap flights from Panama City, FL to Greenville (ECP - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/31. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — GSP
Mar 22 — Mar 291
Sun 3/22
Sun 3/29
1 adult, Economy
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Cheap flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2026.

This Southwest deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/281:30 pm
ECP
-
GSP
1 stop3h 50m
Southwest
Mon 8/317:00 am
GSP
-
ECP
1 stop3h 25m
Southwest
Deal found 2/18$337
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:30 am
ECP
-
GSP
1 stop4h 07m
American Airlines
Sun 8/235:00 am
GSP
-
ECP
1 stop5h 38m
American Airlines
Deal found 2/18$347
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/121:20 pm
ECP
-
GSP
1 stop9h 22m
American Airlines
Tue 3/245:20 am
GSP
-
ECP
1 stop5h 16m
American Airlines
Deal found 2/19$369
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:15 pm
ECP
-
GSP
1 stop5h 56m
United Airlines
Sun 8/236:00 am
GSP
-
ECP
2 stops8h 09m
United Airlines
Deal found 2/18$392
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:19 am
ECP
-
GSP
1 stop3h 41m
American Airlines
Tue 3/175:20 am
GSP
-
ECP
1 stop5h 16m
American Airlines
Deal found 2/19$399
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:25 am
ECP
-
GSP
1 stop3h 35m
Southwest
Sat 3/146:00 pm
GSP
-
ECP
1 stop3h 25m
Southwest
Deal found 2/19$413
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/710:24 am
ECP
-
GSP
2 stops12h 35m
United Airlines
Tue 3/176:30 am
GSP
-
ECP
1 stop7h 44m
United Airlines
Deal found 2/19$414
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/54:04 pm
ECP
-
GSP
1 stop4h 34m
Delta
Mon 3/167:59 pm
GSP
-
ECP
1 stop4h 05m
Delta
Deal found 2/19$420
This Southwest deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:20 am
ECP
-
GSP
1 stop3h 25m
Southwest
Sat 3/76:20 am
GSP
-
ECP
1 stop3h 45m
Southwest
Deal found 2/17$439

Find flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$369
(American Airlines)

One-way from

$169
(Southwest)

Popular in

April

Cheapest in

September

Average price

$347
Provider with most accurate pricing for Panama City NW Florida Beaches-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Greenville flights.
Search Deals
From Panama City NW Florida Beaches to Greenville
Search Deals
One-way flight from Panama City NW Florida Beaches to Greenville
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($62 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Panama City

Fly to

Greenville

Route

Depart

Return

Price

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 3/12

1:20 pm-11:42 pm

1 stop9h 22m

Greenville

Tue 3/24

5:20 am-9:36 am

1 stop5h 16m

$369

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 3/5

7:19 am-6:56 pm

2 stops10h 37m

Greenville

Tue 3/17

5:20 am-9:36 am

1 stop5h 16m

$404

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sat 3/7

7:25 am-12:00 pm

1 stop3h 35m

Greenville

Sat 3/14

6:00 pm-8:25 pm

1 stop3h 25m

$413

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 3/10

7:05 am-1:45 pm

1 stop5h 40m

Greenville

Mon 3/16

7:59 pm-11:04 pm

1 stop4h 05m

$420

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 3/9

6:43 pm-11:54 pm

1 stop4h 11m

Greenville

Mon 3/16

7:59 pm-11:04 pm

1 stop4h 05m

$420

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sat 3/7

9:26 am-3:21 pm

1 stop4h 55m

Greenville

Mon 3/16

7:59 pm-11:04 pm

1 stop4h 05m

$420

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 3/5

4:04 pm-9:38 pm

1 stop4h 34m

Greenville

Mon 3/16

7:59 pm-11:04 pm

1 stop4h 05m

$420

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 3/9

10:24 am-11:59 pm

2 stops12h 35m

Greenville

Mon 3/16

4:55 pm-9:57 pm

1 stop6h 02m

$439

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 3/6

7:20 am-11:45 am

1 stop3h 25m

Greenville

Sat 3/7

6:20 am-9:05 am

1 stop3h 45m

$439

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sat 3/7

12:15 pm-11:59 pm

2 stops10h 44m

Greenville

Mon 3/16

4:55 pm-9:57 pm

1 stop6h 02m

$439

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/18

Showing 1-10 of 17 results
1
2

Compare providers for flights from Panama City to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Greenville in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Greenville

What is the cheapest month to book a flight from Panama City, Florida to Greenville?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $76). Flying from Panama City, Florida to Greenville in February is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated February 20, 2026.
Peruse reviews from past customers who have flown with Delta from Panama City to Greenville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,215 reviews

Comfort

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,215 reviews
Delta
7.9
Good
8,215 reviews

Comfort

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Greenville?

    American Airlines, Southwest, and Delta can get you from Panama City, Florida to Greenville in just under 3h 35m. Your travel time can differ by up to 5h 47m. There are 376 mi between Panama City, Florida and Greenville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Panama City, Florida to Greenville round-trip?

    Currently priced at $202, Delta will fly you from Panama City, Florida to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. You may be able to fly from Panama City, Florida to Greenville for 50% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Greenville?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Greenville (average of $76). Flying from Panama City, Florida to Greenville in February is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top airline flying from Panama City to Greenville

Discover the top airline that operate flights from Panama City to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$202Average$265FlexibilityNo cancel feeOn-timeN/A

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