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$402+ Cheap flights from Medford to Greenville (MFR - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/3. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — GSP
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheap flight deals from Medford to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$402
(Delta)

Popular in

November

Cheapest in

January

Average price

$553
Provider with most accurate pricing for Medford-Greenville flight deals.
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Provider most trusted by Cheapflights users for Medford-Greenville flights.
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From Medford to Greenville
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Highest demand for flights based on searches. 32% potential increase in price ($229 potential increase over avg. RT price).
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Cheapest flight prices on average. 9% potential price decrease ($44 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Medford to Greenville

Cheapest flights from Medford to Greenville
Explore the most affordable flight options available from Medford to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:00 amMFR - GSP
2 stops13h 18mDelta
Tue 11/45:30 amGSP - MFR
2 stops9h 28mDelta
Deal found 10/16$518
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/315:00 amMFR - GSP
1 stop6h 59mUnited Airlines
Tue 11/44:56 pmGSP - MFR
2 stops23h 27mUnited Airlines
Deal found 10/16$553
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:00 amMFR - GSP
1 stop6h 59mUnited Airlines
Sun 11/305:28 pmGSP - MFR
3 stops32h 02mUnited Airlines
Deal found 10/15$771
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:36 pmMFR - GSP
2 stops17h 23mUnited Airlines
Sun 11/305:28 pmGSP - MFR
3 stops32h 02mUnited Airlines
Deal found 10/15$876
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/315:19 amMFR - GSP
3 stops12h 05mAmerican Airlines
Tue 11/46:01 amGSP - MFR
2 stops10h 58mAmerican Airlines
Deal found 10/16$972
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:47 pmMFR - GSP
2 stops8h 49mAmerican Airlines
Sat 12/278:00 amGSP - MFR
2 stops15h 20mAmerican Airlines
Deal found 10/16$1,279

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Medford to Greenville that are best for you.

Fly from

Medford

Fly to

Greenville

Route

Depart

Return

Price

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Tue 3/3

6:05 am-10:05 pm

2 stops13h 00m

Greenville

Sat 3/7

5:45 am-11:09 pm

2 stops20h 24m

$402

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Fri 10/31

6:00 am-10:18 pm

2 stops13h 18m

Greenville

Tue 11/4

5:30 am-11:58 am

2 stops9h 28m

$518

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Fri 10/31

5:00 am-2:59 pm

1 stop6h 59m

Greenville

Tue 11/4

4:56 pm-1:23 pm

2 stops23h 27m

$553

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Tue 3/3

5:10 am-3:10 pm

1 stop7h 00m

Greenville

Sat 3/7

6:40 am-9:23 pm

2 stops17h 43m

$593

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Mon 11/24

5:00 am-2:59 pm

1 stop6h 59m

Greenville

Sun 11/30

5:28 pm-10:30 pm

3 stops32h 02m

$771

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/14

Compare providers for flights from Medford to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Greenville in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Medford-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Medford-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Medford to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to Greenville

What is the cheapest month to book a flight from Medford to Greenville?

Currently, July is the cheapest month in which you can book a flight from Medford to Greenville (average of $175). Flying from Medford to Greenville in April is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated October 16, 2025.
Read through reviews of airlines operating flights from Medford to Greenville, such as Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,984 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,984 reviews
Delta
8.0
Very good
7,984 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,982 reviews
Delta
8.0
Very good
7,984 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Medford to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to Greenville?

    For as low as $553, Delta can have you in Greenville from Medford in 6h 59m. There are 2230 mi between Medford and Greenville. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Medford to Greenville round-trip?

    Our cheapest airline available from Medford to Greenville is United Airlines. Our recent data shows that you can find tickets from as low as $234 on this airline. An additional option worth looking into is Delta, starting at $274. United Airlines is 51% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Medford to Greenville that include hotel bookings?

    Yes. In addition to deals on Medford to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Greenville.

  • Can I find deals for business class flights from Medford to Greenville?

    Yes. Cheapflights offers flight deals from Medford to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to Greenville?

    Currently, July is the cheapest month in which you can book a flight from Medford to Greenville (average of $175). Flying from Medford to Greenville in April is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 2 airlines flying from Medford to Greenville

Discover the top 2 airlines that operate flights from Medford to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$234Average$574FlexibilityNo cancel feeOn-time69%
DeltaCheapest$274Average$369FlexibilityNo cancel feeOn-timeN/A

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