HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Greenville

$261+ Cheap flights from Medford to Greenville (MFR - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/23. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — GSP
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Medford to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Medford to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$261
(Delta)

Popular in

November

Cheapest in

January

Average price

$513
From Medford to Greenville
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($222 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($56 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals

Find flight deals from Medford to Greenville

Cheapest flights from Medford to Greenville
Explore the most affordable flight options available from Medford to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/235:55 amMFR - GSP
2 stops8h 46mDelta
Wed 10/13:42 pmGSP - MFR
2 stops10h 27mDelta
Deal found 6/11$261
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/235:00 amMFR - GSP
2 stops8h 53mUnited Airlines
Wed 10/19:35 amGSP - MFR
2 stops11h 17mUnited Airlines
Deal found 6/11$361
This Alaska Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/235:45 amMFR - GSP
2 stops13h 16mAlaska Airlines
Tue 9/307:15 amGSP - MFR
2 stops12h 51mAlaska Airlines
Deal found 6/11$415
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/305:35 amMFR - GSP
2 stops11h 51mAmerican Airlines
Mon 7/74:07 pmGSP - MFR
2 stops9h 59mAmerican Airlines
Deal found 6/9$749

Cheapflights Fare Finder

Customize your flight search to find flights from Medford to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Medford to Greenville that are best for you.

Fly from

Medford

Fly to

Greenville

Route

Depart

Return

Price

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Tue 9/23

5:55 am-5:41 pm

2 stops8h 46m

Greenville

Wed 10/1

3:42 pm-11:09 pm

2 stops10h 27m

$261

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Tue 9/23

5:00 am-4:53 pm

2 stops8h 53m

Greenville

Wed 10/1

9:35 am-5:52 pm

2 stops11h 17m

$361

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Tue 9/23

5:45 am-10:01 pm

2 stops13h 16m

Greenville

Tue 9/30

7:15 am-5:06 pm

2 stops12h 51m

$415

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Mon 6/30

5:35 am-8:26 pm

2 stops11h 51m

Greenville

Mon 7/7

4:07 pm-11:06 pm

2 stops9h 59m

$749

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from Medford to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to Greenville

What is the cheapest month to book a flight from Medford to Greenville?

Currently, January is the cheapest month in which you can book a flight from Medford to Greenville (average of $329). Flying from Medford to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Greenville by month

Plan your trip to Greenville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Greenville ranges from 3.6 - 5.1 inches per month. March is typically the wettest month, when rainfall can reach 5.1 in. November is typically the driest time to visit Greenville when rainfall is around 3.6 in.

Temperature in Greenville by month

Plan your trip to Greenville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Greenville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated June 12, 2025.
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Boarding

8.1

Entertainment

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Boarding

8.1

Entertainment

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,950 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Boarding

8.1

Entertainment

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,790 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Boarding

8.1

Entertainment

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Boarding

8.1

Entertainment

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Medford to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Medford to Greenville round-trip?

    Our cheapest airline available from Medford to Greenville is Delta. Our recent data shows that you can find tickets from as low as $261 on this airline. Additional options worth looking into are United Airlines and Alaska Airlines, starting at $361 and $415 round-trip. Delta is 50% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Medford to Greenville that include hotel bookings?

    Yes. In addition to deals on Medford to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Greenville.

  • Can I find deals for business class flights from Medford to Greenville?

    Yes. Cheapflights offers flight deals from Medford to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Medford to Greenville (average of $329). Flying from Medford to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Medford?

Book flights to Medford if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Medford to Greenville

See prices for flight routes from nearby airports that may be better suited for you.
Portland to Charlotte flights
Portland to Greenville flights
Portland to Charleston flights
Boise to Charlotte flights
Portland to Myrtle Beach flights
Portland to Savannah flights
Eugene to Savannah flights
Boise to Charleston flights
Redmond to Charlotte flights
Boise to Savannah flights
Boise to Greenville flights
Yakima to Charleston flights
Eugene to Charlotte flights
Portland to Hilton Head Island flights
Boise to Myrtle Beach flights
Eugene to Charleston flights
Eugene to Columbia flights
Portland to Columbia flights
Redmond to Greenville flights
Eugene to Greenville flights
Redmond to Myrtle Beach flights
Portland to Augusta flights
Medford to Columbia flights
Redmond to Savannah flights
Pendleton to Charlotte flights
Medford to Charlotte flights
Yakima to Hilton Head Island flights
Portland to Florence flights
Eugene to Augusta flights
Yakima to Charlotte flights

Top 2 airlines flying from Medford to Greenville

Discover the top 2 airlines that operate flights from Medford to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$254Average$574FlexibilityNo cancel feeOn-time69%
DeltaCheapest$274Average$369FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.