$127+ Cheap flights from Detroit to Greenville (DTT - GSP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/3. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — GSP
May 3 — May 101
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Detroit to Greenville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Greenville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Detroit to GreenvilleExplore the most affordable flight options available from Detroit to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.
Explore the most affordable flight options available from Detroit to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:05 am
DTW
- GSP
1 stop14h 33m
Multiple Airlines
Mon 4/135:43 pm
GSP
- DTW
1 stop30h 03m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/119:28 pm
DTW
- GSP
1 stop14h 37m
Multiple Airlines
Mon 4/135:43 pm
GSP
- DTW
1 stop30h 03m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:31 pm
DTW
- GSP
1 stop26h 07m
Multiple Airlines
Thu 4/163:54 pm
GSP
- DTW
1 stop29h 17m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:10 am
DTW
- GSP
1 stop10h 43m
Multiple Airlines
Mon 5/44:07 pm
GSP
- DTW
2 stops20h 29m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:45 am
DTW
- GSP
1 stop14h 22m
Multiple Airlines
Mon 4/278:18 pm
GSP
- DTW
2 stops15h 20m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:20 pm
DTW
- GSP
1 stop19h 13m
Multiple Airlines
Mon 4/275:43 pm
GSP
- DTW
2 stops25h 19m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:42 pm
DTW
- GSP
1 stop23h 11m
Multiple Airlines
Mon 5/118:28 pm
GSP
- DTW
2 stops17h 26m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:19 am
DTW
- GSP
2 stops9h 19m
Multiple Airlines
Mon 5/118:28 pm
GSP
- DTW
1 stop15h 32m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$305
Best flights from Detroit to GreenvilleDiscover carefully curated flight deals from Detroit to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 3, 2026.
Discover carefully curated flight deals from Detroit to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 3, 2026.
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:15 am
DTW
- GSP
1 stop5h 35m
Southwest
Sat 5/235:25 pm
GSP
- DTW
1 stop4h 00m
Southwest
Deal found 4/1![Southwest logo]()
$375
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:59 pm
DTW
- GSP
Nonstop1h 39m
Delta
Sat 5/167:20 am
GSP
- DTW
Nonstop1h 52m
Delta
Deal found 3/29![Delta logo]()
$439
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:20 am
DTW
- GSP
2 stops9h 15m
Southwest
Sat 5/1610:45 am
GSP
- DTW
1 stop4h 15m
Southwest
Deal found 3/29![Southwest logo]()
$380
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/24:10 pm
DTW
- GSP
1 stop5h 30m
Southwest
Fri 6/56:50 pm
GSP
- DTW
1 stop5h 15m
Southwest
Deal found 3/29![Southwest logo]()
$406
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:15 am
DTW
- GSP
1 stop4h 36m
Delta
Mon 5/257:20 am
GSP
- DTW
Nonstop1h 52m
Delta
Deal found 3/31![Delta logo]()
$449
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:00 am
DTW
- GSP
1 stop6h 00m
Southwest
Sun 5/108:00 am
GSP
- DTW
1 stop4h 00m
Southwest
Deal found 4/1![Southwest logo]()
$432
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:30 am
DTW
- GSP
1 stop5h 45m
Southwest
Sat 6/136:55 am
GSP
- DTW
1 stop5h 45m
Southwest
Deal found 3/29![Southwest logo]()
$437
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/201:20 pm
DTW
- GSP
2 stops9h 30m
Southwest
Tue 6/2312:50 pm
GSP
- DTW
2 stops9h 20m
Southwest
Deal found 3/31![Southwest logo]()
$447
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:00 am
DTW
- GSP
2 stops10h 50m
Southwest
Mon 5/111:50 pm
GSP
- DTW
2 stops8h 30m
Southwest
Deal found 3/29![Southwest logo]()
$464
Last-minute flights from Detroit to GreenvilleDiscover last-minute flight deals from Detroit to Greenville. Data last updated April 3, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Greenville. Data last updated April 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:31 pm
DTW
- GSP
1 stop26h 07m
Multiple Airlines
Thu 4/163:54 pm
GSP
- DTW
1 stop29h 17m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:05 am
DTW
- GSP
1 stop14h 33m
Multiple Airlines
Mon 4/135:43 pm
GSP
- DTW
1 stop30h 03m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/119:28 pm
DTW
- GSP
1 stop14h 37m
Multiple Airlines
Mon 4/135:43 pm
GSP
- DTW
1 stop30h 03m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:20 pm
DTW
- GSP
1 stop19h 13m
Multiple Airlines
Mon 4/275:43 pm
GSP
- DTW
2 stops25h 19m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:45 am
DTW
- GSP
1 stop14h 22m
Multiple Airlines
Mon 4/278:18 pm
GSP
- DTW
2 stops15h 20m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:10 am
DTW
- GSP
1 stop10h 43m
Multiple Airlines
Mon 5/44:07 pm
GSP
- DTW
2 stops20h 29m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:19 am
DTW
- GSP
2 stops9h 19m
Multiple Airlines
Mon 5/118:28 pm
GSP
- DTW
1 stop15h 32m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:42 pm
DTW
- GSP
1 stop23h 11m
Multiple Airlines
Mon 5/118:28 pm
GSP
- DTW
2 stops17h 26m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$302
One-way flights from Detroit to GreenvilleSearch for one-way flight options from Detroit to Greenville. Find affordable one-way fares based on user searches. Data last updated April 3, 2026.
Search for one-way flight options from Detroit to Greenville. Find affordable one-way fares based on user searches. Data last updated April 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:05 pm
DTW
- GSP
2 stops25h 49m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:50 am
DTW
- GSP
1 stop10h 03m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/308:43 pm
DTW
- GSP
2 stops22h 55m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:45 am
DTW
- GSP
2 stops32h 13m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:20 am
DTW
- GSP
2 stops9h 55m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:20 am
DTW
- GSP
2 stops37h 19m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$137
Find flight deals from Detroit to Greenville
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $284 (Kiwi.com) |
One-way from | $127 (Kiwi.com) |
Popular in | June |
Cheapest in | February |
Average price | $438 |
Good round-trip deal | $449 or less |
Good one-way deal | $333 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from Detroit to Greenville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitGreenville
DTW - GSP
DTWGSP
Detroit Metropolitan Wayne County
Sat 5/16
6:15 am-11:50 am
1 stop5h 35m
Greenville
Sat 5/23
5:25 pm-9:25 pm
1 stop4h 00m
$375
DetroitGreenville
DTW - GSP
DTWGSP
Detroit Metropolitan Wayne County
Sat 5/9
7:20 am-4:35 pm
2 stops9h 15m
Greenville
Sat 5/16
10:45 am-3:00 pm
1 stop4h 15m
$380
DetroitGreenville
DTW - GSP
DTWGSP
Detroit Metropolitan Wayne County
Tue 6/2
4:10 pm-9:40 pm
1 stop5h 30m
Greenville
Fri 6/5
6:50 pm-12:05 am
1 stop5h 15m
$406
DetroitGreenville
DTW - GSP
DTWGSP
Detroit Metropolitan Wayne County
Mon 5/4
6:00 am-12:00 pm
1 stop6h 00m
Greenville
Sun 5/10
8:00 am-12:00 pm
1 stop4h 00m
$432
DetroitGreenville
DTW - GSP
DTWGSP
Detroit Metropolitan Wayne County
Thu 6/11
6:30 am-12:15 pm
1 stop5h 45m
Greenville
Sat 6/13
6:55 am-12:40 pm
1 stop5h 45m
$437
Quickest round-trip
DetroitGreenville
DTW - GSP
DTWGSP
Detroit Metropolitan Wayne County
Sat 5/9
7:59 pm-9:38 pm
Nonstop1h 39m
Greenville
Sat 5/16
7:20 am-9:12 am
Nonstop1h 52m
$439
DetroitGreenville
DTW - GSP
DTWGSP
Detroit Metropolitan Wayne County
Sat 6/20
1:20 pm-10:50 pm
2 stops9h 30m
Greenville
Tue 6/23
12:50 pm-10:10 pm
2 stops9h 20m
$447
DetroitGreenville
DTW - GSP
DTWGSP
Detroit Metropolitan Wayne County
Sat 5/23
6:15 am-10:51 am
1 stop4h 36m
Greenville
Mon 5/25
7:20 am-9:12 am
Nonstop1h 52m
$449
DetroitGreenville
DTW - GSP
DTWGSP
Detroit Metropolitan Wayne County
Thu 5/7
7:00 am-5:50 pm
2 stops10h 50m
Greenville
Mon 5/11
1:50 pm-10:20 pm
2 stops8h 30m
$464
Cheapest one-way
DetroitGreenville
DTW - GSP
DTWGSP
Detroit Metropolitan Wayne County
Sat 5/16
4:05 pm-9:55 pm
1 stop5h 50m
$188
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Detroit to Greenville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Greenville in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit-Greenville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Greenville
Have a flexible travel schedule? Discover the best time to fly to Greenville from Detroit with our price prediction graph.
DTT-GSP
DTW-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit to Greenville
DTT-GSP
DTW-GSP
What is the cheapest month to book a flight from Detroit to Greenville?
Currently, September is the cheapest month in which you can book a flight from Detroit to Greenville (average of $109). Flying from Detroit to Greenville in December is currently the most expensive (average of $151). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DTT to GSP?
Find hourly flight availability from Detroit to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 3, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Detroit to Greenville as you normally would.
Weekly flight availability from Detroit to Greenville
Explore weekly flight availability from Detroit to Greenville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated April 3, 2026.
The most flights from DTT to GSP are scheduled on a Monday (12 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (6 on average).
How much does it cost to fly round-trip from Detroit to Greenville?
Reviews of airlines servicing Greenville
Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated April 3, 2026.
Get a feel of what it's like to fly with Southwest and Delta from Detroit to Greenville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Detroit to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Greenville?
Book flights to Greenville if you plan to visit one of these locationsGreer
Simpsonville
Duncan
Seneca
Anderson
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Greenville flight routes
Other flight options
Other flights from Detroit
Popular flights
Alternative routes for Detroit to Greenville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Greenville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Detroit to Greenville by cabin class
Find flights from Detroit to Greenville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Greenville
Explore flights to Greenville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 3, 2026.
Detroit and Greenville flights
Browse other Detroit and Greenville flight options. Last updated on April 3, 2026.
Other flights from Detroit
Browse through other flights departing from Detroit. Flights are based on user searches made on Cheapflights and were last updated on April 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Detroit to Greenville
Discover the top 3 airlines that operate flights from Detroit to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$208 | Average$316 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$293 | Average$366 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$399 | Average$513 | FlexibilityNo cancel fee | On-timeN/A |