$103+ Cheap flights from Detroit to Greenville (DTT - GSP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/6. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — GSP
Nov 8 — Nov 151
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Detroit to Greenville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Greenville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Detroit to GreenvilleExplore the most affordable flight options available from Detroit to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 9, 2026.
Explore the most affordable flight options available from Detroit to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/92:53 pm -
1 stop29h 06m
Mon 12/142:42 pm -
1 stop20h 31m
Deal found 10/5![Multiple Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2311:27 am -
1 stop20h 47m
Thu 12/310:12 am -
1 stop7h 12m
Deal found 10/6![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:41 pm -
1 stop23h 03m
Wed 11/48:24 pm -
1 stop21h 29m
Deal found 10/8![Multiple Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:25 am -
2 stops9h 04m
Tue 11/249:04 am -
1 stop10h 05m
Deal found 10/6![Multiple Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/169:19 pm -
1 stop18h 10m
Sat 11/218:47 pm -
2 stops18h 35m
Deal found 10/4![Multiple Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2311:27 am -
1 stop20h 47m
Tue 1/511:28 am -
1 stop13h 15m
Deal found 10/4![Multiple Airlines logo]()
$291
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:25 am -
1 stop4h 00m
Wed 11/47:05 am -
1 stop6h 15m
Deal found 10/8![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:10 pm -
1 stop4h 25m
Tue 11/107:05 am -
1 stop6h 15m
Deal found 10/5![Southwest logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:40 pm -
2 stops26h 48m
Wed 11/48:24 pm -
1 stop21h 29m
Deal found 10/8![Multiple Airlines logo]()
$298
Best flights from Detroit to GreenvilleDiscover carefully curated flight deals from Detroit to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 9, 2026.
Discover carefully curated flight deals from Detroit to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 9, 2026.
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:10 pm -
1 stop4h 25m
Tue 11/107:05 am -
1 stop6h 15m
Deal found 10/5![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:35 pm -
Nonstop1h 55m
Mon 12/77:10 pm -
Nonstop1h 50m
Deal found 10/8![Delta logo]()
$437
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:50 am -
2 stops9h 20m
Sat 11/2112:05 pm -
2 stops11h 05m
Deal found 10/4![Southwest logo]()
$367
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:30 am -
2 stops8h 40m
Wed 11/117:05 am -
1 stop6h 15m
Deal found 10/5![Southwest logo]()
$394
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:45 pm -
Nonstop1h 42m
Fri 11/137:20 am -
Nonstop1h 52m
Deal found 10/8![Delta logo]()
$437
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:45 pm -
Nonstop1h 42m
Tue 10/277:20 am -
Nonstop1h 47m
Deal found 10/6![Delta logo]()
$441
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:30 pm -
2 stops9h 30m
Wed 12/28:05 am -
2 stops13h 20m
Deal found 10/7![Southwest logo]()
$407
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:45 pm -
Nonstop1h 42m
Sun 11/87:20 am -
Nonstop1h 47m
Deal found 10/6![Delta logo]()
$441
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:30 pm -
1 stop6h 40m
Mon 11/96:40 am -
1 stop6h 05m
Deal found 10/7![Southwest logo]()
$420
This Delta deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:45 pm -
Nonstop1h 42m
Tue 10/207:20 am -
Nonstop1h 47m
Deal found 10/4![Delta logo]()
$441
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/215:15 am -
1 stop4h 45m
Mon 12/288:05 am -
1 stop4h 00m
Deal found 10/7![Southwest logo]()
$431
Last-minute flights from Detroit to GreenvilleDiscover last-minute flight deals from Detroit to Greenville. Data last updated October 9, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Greenville. Data last updated October 9, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:41 pm -
1 stop23h 03m
Wed 11/48:24 pm -
1 stop21h 29m
Deal found 10/8![Multiple Airlines logo]()
$274
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:25 am -
1 stop4h 00m
Wed 11/47:05 am -
1 stop6h 15m
Deal found 10/8![Southwest logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:40 pm -
2 stops26h 48m
Wed 11/48:24 pm -
1 stop21h 29m
Deal found 10/8![Multiple Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/31:25 pm -
1 stop4h 45m
Thu 11/51:00 pm -
1 stop10h 55m
Deal found 10/8![Southwest logo]()
$300
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:10 pm -
1 stop4h 25m
Tue 11/107:05 am -
1 stop6h 15m
Deal found 10/5![Southwest logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/169:19 pm -
1 stop18h 10m
Sat 11/218:47 pm -
2 stops18h 35m
Deal found 10/4![Multiple Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:25 am -
2 stops9h 04m
Tue 11/249:04 am -
1 stop10h 05m
Deal found 10/6![Multiple Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2311:27 am -
1 stop20h 47m
Thu 12/310:12 am -
1 stop7h 12m
Deal found 10/6![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2311:27 am -
1 stop20h 47m
Tue 1/511:28 am -
1 stop13h 15m
Deal found 10/4![Multiple Airlines logo]()
$291
One-way flights from Detroit to GreenvilleSearch for one-way flight options from Detroit to Greenville. Find affordable one-way fares based on user searches. Data last updated October 9, 2026.
Search for one-way flight options from Detroit to Greenville. Find affordable one-way fares based on user searches. Data last updated October 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/610:08 am -
1 stop28h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Multiple Airlines logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/910:07 am -
2 stops29h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/69:33 pm -
1 stop10h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Multiple Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:50 am -
1 stop25h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:30 am -
1 stop7h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$124
Find flight deals from Detroit to Greenville
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $234 (Kiwi.com) |
One-way from | $103 (Kiwi.com) |
Popular in | March |
Cheapest in | February |
Average price | $399 |
Good round-trip deal | $447 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 9, 2026.
Use the filters below to find and compare flights from Detroit to Greenville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitGreenville
DTW Detroit Metropolitan Wayne County - GSP Greenville
DTWGSP
Detroit Metropolitan Wayne County
Wed 1/6
10:50 am-9:32 am
2 stops22h 42m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$140
DetroitGreenville
DTW Detroit Metropolitan Wayne County - GSP Greenville
DTWGSP
Detroit Metropolitan Wayne County
Sat 10/31
11:25 am-3:25 pm
1 stop4h 00m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$149
DetroitGreenville
DTW Detroit Metropolitan Wayne County - GSP Greenville
DTWGSP
Detroit Metropolitan Wayne County
Sat 12/5
9:00 am-7:30 pm
2 stops10h 30m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$154
DetroitGreenville
DTW Detroit Metropolitan Wayne County - GSP Greenville
DTWGSP
Detroit Metropolitan Wayne County
Fri 12/4
8:50 am-7:50 pm
2 stops11h 00m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$195
DetroitGreenville
DTW Detroit Metropolitan Wayne County - GSP Greenville
DTWGSP
Detroit Metropolitan Wayne County
Sun 10/11
6:05 am-12:20 pm
1 stop6h 15m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$231
DetroitGreenville
DTW Detroit Metropolitan Wayne County - GSP Greenville
DTWGSP
Detroit Metropolitan Wayne County
Tue 10/13
7:00 am-12:40 pm
2 stops5h 40m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$236
DetroitGreenville
DTW Detroit Metropolitan Wayne County - GSP Greenville
DTWGSP
Detroit Metropolitan Wayne County
Mon 10/12
2:45 pm-10:50 pm
2 stops8h 05m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$285
DetroitGreenville
DTW Detroit Metropolitan Wayne County - GSP Greenville
DTWGSP
Detroit Metropolitan Wayne County
Sat 11/7
3:10 pm-7:35 pm
1 stop4h 25m
Greenville
Tue 11/10
7:05 am-1:20 pm
1 stop6h 15m
$297
DetroitGreenville
DTW Detroit Metropolitan Wayne County - GSP Greenville
DTWGSP
Detroit Metropolitan Wayne County
Tue 11/10
7:25 am-3:45 pm
1 stop8h 20m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$307
Quickest round-trip
DetroitGreenville
DTW Detroit Metropolitan Wayne County - GSP Greenville
DTWGSP
Detroit Metropolitan Wayne County
Wed 1/6
3:55 pm-5:41 pm
Nonstop1h 46m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$319
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Detroit to Greenville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Greenville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit-Greenville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Greenville
Have a flexible travel schedule? Discover the best time to fly to Greenville from Detroit with our price prediction graph.
DTT-GSP
DTW-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit to Greenville
DTT-GSP
DTW-GSP
What is the cheapest month to book a flight from Detroit to Greenville?
Currently, February is the cheapest month in which you can book a flight from Detroit to Greenville (average of $390). Flying from Detroit to Greenville in January is currently the most expensive (average of $693). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DTT to GSP?
Find hourly flight availability from Detroit to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 9, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Detroit to Greenville as you normally would.
Weekly flight availability from Detroit to Greenville
Explore weekly flight availability from Detroit to Greenville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated October 9, 2026.
The most flights from DTT to GSP are scheduled on a Tuesday (12 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (3 on average).
Reviews of airlines servicing Greenville
Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated October 9, 2026.
Get a feel of what it's like to fly with Delta from Detroit to Greenville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.8
Overall
7.8
Food
7.2
Crew
8.5
Comfort
7.8
Reviews
1 / 20
4.0
OkayLaura,Aug 2023
DTW - BOS
Boarding
8.1
Entertainment
7.8
Overall
7.8
Food
7.2
Crew
8.5
Comfort
7.8
Reviews
1 / 20
4.0
OkayLaura,Aug 2023
DTW - BOS
Related info for your journey
Find useful and relevant information for your journey from Detroit to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Greenville?
Book flights to Greenville if you plan to visit one of these locationsGreer
Simpsonville
Greenwood
Duncan
Anderson
Seneca
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Greenville flight routes
Other flight options
Other flights from Detroit
Popular flights
Alternative routes for Detroit to Greenville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Greenville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Detroit to Greenville by cabin class
Find flights from Detroit to Greenville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Greenville
Explore flights to Greenville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 9, 2026.
Detroit and Greenville flights
Browse other Detroit and Greenville flight options. Last updated on October 9, 2026.
Other flights from Detroit
Browse through other flights departing from Detroit. Flights are based on user searches made on Cheapflights and were last updated on October 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Detroit to Greenville
Discover the top 2 airlines that operate flights from Detroit to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$271 | Average$391 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$399 | Average$508 | FlexibilityNo cancel fee | On-timeN/A |